In recent years,the incidence of Precancerous lesions of gastric cancer(PLGC)has gradually increased,and it is difficult to be cured and easy to recur.Traditional Chinese Medicine(TCM)emphasizes the prevention before ...In recent years,the incidence of Precancerous lesions of gastric cancer(PLGC)has gradually increased,and it is difficult to be cured and easy to recur.Traditional Chinese Medicine(TCM)emphasizes the prevention before the disease.The regulation of PLGC related tumor genes by Chinese medicine has become a research hotspot.This paper summarized PLGC related proto-oncogenes,tumor suppressor genes and apoptosis related genes,and discussed the mechanism of Chinese Medicine Therapy PLGC from the perspective of gene expression,providing new ideas and methods for clinical treatment of PLGC.展开更多
Objective: To evaluate the efficacy and safety of Shugan Yiyang Capsule (SGYY,疏肝益阳胶囊 ) in treating psychogenic and mild arteriogenic erectile dysfunction (ED) of Gan stagnation and Shen deficiency Syndrome type ...Objective: To evaluate the efficacy and safety of Shugan Yiyang Capsule (SGYY,疏肝益阳胶囊 ) in treating psychogenic and mild arteriogenic erectile dysfunction (ED) of Gan stagnation and Shen deficiency Syndrome type with or without blood stasis. Methods: A multi-centered, randomized, double-blinded, placebo-controlled trial in 304 patients was conducted by dividing them into 3 groups, who received respectively SGYY (n = 102), placebo (n = 101) and Suoyang Bushen capsule (锁阳补肾胶囊, SYBS, n = 101), 1.0g taken three times a day for 4 weeks. Besides, 205 patients were arranged in an open-label study and treated with SGYY 1.0 g taken three times a day for 4 weeks. The total effective rate, total remarkably effective rate, erection recovery rate tested by penis hardness test ring, time taken for improving erection a-mong groups, as well as therapeutic effect between psychogenic ED group and mild arteriogenic ED group were compared. Adverse reactions related to SGYY were recorded. And a 3-month follow-up study was conducted on 105 cured patients. Results: The trial was completed in 500 patients. The total effective rate and total remarkably effective rate in the SGYY treated double-blinded group were 88. 0% and 64. 0% respectively, and those in the open-label group 90. 5% and 65. 0% , respectively, all significantly higher than those in the placebo (21.0%, 6. 0% ) and SYBS groups (60. 0% , 29.0%), P<0.01. At the same time, the e-rection recovery rate and improving time in SGYY group were significantly better than those in other groups ( P<0. 01). No adverse reactions related to SGYY were found. The successful rate of potency to have intercourse within 3 months was over 80% (100 patients out of the 105 cured patients). Conclusion: SGYY was an effective and safe treatment for patients with psychogenic and mild arteriogenic ED of Gan stagnation and Shen deficiency Syndrome type with or without blood stasis, especially for psychogenic ED patients.展开更多
Objective： to investigate the effect moxibustion on white blood cell amount and of Radi.r Astragali （ 黄芪 ） Injection and cellular immunity in patients with postchemotherapy leukopenia. Methods： eighty-six cases...Objective： to investigate the effect moxibustion on white blood cell amount and of Radi.r Astragali （ 黄芪 ） Injection and cellular immunity in patients with postchemotherapy leukopenia. Methods： eighty-six cases of post chemotherpy leucopenia were allocated into group of acupoint injection with Radix Astragali （黄芪） plus mild moxibustion with moxa stick（treatment group） and group of westerm medicine orally took（control group）, and the clinical symptoms, white blood cell amount, and the change of CD3^＋ , CD4^＋ and CD8^＋ before and after the treatment were observed. Results. acupoint injection with Radicc Astragali（黄芪） plus mild moxibustion with moxa stick could enhance the white blood cell amount more markedly than western medicine. The former could increase the contents of CD3^＋ and CD2^＋, and promote the ratio of CD4^＋ /CD^＋ of the patients with tumor, meanwhile, improve the general weak, and there is a significant different between the two groups（P〈 0.01）.展开更多
基金Postdoctoral Scientific Research Developmental Fund(No.LBH-Q17169)National Training Program for key personnel of clinical characteristic technology of traditional Chinese medicine(National Traditional Chinese Medicine Ren Jiao Han(No.[2019]36)The sixth batch of national old Chinese Medicine Experts Academic Experience Inheritance Work Project(No:National People's education of Chinese medicine(No.[2017]29)。
文摘In recent years,the incidence of Precancerous lesions of gastric cancer(PLGC)has gradually increased,and it is difficult to be cured and easy to recur.Traditional Chinese Medicine(TCM)emphasizes the prevention before the disease.The regulation of PLGC related tumor genes by Chinese medicine has become a research hotspot.This paper summarized PLGC related proto-oncogenes,tumor suppressor genes and apoptosis related genes,and discussed the mechanism of Chinese Medicine Therapy PLGC from the perspective of gene expression,providing new ideas and methods for clinical treatment of PLGC.
