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经动脉灌注5-FU缓释微球治疗兔VX2肝肿瘤 被引量:2
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作者 关键 胡道予 +2 位作者 卢凌 徐涛 潘初 《介入放射学杂志》 CSCD 2008年第11期799-802,共4页
目的研究5-FU缓释微球经胃十二指肠动脉灌注对兔VX2肝肿瘤的治疗作用。方法将成功接种肝VX2肿瘤的模型兔随机分成4组,每组10只,用显微外科手术临时阻断肝总动脉血流,经胃十二指肠动脉插管至肝固有动脉起始部给药行介入治疗,术毕结扎胃... 目的研究5-FU缓释微球经胃十二指肠动脉灌注对兔VX2肝肿瘤的治疗作用。方法将成功接种肝VX2肿瘤的模型兔随机分成4组,每组10只,用显微外科手术临时阻断肝总动脉血流,经胃十二指肠动脉插管至肝固有动脉起始部给药行介入治疗,术毕结扎胃十二指肠动脉。A组(生理盐水对照组),注射生理盐水0.5~1ml;B组(碘佛醇对照组)注射碘佛醇0.5~1ml;C组为碘油组(疗效对比组),注射超液化碘油0.5~1.0ml;D组为5-FU缓释微球组,注射5-FU缓释微球10mg和碘佛醇1ml混合溶液。4组实验动物于治疗1周后观察肿瘤生长情况、坏死程度,并采用原位末端标记法(TUNEL)检测肿瘤细胞凋亡指数(AI)。结果治疗1周后5-FU缓释微球组肿瘤生长受到抑制,肿瘤生长率低于生理盐水对照组和碘佛醇对照组(P﹤0.05),与碘油组差异无统计学意义(P>0.05)。4组肿瘤均有不同程度坏死,5-FU缓释微球组和碘油组肿瘤坏死率明显高于另两组(P<0.05)。生理盐水对照组、碘佛醇对照组和5-FU缓释微球组肿瘤细胞凋亡指数分别为1.69±0.18、1.75±0.27和8.03±0.63,5-FU缓释微球组与各对照组相比差异有统计学意义(P<0.05)。结论5-FU缓释微球经动脉灌注可抑制肝肿瘤生长,诱导肿瘤细胞凋亡,促进肿瘤坏死,是有效的化疗栓塞剂。 展开更多
关键词 肝肿瘤 VX2肿瘤 缓释微球 凋亡 化疗栓塞
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Expression Profiles of TRAIL Receptors and Their Clinical Significance in Human Hepatocellular Carcinoma 被引量:1
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作者 何松青 陈孝平 +4 位作者 赵永忠 张万广 王海平 杨彩虹 王少发 《The Chinese-German Journal of Clinical Oncology》 CAS 2003年第1期25-29,59,共6页
Objective To investigate the expression profiles and their clinical significance of TRAIL receptors (TRAILR) in human hepatocellular carcinoma (HCC). Methods The expression profiles of TRAILR were determined in 60 s... Objective To investigate the expression profiles and their clinical significance of TRAIL receptors (TRAILR) in human hepatocellular carcinoma (HCC). Methods The expression profiles of TRAILR were determined in 60 samples from hepatocellular carcinoma, 20 from normal liver tissue and two HCC cell lines HepG2, SMMC-7721 by in situ hybridization. Results Both DR4 and DR5 were present in all HCC tissues as well as normal hepatic tissues. In contrast, 54 HCC tissues did not express DcR1 and 25 did not express DcR2. But both DcR were detectable in all of the normal liver tissues. The expression patterns of DR and DcR in HCC samples (higher DR expression level and lower DcR expression level) were quite different from those in normal tissue. DR5, DR4, and DcR2 expressed in both cell lines, while no DcR1 expression was detected. The expression level of DR was correlated with HCC differentiation and stage. The weaker expression was more commonly found in HCC with poor differentiation and late stage, while the stronger expression was more common in HCC with middle to high-differentiation and early stage. No relationship was found between DR and gender, age, negative or positive HBsAg, tumor size, grade or metastasis. Multidrug resistance cell lines expressed lower level DR. Conclusion TRAILR expression was prevalent and discrepancy of receptor types was exited in HCC. Loss of DcR1 may contribute for TRAIL therapy for HCC. Key words TRAILR - apoptosis - hepatocellular carcinoma Supported by the Major Fundation of Ministry of Health, NO. 2001–2003 展开更多
关键词 TRAILR APOPTOSIS hepatocellular carcinoma
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Studies on the Relationship between Multidrug Resistance 1 Gene and Pancreatic Cancer
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作者 王百林 肖震宇 +1 位作者 陈孝平 翟淑萍 《The Chinese-German Journal of Clinical Oncology》 CAS 2004年第1期15-19,64,65,共7页
Objective: To study the relationship between the expressions of multidrug-resistance, 1 (mdr1) gene-coded mRNA and its product P-glycoprotein (P-gp) and biological characteristics of tumor cells in ... Objective: To study the relationship between the expressions of multidrug-resistance, 1 (mdr1) gene-coded mRNA and its product P-glycoprotein (P-gp) and biological characteristics of tumor cells in patients with previously untreated primary pancreatic cancer (PC) for guiding signi?cance to the clinical treatment. Methods: Expression of mdr1 mRNA and P-gp on para?n embedded sections was detected by in situ polymerase chain reaction (ISPCR) and immunohistochemistry correspondingly from 150 cases of normal and abnormal pancreatic tissues including 97, 32 and 21 cases of pancreatic cancer, pancreatitis and normal pancreatic tissues respectively. Results: Distributions of positive staining in mdr1 mRNA and P-gp were mainly found on the apical plasma membranes and in cytoplasms of endothelial duct cells in tumor and normal tissues. The positive staining rates of expression of the mdr1 mRNA and P-gp detected in all pancreatic tumors were signi?cantly higher than that in pancreatitis and normal tissues correspondingly (P <0.05). Moreover, higher expressions of mdr1 mRNA and P-gp in tumor cells were correlated with some biological characteristics of PC, such as the degree of di?erentiation, aggressiveness and TNM stage of tumors (P <0.05). However, there was no correlation between the rate of expression of mdr1 mRNA and P-gp and some clinical ?ndings including age, sex, location and tumor size. Conclusion: The expression of mdr1 gene was associated with “natural” multi-drug resistance in PC. There was an important guiding signi?cance between the detection of expression of mdr1 gene and prediction of the sensitivity to chemotherapy of PC. Meanwhile, it probably could be used as one of profoundly parameters to assess the degrees of di?erentiation and prognosis in PC. 展开更多
关键词 pancreatic neoplasm multidrug-resistence 1 gene EXPRESSION
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