微/纳米马达在生物医学中的应用在近年来引起了广泛的研究,结合囊泡的微/纳米马达在生物医学领域具有极大的应用潜力,由于微/纳米马达的自驱动力以及囊泡本身具有的良好的生物相容性使其在药物递送、光热疗法、解毒等领域均有所应用。...微/纳米马达在生物医学中的应用在近年来引起了广泛的研究,结合囊泡的微/纳米马达在生物医学领域具有极大的应用潜力,由于微/纳米马达的自驱动力以及囊泡本身具有的良好的生物相容性使其在药物递送、光热疗法、解毒等领域均有所应用。本文回顾了结合囊泡的微/纳米马达的制备方式,以及结合不同类型囊泡的微纳米马达的驱动力、结合方式及应用。总而言之,结合囊泡的微/纳米马达有望推进微/纳米马达在生物医学领域的应用,并促进其临床转化。The application of micro/nanomotors in biomedicine has garnered widespread attention in recent years. The integration of vesicles with micro/nanomotors holds significant potential in the biomedical field. Due to the self-propelling nature of micro/nanomotors and the excellent biocompatibility of vesicles, they have been applied in areas such as drug delivery, photothermal therapy, and detoxification. This article reviews the preparation methods of micro/nanomotors combined with vesicles, as well as the driving forces, coupling methods, and applications of micro/nanomotors integrated with different types of vesicles. In summary, micro/nanomotors combined with vesicles are expected to advance the application of micro/nanomotors in biomedicine and promote their clinical translation.展开更多
干细胞具有迁移、分化以及分泌各种治疗因子(如免疫调节因子)等功能,为攻克多种疾病难题提供了全新的思路与方向。当前,干细胞治疗虽已取得阶段性成果,但仍面临细胞存活率欠佳、靶向归巢效率低下、分化精准度不足等问题。为进一步提升...干细胞具有迁移、分化以及分泌各种治疗因子(如免疫调节因子)等功能,为攻克多种疾病难题提供了全新的思路与方向。当前,干细胞治疗虽已取得阶段性成果,但仍面临细胞存活率欠佳、靶向归巢效率低下、分化精准度不足等问题。为进一步提升干细胞的治疗效能并赋予其全新的功能特性,越来越多的研究致力于工程化干细胞改造,并应用到组织再生领域,且已初步展现出成效。本综述简要回顾干细胞的工程化策略,并重点阐述工程化干细胞在创伤修复、软骨愈合、骨修复、免疫调控等组织再生领域的应用进展。Stem cells possess the abilities of migration, differentiation, and secretion of various therapeutic factors (such as immunomodulatory factors), which provide entirely new ideas and directions for conquering numerous disease challenges. In current clinical practice, although stem cell therapy has achieved phased results, there are still problems such as poor cell survival rate, low targeted homing efficiency, and insufficient differentiation accuracy. To further enhance the therapeutic efficacy of stem cells and endow them with new functional characteristics, an increasing number of studies are dedicated to the modification of engineered stem cells and their application in the field of tissue regeneration, and initial effects have been demonstrated. This review briefly reviews the engineering strategies of stem cells and focuses on elaborating the application progress of engineered stem cells in aspects such as wound repair, cartilage healing, bone repair, and immune regulation in tissue regeneration.展开更多
牙周组织缺损是牙周炎治疗的难点,传统治疗方法难以有效恢复牙周组织的结构和功能。引导组织再生术(Guided Tissue Regeneration, GTR)作为一种再生医学技术,利用生物屏障膜隔离牙周缺损区域,为牙周组织再生创造有利空间,从而促进牙周...牙周组织缺损是牙周炎治疗的难点,传统治疗方法难以有效恢复牙周组织的结构和功能。引导组织再生术(Guided Tissue Regeneration, GTR)作为一种再生医学技术,利用生物屏障膜隔离牙周缺损区域,为牙周组织再生创造有利空间,从而促进牙周功能的恢复。可吸收生物膜因其无需二次手术取出、生物相容性好、可控降解等优势,成为GTR的理想材料。本文综述了不同种类可吸收生物膜在GTR中的研究进展,重点关注其理化特性、生物学效应以及临床应用效果,并探讨了该领域目前存在的挑战及未来研究方向,旨在为GTR的临床实践提供指导并推动治疗方式优化。Periodontal tissue defects, characterized by gingival recession and alveolar bone loss, pose significant challenges in periodontitis treatment, as conventional therapies often fail to fully restore tissue structure and function. Guided tissue regeneration (GTR) offers a regenerative medicine approach, employing barrier membranes to isolate the defect site and foster a conducive environment for periodontal tissue regeneration, ultimately promoting functional recovery. Resorbable membranes, owing to their advantages of eliminating the need for a second surgical procedure, coupled with favorable biocompatibility and controlled degradation profiles, have emerged as ideal GTR materials. This review summarizes the research progress of various resorbable membranes in GTR, focusing on their physicochemical properties, biological effects, and clinical outcomes. Furthermore, it explores current challenges and future research directions in this field, aiming to inform and enhance clinical practice in GTR.展开更多
