亚急性甲状腺炎属于自身免疫反应介导的疾病,其临床表现复杂多样,常因症状与感冒相似而被误诊,给患者的生活质量带来负面影响。中医通过中药汤剂、针灸、外敷等方法治疗本病,颇有疗效。本文根据近年来中医治疗亚急性甲状腺炎的临床研究...亚急性甲状腺炎属于自身免疫反应介导的疾病,其临床表现复杂多样,常因症状与感冒相似而被误诊,给患者的生活质量带来负面影响。中医通过中药汤剂、针灸、外敷等方法治疗本病,颇有疗效。本文根据近年来中医治疗亚急性甲状腺炎的临床研究,从病因病机及辨证论治方面进行综合论述,为今后亚急性甲状腺炎的治疗提供参考。Subacute thyroiditis is an autoimmune disease, and its clinical manifestations are complex and diverse, and it is often misdiagnosed because the symptoms are similar to those of a cold, which has a negative impact on the quality of life of patients. Traditional Chinese medicine (TCM) uses traditional Chinese medicine decoction, acupuncture, external application and other methods to treat this disease, which is quite effective. Based on the clinical research on the treatment of subacute thyroiditis by traditional Chinese medicine in recent years, this article comprehensively discusses the etiology, pathogenesis, syndrome differentiation and treatment, so as to provide reference for the treatment of subacute thyroiditis in the future.展开更多
糖尿病周围神经病变(Diabetic peripheral neuropathy, DPN)患病率高、且症状复杂,主要以凉、麻、痛、痿为特征。西医治疗DPN主要以降糖为基础,辅以营养神经或抗炎等手段,而中医则从改善患者症状入手,大大地减轻了患者的痛苦,从而提高...糖尿病周围神经病变(Diabetic peripheral neuropathy, DPN)患病率高、且症状复杂,主要以凉、麻、痛、痿为特征。西医治疗DPN主要以降糖为基础,辅以营养神经或抗炎等手段,而中医则从改善患者症状入手,大大地减轻了患者的痛苦,从而提高患者的生存质量。近些年来应用中医药治疗DPN,取得了可观的疗效进展,有辨证论治、中药自拟方治疗、中药复方治疗、中药特色分期治疗、中药外治及针灸治疗等多种治疗方案。本文从以上几个方面综述近些年来运用中医药治疗糖尿病周围神经病变的最新研究进展,为糖尿病周围神经病变的治疗研究提供基础。The prevalence rate of diabetic peripheral neuropathy is high, and the symptoms are complex, mainly characterized by cold, numbness, pain and flaccidity. Western medicine treats DPN mainly on the basis of hypoglycemia, supplemented by nutritional nerve or anti-inflammatory means, while Chinese medicine starts with improving the symptoms of patients, greatly alleviating the pain of patients, and thus improving the quality of life of patients. In recent years, the treatment of diabetic peripheral neuropathy by traditional Chinese medicine has made great progress in curative effect. There are many treatment schemes, such as syndrome differentiation treatment, TCM self-formulated treatment, TCM compound treatment, TCM characteristic staging treatment, TCM external treatment and acupuncture treatment. This article reviews the latest research progress in the treatment of diabetic peripheral neuropathy with traditional Chinese medicine in recent years from the above aspects, and provides the basis for the treatment of diabetic peripheral neuropathy.展开更多
2型糖尿病(T2DM)合并失眠的发病率持续增长,严重影响患者的生活质量。当前西医治疗T2DM合并失眠,通常在控制且稳定血糖的基础上,协同应用镇静催眠类药物,但该类药物长期使用易产生耐药性。中医治疗T2DM合并失眠不仅取得了较好的疗效,而...2型糖尿病(T2DM)合并失眠的发病率持续增长,严重影响患者的生活质量。当前西医治疗T2DM合并失眠,通常在控制且稳定血糖的基础上,协同应用镇静催眠类药物,但该类药物长期使用易产生耐药性。中医治疗T2DM合并失眠不仅取得了较好的疗效,而且副作用小。本文对近几年临床上中医治疗T2DM合并失眠的研究进行收集整理,以期为后续中医治疗本病提供新思路和方法。