With the rapid development of the technology of information network and the era of big data,information technology is now widely used in the field of education.Comprehensive popularity of mobile phones,computers,table...With the rapid development of the technology of information network and the era of big data,information technology is now widely used in the field of education.Comprehensive popularity of mobile phones,computers,tablet computers and portable communication devices and WIFI also facilitate the widespread use of online learning,learning in free time,free learning and other modes.The emergence of microlecture follows the learning mode and trend of modern society,special for young medical students who are highly passionate in accepting new things and have a strong ability in using information technology.In this paper,the necessity and feasibility of self-directed teaching methods related to microlecture and flipped classroom in the teaching in a non-directly affiliated hospital.Using the advantages of the"microlecture and flipped classroom"teaching model,it is possible to improve the learning effect of medical students,construct high-quality online courses,and make quality teaching resources widely shared.展开更多
Background:To study the efficacy of Fujing prescription combined with auricular acupoint application in premature ovarian failure and its effect on hormone levels.Methods:From March 2018 to March 2020,100 patients wit...Background:To study the efficacy of Fujing prescription combined with auricular acupoint application in premature ovarian failure and its effect on hormone levels.Methods:From March 2018 to March 2020,100 patients with premature ovarian failure treated in our outpatient clinic were selected and randomly divided into a control group of 50 cases and a treatment group of 50 cases.The control group was treated with Femoston for 28 consecutive days,and the treatment group was treated with not only Femoston,but also Fujing prescription and auricular acupoint application.The patients in the two groups were treated with a 3-month course of treatment.The clinical efficacy,traditional Chinese medicine integral,serum hormone level,immune index and the occurrence of adverse reactions were compared between the two groups.Results:After treatment,the indexes of IgG,IgM and IgA in the treatment group were all increased(P<0.05 for all);compared with the control group,the incidence of adverse reactions in the treatment group was lower(P<0.05).Conclusion:The combination of Fujing prescription and auricular acupoint application in the treatment of premature ovarian failure can improve patients'clinical symptoms significantly,resulting in a decrease in follicle-stimulating hormone levels and an increase in estrogen levels.The combination of Fujing prescription and acupoint application has provided a clinical basis for the TCM treatment of premature ovarian failure.展开更多
Objective:To discuss the clinical application of the"seven,five and three"odd-numbered law theory and analyze the effect on serum sex hormone level.Methods:A total of 100 patients with early threatened abort...Objective:To discuss the clinical application of the"seven,five and three"odd-numbered law theory and analyze the effect on serum sex hormone level.Methods:A total of 100 patients with early threatened abortion admitted from January 2021 to October 2021 were randomly divided into study group and control group,with 50 patients in each group.Patients in the control group were treated with dydrogesterone tablets,while patients in the study group were treated with Bushen JianpiGutai Decoction combined with dydrogesterone tablets.Clinical efficacy and progesterone level before and after treatment were observed and compared between the two groups,as well as clinical symptom relief time of the two groups,including hemostasis time,abdominal pain relief time and lumbar acid relief time,and sex hormone level of the two groups were observed and compared.Results:The clinical efficacy was significantly better than control patients(P<0.05),no significant difference in progesterone level comparison before treatment(P>0.05),significantly better than control patients(P<0.05),hemostasis,abdominal pain remission and waist acid remission were significantly shorter than control patients(P<0.05),and both significantly better sex hormone levels after treatment(P<0.05).Conclusion:Traditional Chinese medicine has certain advantages in the treatment of threatened abortion,odd-numbered law theoryguidesthe regulation of Yin and Yang in the female menstrual cycle and reproductive function is mainly the regular change of Yin and Yang.Under the guidance of"seven,five,three"odd-numbered law theoryof Traditional Chinese medicine master Xia Guicheng,master the key date and the best time of its transformation,regulate Yin and Yang in the female body,to prevent the occurrence and development of menstrual diseases and adverse childbirth.Bushen Jianpi Gutai decoction can effectively treat threatened abortion,significantly improve the clinical symptoms,improve the level of serum sex hormone,worthy of clinical promotion.展开更多
