神经胶质细胞在神经系统中扮演着重要角色,在广泛的认知中,神经胶质细胞起到了支持、运输营养物质,修复神经元,维持离子平衡,调节神经递质代谢等作用。对维持神经元周围局部微环境的稳定、实现神经元的功能具有重要意义。近年来,神经胶...神经胶质细胞在神经系统中扮演着重要角色,在广泛的认知中,神经胶质细胞起到了支持、运输营养物质,修复神经元,维持离子平衡,调节神经递质代谢等作用。对维持神经元周围局部微环境的稳定、实现神经元的功能具有重要意义。近年来,神经胶质细胞的生理功能及其在脑疾病中的重要作用逐渐得到广泛深入的研究。对睡眠的研究以往多集中在神经元上,近年来睡眠或者睡眠障碍与神经胶质的关系受到了诸多关注,本文就神经胶质细胞对维持昼夜节律以及服务于睡眠功能的相关性进行综述。Neuroglial cells play an important role in the nervous system, and in a wide range of perceptions, neuroglial cells play a role in supporting and transporting nutrients, repairing neurons, maintaining ionic homeostasis, and regulating neurotransmitter metabolism. It is important for maintaining the stability of the local microenvironment around neurons and realizing the function of neurons. In recent years, the physiological functions of neuroglia and their important role in brain diseases have gradually been widely and deeply studied. Research on sleep used to focus on neurons, but in recent years, the relationship between sleep or sleep disorders and neuroglia has received much attention, and this paper reviews the relevance of neuroglia to the maintenance of circadian rhythms and the service of sleep function.展开更多
免疫原性细胞死亡(immunogenic cell death, ICD)在肝癌的治疗中有重要作用。机体发生ICD时,细胞分泌多种损伤相关分子模式(damage-associated molecular patterns, DAMPs),包括三磷酸腺苷(adenosine triphosphate, ATP)、钙网蛋白(calr...免疫原性细胞死亡(immunogenic cell death, ICD)在肝癌的治疗中有重要作用。机体发生ICD时,细胞分泌多种损伤相关分子模式(damage-associated molecular patterns, DAMPs),包括三磷酸腺苷(adenosine triphosphate, ATP)、钙网蛋白(calreticulin, CRT)、高迁移率族蛋白B1 (high mobility group box protein B1, HMGB1)、热休克蛋白(heat shock protein, HSP)和干扰素(Interferon, IFN)等。DAMPs通过各种模式识别受体吸引自然杀伤细胞、巨噬细胞、树突状细胞等免疫细胞,并促进其成熟、活化从而增强抗肿瘤免疫反应。目前诱导ICD治疗肝癌主要通过药物方式(化疗药物、靶向药物等)、生物方式(溶瘤病毒)及物理方式(纳米脉冲刺激、光动力疗法等)。本文就ICD的相关分子及在肝癌治疗中的研究进展作一综述,以期在临床上为肝癌患者的治疗提供一些有益参考。Immunogenic cell death (ICD) has an important role in the treatment of hepatocellular carcinoma. When ICD occurs in the body, cells secrete various damage-associated molecular patterns (DAMPs), and the major DAMPs include adenosine triphosphate (ATP), calreticulin (CRT), high mobility group box protein B1 (HMGB1), heat shock protein (HSP), and interferon (IFN), etc. DAMPs attract natural killer cells, macrophages, dendritic cells and other immune cells through various pattern recognition receptors, and promote their maturation and activation to enhance anti-tumor immune responses. Currently, the induction of ICD in hepatocellular carcinoma treatment is mainly done by pharmacological (chemotherapeutic drugs, targeted drugs, etc.), biological (oncolytic viruses), and physical (nano-pulse stimulation, photodynamic therapy, etc.) modalities. In this article, we present a review of the important molecules related to ICD and the research progress of induced ICD in hepatocellular carcinoma treatment, in order to help design more effective and precise strategies to treat hepatocellular carcinoma in the future.展开更多
近些年,早发性结直肠癌(early-onset colorectal cancer, EOCRC)的发病率逐年上升。虽然目前其发病机制尚未完全明确,但与其相关潜在的危险因素,例如生活方式、饮食习惯、遗传易感性及肠道菌群的影响等逐渐被各项研究报道。本文通过回...近些年,早发性结直肠癌(early-onset colorectal cancer, EOCRC)的发病率逐年上升。虽然目前其发病机制尚未完全明确,但与其相关潜在的危险因素,例如生活方式、饮食习惯、遗传易感性及肠道菌群的影响等逐渐被各项研究报道。本文通过回顾国内外相关文献报道,对EOCRC的相关危险因素、预防做一综述,以提高人群对于EOCRC的预防意识,从而降低疾病的发生率。In recent years, the incidence rate of early-onset colorectal cancer (EOCRC) has increased year by year. Although its pathogenesis is not yet fully pinpointed, potential risk factors related to it, such as lifestyle, dietary habits, genetic susceptibility, and the influence of gut microbiota, have gradually been reported in various studies. This article reviews relevant literature reports at home and abroad to provide a review of the risk factors and prevention of EOCRC, in order to enhance the population’s awareness of EOCRC prevention, and thereby reduce the incidence of the disease.展开更多