The incidence of type 2 diabetes mellitus (T2DM) combined with insomnia continues to increase, which seriously affects the quality of life of patients. At present, Western medicine for T2DM combined with insomnia usually uses sedation-hypnosis drugs on the basis of controlling and stabilizing blood sugar, and long-term use of such drugs easily produces drug resistance. Traditional Chinese medicine treatment of T2DM combined with insomnia has not only achieved good curative effects, but also the side effects are small. This paper collects and collates the clinical research of traditional Chinese medicine treatment of T2DM combined with insomnia in recent years, in order to provide new ideas and methods for the follow-up TCM treatment of this disease.展开更多
妊娠糖尿病(GDM)是在妊娠期糖代谢异常的代谢性疾病,近年来,GDM发病率逐年上升,对孕产妇的健康有着严重威胁,甚至对子代产生不良影响。目前GDM的治疗以基础治疗配合西医治疗为主,由于中医学临床研究越来越深入,临床出现越来越多中医治疗...妊娠糖尿病(GDM)是在妊娠期糖代谢异常的代谢性疾病,近年来,GDM发病率逐年上升,对孕产妇的健康有着严重威胁,甚至对子代产生不良影响。目前GDM的治疗以基础治疗配合西医治疗为主,由于中医学临床研究越来越深入,临床出现越来越多中医治疗GDM的方案,疗效比较理想。本文介绍了GDM的治疗现状,旨在促进GDM的临床研究,为获取更多有利的治疗方案提供参考。Gestational diabetes mellitus (GDM) is a metabolic disorder in which glucose metabolism is abnormal during pregnancy. In recent years, the incidence of GDM has been increasing year by year, posing a serious threat to maternal health and even adversely affecting the offspring. At present, the treatment of GDM is mainly based on basic treatment together with western medical treatment. Due to the increasing depth of the clinical research of Chinese medicine, more and more programs of Chinese medicine for the treatment of GDM have appeared in the clinic, and the therapeutic efficacy is relatively satisfactory. This article describes the current status of the treatment of GDM, aiming to promote clinical research on GDM and provide a reference for obtaining more favorable treatment options.展开更多
交泰丸是传统治疗心肾不交型失眠的基础方,随着我国糖尿病患病人群的增加,近年来在治疗糖尿病方面有所发挥。临床上糖尿病和失眠相互影响和相互关联,使用交泰丸治疗虽却有疗效,但缺乏系统性的理论依据,并且由于交泰丸配伍和剂型的特殊性...交泰丸是传统治疗心肾不交型失眠的基础方,随着我国糖尿病患病人群的增加,近年来在治疗糖尿病方面有所发挥。临床上糖尿病和失眠相互影响和相互关联,使用交泰丸治疗虽却有疗效,但缺乏系统性的理论依据,并且由于交泰丸配伍和剂型的特殊性,不断有新的临床研究和药理实验对其深入研究,本文将从交泰丸的历史源流,临床进展,药理作用等方面对交泰丸治疗糖尿病合并失眠的研究进展进行阐述。Jiaotai pill is the basic prescription of the traditional treatment of heart-kidney disharmony type insomnia. With the increase of diabetes patients in China, it has played a great role in the treatment of diabetes in recent years. Clinical diabetes and insomnia influence and mutual correlation, use Jiaotai pill treatment has curative effect, but the lack of systematic theoretical basis, and because of the particularity of Jiaotai pill compatibility and dosage form, constantly have new clinical research and pharmacological experiments on the further study, this article will from the history of tai pills, clinical progress, pharmacological effect of the treatment of diabetes with insomnia.展开更多