The Double Ribbons campaign is a combination of the pink ribbon and the blue ribbon.China has launched the"Double Ribbon Campaign,"which includes free screening for both breast and cervical cancers.In this p...The Double Ribbons campaign is a combination of the pink ribbon and the blue ribbon.China has launched the"Double Ribbon Campaign,"which includes free screening for both breast and cervical cancers.In this paper,by briefly describing the characteristics of breast cancer and cervical cancer,this paper summarizes the screening data of Changle County People's Hospital in Shandong Province in the past ten years,clarifies the importance of early screening,early diagnosis and early treatment of diseases,summarizes experience,defines goals,and promotes the long-term development of China's health cause.展开更多
Objective:To clarify the effectiveness and safety of the Biostimble therapeutic instrument in postoperative gastrointestinal dysfunction in gynecology.Methods:Eighty cases of gynecological surgery patients from Changl...Objective:To clarify the effectiveness and safety of the Biostimble therapeutic instrument in postoperative gastrointestinal dysfunction in gynecology.Methods:Eighty cases of gynecological surgery patients from Changle County People's Hospital in Shandong Province were selected and divided into the experimental group and the control group,with 40 patients in each group.Low-frequency pulse electrical stimulation on the Zu San Li acupoint with Biostimble therapy instrument was carried in the experimental group.Electrode pads were arranged at the location of the bilateral Zu San Li acupoints,and the Biostimble treatment was applied twice a day for 30 minutes each time.The patients in the control group received stand postoperative nursing.The time of first anal venting,the time of recovery of bowel sounds,the duration of abdominal distension,the duration of abdominal pain,and the postoperative symptom score were observed in the two groups.Adverse events were recorded.Results:Compared to the control group,the experimental group demonstrated significantly shorter bowel sound recovery time,first anal exhaust time(all P<0.001).The duration of abdominal distension was 23.79±5.12 hours,and the duration of abdominal pain was 30.15±4.24 hours in the experimental group.While the duration of abdominal distension was 29.07±5.06 hours,and the duration of abdominal pain was 37.17±5.24 hours in the control group.There was a significant difference between the two groups(All P<0.001).The mean postoperative symptoms scores in the experimental group(1.17±1.03)were lower than those in the control group(2.08±1.71)at the 72-hour after the operation(P=0.005).The complete recovery rate in the experimental group was higher than that in the control group.The difference in treatment outcome between experimental and control was statistically significant(P=0.013).Conclusion:Biostimble therapy instrument electrostimulation on Zu San Li acupoints can promote rapid recovery of gastrointestinal function in patients after general gynecological surgery.展开更多
Objective:To observe the effect of continuous hemofiltration combined with norepinephrine in the treatment of septic shock,and to explore the value of blood purification in the treatment of septic shock.Methods:From N...Objective:To observe the effect of continuous hemofiltration combined with norepinephrine in the treatment of septic shock,and to explore the value of blood purification in the treatment of septic shock.Methods:From November 2018 to December 2020,100 patients with septic shock in the Intensive care unit of our hospital were selected and randomly divided into observation group and control group,with 50 cases in each group.The control group was given conventional treatment,while the observation group was given continuous hemofiltration combined with norepinephrine intervention.The clinical efficacy,Scv02,MAP and oxygenation index(PO_(2)/FiO_(2))of the two groups were compared.The levels of interleukin-6(IL-6),procalcitonin(PCT)and the total number of leukocytes and other inflammatory factors were compared 72 hours after treatment,and the 28-day mortality of the two groups was counted.Results:The total effective rate of the observation group(92.00%)was significantly higher than that of the control group(86.00%),the difference was statistically significant(p<0.05);the 28-day mortality of the two groups was 8.00%in the observation group and 14.00%in the control group,the difference was statistically significant(χ^(2)=4.629,p=0.038);Before treatment,the Scv02,MAP and PO_(2)/FiO_(2)levels of the two groups were significantly higher than those of post-therapy.There was no significant difference between the two groups(p>0.05);After 48 hours of treatment,the levels of Scv02,MAP and PO_(2)/FiO_(2)in the two groups were significantly increased,while the levels of scv02,map,PO_(2)/FiO_(2)in the observation group were more significantly increased than those in the control group(p<0.05);Before treatment,the levels of IL-6,PCT and total white blood cells in the two groups were significantly higher than those of post-therapy(p<0.05)After 72 hours of treatment,the levels of IL-6,PCT and the total number of white blood cells in the two groups decreased significantly,while the levels of IL-6,PCT and the total number of white blood cells in the observation group decreased more significantly than those in the control group(p<0.05).Conclusion:Continuous blood purification combined with norepinephrine can effectively reduce the level of serum inflammatory factors in patients with septic shock,improve hemodynamic indexes,improve survival rate,which is worthy of clinical application.展开更多
