目的:探讨我国老年人健康行为对慢性病共病的影响并利用关联规则探索共病模式,为制定健康相关行为预防策略提供参考依据。方法:基于中国老年健康影响因素跟踪调查(CLHLS)中10,747名65岁老年人的相关数据,利用多因素logistic回归模型分...目的:探讨我国老年人健康行为对慢性病共病的影响并利用关联规则探索共病模式,为制定健康相关行为预防策略提供参考依据。方法:基于中国老年健康影响因素跟踪调查(CLHLS)中10,747名65岁老年人的相关数据,利用多因素logistic回归模型分析健康生活相关行为对慢性病共病的影响;通过关联规则分析慢性病共病组合。结果:研究对象 ≥ 65岁共计10,381名,慢性病共病患病率为36.04%。基于睡眠质量、睡眠时间、健康饮食、无吸烟史、无饮酒史、锻炼以及户外社交活动等7个健康生活相关行为变量的得分,分为健康行为组别人群3023人(29.12%)和不健康行为组别7358人(70.88%)。多因素logistic回归分析结果显示,年龄组别为65~74岁(OR = 1.16, 95%CI: 1.02~1.32)和75~84岁人群(OR = 1.56, 95%CI: 1.40~1.74)、户籍为城市(OR = 2.50, 95%CI: 2.26~2.75)人群是慢性病共病的危险因素。男性、学历组别为文盲和小学、正常BMI以及健康行为是慢性病共病的保护因素。不同健康行为组别的共病组合存在差异。健康生活方式与慢性病共病低风险相关,从健康行为上对老年人加以引导和宣传并加强常见共病模式慢性病的筛查与预防不失为有效降低慢性病共病的途径。Objective: To explore the influence of health behaviors on chronic disease comorbidities among elderly in China and the comorbidity patterns using association rules, to provide a reference for formulating health-related behavior prevention strategies. Methods: Based on the data of 10,747 65-year-old elderly people in the Chinese Longitudinal Healthy Longevity Survey (CLHLS), a multivariate logistic regression model was used to analyze the influence of healthy life-related behaviors on chronic disease comorbidities. The combination of chronic diseases comorbidities was analyzed by association rules. Results: There were 10,381 subjects ≥ 65 years old, and the prevalence of chronic diseases was 36.04%. Based on the scores of 7 behavioral variables related to a healthy life, including sleep quality, sleep time, healthy diet, no smoking history, no drinking history, exercise, and outdoor social activities, the population was divided into 3023 people (29.12%) in the healthy behavior group and 7358 people (70.88%) in the unhealthy behavior group. Multivariate logistic regression analysis showed that the age group of 65~74 years old (OR = 1.16, 95%CI: 1.02~1.32) and 75~84 years old population (OR = 1.56, 95%CI: 1.40~1.74), and the household registration of urban (OR = 2.50, 95%CI: 2.26~2.75) were risk factors for chronic disease comorbidity. Male, educational group illiteracy and primary school, normal BMI, and healthy behaviors were protective factors for chronic disease comorbidities. The comorbidities of different health behavior groups were different. A healthy lifestyle is associated with a low risk of chronic disease comorbidities. It is an effective way to reduce chronic disease comorbidities by guiding and propagandizing the elderly from health behaviors and strengthening the screening and prevention of common comorbidities.展开更多
目的:研究妊娠肝内胆汁淤积症(Intrahepatic cholestasis of pregnancy,ICP)患者血清中牛磺结合型胆汁酸的变化。方法:收集ICP及ICP伴糖尿病、ICP伴病毒性肝炎患者和正常孕妇血清,经固相萃取,采用高效液相色谱-串联质谱(Highperfor-manc...目的:研究妊娠肝内胆汁淤积症(Intrahepatic cholestasis of pregnancy,ICP)患者血清中牛磺结合型胆汁酸的变化。方法:收集ICP及ICP伴糖尿病、ICP伴病毒性肝炎患者和正常孕妇血清,经固相萃取,采用高效液相色谱-串联质谱(Highperfor-mance liquid chromatography-tendem mass spectrometry,HPLC-MS/MS)法测定牛磺结合型胆汁酸的含量。结果:ICP及ICP伴糖尿病、ICP伴病毒性肝炎患者血清中牛磺胆酸(Taurocholicacid,TCA)、牛磺鹅脱氧胆酸(Taurochenodeoxycholic acid,TCDCA)、牛磺脱氧胆酸(Taurodeoxycholic acid,TDCA)分别比正常孕妇有10倍、5倍和3倍以上的显著性增高(P<0.01)。ICP及ICP伴糖尿病、ICP伴病毒性肝炎三组间TCA和TCDCA的差异均有显著性(P<0.05)。结论:ICP患者有特征的血清牛磺结合型胆汁酸变化。展开更多