目的:基于网络药理学方法探讨桃仁–大黄治疗糖尿病性视网膜病变的作用机制。方法:运用NGO算法完成对目标药物的优化求解,从中药系统药理学数据库和分析平台(TCMSP)数据库获取桃仁–大黄的药对有效成分及预测药物作用靶点;通过人类基因...目的:基于网络药理学方法探讨桃仁–大黄治疗糖尿病性视网膜病变的作用机制。方法:运用NGO算法完成对目标药物的优化求解,从中药系统药理学数据库和分析平台(TCMSP)数据库获取桃仁–大黄的药对有效成分及预测药物作用靶点;通过人类基因数据库(GeneCards)和人类基因–疾病关联数据库(DisGeNET)识别与糖尿病性视网膜病变相关的基因。筛选出交集靶标基因后,利用STRING数据库分析这些基因的相互作用,并进一步探讨其潜在作用机制。结果:筛选出桃仁–大黄药对的39个活性成分,并预测出462个靶点基因。在糖尿病性视网膜病变中,鉴定出1352个相关基因,其中155个基因为药物–疾病交集靶标基因。通过基因本体(GO)功能富集分析,这些基因主要涉及分子功能、细胞组成以及生物过程。京都基因和基因组百科KEGG路径富集分析显示,桃仁–大黄药对治疗糖尿病性视网膜病变主要通过癌症通路、AGE-RAGE通路、IL-17通路和TNF通路等途径发挥作用。结论:桃仁–大黄主要通过TNF、AKT1、IL1B、EGFR、PPARG等关键靶点以及调节TNF信号通路、糖尿病并发症中的AGE-RAGE信号通路、血脂与动脉粥样硬化等多途径、多靶点发挥治疗糖尿病性视网膜病变的作用。Objective: To explore the mechanism of action of peach kernel and rhubarb in the treatment of diabetic retinopathy based on the network pharmacology approach. Methods: The optimisation of the target drug was completed by using the NGO algorithm, and the active ingredients and predicted targets of peach kernel and rhubarb were obtained from the Traditional Chinese Medicine Systematic Pharmacology Database and Platform (TCMSP) database;the genes related to diabetic retinopathy were identified through the GeneCards and DisGeNET databases. After screening the intersecting target genes, the STRING database was used to analyse the interactions of these genes and further explore their potential mechanisms of action. Results: Thirty-nine active components of peach kernel-rhubarb pairs were screened and 462 target genes were predicted. In diabetic retinopathy, 1352 related genes were identified, of which 155 genes were drug-disease intersection target genes. These genes were mainly involved in molecular function, cellular composition, and biological processes by Gene Ontology (GO) functional enrichment analysis. Kyoto Gene and Genome Encyclopedia KEGG pathway enrichment analyses showed that peach kernel-rhubarb drug pairs for the treatment of diabetic retinopathy acted mainly through the cancer pathway, AGE-RAGE pathway, IL-17 pathway, and TNF pathway. Conclusion: Peach kernel-rhubarb exerts its therapeutic effects on diabetic retinopathy mainly through multiple pathways and targets, such as key targets of TNF, AKT1, IL1B, EGFR, and PPARG, as well as regulating the TNF signalling pathway, AGE-RAGE signalling pathway in diabetic complications, and blood lipids and atherosclerosis.展开更多
气阴两虚型是糖尿病的重要证型,且在临床中极为常见。传统中医治疗注重益气生津,养阴清热,现代中医发现患者多有瘀血表现,随患病时间增加,瘀血随之加重。本文综合多位医家对气阴两虚型糖尿病的治疗方法和学界前沿成果,分析益气养阴活血...气阴两虚型是糖尿病的重要证型,且在临床中极为常见。传统中医治疗注重益气生津,养阴清热,现代中医发现患者多有瘀血表现,随患病时间增加,瘀血随之加重。本文综合多位医家对气阴两虚型糖尿病的治疗方法和学界前沿成果,分析益气养阴活血法在治疗气阴两虚型2型糖尿病过程中,改善患者症状并降低并发症发生率、改善患者预后的效果。Qi and Yin deficiency is an important type of diabetes mellitus and is extremely common in clinical practice. Traditional Chinese medicine treatment focuses on benefiting qi and generating fluids, nourishing yin and clearing heat, but modern Chinese medicine practitioners have found that patients often have stasis, which is aggravated with the increase of disease time. In this paper, we synthesize the treatment methods of many medical doctors for diabetes mellitus with deficiency of qi and yin and the cutting-edge achievements of the academic field, and analyze the effect of the method of promoting qi, nourishing yin and activating blood stasis in the treatment of diabetes mellitus with deficiency of qi and yin in the process of improving the symptoms of the patients, decreasing the incidence of complications, and improving the prognosis of the patients.展开更多