Premature ovarian failure (POF) refers to ovarian failure in patients before the age of 40, which is manifested by aseries of symptoms such as hot flashes, hyperhidrosis, facial flushing, low sexual desire, amenorrhea...Premature ovarian failure (POF) refers to ovarian failure in patients before the age of 40, which is manifested by aseries of symptoms such as hot flashes, hyperhidrosis, facial flushing, low sexual desire, amenorrhea, etc.Gynecological endocrine tests show that estrogen level of patients decreases while follicle stimulating hormonelevel increases, affecting pregnancy of women of childbearing age and seriously causing changes in the quality oflife of patients. The causes of POF are complex with poor therapeutic effect, which seriously endangers thephysical and mental health of patients. This paper summarized the a general description of Chinese medicine (CM)and Western medicine (WM) treating POF from the aspects of clinical application according to the existingliterature. Although WM can significantly contribute to the treatment of POF, the side effects are serious bylong-term application. CM has unique advantages, including reduced adverse reactions and higher patientcompliance. It may also fill in the shortcomings of WM in the intermittent period treatment of POF. Thecombination of Chinese and western medicine has proven to become an important direction for POF treatment.展开更多
At present,the main body of clinical teaching in obstetrics and gynecology is still the traditional clinical teaching method,in which clinical teachers are the main body,and interns are the passive.It is not conducive...At present,the main body of clinical teaching in obstetrics and gynecology is still the traditional clinical teaching method,in which clinical teachers are the main body,and interns are the passive.It is not conducive to giving full play to interns'learning enthusiasm and ability to actively solve problems if lack of stimulating the clinical thinking and cultivating the ability to raise questions.In the face of the problems and deficiencies in gynecological clinical teaching in the new era,our team tries to adopt diversified teaching methods,such as medical record teaching method,multimedia teaching method,main-role teaching method,problem-based learning teaching method and so on,so as to improve students'ability of autonomous learning and problem-solving,as well as students'ability of innovation and cooperation.Therefore,clinical teaching teachers and teaching managers should keep pace with the times to carry out diversified teaching mode reform in gynecological clinical teaching.展开更多
Objective:In general hospitals,pharmaceutical care was carried out to reduce the incidence of adverse drug reactions(ADR),and this effect was significant.It can significantly reduce the incidence of adverse drug react...Objective:In general hospitals,pharmaceutical care was carried out to reduce the incidence of adverse drug reactions(ADR),and this effect was significant.It can significantly reduce the incidence of adverse drug reactions and improve the safety of drug therapy.The Joint Surgery Department and the Department of Neurology of Changle County People's Hospital in Shandong province were investigated for the effect of pharmaceutical care on reducing adverse drug reactions.Methods:120 patients were selected from the Department of Joint Surgery and Neurology,Changle County People's Hospital,Shandong Province from May 2015 to May 2020.According to the random table method,the patients were divided into experimental group(60 cases)and control group(60 cases).Control group:routine drug therapy.Experimental group:pharmaceutical care treatment was carried out jointly,and the incidence of adverse reactions was compared between the two groups.Results:The incidence of adverse reactions in experimental group was lower than that in control group.Conclusion:In general hospitals,pharmaceutical care is effective in reducing adverse drug reactions,which can significantly reduce the incidence of adverse drug reactions.At the same time,this improves the safety of drug treatment,which is worthy of clinical promotion.展开更多
Objective:To investigate the role of interleukin-6(IL-6)and survivin in the pathogenesis of embryonic damage and to provide theoretical basis for the diagnosis and treatment of embryonic arrest.Methods:A total of 50 p...Objective:To investigate the role of interleukin-6(IL-6)and survivin in the pathogenesis of embryonic damage and to provide theoretical basis for the diagnosis and treatment of embryonic arrest.Methods:A total of 50 patients with embryo arrest for unknown reasons in People's Hospital of Changle County,Shandong Province were selected as the embryo termination group,and 50 patients with normal pregnancy were selected as the normal pregnancy group.Serum and chorionic tissue of each group were collected,and the serum IL-6 concentration of the subjects in both groups was determined by enzymatic linked immunosorbency assay.The mRNA expression levels of interleukin 6 and survivin in villus were determined by real-time quantitative PCR.The expression and distribution of interleukin 6 and survivin in villi were detected by SP immunohistochemical method.Results:The mRNA and protein levels of survivin in embryo suspension group were significantly lower than those in normal pregnancy group.Conclusion:The normal expression of interleukin-6 and survivin in the early pregnancy villus tissue is very important to maintain the normal development of early embryo.展开更多
