Objective To observe changes of plain MR T1WI signal intensity of dentate nucleus in nasopharyngeal carcinoma patients after radiotherapy and multiple times of intravenous injection of gadolinium-based contrast agent(...Objective To observe changes of plain MR T1WI signal intensity of dentate nucleus in nasopharyngeal carcinoma patients after radiotherapy and multiple times of intravenous injection of gadolinium-based contrast agent(GBCA).Methods Fifty patients with pathologically confirmed nasopharyngeal carcinoma and received intensity-modulated radiotherapy were retrospectively enrolled as the nasopharyngeal carcinoma group,and 50 patients with other malignant tumors and without history of brain radiotherapy were retrospectively enrolled as the control group.All patients received yearly GBCA enhanced MR examinations for the nasopharynx or the head.T1WI signal intensities of the dentate nucleus and the pons on same plane were measured based on images in the year of confirmed diagnosis(recorded as the first year)and in the second to the fifth years.T1WI signal intensity ratio of year i(ranging from 1 to 5)was calculated with values of dentate nucleus divided by values of the pons(ΔSI i),while the percentage of relative changes of year j(ranging from 2 to 5)was calculated withΔSI j compared toΔSI 1(Rchange j).The values of these two parameters were compared,and the correlation ofΔSI and GBCA injection year-time was evaluated within each group.Results No significant difference of gender,age norΔSI 1 was found between groups(all P>0.05).The second to the fifth yearΔSI and Rchange in nasopharyngeal carcinoma group were all higher than those in control group(all P<0.05).Within both groups,ΔSI was positively correlated with GBCA injection year-time(both P<0.05).Conclusion Patients with nasopharyngeal carcinoma who underwent radiotherapy and multiple times of intravenous injection of GBCA tended to be found with gradually worsening GBCA deposition in dentate nucleus,for which radiotherapy might be a risk factor.展开更多
目的:探讨基于影像组学的多参数MRI定量指标在膀胱癌肌层浸润分析中的价值。方法:回顾性收集符合纳入标准的膀胱癌患者225例,其中非肌层浸润性膀胱癌125例,肌层浸润性膀胱癌100例。在MR T2WI、DWI及增强图像上测量肿瘤-壁界面,并运用影...目的:探讨基于影像组学的多参数MRI定量指标在膀胱癌肌层浸润分析中的价值。方法:回顾性收集符合纳入标准的膀胱癌患者225例,其中非肌层浸润性膀胱癌125例,肌层浸润性膀胱癌100例。在MR T2WI、DWI及增强图像上测量肿瘤-壁界面,并运用影像组学软件对肿瘤区域进行勾画及特征筛选,然后基于3组特征的概率值构建单参数及多参数联合模型,选择最优概率值与肿瘤-壁界面构建诺模图模型,在外部验证集中测试其诊断性能。ROC曲线及校准曲线对模型准确性进行评估。结果:最终选用基于6个特征的多参数联合概率值,与肿瘤-壁界面联合构建Nomogram模型,在ROC曲线上训练集和测试集曲线下面积(Area under curve,AUC)分别为0.892、0.875,表现出良好的诊断性能,较单独的组学模型或肿瘤-壁界面模型有更好的准确性。外部验证模型的AUC为0.846,进一步证明该模型有较好的预测性能。结论:基于多参数MRI和肿瘤-壁界面构建的Nomogram模型在膀胱癌是否有肌层浸润的鉴别上具有较好的诊断性能及可重复性,可以协助临床医生做出有效评估。展开更多
文摘Objective To observe changes of plain MR T1WI signal intensity of dentate nucleus in nasopharyngeal carcinoma patients after radiotherapy and multiple times of intravenous injection of gadolinium-based contrast agent(GBCA).Methods Fifty patients with pathologically confirmed nasopharyngeal carcinoma and received intensity-modulated radiotherapy were retrospectively enrolled as the nasopharyngeal carcinoma group,and 50 patients with other malignant tumors and without history of brain radiotherapy were retrospectively enrolled as the control group.All patients received yearly GBCA enhanced MR examinations for the nasopharynx or the head.T1WI signal intensities of the dentate nucleus and the pons on same plane were measured based on images in the year of confirmed diagnosis(recorded as the first year)and in the second to the fifth years.T1WI signal intensity ratio of year i(ranging from 1 to 5)was calculated with values of dentate nucleus divided by values of the pons(ΔSI i),while the percentage of relative changes of year j(ranging from 2 to 5)was calculated withΔSI j compared toΔSI 1(Rchange j).The values of these two parameters were compared,and the correlation ofΔSI and GBCA injection year-time was evaluated within each group.Results No significant difference of gender,age norΔSI 1 was found between groups(all P>0.05).The second to the fifth yearΔSI and Rchange in nasopharyngeal carcinoma group were all higher than those in control group(all P<0.05).Within both groups,ΔSI was positively correlated with GBCA injection year-time(both P<0.05).Conclusion Patients with nasopharyngeal carcinoma who underwent radiotherapy and multiple times of intravenous injection of GBCA tended to be found with gradually worsening GBCA deposition in dentate nucleus,for which radiotherapy might be a risk factor.
文摘目的:探讨基于影像组学的多参数MRI定量指标在膀胱癌肌层浸润分析中的价值。方法:回顾性收集符合纳入标准的膀胱癌患者225例,其中非肌层浸润性膀胱癌125例,肌层浸润性膀胱癌100例。在MR T2WI、DWI及增强图像上测量肿瘤-壁界面,并运用影像组学软件对肿瘤区域进行勾画及特征筛选,然后基于3组特征的概率值构建单参数及多参数联合模型,选择最优概率值与肿瘤-壁界面构建诺模图模型,在外部验证集中测试其诊断性能。ROC曲线及校准曲线对模型准确性进行评估。结果:最终选用基于6个特征的多参数联合概率值,与肿瘤-壁界面联合构建Nomogram模型,在ROC曲线上训练集和测试集曲线下面积(Area under curve,AUC)分别为0.892、0.875,表现出良好的诊断性能,较单独的组学模型或肿瘤-壁界面模型有更好的准确性。外部验证模型的AUC为0.846,进一步证明该模型有较好的预测性能。结论:基于多参数MRI和肿瘤-壁界面构建的Nomogram模型在膀胱癌是否有肌层浸润的鉴别上具有较好的诊断性能及可重复性,可以协助临床医生做出有效评估。