在2型糖尿病(Type 2 diabetes mellitus, T2DM)传统的辨证施治体系中,三消辨证法最为详尽,其核心多围绕阴虚燥热之病机,归咎于肺、胃、肾三脏的功能失调。然而,仅依据“三消”理论进行论治已难以满足当前临床治疗的实际需求,鉴于此,众...在2型糖尿病(Type 2 diabetes mellitus, T2DM)传统的辨证施治体系中,三消辨证法最为详尽,其核心多围绕阴虚燥热之病机,归咎于肺、胃、肾三脏的功能失调。然而,仅依据“三消”理论进行论治已难以满足当前临床治疗的实际需求,鉴于此,众多医家勇于突破传统“三消”框架,当融合脏腑定位与气血阴阳的精细辨证,以分型施治。本文深入探讨了肝脾两脏与T2DM发病机制的内在联系,为基于“肝脾”理论治疗T2DM奠定了坚实的理论基础。In the traditional system of diagnosis and treatment of thirst-quenching disease, the three elimination method is the most detailed, the core of which is centered around the disease mechanism of Yin deficiency and dryness and heat, attributed to the dysfunction of the lungs, stomach and kidneys. However, it is difficult to meet the actual needs of current clinical treatment only based on the theory of “three eliminations”. In view of this, many medical practitioners have the courage to break through the traditional framework of “three eliminations” when integrating the positioning of internal organs and the fine identification of qi, blood, yin and yang, in order to differentiate and administer the treatment. In this paper, the intrinsic connection between the liver and spleen and the pathogenesis of type 2 diabetes mellitus (T2DM) is discussed in depth, which lays a solid theoretical foundation for the treatment of type 2 diabetes mellitus based on the theory of liver and spleen.展开更多
甲状腺结节是一种常见的内分泌系统疾病,以良性结节更为多见。部分良性结节患者无明显不适症状,常见颈部肿胀、颈前区异物感、咽部阻塞感,通常都比较轻微,不易被重视。近年来,随着人们生活压力渐增以及临床诊疗技术的进步,甲状腺结节发...甲状腺结节是一种常见的内分泌系统疾病,以良性结节更为多见。部分良性结节患者无明显不适症状,常见颈部肿胀、颈前区异物感、咽部阻塞感,通常都比较轻微,不易被重视。近年来,随着人们生活压力渐增以及临床诊疗技术的进步,甲状腺结节发病率与检出率均有所提高。中医将该病归属于瘿病、瘿瘤范畴,对其病因机制认识历史悠久。气一元论认为,气是构成世界万物的本原,也是构成人体和维持生命活动的基本物质。气的运动,称为气机,气运动产生的变化称为气化,甲状腺结节的发病机制与气化功能障碍和气机失调密切相关。现阶段西医针对本病尚未研发出特效疗法,主要是定期进行随访观察,某些特殊情况下实施药物及手术治疗,虽能取得一定疗效,但存在功能减退、组织破坏等风险,还极有可能带来一系列不良反应。而中医在治疗瘿类病方面治疗经验丰富,治疗方法独特而多样,在缩小结节体积、减轻临床症状等方面均取得了较为可观的疗效,且不良反应也较少,兼具有效性和安全性。Thyroid nodules are a common endocrine system disease, and benign nodules are more common. Some patients with benign nodules have no obvious discomfort symptoms, common neck swelling, foreign body sensation in the anterior neck area, and pharyngeal obstruction, which are usually relatively mild and not easy to pay attention to. In recent years, with the increasing pressure on people’s lives and the progress of clinical diagnosis and treatment technology, the incidence and detection rates of thyroid nodules have increased. The disease belongs to the category of gall disease and gall tumor in traditional Chinese medicine, and its etiological mechanism has been known for a long time. Qi monism holds that qi is the origin of all things in the world, and it is also the basic material that constitutes the human body and sustains life activities. The movement of qi is called qi machine, and the changes produced by qi machine are called