Chloasma is a common and refractory skin disease,which is a discosmetic dermatosis in which pigment is deposited on the face,cheeks,forehead and other parts due to the pigment metabolism disorder.It is manifested as f...Chloasma is a common and refractory skin disease,which is a discosmetic dermatosis in which pigment is deposited on the face,cheeks,forehead and other parts due to the pigment metabolism disorder.It is manifested as facial yellow-brown patches,with different shades,different shapes,and often symmetrically distributed.The prevalence rate of chloasma is still increasing year by year,which reflects the physical and mental health of women.Because the cause of disease is unknown,and at present there is no uniform treatment.This paper discusses the etiology of chloasma from modern medicine and traditional Chinese medicine to provide reference for clinical therapy.展开更多
Objective:To explore the pattern of medication used in the treatment of dysmenorrhea by famous Chinese gynecologists based on the data mining method.Method:The electronic search of the Chinese journal full-text databa...Objective:To explore the pattern of medication used in the treatment of dysmenorrhea by famous Chinese gynecologists based on the data mining method.Method:The electronic search of the Chinese journal full-text database CNKI,WIP database,Wanfang database,and biomedical database was used to download the experience awareness of famous Chinese gynecologists on the literature of dysmenorrhea treatment,including the self-experience introduction of Chinese gynecologists and the experience summary of students.Conduct a manual search to extract relevant literature on dysmenorrhea treatment.An Excel sheet was used to create a statistical summary table from which all data collected were classified into dysmenorrhea,TCM diagnosis,Western medicine diagnosis,TCM evidence differentiation,and high-frequency pharmacological gender classification.Statistical methods were used to perform frequency statistics for all syndromes,formulations and herbal medicines and to apply association rules to mine potential connections between two diseases,syndromes,prescriptions and herbal medicines to summarize the pharmacological patterns of TCM gynecology treatment of dysmenorrhea.The method was used to provide evidence for differentiation and drug ideas and to improve the efficacy of the clinical treatment of dysmenorrhea.Results:Among the 50 gynecologists in The Experience of Famous Chinese Gynecologists,153 journal articles and 22 monographs that met the requirements were collected,and the total number of prescriptions finally collected was 715.A total of 294 medical cases were included,and the high-risk age group for the onset of dysmenorrhea was concentrated between 27–36 years old.The types of dysmenorrhea can be categorized into eight types,and the number of occurrences in descending order:Qi stagnation and blood stasis,cold clotting and blood stasis,kidney deficiency and blood stasis,heat burning and blood stasis,Qi and blood deficiency,damp-heat stasis,Qi deficiency and blood stasis,and liver and kidney deficiency.Famous TCM gynecologists used 296 kinds of herbs for treating dysmenorrhea,with a total drug frequency of 8020 times,of which the total frequency of the top 100 herbs was 7355 times,accounting for 91.71%of the total frequency.Conclusion:(1)Famous Chinese gynecologists treat dysmenorrhea with the guiding principle of"if it does not pass,it hurts;if it does not glory,it hurts".Blood stasis is the main type of dysmenorrhea,and the method of activating blood stasis is the main treatment for dysmenorrhea.(2)Dysmenorrhea is mainly caused by real evidence,among which primary dysmenorrhea can be caused by real evidence,deficiency evidence and mixed evidence of deficiency and real,and the prescriptions used are mainly sutra prescriptions;secondary dysmenorrhea is mainly caused by real evidence and mixed evidence of deficiency and real,and the prescriptions used are mainly empirical prescriptions and are often used together with drugs to disperse nodules.(3)Commonly used herbal medicines for treating dysmenorrhea include Danggui,Baishao,Chuanxiong,Xiangfu,Yanhusuo,Chishao,Gancao and Wulingzhi.Common classic formulas include Siwu Tang,Wenjing Tang,Shixiao San,Shaofuzhuyu Tang,Sini San,Jinlingzi San,and Xiaoyao San.Typical experienced formulas:Neiyi 1 Fang,Neiyi 2 Fang,Neiyi 3 Fang,Jiaweimojie Tang,Bailiansanjie Tang,Neiyizhitong Tang,Huoxuequyuhuazheng Tang,etc.展开更多
基金This work was supported by the Weifang Medical College 2019 University-level Teaching Reform and Research Project(Grant No:2019ZXSJ029).
