脊髓损伤(SCI)是一种严重的神经系统疾病,通常会导致长期的功能丧失和生活质量的下降。尽管现代医学在治疗该病方面已取得一定进展,但临床效果仍然有限。近年来,人们对脊髓损伤后免疫系统的反应越来越关注,特别是巨噬细胞在修复过程中...脊髓损伤(SCI)是一种严重的神经系统疾病,通常会导致长期的功能丧失和生活质量的下降。尽管现代医学在治疗该病方面已取得一定进展,但临床效果仍然有限。近年来,人们对脊髓损伤后免疫系统的反应越来越关注,特别是巨噬细胞在修复过程中的作用。巨噬细胞能够表现出不同的极化状态,其中M2型巨噬细胞在抗炎、促进修复和组织再生方面发挥着重要作用。本文回顾了M2型巨噬细胞在脊髓损伤中的作用机制及相关研究,探讨了其在改善炎症反应、促进神经保护与修复中新型技术应用的潜力,并评估了其作为临床治疗策略的前景。Spinal cord injury (SCI) is a severe neurological condition that often results in long-term functional loss and a decline in quality of life. Although significant progress has been made in the treatment of SCI through modern medicine, clinical outcomes remain limited. In recent years, there has been increasing attention on the immune system’s response following spinal cord injury, particularly the role of macrophages in the repair process. Macrophages can exhibit different polarization states, with M2 macrophages playing a key role in anti-inflammatory responses, promoting repair, and facilitating tissue regeneration. This review explores the mechanisms underlying the role of M2 macrophages in spinal cord injury, discusses the potential of novel technologies in improving inflammation, neuroprotection, and repair, and evaluates their prospects as a clinical therapeutic strategy.展开更多
目的采用文献计量学方法分析聚甲基丙烯酸甲酯(PMMA)骨水泥相关研究的发文量、发文国家、研究机构、发文期刊、作者和关键词,探究PMMA骨水泥的研究现状及研究热点。方法以Web of Science核心合集数据库为数据来源,基于CiteSpace软件和...目的采用文献计量学方法分析聚甲基丙烯酸甲酯(PMMA)骨水泥相关研究的发文量、发文国家、研究机构、发文期刊、作者和关键词,探究PMMA骨水泥的研究现状及研究热点。方法以Web of Science核心合集数据库为数据来源,基于CiteSpace软件和文献计量学在线分析平台对纳入的文献数据进行处理和可视化分析。结果共纳入1951篇文献,美国是发文量(444篇)和中心性(0.43)均位居第一的国家。发文量排名前3位的研究机构是瑞士伯尔尼大学(39篇)、瑞士AO基金会(34篇)、中国台湾长庚纪念医院(34篇)和中国苏州大学(33篇)。关键词突现分析中突现程度最高的关键词是全髋关节置换术(突现强度为15.28)。结论PMMA骨水泥研究主要集中于骨水泥临床使用适应证和材料性能改性研究,我国在该领域研究形成了科研能力较强的研究团队,但还需注重研究的深度和广度,加强国际合作。展开更多
文摘脊髓损伤(SCI)是一种严重的神经系统疾病,通常会导致长期的功能丧失和生活质量的下降。尽管现代医学在治疗该病方面已取得一定进展,但临床效果仍然有限。近年来,人们对脊髓损伤后免疫系统的反应越来越关注,特别是巨噬细胞在修复过程中的作用。巨噬细胞能够表现出不同的极化状态,其中M2型巨噬细胞在抗炎、促进修复和组织再生方面发挥着重要作用。本文回顾了M2型巨噬细胞在脊髓损伤中的作用机制及相关研究,探讨了其在改善炎症反应、促进神经保护与修复中新型技术应用的潜力,并评估了其作为临床治疗策略的前景。Spinal cord injury (SCI) is a severe neurological condition that often results in long-term functional loss and a decline in quality of life. Although significant progress has been made in the treatment of SCI through modern medicine, clinical outcomes remain limited. In recent years, there has been increasing attention on the immune system’s response following spinal cord injury, particularly the role of macrophages in the repair process. Macrophages can exhibit different polarization states, with M2 macrophages playing a key role in anti-inflammatory responses, promoting repair, and facilitating tissue regeneration. This review explores the mechanisms underlying the role of M2 macrophages in spinal cord injury, discusses the potential of novel technologies in improving inflammation, neuroprotection, and repair, and evaluates their prospects as a clinical therapeutic strategy.
基金National Key Research and Development Program of China(2021YFB3800800)National Natural Science Foundation of China(32000960)Shanghai Science and Technology Innovation Action Plan(22S31906500)。
文摘目的采用文献计量学方法分析聚甲基丙烯酸甲酯(PMMA)骨水泥相关研究的发文量、发文国家、研究机构、发文期刊、作者和关键词,探究PMMA骨水泥的研究现状及研究热点。方法以Web of Science核心合集数据库为数据来源,基于CiteSpace软件和文献计量学在线分析平台对纳入的文献数据进行处理和可视化分析。结果共纳入1951篇文献,美国是发文量(444篇)和中心性(0.43)均位居第一的国家。发文量排名前3位的研究机构是瑞士伯尔尼大学(39篇)、瑞士AO基金会(34篇)、中国台湾长庚纪念医院(34篇)和中国苏州大学(33篇)。关键词突现分析中突现程度最高的关键词是全髋关节置换术(突现强度为15.28)。结论PMMA骨水泥研究主要集中于骨水泥临床使用适应证和材料性能改性研究,我国在该领域研究形成了科研能力较强的研究团队,但还需注重研究的深度和广度,加强国际合作。