gasification. The pathogenesis of thyroid nodules is closely related to the dysfunction of gasification and qi machine. At present, Western medicine has not developed specific therapies for this disease, mainly regular follow-up observation, in some special cases, the implementation of drugs and surgical treatment. Although it can achieve a certain effect, there is a risk of functional decline and tissue destruction, which is very likely to bring a series of adverse reactions. However, Chinese medicine has rich experience in the treatment of gall diseases, unique and diverse treatment methods, and has achieved considerable efficacy in reducing the volume of nodules and alleviating clinical symptoms, with fewer adverse reactions, both effective and safe.展开更多
文摘亚急性甲状腺炎属于自身免疫反应介导的疾病,其临床表现复杂多样,常因症状与感冒相似而被误诊,给患者的生活质量带来负面影响。中医通过中药汤剂、针灸、外敷等方法治疗本病,颇有疗效。本文根据近年来中医治疗亚急性甲状腺炎的临床研究,从病因病机及辨证论治方面进行综合论述,为今后亚急性甲状腺炎的治疗提供参考。Subacute thyroiditis is an autoimmune disease, and its clinical manifestations are complex and diverse, and it is often misdiagnosed because the symptoms are similar to those of a cold, which has a negative impact on the quality of life of patients. Traditional Chinese medicine (TCM) uses traditional Chinese medicine decoction, acupuncture, external application and other methods to treat this disease, which is quite effective. Based on the clinical research on the treatment of subacute thyroiditis by traditional Chinese medicine in recent years, this article comprehensively discusses the etiology, pathogenesis, syndrome differentiation and treatment, so as to provide reference for the treatment of subacute thyroiditis in the future.
文摘糖尿病周围神经病变(Diabetic peripheral neuropathy, DPN)患病率高、且症状复杂,主要以凉、麻、痛、痿为特征。西医治疗DPN主要以降糖为基础,辅以营养神经或抗炎等手段,而中医则从改善患者症状入手,大大地减轻了患者的痛苦,从而提高患者的生存质量。近些年来应用中医药治疗DPN,取得了可观的疗效进展,有辨证论治、中药自拟方治疗、中药复方治疗、中药特色分期治疗、中药外治及针灸治疗等多种治疗方案。本文从以上几个方面综述近些年来运用中医药治疗糖尿病周围神经病变的最新研究进展,为糖尿病周围神经病变的治疗研究提供基础。The prevalence rate of diabetic peripheral neuropathy is high, and the symptoms are complex, mainly characterized by cold, numbness, pain and flaccidity. Western medicine treats DPN mainly on the basis of hypoglycemia, supplemented by nutritional nerve or anti-inflammatory means, while Chinese medicine starts with improving the symptoms of patients, greatly alleviating the pain of patients, and thus improving the quality of life of patients. In recent years, the treatment of diabetic peripheral neuropathy by traditional Chinese medicine has made great progress in curative effect. There are many treatment schemes, such as syndrome differentiation treatment, TCM self-formulated treatment, TCM compound treatment, TCM characteristic staging treatment, TCM external treatment and acupuncture treatment. This article reviews the latest research progress in the treatment of diabetic peripheral neuropathy with traditional Chinese medicine in recent years from the above aspects, and provides the basis for the treatment of diabetic peripheral neuropathy.
