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Mechanistic insights on immunosenescence and chronic immune activation in HIV-tuberculosis co-infection 被引量:1
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作者 Esaki M Shankar Vijayakumar Velu +1 位作者 Adeeba Kamarulzaman Marie Larsson 《World Journal of Virology》 2015年第1期17-24,共8页
Immunosenescence is marked by accelerated degradation of host immune responses leading to the onset of opportunistic infections, where senescent T cells show remarkably higher ontogenic defects as compared to healthy ... Immunosenescence is marked by accelerated degradation of host immune responses leading to the onset of opportunistic infections, where senescent T cells show remarkably higher ontogenic defects as compared to healthy T cells. The mechanistic association between T-cell immunosenescence and human immunodeficiency virus(HIV) disease progression, and functional T-cell responses in HIV-tuberculosis(HIV-TB) co-infection remains to be elaborately discussed. Here, we discussed the association of immunosenescence and chronic immune activation in HIV-TB co-infection and reviewed the role played by mediators of immune deterioration in HIV-TB coinfection necessitating the importance of designing therapeutic strategies against HIV disease progression and pathogenesis. 展开更多
关键词 Cluster of differentiation 38 Human IMMUNODEFICIENCY virus-tuberculosis CO-INFECTION IMMUNOSENESCENCE
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