Toll样受体(TLRs)是一种I型跨膜蛋白,作为一种模式识别受体,可以诱导天然免疫。近年来,TLRs在神经系统相关疾病中的作用受到了人们广泛的关注,大量的研究表明,TLRs介导的神经炎症反应在脑血管疾病、神经退行性疾病以及中枢脱髓鞘疾病中...Toll样受体(TLRs)是一种I型跨膜蛋白,作为一种模式识别受体,可以诱导天然免疫。近年来,TLRs在神经系统相关疾病中的作用受到了人们广泛的关注,大量的研究表明,TLRs介导的神经炎症反应在脑血管疾病、神经退行性疾病以及中枢脱髓鞘疾病中有着重要的作用。故本文就其在几种较为典型的神经系统疾病中的研究进展做一综述,以期为相关领域研究提供参考。Toll-like receptors (TLRs) are a type I transmembrane protein that acts as a pattern recognition receptor and can induce innate immunity. In recent years, the role of TLRs in nervous system-related diseases has received extensive attention. A large number of studies have shown that TLRs mediated neuroinflammatory response plays an important role in cerebrovascular diseases, neurodegenerative diseases and central demyelinating diseases. Therefore, this article reviews the research progress in several typical nervous system diseases in order to provide reference for the research in related fields.展开更多
文摘Toll样受体(TLRs)是一种I型跨膜蛋白,作为一种模式识别受体,可以诱导天然免疫。近年来,TLRs在神经系统相关疾病中的作用受到了人们广泛的关注,大量的研究表明,TLRs介导的神经炎症反应在脑血管疾病、神经退行性疾病以及中枢脱髓鞘疾病中有着重要的作用。故本文就其在几种较为典型的神经系统疾病中的研究进展做一综述,以期为相关领域研究提供参考。Toll-like receptors (TLRs) are a type I transmembrane protein that acts as a pattern recognition receptor and can induce innate immunity. In recent years, the role of TLRs in nervous system-related diseases has received extensive attention. A large number of studies have shown that TLRs mediated neuroinflammatory response plays an important role in cerebrovascular diseases, neurodegenerative diseases and central demyelinating diseases. Therefore, this article reviews the research progress in several typical nervous system diseases in order to provide reference for the research in related fields.
