采用反相高效液相色谱法测定了正常人单剂量口服川芎单煎剂后体内阿魏酸(FA)的经时浓度。汤剂中 FA 含量为0.7895±0.0090mg/g(川芎生药量),给药剂量为1g(川芎生药量)/kg,药代动力学参数值为:Ka=0.0912±0.0494/min;Ke=0.0605&#...采用反相高效液相色谱法测定了正常人单剂量口服川芎单煎剂后体内阿魏酸(FA)的经时浓度。汤剂中 FA 含量为0.7895±0.0090mg/g(川芎生药量),给药剂量为1g(川芎生药量)/kg,药代动力学参数值为:Ka=0.0912±0.0494/min;Ke=0.0605±0.0118/min;t_(1/2)(Ka)=7.6028±1.0736min;t_(1/2)(Ke)=11.4604±3.2316min;T(peak)=17.7491±1.1418min;C(max)=334.6694±58.8826ng/ml;AUC=12423.6211±4446.6597(ng/ml)min;CL/F(s)=0.0036±0.0013mg/min(ng/ml);V/F(c)=0.0586±0.0183mg/(ng/ml)。结果表明 FA 的体内分布和代谢符合单室模型。展开更多
文摘采用反相高效液相色谱法测定了正常人单剂量口服川芎单煎剂后体内阿魏酸(FA)的经时浓度。汤剂中 FA 含量为0.7895±0.0090mg/g(川芎生药量),给药剂量为1g(川芎生药量)/kg,药代动力学参数值为:Ka=0.0912±0.0494/min;Ke=0.0605±0.0118/min;t_(1/2)(Ka)=7.6028±1.0736min;t_(1/2)(Ke)=11.4604±3.2316min;T(peak)=17.7491±1.1418min;C(max)=334.6694±58.8826ng/ml;AUC=12423.6211±4446.6597(ng/ml)min;CL/F(s)=0.0036±0.0013mg/min(ng/ml);V/F(c)=0.0586±0.0183mg/(ng/ml)。结果表明 FA 的体内分布和代谢符合单室模型。
