Immunosenescence is marked by accelerated degradation of host immune responses leading to the onset of opportunistic infections, where senescent T cells show remarkably higher ontogenic defects as compared to healthy ...Immunosenescence is marked by accelerated degradation of host immune responses leading to the onset of opportunistic infections, where senescent T cells show remarkably higher ontogenic defects as compared to healthy T cells. The mechanistic association between T-cell immunosenescence and human immunodeficiency virus(HIV) disease progression, and functional T-cell responses in HIV-tuberculosis(HIV-TB) co-infection remains to be elaborately discussed. Here, we discussed the association of immunosenescence and chronic immune activation in HIV-TB co-infection and reviewed the role played by mediators of immune deterioration in HIV-TB coinfection necessitating the importance of designing therapeutic strategies against HIV disease progression and pathogenesis.展开更多
基金Supported by a grant from the University of Malaya Research Grant RG448-12HTM of the Health and Translational Medicine Research Cluster to Esaki M ShankarUM.C/625/1/HIR/Mo HE/MED/014 to Adeeba Kamarulzaman by the High Impact Research(HIR)+3 种基金University of Malaya,SIDA SARC,VINNMER for Vinnova,Linkping University Hospital Research Fund,CALF and the Swedish Society of Medicinethe Swedish International Development Cooperation Agencythe Swedish Physicians against AIDS Research Foundationthe Swedish Research Council,Marie Larsson,No.AI52731
文摘Immunosenescence is marked by accelerated degradation of host immune responses leading to the onset of opportunistic infections, where senescent T cells show remarkably higher ontogenic defects as compared to healthy T cells. The mechanistic association between T-cell immunosenescence and human immunodeficiency virus(HIV) disease progression, and functional T-cell responses in HIV-tuberculosis(HIV-TB) co-infection remains to be elaborately discussed. Here, we discussed the association of immunosenescence and chronic immune activation in HIV-TB co-infection and reviewed the role played by mediators of immune deterioration in HIV-TB coinfection necessitating the importance of designing therapeutic strategies against HIV disease progression and pathogenesis.