文摘目的:探讨我国老年人健康行为对慢性病共病的影响并利用关联规则探索共病模式,为制定健康相关行为预防策略提供参考依据。方法:基于中国老年健康影响因素跟踪调查(CLHLS)中10,747名65岁老年人的相关数据,利用多因素logistic回归模型分析健康生活相关行为对慢性病共病的影响;通过关联规则分析慢性病共病组合。结果:研究对象 ≥ 65岁共计10,381名,慢性病共病患病率为36.04%。基于睡眠质量、睡眠时间、健康饮食、无吸烟史、无饮酒史、锻炼以及户外社交活动等7个健康生活相关行为变量的得分,分为健康行为组别人群3023人(29.12%)和不健康行为组别7358人(70.88%)。多因素logistic回归分析结果显示,年龄组别为65~74岁(OR = 1.16, 95%CI: 1.02~1.32)和75~84岁人群(OR = 1.56, 95%CI: 1.40~1.74)、户籍为城市(OR = 2.50, 95%CI: 2.26~2.75)人群是慢性病共病的危险因素。男性、学历组别为文盲和小学、正常BMI以及健康行为是慢性病共病的保护因素。不同健康行为组别的共病组合存在差异。健康生活方式与慢性病共病低风险相关,从健康行为上对老年人加以引导和宣传并加强常见共病模式慢性病的筛查与预防不失为有效降低慢性病共病的途径。Objective: To explore the influence of health behaviors on chronic disease comorbidities among elderly in China and the comorbidity patterns using association rules, to provide a reference for formulating health-related behavior prevention strategies. Methods: Based on the data of 10,747 65-year-old elderly people in the Chinese Longitudinal Healthy Longevity Survey (CLHLS), a multivariate logistic regression model was used to analyze the influence of healthy life-related behaviors on chronic disease comorbidities. The combination of chronic diseases comorbidities was analyzed by association rules. Results: There were 10,381 subjects ≥ 65 years old, and the prevalence of chronic diseases was 36.04%. Based on the scores of 7 behavioral variables related to a healthy life, including sleep quality, sleep time, healthy diet, no smoking history, no drinking history, exercise, and outdoor social activities, the population was divided into 3023 people (29.12%) in the healthy behavior group and 7358 people (70.88%) in the unhealthy behavior group. Multivariate logistic regression analysis showed that the age group of 65~74 years old (OR = 1.16, 95%CI: 1.02~1.32) and 75~84 years old population (OR = 1.56, 95%CI: 1.40~1.74), and the household registration of urban (OR = 2.50, 95%CI: 2.26~2.75) were risk factors for chronic disease comorbidity. Male, educational group illiteracy and primary school, normal BMI, and healthy behaviors were protective factors for chronic disease comorbidities. The comorbidities of different health behavior groups were different. A healthy lifestyle is associated with a low risk of chronic disease comorbidities. It is an effective way to reduce chronic disease comorbidities by guiding and propagandizing the elderly from health behaviors and strengthening the screening and prevention of common comorbidities.
文摘目的:研究妊娠肝内胆汁淤积症(Intrahepatic cholestasis of pregnancy,ICP)患者血清中牛磺结合型胆汁酸的变化。方法:收集ICP及ICP伴糖尿病、ICP伴病毒性肝炎患者和正常孕妇血清,经固相萃取,采用高效液相色谱-串联质谱(Highperfor-mance liquid chromatography-tendem mass spectrometry,HPLC-MS/MS)法测定牛磺结合型胆汁酸的含量。结果:ICP及ICP伴糖尿病、ICP伴病毒性肝炎患者血清中牛磺胆酸(Taurocholicacid,TCA)、牛磺鹅脱氧胆酸(Taurochenodeoxycholic acid,TCDCA)、牛磺脱氧胆酸(Taurodeoxycholic acid,TDCA)分别比正常孕妇有10倍、5倍和3倍以上的显著性增高(P<0.01)。ICP及ICP伴糖尿病、ICP伴病毒性肝炎三组间TCA和TCDCA的差异均有显著性(P<0.05)。结论:ICP患者有特征的血清牛磺结合型胆汁酸变化。
