慢性阻塞性肺病(COPD)是一种常见的异质性呼吸道疾病,其特征是持续性和不完全可逆的气流受限。由于COPD的异质性和表型复杂性,传统的诊断方法只能提供有限的预测结果和治疗信息,不足以进行准确的诊断和评估。随着近年来组学技术的发展,...慢性阻塞性肺病(COPD)是一种常见的异质性呼吸道疾病,其特征是持续性和不完全可逆的气流受限。由于COPD的异质性和表型复杂性,传统的诊断方法只能提供有限的预测结果和治疗信息,不足以进行准确的诊断和评估。随着近年来组学技术的发展,基因组学、蛋白质组学和代谢组学被广泛应用于COPD的研究,为发现生物标志物以诊断和阐明COPD的复杂机制提供了良好的工具。在这篇综述中,我们基于近年来报道的代谢组学、蛋白质组学和转录组学研究,总结了COPD不同的代谢途径、生物标志物、潜在治疗靶点、代谢组学的手段,蛋白标志物,部分基因,以解释COPD的发病机制。最后,提出了COPD研究的前景和挑战。期望这篇综述将为COPD诊断方法的发展和发病机制的阐明提供一些参考。Chronic obstructive pulmonary disease (COPD) is a common heterogeneous respiratory disease characterized by persistent and incompletely reversible airflow restriction. Due to the heterogene-ity and phenotypic complexity of COPD, traditional diagnostic methods can only provide limited predictive results and treatment information, which is insufficient for accurate diagnosis and eval-uation. With the development of omics technology in recent years, Genomics, Proteomics and metabonomics have been widely used in the study of COPD, providing a good tool for discovering biomarkers to diagnose and clarify the complex mechanism of COPD. In this review, based on metabonomics, Proteomics and Transcriptome studies reported in recent years, we summarized the different metabolic pathways, biomarkers, potential therapeutic targets, metabonomics means, protein markers, and some genes of COPD to explain the pathogenesis of COPD. Finally, the pro-spects and challenges of COPD research were proposed. It is expected that this review will provide some reference for the development of diagnostic methods and elucidation of the pathogenesis of COPD.展开更多
文摘慢性阻塞性肺病(COPD)是一种常见的异质性呼吸道疾病,其特征是持续性和不完全可逆的气流受限。由于COPD的异质性和表型复杂性,传统的诊断方法只能提供有限的预测结果和治疗信息,不足以进行准确的诊断和评估。随着近年来组学技术的发展,基因组学、蛋白质组学和代谢组学被广泛应用于COPD的研究,为发现生物标志物以诊断和阐明COPD的复杂机制提供了良好的工具。在这篇综述中,我们基于近年来报道的代谢组学、蛋白质组学和转录组学研究,总结了COPD不同的代谢途径、生物标志物、潜在治疗靶点、代谢组学的手段,蛋白标志物,部分基因,以解释COPD的发病机制。最后,提出了COPD研究的前景和挑战。期望这篇综述将为COPD诊断方法的发展和发病机制的阐明提供一些参考。Chronic obstructive pulmonary disease (COPD) is a common heterogeneous respiratory disease characterized by persistent and incompletely reversible airflow restriction. Due to the heterogene-ity and phenotypic complexity of COPD, traditional diagnostic methods can only provide limited predictive results and treatment information, which is insufficient for accurate diagnosis and eval-uation. With the development of omics technology in recent years, Genomics, Proteomics and metabonomics have been widely used in the study of COPD, providing a good tool for discovering biomarkers to diagnose and clarify the complex mechanism of COPD. In this review, based on metabonomics, Proteomics and Transcriptome studies reported in recent years, we summarized the different metabolic pathways, biomarkers, potential therapeutic targets, metabonomics means, protein markers, and some genes of COPD to explain the pathogenesis of COPD. Finally, the pro-spects and challenges of COPD research were proposed. It is expected that this review will provide some reference for the development of diagnostic methods and elucidation of the pathogenesis of COPD.
