Introduction: The tuberculosis (TB) and HIV co-infection is a deadly combination, each accelerating the progression of the other. TB, caused by Mycobacterium tuberculosis (M. tuberculosis), is the leading cause of dea...Introduction: The tuberculosis (TB) and HIV co-infection is a deadly combination, each accelerating the progression of the other. TB, caused by Mycobacterium tuberculosis (M. tuberculosis), is the leading cause of deaths among people living with HIV, accounting for around 40% of all HIV-positive deaths. The aim of this study was to estimate the prevalence of the tuberculosis-HIV co-infection in women. Material and Methods: The study population consisted of all suspected patients visiting the laboratory of the Bogodogo University Hospital, from May 2023 to January 2024, to be screened for M. tuberculosis. This was a descriptive cross-sectional study. Socio-demographic data were collected during individual interviews with consenting patients. M. tuberculosis was identified using the GeneXpert device, and HIV was diagnosed using the Abbott Determine diagnostic test. Results: Our study population was aged, on average, 37 ± 17.5 years. The overall tuberculosis infection rate was 65%, and 35% were married. Housewives were the most infected with 22.5%. The most infected age group was the ]20 - 40], with 32.5%. Some 37.5% of the women were anorexic and 45% had asthenia. Of the suspected cases, 47.5% were people who had contact with infected persons. TB/HIV co-infection was 5%. Conclusion: Tuberculosis is still rife in many parts of the world. It infects both men and women very quickly. HIV-tuberculosis co-infection is a reality, with HIV accelerating the progression of tuberculosis and vice versa. Raising awareness of HIV and tuberculosis should be done in tandem, as their co-infection leads to a poor vital prognosis.展开更多
Background: Surgical treatment of upper mesocolic organs is improved by preoperative diagnosis of anatomical variants of celiac trunk. According to the literature, these anatomical variants are little known in sub-Sah...Background: Surgical treatment of upper mesocolic organs is improved by preoperative diagnosis of anatomical variants of celiac trunk. According to the literature, these anatomical variants are little known in sub-Saharan Africa. Purpose: To evaluate the prevalence of anatomical variants of celiac trunk in relation to its branching. Materials and methods: This was a cross-sectional study of descriptive type. It retrospectively evaluated 160 abdominal contrast enhanced CT-scan, from patients attending Yalgado OUEDRAOGO teaching hospital, from 1 January 2015 to 30 September 2016. Patients with a history of heavy abdominal surgery were excluded. Images obtained by 64-row CT-scan were analyzed for anatomical variants of the celiac trunk. Results: One hundred and twenty-eight patients (80%) had a classic anatomical configuration of celiac trunk, while thirty-two (20%) had at least one anatomical variant. Two anatomical variants were found in fifteen patients (9.4%) while five other patients (3.1%) had more than two variants. The most frequent anatomical variant was the hepato-splenic bifurcation, found in fourteen patients (8, 8%). It was followed by common celiac and mesenteric trunk, and then collateral arteries, in particular left hepatic artery and right lower diaphragmatic artery, each with three patients (1.9%). Conclusion: Anatomical variants related to celiac trunk branching, are as frequent in our study as in the literature. However, the two most common anatomical variants were hepato-splenic bifurcation and common celiac and mesenteric trunk.展开更多
Background: Plasmodium falciparum has developed elaborate strategies to survive in the hostile intracellular environment of the infected host cell, including resistance to oxidative stress. Cysteine is a metabolic pro...Background: Plasmodium falciparum has developed elaborate strategies to survive in the hostile intracellular environment of the infected host cell, including resistance to oxidative stress. Cysteine is a metabolic product of homocysteine and a precursor of the antioxidant glutathione used by Plasmodium falciparum to escape harmful oxidation. Objectives: In the present study we aimed to assess whether Plasmodium falciparum can induce homocysteinemia in malaria patients of Burkina Faso. Methods: Eighty-five (85) individuals including 25 affected by severe malaria, 44 by simple malaria, and 12 negative controls for P. falciparum infection were included in the present study. An enzymatic assay of plasma homocysteinemia was performed using the Homocysteine Enzymatic Assay reagent (ref 05385415 190) on the Roche/ Hitachi Cobas c. Results: The results of the present study show that the mean plasma homocysteine concentrations were 15.1 ± 8.4 μmol/L among patients with severe malaria, 14.0 ± 6.0 μmol/L in patients with uncomplicated malaria, and 12.6 ± 4.1 μmol/L in negative controls for malaria parasite. Conclusions: Our findings suggest high homocysteinemia in malaria patients, especially in those with severe malaria. Monitoring homocysteinemia in the latter group will be useful to avoid complications when an elevated plasma level of homocysteine is a known risk factor for cardiovascular diseases.展开更多
