目的探讨使用自制新型免充气拉钩行经口联合颏下入路腔镜甲状腺手术(transoral endoscopic thyroidectomy via submental and vestibular approach,TOETSMVA)的安全性。方法回顾性分析2021年1月~2022年6月119例单侧叶甲状腺肿瘤手术资料...目的探讨使用自制新型免充气拉钩行经口联合颏下入路腔镜甲状腺手术(transoral endoscopic thyroidectomy via submental and vestibular approach,TOETSMVA)的安全性。方法回顾性分析2021年1月~2022年6月119例单侧叶甲状腺肿瘤手术资料,其中37例使用新型免充气拉钩行免充气TOETSMVA(免充气组),37例行充气TOETSMVA(充气组),45例行传统颈前开放甲状腺手术(开放组)。比较3组手术指标、术后并发症、患者对切口满意度的差异。结果与开放组相比,免充气组手术时间长[(131.0±20.1)min vs.(81.1±15.7)min,P=0.000],但术中出血量少[19(15,27)ml vs.30(25,37)ml,P=0.000],术后第1天疼痛评分低[(4.8±2.1)分vs.(6.4±1.9)分,P=0.000],患者对切口满意度高(非常不满意、不满意、满意、较为满意、非常满意的例数分别为0、0、6、16、15 vs.4、3、19、17、2,P=0.000)。与充气组相比,免充气组手术时间短[(131.0±20.1)min vs.(141.8±22.9)min,P=0.019],术中出血量、术后第1天疼痛评分、患者对切口满意度差异无统计学意义(P>0.05)。3组淋巴结清扫数量、术后总引流量、术后1天甲状旁腺激素(parathyroid hormone,PTH)水平差异无统计学意义(P>0.05)。开放组术后出血1例,免充气组颈部皮下瘀斑1例、声音嘶哑1例,3组均无气管食管损伤、严重皮下气肿、高碳酸血症、气体栓塞等并发症。结论新型免充气拉钩在TOETSMVA术中能够有效地维持空间,与传统颈前开放甲状腺手术和常规充气TOETSMVA相比,手术安全性好。展开更多
绞股蓝皂苷作为绞股蓝中的一种重要天然活性成分,近年来受到广泛关注。研究表明,绞股蓝皂苷具有多种生物活性,包括抗氧化、抗炎、降糖、降脂、心血管保护及免疫调节等作用,其中抗肿瘤活性尤为突出,可能与其调节细胞增殖、诱导凋亡、抑...绞股蓝皂苷作为绞股蓝中的一种重要天然活性成分,近年来受到广泛关注。研究表明,绞股蓝皂苷具有多种生物活性,包括抗氧化、抗炎、降糖、降脂、心血管保护及免疫调节等作用,其中抗肿瘤活性尤为突出,可能与其调节细胞增殖、诱导凋亡、抑制肿瘤细胞转移等机制密切相关。对绞股蓝皂苷的抗肿瘤活性成分及作用机制进行了系统归纳和分析,旨在为绞股蓝皂苷在抗癌药理作用领域的进一步研究提供参考。Gypenosides, as an important natural active ingredient found in Gynostemma pentaphyllum, has received widespread attention in recent years. Studies have shown that gypenosides exhibit various biological activities, including anti-oxidant, anti-inflammatory, hypoglycemic, hypolipidemic, cardiovascular protection and immunomodulatory effects, among which the antitumour activity is particularly prominent, which may be closely related to its mechanisms of regulating cell proliferation, inducing apoptosis and inhibiting tumour cell metastasis. This article systematically summarizes and analyzes the anti-tumor bioactive components and mechanisms of gypenosides, aiming to provide reference and support for further research on their pharmacological effects in cancer treatment.展开更多
文摘绞股蓝皂苷作为绞股蓝中的一种重要天然活性成分,近年来受到广泛关注。研究表明,绞股蓝皂苷具有多种生物活性,包括抗氧化、抗炎、降糖、降脂、心血管保护及免疫调节等作用,其中抗肿瘤活性尤为突出,可能与其调节细胞增殖、诱导凋亡、抑制肿瘤细胞转移等机制密切相关。对绞股蓝皂苷的抗肿瘤活性成分及作用机制进行了系统归纳和分析,旨在为绞股蓝皂苷在抗癌药理作用领域的进一步研究提供参考。Gypenosides, as an important natural active ingredient found in Gynostemma pentaphyllum, has received widespread attention in recent years. Studies have shown that gypenosides exhibit various biological activities, including anti-oxidant, anti-inflammatory, hypoglycemic, hypolipidemic, cardiovascular protection and immunomodulatory effects, among which the antitumour activity is particularly prominent, which may be closely related to its mechanisms of regulating cell proliferation, inducing apoptosis and inhibiting tumour cell metastasis. This article systematically summarizes and analyzes the anti-tumor bioactive components and mechanisms of gypenosides, aiming to provide reference and support for further research on their pharmacological effects in cancer treatment.
