睡眠呼吸障碍(sleep disordered breathing, SDB)是老年人群中仅次于失眠的第二大睡眠障碍疾病,其中以阻塞性睡眠呼吸暂停(obstructive sleep apnea, OSA)最为常见。OSA是指睡眠过程中反复出现呼吸暂停和低通气,引起多器官功能损伤的临...睡眠呼吸障碍(sleep disordered breathing, SDB)是老年人群中仅次于失眠的第二大睡眠障碍疾病,其中以阻塞性睡眠呼吸暂停(obstructive sleep apnea, OSA)最为常见。OSA是指睡眠过程中反复出现呼吸暂停和低通气,引起多器官功能损伤的临床综合征。OSA患病率随年龄增长而增加,好发于老年人,可严重降低老年人生活质量。随着人口老龄化进程加剧,老年OSA正引发全社会关注。目前,国内关于老年OSA具体发病机制的相关研究较少,探讨老年OSA的危险因素及发病机制,明确衰老在OSA发病中的作用及机制有望为老年OSA患者未来的个体化治疗提供依据。Sleep disordered breathing (SDB) is the second to the insomnia sleep disorders in the elderly diseases, among them with obstructive sleep apnea (OSA) is the most common. OSA refers to the clinical syndrome of multiple organ function impairment caused by repeated apnea and hypopnea during sleep. The prevalence of OSA increases with age and tends to occur in the elderly, which can seriously reduce the quality of life of the elderly. With the acceleration of population aging process, elderly OSA is attracting the attention of the whole society. At present, there are few relevant studies on the specific pathogenesis of elderly OSA in China. To explore the risk factors and pathogenesis of elderly OSA, and clarify the role and mechanism of aging in the pathogenesis of OSA is expected to provide a basis for future individualized treatment of elderly OSA patients.展开更多
目的观察鼻息肉患者磷酸化信号转导与转录激活因子3(phospho-signal transducers and activators of transcription,p-STAT3)、SOCS3(suppressor of cytokine signaling,SOCS3)及Th17相关因子的水平,初步探讨STAT3及SOCS3对鼻息肉患者T...目的观察鼻息肉患者磷酸化信号转导与转录激活因子3(phospho-signal transducers and activators of transcription,p-STAT3)、SOCS3(suppressor of cytokine signaling,SOCS3)及Th17相关因子的水平,初步探讨STAT3及SOCS3对鼻息肉患者Th17细胞功能的作用。方法选取40例鼻息肉患者标本及15例对照组标本,采用免疫组化和蛋白免疫印迹法检测p-STAT3及SOCS3在鼻息肉组织中的分布及表达,运用ELISA法检测IL-6和IL-17A的表达情况,采用RT-PCR检测RORγt的表达水平,并对数据进行统计学分析。结果鼻息肉组的p-STAT3、IL-6、IL-17A以及RORγt表达明显高于对照组(P<0.01),SOCS3在鼻息肉组中的表达则低于对照组(P<0.01)。相关性分析显示p-STAT3、RORγt及IL-17A与SOCS3呈负相关(p-STAT3/SOCS3:r=-0.545,P<0.01;RORγt/SOCS3:r=-0.627,P<0.05;IL-17A/SOCS3:r=-0.631,P<0.01),而p-STAT3与RORγt、IL-6、IL-17A呈正相关(p-STAT3/RORγt:r=0.594,P<0.001;p-STAT3/IL-6:r=0.632,P<0.001;p-STAT3/IL-17A:r=0.647,P<0.01)。结论 STAT3异常活化,以及SOCS3低表达所致抑制作用缺失可能是造成鼻息肉中Th17细胞过度活化的重要原因。展开更多
文摘睡眠呼吸障碍(sleep disordered breathing, SDB)是老年人群中仅次于失眠的第二大睡眠障碍疾病,其中以阻塞性睡眠呼吸暂停(obstructive sleep apnea, OSA)最为常见。OSA是指睡眠过程中反复出现呼吸暂停和低通气,引起多器官功能损伤的临床综合征。OSA患病率随年龄增长而增加,好发于老年人,可严重降低老年人生活质量。随着人口老龄化进程加剧,老年OSA正引发全社会关注。目前,国内关于老年OSA具体发病机制的相关研究较少,探讨老年OSA的危险因素及发病机制,明确衰老在OSA发病中的作用及机制有望为老年OSA患者未来的个体化治疗提供依据。Sleep disordered breathing (SDB) is the second to the insomnia sleep disorders in the elderly diseases, among them with obstructive sleep apnea (OSA) is the most common. OSA refers to the clinical syndrome of multiple organ function impairment caused by repeated apnea and hypopnea during sleep. The prevalence of OSA increases with age and tends to occur in the elderly, which can seriously reduce the quality of life of the elderly. With the acceleration of population aging process, elderly OSA is attracting the attention of the whole society. At present, there are few relevant studies on the specific pathogenesis of elderly OSA in China. To explore the risk factors and pathogenesis of elderly OSA, and clarify the role and mechanism of aging in the pathogenesis of OSA is expected to provide a basis for future individualized treatment of elderly OSA patients.
文摘目的观察鼻息肉患者磷酸化信号转导与转录激活因子3(phospho-signal transducers and activators of transcription,p-STAT3)、SOCS3(suppressor of cytokine signaling,SOCS3)及Th17相关因子的水平,初步探讨STAT3及SOCS3对鼻息肉患者Th17细胞功能的作用。方法选取40例鼻息肉患者标本及15例对照组标本,采用免疫组化和蛋白免疫印迹法检测p-STAT3及SOCS3在鼻息肉组织中的分布及表达,运用ELISA法检测IL-6和IL-17A的表达情况,采用RT-PCR检测RORγt的表达水平,并对数据进行统计学分析。结果鼻息肉组的p-STAT3、IL-6、IL-17A以及RORγt表达明显高于对照组(P<0.01),SOCS3在鼻息肉组中的表达则低于对照组(P<0.01)。相关性分析显示p-STAT3、RORγt及IL-17A与SOCS3呈负相关(p-STAT3/SOCS3:r=-0.545,P<0.01;RORγt/SOCS3:r=-0.627,P<0.05;IL-17A/SOCS3:r=-0.631,P<0.01),而p-STAT3与RORγt、IL-6、IL-17A呈正相关(p-STAT3/RORγt:r=0.594,P<0.001;p-STAT3/IL-6:r=0.632,P<0.001;p-STAT3/IL-17A:r=0.647,P<0.01)。结论 STAT3异常活化,以及SOCS3低表达所致抑制作用缺失可能是造成鼻息肉中Th17细胞过度活化的重要原因。