文摘Objective: To evaluate the efficacy and safety of Shugan Yiyang Capsule (SGYY,疏肝益阳胶囊 ) in treating psychogenic and mild arteriogenic erectile dysfunction (ED) of Gan stagnation and Shen deficiency Syndrome type with or without blood stasis. Methods: A multi-centered, randomized, double-blinded, placebo-controlled trial in 304 patients was conducted by dividing them into 3 groups, who received respectively SGYY (n = 102), placebo (n = 101) and Suoyang Bushen capsule (锁阳补肾胶囊, SYBS, n = 101), 1.0g taken three times a day for 4 weeks. Besides, 205 patients were arranged in an open-label study and treated with SGYY 1.0 g taken three times a day for 4 weeks. The total effective rate, total remarkably effective rate, erection recovery rate tested by penis hardness test ring, time taken for improving erection a-mong groups, as well as therapeutic effect between psychogenic ED group and mild arteriogenic ED group were compared. Adverse reactions related to SGYY were recorded. And a 3-month follow-up study was conducted on 105 cured patients. Results: The trial was completed in 500 patients. The total effective rate and total remarkably effective rate in the SGYY treated double-blinded group were 88. 0% and 64. 0% respectively, and those in the open-label group 90. 5% and 65. 0% , respectively, all significantly higher than those in the placebo (21.0%, 6. 0% ) and SYBS groups (60. 0% , 29.0%), P<0.01. At the same time, the e-rection recovery rate and improving time in SGYY group were significantly better than those in other groups ( P<0. 01). No adverse reactions related to SGYY were found. The successful rate of potency to have intercourse within 3 months was over 80% (100 patients out of the 105 cured patients). Conclusion: SGYY was an effective and safe treatment for patients with psychogenic and mild arteriogenic ED of Gan stagnation and Shen deficiency Syndrome type with or without blood stasis, especially for psychogenic ED patients.
文摘Objective： to investigate the effect moxibustion on white blood cell amount and of Radi.r Astragali （ 黄芪 ） Injection and cellular immunity in patients with postchemotherapy leukopenia. Methods： eighty-six cases of post chemotherpy leucopenia were allocated into group of acupoint injection with Radix Astragali （黄芪） plus mild moxibustion with moxa stick（treatment group） and group of westerm medicine orally took（control group）, and the clinical symptoms, white blood cell amount, and the change of CD3^＋ , CD4^＋ and CD8^＋ before and after the treatment were observed. Results. acupoint injection with Radicc Astragali（黄芪） plus mild moxibustion with moxa stick could enhance the white blood cell amount more markedly than western medicine. The former could increase the contents of CD3^＋ and CD2^＋, and promote the ratio of CD4^＋ /CD^＋ of the patients with tumor, meanwhile, improve the general weak, and there is a significant different between the two groups（P〈 0.01）.