文摘Introduction: The tuberculosis (TB) and HIV co-infection is a deadly combination, each accelerating the progression of the other. TB, caused by Mycobacterium tuberculosis (M. tuberculosis), is the leading cause of deaths among people living with HIV, accounting for around 40% of all HIV-positive deaths. The aim of this study was to estimate the prevalence of the tuberculosis-HIV co-infection in women. Material and Methods: The study population consisted of all suspected patients visiting the laboratory of the Bogodogo University Hospital, from May 2023 to January 2024, to be screened for M. tuberculosis. This was a descriptive cross-sectional study. Socio-demographic data were collected during individual interviews with consenting patients. M. tuberculosis was identified using the GeneXpert device, and HIV was diagnosed using the Abbott Determine diagnostic test. Results: Our study population was aged, on average, 37 ± 17.5 years. The overall tuberculosis infection rate was 65%, and 35% were married. Housewives were the most infected with 22.5%. The most infected age group was the ]20 - 40], with 32.5%. Some 37.5% of the women were anorexic and 45% had asthenia. Of the suspected cases, 47.5% were people who had contact with infected persons. TB/HIV co-infection was 5%. Conclusion: Tuberculosis is still rife in many parts of the world. It infects both men and women very quickly. HIV-tuberculosis co-infection is a reality, with HIV accelerating the progression of tuberculosis and vice versa. Raising awareness of HIV and tuberculosis should be done in tandem, as their co-infection leads to a poor vital prognosis.
文摘Background: Surgical treatment of upper mesocolic organs is improved by preoperative diagnosis of anatomical variants of celiac trunk. According to the literature, these anatomical variants are little known in sub-Saharan Africa. Purpose: To evaluate the prevalence of anatomical variants of celiac trunk in relation to its branching. Materials and methods: This was a cross-sectional study of descriptive type. It retrospectively evaluated 160 abdominal contrast enhanced CT-scan, from patients attending Yalgado OUEDRAOGO teaching hospital, from 1 January 2015 to 30 September 2016. Patients with a history of heavy abdominal surgery were excluded. Images obtained by 64-row CT-scan were analyzed for anatomical variants of the celiac trunk. Results: One hundred and twenty-eight patients (80%) had a classic anatomical configuration of celiac trunk, while thirty-two (20%) had at least one anatomical variant. Two anatomical variants were found in fifteen patients (9.4%) while five other patients (3.1%) had more than two variants. The most frequent anatomical variant was the hepato-splenic bifurcation, found in fourteen patients (8, 8%). It was followed by common celiac and mesenteric trunk, and then collateral arteries, in particular left hepatic artery and right lower diaphragmatic artery, each with three patients (1.9%). Conclusion: Anatomical variants related to celiac trunk branching, are as frequent in our study as in the literature. However, the two most common anatomical variants were hepato-splenic bifurcation and common celiac and mesenteric trunk.
文摘Background: Plasmodium falciparum has developed elaborate strategies to survive in the hostile intracellular environment of the infected host cell, including resistance to oxidative stress. Cysteine is a metabolic product of homocysteine and a precursor of the antioxidant glutathione used by Plasmodium falciparum to escape harmful oxidation. Objectives: In the present study we aimed to assess whether Plasmodium falciparum can induce homocysteinemia in malaria patients of Burkina Faso. Methods: Eighty-five (85) individuals including 25 affected by severe malaria, 44 by simple malaria, and 12 negative controls for P. falciparum infection were included in the present study. An enzymatic assay of plasma homocysteinemia was performed using the Homocysteine Enzymatic Assay reagent (ref 05385415 190) on the Roche/ Hitachi Cobas c. Results: The results of the present study show that the mean plasma homocysteine concentrations were 15.1 ± 8.4 μmol/L among patients with severe malaria, 14.0 ± 6.0 μmol/L in patients with uncomplicated malaria, and 12.6 ± 4.1 μmol/L in negative controls for malaria parasite. Conclusions: Our findings suggest high homocysteinemia in malaria patients, especially in those with severe malaria. Monitoring homocysteinemia in the latter group will be useful to avoid complications when an elevated plasma level of homocysteine is a known risk factor for cardiovascular diseases.