文摘With the rapid development of the technology of information network and the era of big data,information technology is now widely used in the field of education.Comprehensive popularity of mobile phones,computers,tablet computers and portable communication devices and WIFI also facilitate the widespread use of online learning,learning in free time,free learning and other modes.The emergence of microlecture follows the learning mode and trend of modern society,special for young medical students who are highly passionate in accepting new things and have a strong ability in using information technology.In this paper,the necessity and feasibility of self-directed teaching methods related to microlecture and flipped classroom in the teaching in a non-directly affiliated hospital.Using the advantages of the"microlecture and flipped classroom"teaching model,it is possible to improve the learning effect of medical students,construct high-quality online courses,and make quality teaching resources widely shared.
基金supported by the Scientific Research Project Plan of Traditional Chinese Medicine of Shandong Weifang Health Committee(No.064 of 2020).
文摘Background:To study the efficacy of Fujing prescription combined with auricular acupoint application in premature ovarian failure and its effect on hormone levels.Methods:From March 2018 to March 2020,100 patients with premature ovarian failure treated in our outpatient clinic were selected and randomly divided into a control group of 50 cases and a treatment group of 50 cases.The control group was treated with Femoston for 28 consecutive days,and the treatment group was treated with not only Femoston,but also Fujing prescription and auricular acupoint application.The patients in the two groups were treated with a 3-month course of treatment.The clinical efficacy,traditional Chinese medicine integral,serum hormone level,immune index and the occurrence of adverse reactions were compared between the two groups.Results:After treatment,the indexes of IgG,IgM and IgA in the treatment group were all increased(P<0.05 for all);compared with the control group,the incidence of adverse reactions in the treatment group was lower(P<0.05).Conclusion:The combination of Fujing prescription and auricular acupoint application in the treatment of premature ovarian failure can improve patients'clinical symptoms significantly,resulting in a decrease in follicle-stimulating hormone levels and an increase in estrogen levels.The combination of Fujing prescription and acupoint application has provided a clinical basis for the TCM treatment of premature ovarian failure.
基金TCM Scientific Research Project of Weifang Municipal Health Commission(No.2021-4-001).
文摘Objective:To discuss the clinical application of the"seven,five and three"odd-numbered law theory and analyze the effect on serum sex hormone level.Methods:A total of 100 patients with early threatened abortion admitted from January 2021 to October 2021 were randomly divided into study group and control group,with 50 patients in each group.Patients in the control group were treated with dydrogesterone tablets,while patients in the study group were treated with Bushen JianpiGutai Decoction combined with dydrogesterone tablets.Clinical efficacy and progesterone level before and after treatment were observed and compared between the two groups,as well as clinical symptom relief time of the two groups,including hemostasis time,abdominal pain relief time and lumbar acid relief time,and sex hormone level of the two groups were observed and compared.Results:The clinical efficacy was significantly better than control patients(P<0.05),no significant difference in progesterone level comparison before treatment(P>0.05),significantly better than control patients(P<0.05),hemostasis,abdominal pain remission and waist acid remission were significantly shorter than control patients(P<0.05),and both significantly better sex hormone levels after treatment(P<0.05).Conclusion:Traditional Chinese medicine has certain advantages in the treatment of threatened abortion,odd-numbered law theoryguidesthe regulation of Yin and Yang in the female menstrual cycle and reproductive function is mainly the regular change of Yin and Yang.Under the guidance of"seven,five,three"odd-numbered law theoryof Traditional Chinese medicine master Xia Guicheng,master the key date and the best time of its transformation,regulate Yin and Yang in the female body,to prevent the occurrence and development of menstrual diseases and adverse childbirth.Bushen Jianpi Gutai decoction can effectively treat threatened abortion,significantly improve the clinical symptoms,improve the level of serum sex hormone,worthy of clinical promotion.
