Topological supramolecular polymers are responsible for design of innovative materials with unique physical properties but remain a challenging task to prepare by means of supramolecular polymerization.In this contrib...Topological supramolecular polymers are responsible for design of innovative materials with unique physical properties but remain a challenging task to prepare by means of supramolecular polymerization.In this contribution,we present a novel method of region-confined amphiphilic supramolecular polymerization(RASP)in a controllable two-step self-organization pathway,which was certified by a new type of pyridine-oxadiazole alternating 48-membered macrocycles with structurally regional distribution of distinct self-assembling groups that can self-organize into circular supramolecular architectures.Meanwhile,water molecule plays a crucial role in RASP,and the water content in nonpolar solvent chloroform is sensitive to trigger controllable amphiphilic self-organization.Moreover,differing from the traditional rodlike micelles formed by self-assembly of linearly amphiphilic molecules,this approach of RASP exclusively gives rise to the formation of circularly assembled supramolecular polymers.展开更多
Molecular weaving is a powerful approach to make molecularly woven materials that have showed unprecedented characteristics and properties intrinsically distinct to those of non-woven materials.We here report a facile...Molecular weaving is a powerful approach to make molecularly woven materials that have showed unprecedented characteristics and properties intrinsically distinct to those of non-woven materials.We here report a facile and efficient approach for the synthesis of 2D woven supramolecular polymers by differentiated self-assembly through orthogonal noncovalent interactions.Importantly,the difference in binding strength of two orthogonal noncovalent interactions can be used to control the process of molecular weaving.Consequently,single-layered 2D woven supramolecular polymers were synthesized and fully characterized by various techniques.This study demonstrates a controllable method for molecular weaving,and will significantly hasten the development of molecularly woven materials.展开更多
Histopathological diagnosis is a crucial part of surgical treatment,as it determines further treatment decisions and prognosis for patients.Due to the heterogeneity of tumors,traditional histopathological diagnosis re...Histopathological diagnosis is a crucial part of surgical treatment,as it determines further treatment decisions and prognosis for patients.Due to the heterogeneity of tumors,traditional histopathological diagnosis relies on histological and cytological morphological analysis of cryo-slides by well-trained pathologists,which is subjective,time-consuming,and lacks considerable reliability.Therefore,we engineer a series of tumor receptor-seeking dyes to automatically label and visually depict the tumor contour with antibody-free interaction.The meso-chlorine on the cyclohexyl ring of dyes can covalently react with specific thiol groups in various tumor signature proteins to form stable dye@protein complexes.These dye@protein complexes have significantly amplified fluorescence signals in tumor sites,enabling highresolution delineation of tumormargins and providing histological morphology information to potentially determine tumor staging.The orthogonal effect not only avoids errors caused by individual signature proteins,but also amplifies the fluorescence difference between tumor and normal tissues.Notably,our method is easy to operate with a minimal detection time of only 4 min.The tumor receptor-seeking dyes successfully assess tumor-positive margins from 66 resected breast tumor samples and 25 intraoperative cancer patients with 100%accuracy,providing a newgeneration technique for intraoperative pathologic diagnosis of tumor biopsy.展开更多
基金This work was supported by the National Natural Science Foundation of China(Nos.92156012,22071078)the Program for Jilin University Science and Technology Innovative Research Team(JLUSTIRT),China(No.2019TD-36).
文摘Topological supramolecular polymers are responsible for design of innovative materials with unique physical properties but remain a challenging task to prepare by means of supramolecular polymerization.In this contribution,we present a novel method of region-confined amphiphilic supramolecular polymerization(RASP)in a controllable two-step self-organization pathway,which was certified by a new type of pyridine-oxadiazole alternating 48-membered macrocycles with structurally regional distribution of distinct self-assembling groups that can self-organize into circular supramolecular architectures.Meanwhile,water molecule plays a crucial role in RASP,and the water content in nonpolar solvent chloroform is sensitive to trigger controllable amphiphilic self-organization.Moreover,differing from the traditional rodlike micelles formed by self-assembly of linearly amphiphilic molecules,this approach of RASP exclusively gives rise to the formation of circularly assembled supramolecular polymers.
基金supported by the National Natural Science Foundation of China(Nos.92156012 and 22071078).
文摘Molecular weaving is a powerful approach to make molecularly woven materials that have showed unprecedented characteristics and properties intrinsically distinct to those of non-woven materials.We here report a facile and efficient approach for the synthesis of 2D woven supramolecular polymers by differentiated self-assembly through orthogonal noncovalent interactions.Importantly,the difference in binding strength of two orthogonal noncovalent interactions can be used to control the process of molecular weaving.Consequently,single-layered 2D woven supramolecular polymers were synthesized and fully characterized by various techniques.This study demonstrates a controllable method for molecular weaving,and will significantly hasten the development of molecularly woven materials.
基金the National Key Research and Development Program of China(grant no.2022YFC2601900).
文摘Histopathological diagnosis is a crucial part of surgical treatment,as it determines further treatment decisions and prognosis for patients.Due to the heterogeneity of tumors,traditional histopathological diagnosis relies on histological and cytological morphological analysis of cryo-slides by well-trained pathologists,which is subjective,time-consuming,and lacks considerable reliability.Therefore,we engineer a series of tumor receptor-seeking dyes to automatically label and visually depict the tumor contour with antibody-free interaction.The meso-chlorine on the cyclohexyl ring of dyes can covalently react with specific thiol groups in various tumor signature proteins to form stable dye@protein complexes.These dye@protein complexes have significantly amplified fluorescence signals in tumor sites,enabling highresolution delineation of tumormargins and providing histological morphology information to potentially determine tumor staging.The orthogonal effect not only avoids errors caused by individual signature proteins,but also amplifies the fluorescence difference between tumor and normal tissues.Notably,our method is easy to operate with a minimal detection time of only 4 min.The tumor receptor-seeking dyes successfully assess tumor-positive margins from 66 resected breast tumor samples and 25 intraoperative cancer patients with 100%accuracy,providing a newgeneration technique for intraoperative pathologic diagnosis of tumor biopsy.