文摘2型糖尿病(T2DM)合并失眠的发病率持续增长,严重影响患者的生活质量。当前西医治疗T2DM合并失眠,通常在控制且稳定血糖的基础上,协同应用镇静催眠类药物,但该类药物长期使用易产生耐药性。中医治疗T2DM合并失眠不仅取得了较好的疗效,而且副作用小。本文对近几年临床上中医治疗T2DM合并失眠的研究进行收集整理,以期为后续中医治疗本病提供新思路和方法。The incidence of type 2 diabetes mellitus (T2DM) combined with insomnia continues to increase, which seriously affects the quality of life of patients. At present, Western medicine for T2DM combined with insomnia usually uses sedation-hypnosis drugs on the basis of controlling and stabilizing blood sugar, and long-term use of such drugs easily produces drug resistance. Traditional Chinese medicine treatment of T2DM combined with insomnia has not only achieved good curative effects, but also the side effects are small. This paper collects and collates the clinical research of traditional Chinese medicine treatment of T2DM combined with insomnia in recent years, in order to provide new ideas and methods for the follow-up TCM treatment of this disease.
文摘妊娠糖尿病(GDM)是在妊娠期糖代谢异常的代谢性疾病,近年来,GDM发病率逐年上升,对孕产妇的健康有着严重威胁,甚至对子代产生不良影响。目前GDM的治疗以基础治疗配合西医治疗为主,由于中医学临床研究越来越深入,临床出现越来越多中医治疗GDM的方案,疗效比较理想。本文介绍了GDM的治疗现状,旨在促进GDM的临床研究,为获取更多有利的治疗方案提供参考。Gestational diabetes mellitus (GDM) is a metabolic disorder in which glucose metabolism is abnormal during pregnancy. In recent years, the incidence of GDM has been increasing year by year, posing a serious threat to maternal health and even adversely affecting the offspring. At present, the treatment of GDM is mainly based on basic treatment together with western medical treatment. Due to the increasing depth of the clinical research of Chinese medicine, more and more programs of Chinese medicine for the treatment of GDM have appeared in the clinic, and the therapeutic efficacy is relatively satisfactory. This article describes the current status of the treatment of GDM, aiming to promote clinical research on GDM and provide a reference for obtaining more favorable treatment options.
文摘交泰丸是传统治疗心肾不交型失眠的基础方,随着我国糖尿病患病人群的增加,近年来在治疗糖尿病方面有所发挥。临床上糖尿病和失眠相互影响和相互关联,使用交泰丸治疗虽却有疗效,但缺乏系统性的理论依据,并且由于交泰丸配伍和剂型的特殊性,不断有新的临床研究和药理实验对其深入研究,本文将从交泰丸的历史源流,临床进展,药理作用等方面对交泰丸治疗糖尿病合并失眠的研究进展进行阐述。Jiaotai pill is the basic prescription of the traditional treatment of heart-kidney disharmony type insomnia. With the increase of diabetes patients in China, it has played a great role in the treatment of diabetes in recent years. Clinical diabetes and insomnia influence and mutual correlation, use Jiaotai pill treatment has curative effect, but the lack of systematic theoretical basis, and because of the particularity of Jiaotai pill compatibility and dosage form, constantly have new clinical research and pharmacological experiments on the further study, this article will from the history of tai pills, clinical progress, pharmacological effect of the treatment of diabetes with insomnia.
