期刊文献+
共找到1篇文章
< 1 >
每页显示 20 50 100
N-terminal pro-B-type natriuretic peptide and diastolic function measurements by adenosine stress echocardiography in prediction of coronary stenosis in patients 被引量:1
1
作者 ZHENG Ping WANG Hao +8 位作者 TIAN Yue-qin GUO Yuan-lin HE Zuo-xiang LU Ye ZHENG Xin MA Wen-jun XU Nan SUN Xin ZHANG Ling 《Chinese Medical Journal》 SCIE CAS CSCD 2011年第14期2089-2095,共7页
Background Stress echocardiography is mainly used in detection of coronary artery disease (CAD) and to assess risk.This study aimed to use adenosine stress echocardiography (ASE) and N-terminal pro-B-type natriure... Background Stress echocardiography is mainly used in detection of coronary artery disease (CAD) and to assess risk.This study aimed to use adenosine stress echocardiography (ASE) and N-terminal pro-B-type natriuretic peptide (NT-proBNP) to noninvasively assess coronary stenosis in patients with chest pain syndromes or anginal equivalent.Methods NT-proBNP was measured after overnight fast in fifty patients, 42 males and 8 females, who were (57+11)years old. They then underwent echocardiography before and during adenosine administration. Left ventricular (LV)diastolic function analyzed included mitral annular early (E') and late velocity (A') both at the mitral septal and lateral level and the mitral inflow to annulus ratio (E/E'). Coronary angiography was performed the following day after which patients were assigned to three groups: normal results (16 patients), stenosis 50%-69%(17 patients) and stenosis≥70% (17 patients).Results NT-proBNP levels in the groups of stenosis 50%-69% and≥ 70% were significantly higher than that in the group with normal results (P=0.014 and P=0.040). During adenosine stress, the E/E' in the group of stenosis≥70% was higher than in the group of normal results (P=0.024). E'lateral/A'lateral in the group of stenosis 50%-69% and E'septal/A'septal and E'lateral/A'lateral in the group of stenosis≥70% were also decreased during stress compared with baseline (P=0.003,P=0.001, P=0.022). The variation of E'septal/A'septal before and during adenosine stress (△E'septal/A'septal) between the groups of normal results and stenosis ≥70% were significantly different (P=0.001). By receiver operating characteristic (ROC), the specificity of △E'septal/A'septal ≥0.037 predicting coronary stenosis <70% was 94%. The sensitivity and specificity of NT-proBNP≥544.6 fmol/ml in predicting coronary stenosis ≥70% were 93% and 75%, respectively.NT-proBNP inversely correlated with E'lateral/A'lateral (r=-0.390, P=0.014) and positively correlated with E/E'lateral(r=0.550,P=0.001).Conclusions Adenosine might induce diastolic dysfunction in patients with coronary stenosis more than 70% and NT-proBNP could reflect LV diastolic function to a certain extent. We support the prediction that most patients having chest pain syndromes or anginal equivalent with NT-proBNP<544.6 fmol/ml and in ASE AE'septal/A'septal≥0.037 might be spared coronary angiography. 展开更多
关键词 ADENOSINE ECHOCARDIOGRAPHY DIASTOLE coronary stenosis N-terminal pro-B-type natriuretic peptide
原文传递
上一页 1 下一页 到第
使用帮助 返回顶部