随着全球人口老龄化趋势的加剧,主要波及老年人群认知障碍的发病率在全球不同地区均呈现上升趋势,这一现象与老年人免疫功能的减退和口腔卫生维护能力的下降密切相关,进而导致口腔功能受损和牙菌斑积累增加。本文阐述了衰老时口腔结构...随着全球人口老龄化趋势的加剧,主要波及老年人群认知障碍的发病率在全球不同地区均呈现上升趋势,这一现象与老年人免疫功能的减退和口腔卫生维护能力的下降密切相关,进而导致口腔功能受损和牙菌斑积累增加。本文阐述了衰老时口腔结构和功能的改变、微生物的变化、口腔疾病的发生发展特点。探讨了口腔健康不良对认知功能影响的途径。旨在强调重视老年人口腔健康对预防和延缓衰老过程中认知障碍发生发展的重要性,为后续进一步研究及干预策略制定提供参考依据。With the intensification of the global population aging trend, the incidence of cognitive impairment mainly affecting the elderly population is increasing in different regions of the world, which is closely related to the decline of immune function and oral health maintenance ability of the elderly, which in turn leads to the impairment of oral function and the increase of plaque accumulation. This article expounds the changes in oral structure and function, the changes in microorganisms, and the occurrence and development characteristics of oral diseases during aging. The pathways of the impact of poor oral health on cognitive function were explored. The purpose of this study is to emphasize the importance of paying attention to the oral health of the elderly to prevent and delay the occurrence and development of cognitive impairment in the aging process, and to provide a reference for further research and the formulation of intervention strategies.展开更多
间充质干细胞(Mesenchymal stem cells, MSCs)因其多向分化、自我更新、免疫调控等功能,可治疗多种疾病。尽管MSCs疗法在一定程度上已被证明是安全有效的,但在临床应用中,其疗效和安全性仍存在局限性,主要体现在MSCs靶向性不足、分化能...间充质干细胞(Mesenchymal stem cells, MSCs)因其多向分化、自我更新、免疫调控等功能,可治疗多种疾病。尽管MSCs疗法在一定程度上已被证明是安全有效的,但在临床应用中,其疗效和安全性仍存在局限性,主要体现在MSCs靶向性不足、分化能力受限、体内存活率低及药物递送效率不足等方面。为解决这些问题,目前出现多种工程化修饰技术,包括基因工程、表面修饰、物理化学修饰和组织工程等,以提高MSCs疗法的治疗效果和安全性。本文详细介绍了不同工程化修饰策略,并重点阐述各工程化修饰下MSCs功能化的实现和临床应用前景。Mesenchymal stem cells (MSCs) hold significant promise for the treatment of a wide range of diseases, owing to their multi-lineage differentiation potential, self-renewal capabilities, and immune regulatory properties. Although MSCs-based therapies have demonstrated safety and efficacy to some extent, their clinical application remains limited. These limitations are primarily due to challenges such as insufficient targeting of MSCs, restricted differentiation capacity, low in vivo survival rates, and poor drug delivery efficiency. To address these issues, a variety of engineering strategies, including genetic modification, surface functionalization, physicochemical modification, and tissue engineering, have been developed to enhance the therapeutic efficacy and safety of MSCs therapies. This paper provides a comprehensive overview of these engineering approaches and discusses their potential for future clinical application in MSCs-based therapies.展开更多
文摘微/纳米马达在生物医学中的应用在近年来引起了广泛的研究,结合囊泡的微/纳米马达在生物医学领域具有极大的应用潜力,由于微/纳米马达的自驱动力以及囊泡本身具有的良好的生物相容性使其在药物递送、光热疗法、解毒等领域均有所应用。本文回顾了结合囊泡的微/纳米马达的制备方式,以及结合不同类型囊泡的微纳米马达的驱动力、结合方式及应用。总而言之,结合囊泡的微/纳米马达有望推进微/纳米马达在生物医学领域的应用,并促进其临床转化。The application of micro/nanomotors in biomedicine has garnered widespread attention in recent years. The integration of vesicles with micro/nanomotors holds significant potential in the biomedical field. Due to the self-propelling nature of micro/nanomotors and the excellent biocompatibility of vesicles, they have been applied in areas such as drug delivery, photothermal therapy, and detoxification. This article reviews the preparation methods of micro/nanomotors combined with vesicles, as well as the driving forces, coupling methods, and applications of micro/nanomotors integrated with different types of vesicles. In summary, micro/nanomotors combined with vesicles are expected to advance the application of micro/nanomotors in biomedicine and promote their clinical translation.
