Interconnectivity is the key characteristic of bone tissue engineering scaffold modulating cell migration,blood vessels invasion and transport of nutrient and waste.However,efforts and understanding of the interconnec...Interconnectivity is the key characteristic of bone tissue engineering scaffold modulating cell migration,blood vessels invasion and transport of nutrient and waste.However,efforts and understanding of the interconnectivity of porous Mg is limited due to the diverse architectures of pore struts and pore size distribution of Mg scaffold systems.In this work,biomimetic hierarchical porous Mg scaffolds with tailored interconnectivity as well as pore size distribution were prepared by template replication of infiltration casting.Mg scaffold with better interconnectivity showed lower mechanical strength.Enlarging interconnected pores would enhance the interconnectivity of the whole scaffold and reduce the change of ion concentration,pH value and osmolality of the degradation microenvironment due to the lower specific surface area.Nevertheless,the degradation rates of five tested Mg scaffolds were no different because of the same geometry of strut unit.Direct cell culture and evaluation of cell density at both sides of four typical Mg scaffolds indicated that cell migration through hierarchical porous Mg scaffolds could be enhanced by not only bigger interconnected pore size but also larger main pore size.In summary,design of interconnectivity in terms of pore size distribution could regulate mechanical strength,microenvironment in cell culture condition and cell migration potential,and beyond that it shows great potential for personalized therapy which could facilitate the regeneration process.展开更多
In order to analyze the proposed method,this paper takes the cockpit as the complex system,since the traditional cockpit design evaluation method can set up an actual engineering prototype.Although this method can rea...In order to analyze the proposed method,this paper takes the cockpit as the complex system,since the traditional cockpit design evaluation method can set up an actual engineering prototype.Although this method can realize the accurate evaluation of the internal structure layout,control devices,and interface display of the cockpit,it is dif-ficult to make modifications once the production is completed,which is not suitable for multi-scheme comparison and rapid iteration in the early stage of civil aircraft design.In this regard,this paper establishes the civil aircraft cockpit physical environment and the corresponding virtual cockpit environment based on the virtual-real matching tech-nology,then proposes a mixed reality simulation evaluation method so as to realize the real-time ergonomic evaluation of the digital human body followed by a real person.Experimental results show that this mixed reality simulation evaluation method can effectively improve the evaluation accuracy of cockpit design,ensure the efficiency of multi-scheme comparison and optimization iteration in the early stage of cockpit design.展开更多
In order to obtain stable and high-precision motion tracking in mixed reality(MR)simulation of the complex system,an optical-inertial hybrid tracking method is proposed,which combines the accuracy of optical motion ca...In order to obtain stable and high-precision motion tracking in mixed reality(MR)simulation of the complex system,an optical-inertial hybrid tracking method is proposed,which combines the accuracy of optical motion capture equipment and the robustness of inertial motion capture equipment,and can reduce the occlusion problem of entity scene on the premise of ensuring the localization accuracy.The method has been applied to the ergonomic evaluation of large civil aircraft development processes,and the effectiveness and usability of the method have been verified.展开更多
基金supported by grants from Shenzhen Key Medical Subject(No.SZXK023)Shenzhen“SanMing”Project of Medicine(No.SZSM201612092)+3 种基金Shenzhen Research and Development Projects(No.JCYJ20170307111755218)Guangdong Basic and Applied Basic Research Foundation(No.2019A1515011290)National Key Research and Development Program of China(No.2016YFC1102103)China Postdoctoral Science Foundation(No.2020M672756)
文摘Interconnectivity is the key characteristic of bone tissue engineering scaffold modulating cell migration,blood vessels invasion and transport of nutrient and waste.However,efforts and understanding of the interconnectivity of porous Mg is limited due to the diverse architectures of pore struts and pore size distribution of Mg scaffold systems.In this work,biomimetic hierarchical porous Mg scaffolds with tailored interconnectivity as well as pore size distribution were prepared by template replication of infiltration casting.Mg scaffold with better interconnectivity showed lower mechanical strength.Enlarging interconnected pores would enhance the interconnectivity of the whole scaffold and reduce the change of ion concentration,pH value and osmolality of the degradation microenvironment due to the lower specific surface area.Nevertheless,the degradation rates of five tested Mg scaffolds were no different because of the same geometry of strut unit.Direct cell culture and evaluation of cell density at both sides of four typical Mg scaffolds indicated that cell migration through hierarchical porous Mg scaffolds could be enhanced by not only bigger interconnected pore size but also larger main pore size.In summary,design of interconnectivity in terms of pore size distribution could regulate mechanical strength,microenvironment in cell culture condition and cell migration potential,and beyond that it shows great potential for personalized therapy which could facilitate the regeneration process.
文摘In order to analyze the proposed method,this paper takes the cockpit as the complex system,since the traditional cockpit design evaluation method can set up an actual engineering prototype.Although this method can realize the accurate evaluation of the internal structure layout,control devices,and interface display of the cockpit,it is dif-ficult to make modifications once the production is completed,which is not suitable for multi-scheme comparison and rapid iteration in the early stage of civil aircraft design.In this regard,this paper establishes the civil aircraft cockpit physical environment and the corresponding virtual cockpit environment based on the virtual-real matching tech-nology,then proposes a mixed reality simulation evaluation method so as to realize the real-time ergonomic evaluation of the digital human body followed by a real person.Experimental results show that this mixed reality simulation evaluation method can effectively improve the evaluation accuracy of cockpit design,ensure the efficiency of multi-scheme comparison and optimization iteration in the early stage of cockpit design.
基金This work was supported by the National Key R&D Program of China(No.2018YFB1701600).
文摘In order to obtain stable and high-precision motion tracking in mixed reality(MR)simulation of the complex system,an optical-inertial hybrid tracking method is proposed,which combines the accuracy of optical motion capture equipment and the robustness of inertial motion capture equipment,and can reduce the occlusion problem of entity scene on the premise of ensuring the localization accuracy.The method has been applied to the ergonomic evaluation of large civil aircraft development processes,and the effectiveness and usability of the method have been verified.