文摘神经胶质细胞在神经系统中扮演着重要角色,在广泛的认知中,神经胶质细胞起到了支持、运输营养物质,修复神经元,维持离子平衡,调节神经递质代谢等作用。对维持神经元周围局部微环境的稳定、实现神经元的功能具有重要意义。近年来,神经胶质细胞的生理功能及其在脑疾病中的重要作用逐渐得到广泛深入的研究。对睡眠的研究以往多集中在神经元上,近年来睡眠或者睡眠障碍与神经胶质的关系受到了诸多关注,本文就神经胶质细胞对维持昼夜节律以及服务于睡眠功能的相关性进行综述。Neuroglial cells play an important role in the nervous system, and in a wide range of perceptions, neuroglial cells play a role in supporting and transporting nutrients, repairing neurons, maintaining ionic homeostasis, and regulating neurotransmitter metabolism. It is important for maintaining the stability of the local microenvironment around neurons and realizing the function of neurons. In recent years, the physiological functions of neuroglia and their important role in brain diseases have gradually been widely and deeply studied. Research on sleep used to focus on neurons, but in recent years, the relationship between sleep or sleep disorders and neuroglia has received much attention, and this paper reviews the relevance of neuroglia to the maintenance of circadian rhythms and the service of sleep function.
文摘免疫原性细胞死亡(immunogenic cell death, ICD)在肝癌的治疗中有重要作用。机体发生ICD时,细胞分泌多种损伤相关分子模式(damage-associated molecular patterns, DAMPs),包括三磷酸腺苷(adenosine triphosphate, ATP)、钙网蛋白(calreticulin, CRT)、高迁移率族蛋白B1 (high mobility group box protein B1, HMGB1)、热休克蛋白(heat shock protein, HSP)和干扰素(Interferon, IFN)等。DAMPs通过各种模式识别受体吸引自然杀伤细胞、巨噬细胞、树突状细胞等免疫细胞,并促进其成熟、活化从而增强抗肿瘤免疫反应。目前诱导ICD治疗肝癌主要通过药物方式(化疗药物、靶向药物等)、生物方式(溶瘤病毒)及物理方式(纳米脉冲刺激、光动力疗法等)。本文就ICD的相关分子及在肝癌治疗中的研究进展作一综述,以期在临床上为肝癌患者的治疗提供一些有益参考。Immunogenic cell death (ICD) has an important role in the treatment of hepatocellular carcinoma. When ICD occurs in the body, cells secrete various damage-associated molecular patterns (DAMPs), and the major DAMPs include adenosine triphosphate (ATP), calreticulin (CRT), high mobility group box protein B1 (HMGB1), heat shock protein (HSP), and interferon (IFN), etc. DAMPs attract natural killer cells, macrophages, dendritic cells and other immune cells through various pattern recognition receptors, and promote their maturation and activation to enhance anti-tumor immune responses. Currently, the induction of ICD in hepatocellular carcinoma treatment is mainly done by pharmacological (chemotherapeutic drugs, targeted drugs, etc.), biological (oncolytic viruses), and physical (nano-pulse stimulation, photodynamic therapy, etc.) modalities. In this article, we present a review of the important molecules related to ICD and the research progress of induced ICD in hepatocellular carcinoma treatment, in order to help design more effective and precise strategies to treat hepatocellular carcinoma in the future.
文摘近些年,早发性结直肠癌(early-onset colorectal cancer, EOCRC)的发病率逐年上升。虽然目前其发病机制尚未完全明确,但与其相关潜在的危险因素,例如生活方式、饮食习惯、遗传易感性及肠道菌群的影响等逐渐被各项研究报道。本文通过回顾国内外相关文献报道,对EOCRC的相关危险因素、预防做一综述,以提高人群对于EOCRC的预防意识,从而降低疾病的发生率。In recent years, the incidence rate of early-onset colorectal cancer (EOCRC) has increased year by year. Although its pathogenesis is not yet fully pinpointed, potential risk factors related to it, such as lifestyle, dietary habits, genetic susceptibility, and the influence of gut microbiota, have gradually been reported in various studies. This article reviews relevant literature reports at home and abroad to provide a review of the risk factors and prevention of EOCRC, in order to enhance the population’s awareness of EOCRC prevention, and thereby reduce the incidence of the disease.