文摘目的:基于网络药理学方法探讨桃仁–大黄治疗糖尿病性视网膜病变的作用机制。方法:运用NGO算法完成对目标药物的优化求解,从中药系统药理学数据库和分析平台(TCMSP)数据库获取桃仁–大黄的药对有效成分及预测药物作用靶点;通过人类基因数据库(GeneCards)和人类基因–疾病关联数据库(DisGeNET)识别与糖尿病性视网膜病变相关的基因。筛选出交集靶标基因后,利用STRING数据库分析这些基因的相互作用,并进一步探讨其潜在作用机制。结果:筛选出桃仁–大黄药对的39个活性成分,并预测出462个靶点基因。在糖尿病性视网膜病变中,鉴定出1352个相关基因,其中155个基因为药物–疾病交集靶标基因。通过基因本体(GO)功能富集分析,这些基因主要涉及分子功能、细胞组成以及生物过程。京都基因和基因组百科KEGG路径富集分析显示,桃仁–大黄药对治疗糖尿病性视网膜病变主要通过癌症通路、AGE-RAGE通路、IL-17通路和TNF通路等途径发挥作用。结论:桃仁–大黄主要通过TNF、AKT1、IL1B、EGFR、PPARG等关键靶点以及调节TNF信号通路、糖尿病并发症中的AGE-RAGE信号通路、血脂与动脉粥样硬化等多途径、多靶点发挥治疗糖尿病性视网膜病变的作用。Objective: To explore the mechanism of action of peach kernel and rhubarb in the treatment of diabetic retinopathy based on the network pharmacology approach. Methods: The optimisation of the target drug was completed by using the NGO algorithm, and the active ingredients and predicted targets of peach kernel and rhubarb were obtained from the Traditional Chinese Medicine Systematic Pharmacology Database and Platform (TCMSP) database;the genes related to diabetic retinopathy were identified through the GeneCards and DisGeNET databases. After screening the intersecting target genes, the STRING database was used to analyse the interactions of these genes and further explore their potential mechanisms of action. Results: Thirty-nine active components of peach kernel-rhubarb pairs were screened and 462 target genes were predicted. In diabetic retinopathy, 1352 related genes were identified, of which 155 genes were drug-disease intersection target genes. These genes were mainly involved in molecular function, cellular composition, and biological processes by Gene Ontology (GO) functional enrichment analysis. Kyoto Gene and Genome Encyclopedia KEGG pathway enrichment analyses showed that peach kernel-rhubarb drug pairs for the treatment of diabetic retinopathy acted mainly through the cancer pathway, AGE-RAGE pathway, IL-17 pathway, and TNF pathway. Conclusion: Peach kernel-rhubarb exerts its therapeutic effects on diabetic retinopathy mainly through multiple pathways and targets, such as key targets of TNF, AKT1, IL1B, EGFR, and PPARG, as well as regulating the TNF signalling pathway, AGE-RAGE signalling pathway in diabetic complications, and blood lipids and atherosclerosis.
文摘气阴两虚型是糖尿病的重要证型,且在临床中极为常见。传统中医治疗注重益气生津,养阴清热,现代中医发现患者多有瘀血表现,随患病时间增加,瘀血随之加重。本文综合多位医家对气阴两虚型糖尿病的治疗方法和学界前沿成果,分析益气养阴活血法在治疗气阴两虚型2型糖尿病过程中,改善患者症状并降低并发症发生率、改善患者预后的效果。Qi and Yin deficiency is an important type of diabetes mellitus and is extremely common in clinical practice. Traditional Chinese medicine treatment focuses on benefiting qi and generating fluids, nourishing yin and clearing heat, but modern Chinese medicine practitioners have found that patients often have stasis, which is aggravated with the increase of disease time. In this paper, we synthesize the treatment methods of many medical doctors for diabetes mellitus with deficiency of qi and yin and the cutting-edge achievements of the academic field, and analyze the effect of the method of promoting qi, nourishing yin and activating blood stasis in the treatment of diabetes mellitus with deficiency of qi and yin in the process of improving the symptoms of the patients, decreasing the incidence of complications, and improving the prognosis of the patients.