文摘The Double Ribbons campaign is a combination of the pink ribbon and the blue ribbon.China has launched the"Double Ribbon Campaign,"which includes free screening for both breast and cervical cancers.In this paper,by briefly describing the characteristics of breast cancer and cervical cancer,this paper summarizes the screening data of Changle County People's Hospital in Shandong Province in the past ten years,clarifies the importance of early screening,early diagnosis and early treatment of diseases,summarizes experience,defines goals,and promotes the long-term development of China's health cause.
基金supported by Weifang Health and Health Commission Chinese Medicine Research Project(2021-4-125)Shandong Province Chinese Medicine Science and Technology Project(2020M046).
文摘Objective:To clarify the effectiveness and safety of the Biostimble therapeutic instrument in postoperative gastrointestinal dysfunction in gynecology.Methods:Eighty cases of gynecological surgery patients from Changle County People's Hospital in Shandong Province were selected and divided into the experimental group and the control group,with 40 patients in each group.Low-frequency pulse electrical stimulation on the Zu San Li acupoint with Biostimble therapy instrument was carried in the experimental group.Electrode pads were arranged at the location of the bilateral Zu San Li acupoints,and the Biostimble treatment was applied twice a day for 30 minutes each time.The patients in the control group received stand postoperative nursing.The time of first anal venting,the time of recovery of bowel sounds,the duration of abdominal distension,the duration of abdominal pain,and the postoperative symptom score were observed in the two groups.Adverse events were recorded.Results:Compared to the control group,the experimental group demonstrated significantly shorter bowel sound recovery time,first anal exhaust time(all P<0.001).The duration of abdominal distension was 23.79±5.12 hours,and the duration of abdominal pain was 30.15±4.24 hours in the experimental group.While the duration of abdominal distension was 29.07±5.06 hours,and the duration of abdominal pain was 37.17±5.24 hours in the control group.There was a significant difference between the two groups(All P<0.001).The mean postoperative symptoms scores in the experimental group(1.17±1.03)were lower than those in the control group(2.08±1.71)at the 72-hour after the operation(P=0.005).The complete recovery rate in the experimental group was higher than that in the control group.The difference in treatment outcome between experimental and control was statistically significant(P=0.013).Conclusion:Biostimble therapy instrument electrostimulation on Zu San Li acupoints can promote rapid recovery of gastrointestinal function in patients after general gynecological surgery.
基金by Scientific research project plan of Weifang Health Committee(Grant No:wfwsjk2019076).
文摘Objective:To observe the effect of continuous hemofiltration combined with norepinephrine in the treatment of septic shock,and to explore the value of blood purification in the treatment of septic shock.Methods:From November 2018 to December 2020,100 patients with septic shock in the Intensive care unit of our hospital were selected and randomly divided into observation group and control group,with 50 cases in each group.The control group was given conventional treatment,while the observation group was given continuous hemofiltration combined with norepinephrine intervention.The clinical efficacy,Scv02,MAP and oxygenation index(PO_(2)/FiO_(2))of the two groups were compared.The levels of interleukin-6(IL-6),procalcitonin(PCT)and the total number of leukocytes and other inflammatory factors were compared 72 hours after treatment,and the 28-day mortality of the two groups was counted.Results:The total effective rate of the observation group(92.00%)was significantly higher than that of the control group(86.00%),the difference was statistically significant(p<0.05);the 28-day mortality of the two groups was 8.00%in the observation group and 14.00%in the control group,the difference was statistically significant(χ^(2)=4.629,p=0.038);Before treatment,the Scv02,MAP and PO_(2)/FiO_(2)levels of the two groups were significantly higher than those of post-therapy.There was no significant difference between the two groups(p>0.05);After 48 hours of treatment,the levels of Scv02,MAP and PO_(2)/FiO_(2)in the two groups were significantly increased,while the levels of scv02,map,PO_(2)/FiO_(2)in the observation group were more significantly increased than those in the control group(p<0.05);Before treatment,the levels of IL-6,PCT and total white blood cells in the two groups were significantly higher than those of post-therapy(p<0.05)After 72 hours of treatment,the levels of IL-6,PCT and the total number of white blood cells in the two groups decreased significantly,while the levels of IL-6,PCT and the total number of white blood cells in the observation group decreased more significantly than those in the control group(p<0.05).Conclusion:Continuous blood purification combined with norepinephrine can effectively reduce the level of serum inflammatory factors in patients with septic shock,improve hemodynamic indexes,improve survival rate,which is worthy of clinical application.