文摘干细胞具有迁移、分化以及分泌各种治疗因子(如免疫调节因子)等功能,为攻克多种疾病难题提供了全新的思路与方向。当前,干细胞治疗虽已取得阶段性成果,但仍面临细胞存活率欠佳、靶向归巢效率低下、分化精准度不足等问题。为进一步提升干细胞的治疗效能并赋予其全新的功能特性,越来越多的研究致力于工程化干细胞改造,并应用到组织再生领域,且已初步展现出成效。本综述简要回顾干细胞的工程化策略,并重点阐述工程化干细胞在创伤修复、软骨愈合、骨修复、免疫调控等组织再生领域的应用进展。Stem cells possess the abilities of migration, differentiation, and secretion of various therapeutic factors (such as immunomodulatory factors), which provide entirely new ideas and directions for conquering numerous disease challenges. In current clinical practice, although stem cell therapy has achieved phased results, there are still problems such as poor cell survival rate, low targeted homing efficiency, and insufficient differentiation accuracy. To further enhance the therapeutic efficacy of stem cells and endow them with new functional characteristics, an increasing number of studies are dedicated to the modification of engineered stem cells and their application in the field of tissue regeneration, and initial effects have been demonstrated. This review briefly reviews the engineering strategies of stem cells and focuses on elaborating the application progress of engineered stem cells in aspects such as wound repair, cartilage healing, bone repair, and immune regulation in tissue regeneration.
文摘牙周组织缺损是牙周炎治疗的难点,传统治疗方法难以有效恢复牙周组织的结构和功能。引导组织再生术(Guided Tissue Regeneration, GTR)作为一种再生医学技术,利用生物屏障膜隔离牙周缺损区域,为牙周组织再生创造有利空间,从而促进牙周功能的恢复。可吸收生物膜因其无需二次手术取出、生物相容性好、可控降解等优势,成为GTR的理想材料。本文综述了不同种类可吸收生物膜在GTR中的研究进展,重点关注其理化特性、生物学效应以及临床应用效果,并探讨了该领域目前存在的挑战及未来研究方向,旨在为GTR的临床实践提供指导并推动治疗方式优化。Periodontal tissue defects, characterized by gingival recession and alveolar bone loss, pose significant challenges in periodontitis treatment, as conventional therapies often fail to fully restore tissue structure and function. Guided tissue regeneration (GTR) offers a regenerative medicine approach, employing barrier membranes to isolate the defect site and foster a conducive environment for periodontal tissue regeneration, ultimately promoting functional recovery. Resorbable membranes, owing to their advantages of eliminating the need for a second surgical procedure, coupled with favorable biocompatibility and controlled degradation profiles, have emerged as ideal GTR materials. This review summarizes the research progress of various resorbable membranes in GTR, focusing on their physicochemical properties, biological effects, and clinical outcomes. Furthermore, it explores current challenges and future research directions in this field, aiming to inform and enhance clinical practice in GTR.
文摘随着全球人口老龄化趋势的加剧,主要波及老年人群认知障碍的发病率在全球不同地区均呈现上升趋势,这一现象与老年人免疫功能的减退和口腔卫生维护能力的下降密切相关,进而导致口腔功能受损和牙菌斑积累增加。本文阐述了衰老时口腔结构和功能的改变、微生物的变化、口腔疾病的发生发展特点。探讨了口腔健康不良对认知功能影响的途径。旨在强调重视老年人口腔健康对预防和延缓衰老过程中认知障碍发生发展的重要性,为后续进一步研究及干预策略制定提供参考依据。With the intensification of the global population aging trend, the incidence of cognitive impairment mainly affecting the elderly population is increasing in different regions of the world, which is closely related to the decline of immune function and oral health maintenance ability of the elderly, which in turn leads to the impairment of oral function and the increase of plaque accumulation. This article expounds the changes in oral structure and function, the changes in microorganisms, and the occurrence and development characteristics of oral diseases during aging. The pathways of the impact of poor oral health on cognitive function were explored. The purpose of this study is to emphasize the importance of paying attention to the oral health of the elderly to prevent and delay the occurrence and development of cognitive impairment in the aging process, and to provide a reference for further research and the formulation of intervention strategies.
文摘间充质干细胞(Mesenchymal stem cells, MSCs)因其多向分化、自我更新、免疫调控等功能,可治疗多种疾病。尽管MSCs疗法在一定程度上已被证明是安全有效的,但在临床应用中,其疗效和安全性仍存在局限性,主要体现在MSCs靶向性不足、分化能力受限、体内存活率低及药物递送效率不足等方面。为解决这些问题,目前出现多种工程化修饰技术,包括基因工程、表面修饰、物理化学修饰和组织工程等,以提高MSCs疗法的治疗效果和安全性。本文详细介绍了不同工程化修饰策略,并重点阐述各工程化修饰下MSCs功能化的实现和临床应用前景。Mesenchymal stem cells (MSCs) hold significant promise for the treatment of a wide range of diseases, owing to their multi-lineage differentiation potential, self-renewal capabilities, and immune regulatory properties. Although MSCs-based therapies have demonstrated safety and efficacy to some extent, their clinical application remains limited. These limitations are primarily due to challenges such as insufficient targeting of MSCs, restricted differentiation capacity, low in vivo survival rates, and poor drug delivery efficiency. To address these issues, a variety of engineering strategies, including genetic modification, surface functionalization, physicochemical modification, and tissue engineering, have been developed to enhance the therapeutic efficacy and safety of MSCs therapies. This paper provides a comprehensive overview of these engineering approaches and discusses their potential for future clinical application in MSCs-based therapies.