文摘在2型糖尿病(Type 2 diabetes mellitus, T2DM)传统的辨证施治体系中,三消辨证法最为详尽,其核心多围绕阴虚燥热之病机,归咎于肺、胃、肾三脏的功能失调。然而,仅依据“三消”理论进行论治已难以满足当前临床治疗的实际需求,鉴于此,众多医家勇于突破传统“三消”框架,当融合脏腑定位与气血阴阳的精细辨证,以分型施治。本文深入探讨了肝脾两脏与T2DM发病机制的内在联系,为基于“肝脾”理论治疗T2DM奠定了坚实的理论基础。In the traditional system of diagnosis and treatment of thirst-quenching disease, the three elimination method is the most detailed, the core of which is centered around the disease mechanism of Yin deficiency and dryness and heat, attributed to the dysfunction of the lungs, stomach and kidneys. However, it is difficult to meet the actual needs of current clinical treatment only based on the theory of “three eliminations”. In view of this, many medical practitioners have the courage to break through the traditional framework of “three eliminations” when integrating the positioning of internal organs and the fine identification of qi, blood, yin and yang, in order to differentiate and administer the treatment. In this paper, the intrinsic connection between the liver and spleen and the pathogenesis of type 2 diabetes mellitus (T2DM) is discussed in depth, which lays a solid theoretical foundation for the treatment of type 2 diabetes mellitus based on the theory of liver and spleen.
文摘甲状腺结节是一种常见的内分泌系统疾病,以良性结节更为多见。部分良性结节患者无明显不适症状,常见颈部肿胀、颈前区异物感、咽部阻塞感,通常都比较轻微,不易被重视。近年来,随着人们生活压力渐增以及临床诊疗技术的进步,甲状腺结节发病率与检出率均有所提高。中医将该病归属于瘿病、瘿瘤范畴,对其病因机制认识历史悠久。气一元论认为,气是构成世界万物的本原,也是构成人体和维持生命活动的基本物质。气的运动,称为气机,气运动产生的变化称为气化,甲状腺结节的发病机制与气化功能障碍和气机失调密切相关。现阶段西医针对本病尚未研发出特效疗法,主要是定期进行随访观察,某些特殊情况下实施药物及手术治疗,虽能取得一定疗效,但存在功能减退、组织破坏等风险,还极有可能带来一系列不良反应。而中医在治疗瘿类病方面治疗经验丰富,治疗方法独特而多样,在缩小结节体积、减轻临床症状等方面均取得了较为可观的疗效,且不良反应也较少,兼具有效性和安全性。Thyroid nodules are a common endocrine system disease, and benign nodules are more common. Some patients with benign nodules have no obvious discomfort symptoms, common neck swelling, foreign body sensation in the anterior neck area, and pharyngeal obstruction, which are usually relatively mild and not easy to pay attention to. In recent years, with the increasing pressure on people’s lives and the progress of clinical diagnosis and treatment technology, the incidence and detection rates of thyroid nodules have increased. The disease belongs to the category of gall disease and gall tumor in traditional Chinese medicine, and its etiological mechanism has been known for a long time. Qi monism holds that qi is the origin of all things in the world, and it is also the basic material that constitutes the human body and sustains life activities. The movement of qi is called qi machine, and the changes produced by qi machine are called gasification. The pathogenesis of thyroid nodules is closely related to the dysfunction of gasification and qi machine. At present, Western medicine has not developed specific therapies for this disease, mainly regular follow-up observation, in some special cases, the implementation of drugs and surgical treatment. Although it can achieve a certain effect, there is a risk of functional decline and tissue destruction, which is very likely to bring a series of adverse reactions. However, Chinese medicine has rich experience in the treatment of gall diseases, unique and diverse treatment methods, and has achieved considerable efficacy in reducing the volume of nodules and alleviating clinical symptoms, with fewer adverse reactions, both effective and safe.