基金This work was partly supported by Scientific Research Project Plan of Traditional Chinese Medicine of Shandong Weifang Health Committee(NO.0642020).
文摘Premature ovarian failure (POF) refers to ovarian failure in patients before the age of 40, which is manifested by aseries of symptoms such as hot flashes, hyperhidrosis, facial flushing, low sexual desire, amenorrhea, etc.Gynecological endocrine tests show that estrogen level of patients decreases while follicle stimulating hormonelevel increases, affecting pregnancy of women of childbearing age and seriously causing changes in the quality oflife of patients. The causes of POF are complex with poor therapeutic effect, which seriously endangers thephysical and mental health of patients. This paper summarized the a general description of Chinese medicine (CM)and Western medicine (WM) treating POF from the aspects of clinical application according to the existingliterature. Although WM can significantly contribute to the treatment of POF, the side effects are serious bylong-term application. CM has unique advantages, including reduced adverse reactions and higher patientcompliance. It may also fill in the shortcomings of WM in the intermittent period treatment of POF. Thecombination of Chinese and western medicine has proven to become an important direction for POF treatment.
基金Weifang Medical University 2019 School-level Teaching Reform and Research Project+Application of Autonomous Teaching Mode Based on Microlecture and Flipped Classroom in Obstetrics and Gynecology Teaching(Grant No:2019ZXSJ029)Key Research Topic of Scientific and Educational Innovation in Institute of Educational Science,China Academy of Management Sciences(Grant No:KJCX5406).
文摘At present,the main body of clinical teaching in obstetrics and gynecology is still the traditional clinical teaching method,in which clinical teachers are the main body,and interns are the passive.It is not conducive to giving full play to interns'learning enthusiasm and ability to actively solve problems if lack of stimulating the clinical thinking and cultivating the ability to raise questions.In the face of the problems and deficiencies in gynecological clinical teaching in the new era,our team tries to adopt diversified teaching methods,such as medical record teaching method,multimedia teaching method,main-role teaching method,problem-based learning teaching method and so on,so as to improve students'ability of autonomous learning and problem-solving,as well as students'ability of innovation and cooperation.Therefore,clinical teaching teachers and teaching managers should keep pace with the times to carry out diversified teaching mode reform in gynecological clinical teaching.
基金Key Research Project of Scientific and Educational Innovation in the Institute of Educational Science,Chinese Academy of Management Sciences(Grant No:KJCX5406).
文摘Objective:In general hospitals,pharmaceutical care was carried out to reduce the incidence of adverse drug reactions(ADR),and this effect was significant.It can significantly reduce the incidence of adverse drug reactions and improve the safety of drug therapy.The Joint Surgery Department and the Department of Neurology of Changle County People's Hospital in Shandong province were investigated for the effect of pharmaceutical care on reducing adverse drug reactions.Methods:120 patients were selected from the Department of Joint Surgery and Neurology,Changle County People's Hospital,Shandong Province from May 2015 to May 2020.According to the random table method,the patients were divided into experimental group(60 cases)and control group(60 cases).Control group:routine drug therapy.Experimental group:pharmaceutical care treatment was carried out jointly,and the incidence of adverse reactions was compared between the two groups.Results:The incidence of adverse reactions in experimental group was lower than that in control group.Conclusion:In general hospitals,pharmaceutical care is effective in reducing adverse drug reactions,which can significantly reduce the incidence of adverse drug reactions.At the same time,this improves the safety of drug treatment,which is worthy of clinical promotion.
基金supported by Weifang Science and Technology Development Plan(Grant No:KJCX5406).
文摘Objective:To investigate the role of interleukin-6(IL-6)and survivin in the pathogenesis of embryonic damage and to provide theoretical basis for the diagnosis and treatment of embryonic arrest.Methods:A total of 50 patients with embryo arrest for unknown reasons in People's Hospital of Changle County,Shandong Province were selected as the embryo termination group,and 50 patients with normal pregnancy were selected as the normal pregnancy group.Serum and chorionic tissue of each group were collected,and the serum IL-6 concentration of the subjects in both groups was determined by enzymatic linked immunosorbency assay.The mRNA expression levels of interleukin 6 and survivin in villus were determined by real-time quantitative PCR.The expression and distribution of interleukin 6 and survivin in villi were detected by SP immunohistochemical method.Results:The mRNA and protein levels of survivin in embryo suspension group were significantly lower than those in normal pregnancy group.Conclusion:The normal expression of interleukin-6 and survivin in the early pregnancy villus tissue is very important to maintain the normal development of early embryo.
