帕洛诺司琼是第一个获准用于预防迟发性化疗所致恶心、呕吐(chemotherapy-induced nausea and vomiting,CINV)的5-羟色胺3(5-HT3)受体拮抗剂。通过比较,发现帕洛诺司琼治疗急性期CINV至少同第一代5-HT3受体拮抗剂同样有效,对延迟性CINV...帕洛诺司琼是第一个获准用于预防迟发性化疗所致恶心、呕吐(chemotherapy-induced nausea and vomiting,CINV)的5-羟色胺3(5-HT3)受体拮抗剂。通过比较,发现帕洛诺司琼治疗急性期CINV至少同第一代5-HT3受体拮抗剂同样有效,对延迟性CINV的疗效优于第一代5-HT3受体拮抗剂。本文综述了帕洛诺司琼的临床研究进展,并探讨了多剂量给予帕洛诺司琼的安全性和有效性。展开更多
To study the antifungal mechanism and structure-activity relationship of the azole compounds,four triazole compounds were designed and synthesized.All of them were confirmed by 1H-NMR.Antifungal activities of title co...To study the antifungal mechanism and structure-activity relationship of the azole compounds,four triazole compounds were designed and synthesized.All of them were confirmed by 1H-NMR.Antifungal activities of title compounds were evaluated.And the results of the preliminary antifungal test showed that all compounds exhibited inhibitory effects on C.albicans and C.neoformans,especially the effects of 8d and 8b showed more potent than fluconazole.展开更多
文摘帕洛诺司琼是第一个获准用于预防迟发性化疗所致恶心、呕吐(chemotherapy-induced nausea and vomiting,CINV)的5-羟色胺3(5-HT3)受体拮抗剂。通过比较,发现帕洛诺司琼治疗急性期CINV至少同第一代5-HT3受体拮抗剂同样有效,对延迟性CINV的疗效优于第一代5-HT3受体拮抗剂。本文综述了帕洛诺司琼的临床研究进展,并探讨了多剂量给予帕洛诺司琼的安全性和有效性。
文摘To study the antifungal mechanism and structure-activity relationship of the azole compounds,four triazole compounds were designed and synthesized.All of them were confirmed by 1H-NMR.Antifungal activities of title compounds were evaluated.And the results of the preliminary antifungal test showed that all compounds exhibited inhibitory effects on C.albicans and C.neoformans,especially the effects of 8d and 8b showed more potent than fluconazole.