基金the Project of Innovation and Research on Medical and Health Reform(No.YYWS1731)。
文摘Chloasma is a common and refractory skin disease,which is a discosmetic dermatosis in which pigment is deposited on the face,cheeks,forehead and other parts due to the pigment metabolism disorder.It is manifested as facial yellow-brown patches,with different shades,different shapes,and often symmetrically distributed.The prevalence rate of chloasma is still increasing year by year,which reflects the physical and mental health of women.Because the cause of disease is unknown,and at present there is no uniform treatment.This paper discusses the etiology of chloasma from modern medicine and traditional Chinese medicine to provide reference for clinical therapy.
文摘Objective:To explore the pattern of medication used in the treatment of dysmenorrhea by famous Chinese gynecologists based on the data mining method.Method:The electronic search of the Chinese journal full-text database CNKI,WIP database,Wanfang database,and biomedical database was used to download the experience awareness of famous Chinese gynecologists on the literature of dysmenorrhea treatment,including the self-experience introduction of Chinese gynecologists and the experience summary of students.Conduct a manual search to extract relevant literature on dysmenorrhea treatment.An Excel sheet was used to create a statistical summary table from which all data collected were classified into dysmenorrhea,TCM diagnosis,Western medicine diagnosis,TCM evidence differentiation,and high-frequency pharmacological gender classification.Statistical methods were used to perform frequency statistics for all syndromes,formulations and herbal medicines and to apply association rules to mine potential connections between two diseases,syndromes,prescriptions and herbal medicines to summarize the pharmacological patterns of TCM gynecology treatment of dysmenorrhea.The method was used to provide evidence for differentiation and drug ideas and to improve the efficacy of the clinical treatment of dysmenorrhea.Results:Among the 50 gynecologists in The Experience of Famous Chinese Gynecologists,153 journal articles and 22 monographs that met the requirements were collected,and the total number of prescriptions finally collected was 715.A total of 294 medical cases were included,and the high-risk age group for the onset of dysmenorrhea was concentrated between 27–36 years old.The types of dysmenorrhea can be categorized into eight types,and the number of occurrences in descending order:Qi stagnation and blood stasis,cold clotting and blood stasis,kidney deficiency and blood stasis,heat burning and blood stasis,Qi and blood deficiency,damp-heat stasis,Qi deficiency and blood stasis,and liver and kidney deficiency.Famous TCM gynecologists used 296 kinds of herbs for treating dysmenorrhea,with a total drug frequency of 8020 times,of which the total frequency of the top 100 herbs was 7355 times,accounting for 91.71%of the total frequency.Conclusion:(1)Famous Chinese gynecologists treat dysmenorrhea with the guiding principle of"if it does not pass,it hurts;if it does not glory,it hurts".Blood stasis is the main type of dysmenorrhea,and the method of activating blood stasis is the main treatment for dysmenorrhea.(2)Dysmenorrhea is mainly caused by real evidence,among which primary dysmenorrhea can be caused by real evidence,deficiency evidence and mixed evidence of deficiency and real,and the prescriptions used are mainly sutra prescriptions;secondary dysmenorrhea is mainly caused by real evidence and mixed evidence of deficiency and real,and the prescriptions used are mainly empirical prescriptions and are often used together with drugs to disperse nodules.(3)Commonly used herbal medicines for treating dysmenorrhea include Danggui,Baishao,Chuanxiong,Xiangfu,Yanhusuo,Chishao,Gancao and Wulingzhi.Common classic formulas include Siwu Tang,Wenjing Tang,Shixiao San,Shaofuzhuyu Tang,Sini San,Jinlingzi San,and Xiaoyao San.Typical experienced formulas:Neiyi 1 Fang,Neiyi 2 Fang,Neiyi 3 Fang,Jiaweimojie Tang,Bailiansanjie Tang,Neiyizhitong Tang,Huoxuequyuhuazheng Tang,etc.
