Based on the conventional observation data,dual polarization radar data and NCEP reanalysis data,the large-scale circulation background field,mesoscale conditions and formation causes of a heavy rainstorm in Nanchang ...Based on the conventional observation data,dual polarization radar data and NCEP reanalysis data,the large-scale circulation background field,mesoscale conditions and formation causes of a heavy rainstorm in Nanchang on July 7,2020 were studied.It was found that this heavy rainstorm occurred under the weather background of the confrontation between the northward air flow behind the trough and the strong southwest warm and humid air flow to the northwest of the subtropical high.The divergence at the upper level,the shear in the middle and low levels,the southward movement of cold air at the low level,unusually abundant water vapor and high unstable energy caused the heavy rainstorm weather.In this process,under the influence of continuous eastward movement of several strong echo cells,an obvious"train effect"was formed in Nanchang,so that the local rainfall was continuous and intense.Moreover,the average of VIL was about 17 kg/m 2,and its variation characteristics were consistent with the variation trend of 5-min rainfall intensity,which had a certain indicator effect on short-term heavy precipitation.The topography of the Meiling Mountain in the west of Nanchang had a great influence on the formation and precipitation distribution of the heavy rain process.There was a strong rainstorm center near the mountain,and the precipitation was obviously larger than that in the plain area.展开更多
AIM:To evaluate the safety,effectiveness,and predictability of small incision lenticule extraction(SMILE)for the treatment of anisometropia,and to explore the personalized design scheme of SMILE in correcting adult my...AIM:To evaluate the safety,effectiveness,and predictability of small incision lenticule extraction(SMILE)for the treatment of anisometropia,and to explore the personalized design scheme of SMILE in correcting adult myopia anisometropia based on the nomogram.METHODS:It’s a prospective cohort study.Patients with anisometropic myopia of refractive difference≥2.0 diopters(D)who underwent SMILE between September 2020 and March 2021 were enrolled.Clinical features and visual function were assessed preoperatively and at 1wk,1,3,and 6mo after the operation.The examination included tests for uncorrected distance visual acuity(UDVA),corrected distance visual acuity(CDVA),refractive errors,effectiveness index(preoperative CDVA/postoperative UDVA),safety index(postoperative CDVA/preoperative CDVA),nomogram and stereoscopic function.Paired t-test,Wilcoxon signed-rank test and repeated-measures analyses of variance were used for continuous variables,and Pearson Chi-squared test was used for categorical variables.RESULTS:The study involved 45 consecutive patients(average age:25.0±6.9y;82 out of 90 eyes underwent SMILE,while 8 eyes were not operated).The average preoperative spherical equivalent(SE)was-4.74±0.22 D.Six months after surgery,the effectiveness index was 1.05±0.12,and the safety index was 1.09±0.11.Seventy eyes(85.4%)exhibited SE correction error within±0.5 D.The percentage of eyes with Titmus stereoscopic function equal to or less than 200”significantly increased from 55.6%preoperatively to 88.9%postoperatively(P<0.05).There was statistically significant difference between higher myopia eyes and contralateral eyes in average nomogram value/spherical refraction ratio.CONCLUSION:SMILE is safe,effective and predictable in correcting myopic anisometropia,and it improves stereoscopic visual function of anisometropia patients.The precise and individualized design of the nomogram is a vital element to ensure the balance of both eyes after SMILE.展开更多
According to the distribution of abutment stress in a stope,this research established the mechanical model of mining abutment pressure transmission in floor base on the theory of semi-infnite plate body in elasticity....According to the distribution of abutment stress in a stope,this research established the mechanical model of mining abutment pressure transmission in floor base on the theory of semi-infnite plate body in elasticity.This study takes the 762 working face of Haizi Coal Mine as a case in point,and analyzed the dynamic evolution law of seam floor stress during the mining process.With an organic combination of the mining floor stress and surrounding rock stress,the study obtained the change laws of the maximum principle stress and the minimum one for the floor roadway surrounding rock when mining the upper working face.Considering the non-constant pressure force state and the cracks revolution mechanisms of floor roadway surrounding rock,the research built the mechanical model of roadway stress.Simulation results verify the reliability of the above conclusions.Moreover,this model could provide the theoretical basis and technical support for controlling floor roadway surrounding rock.展开更多
The initial cell search plays an important role during the process of downlink synchronization establishment between the User Equipment(UE) and the base station. In particular, the uncertainty of the synchronization s...The initial cell search plays an important role during the process of downlink synchronization establishment between the User Equipment(UE) and the base station. In particular, the uncertainty of the synchronization signals on the frequency domain and the flexibility of frame structure configuration have brought great challenges to the initial cell search for the fifth-generation(5G) new radio(NR). To solve this problem, firstly, we analyze the physical layer frame structure of 5G NR systems. Then, by focusing on the knowledge of synchronization signals, the 5G NR cell search process is designed, and the primary synchronization signal(PSS) timing synchronization algorithm is proposed, including a 5G-based coarse synchronization algorithm and conjugate symmetry-based fine synchronization algorithm. Finally, the performance of the proposed cell search algorithm in 5G NR systems is verified through the combination of Digital Signal Processing(DSP) and personal computer(PC). And the MATLAB simulation proves that the proposed algorithm has better performance than the conventional cross-correlation algorithm when a certain frequency offset exists.展开更多
In order to obtain appropriate spray pressure and enhance the spraying and dust removal efficiency, various factors including the dust characteristics, nozzle spraying angle, effective spraying range, water consumptio...In order to obtain appropriate spray pressure and enhance the spraying and dust removal efficiency, various factors including the dust characteristics, nozzle spraying angle, effective spraying range, water consumption and droplet size are taken into account. The dust characteristics from different mines and atomization parameters of different pressure nozzles were measured. It was found that the internal pressure of coal cutters and roadheaders should be kept at 2 MPa, which could ensure large droplet size, large spraying angle and low water consumption and hence realizing a large-area covering and capture for large particle dusts. However, the external spray pressure should be kept at 4 MPa for smaller droplet size and longer effective spraying range, leading to effective dust removal in the operator zone. The spray pressure of support moving, drawing opening, and stage loader on a fully mechanized caving face and stage loader on a fully mechanized driving face should be kept at 8 MPa, under which the nozzles have long effective spraying range, high water flow and small droplet size for the rapid capture of instantaneous, high-concentration and small size dust groups. From the applications on the caving and driving faces in the coal mines, it is indicated that the optimization of spray pressure in different spraying positions could effectively enhance dust removal efficiency. Selecting appropriate nozzles according to the dust characteristics at different positions is also favorable for dust removal efficiency. With the selected nozzles under optimal pressures, the removal rates of both total dust and respirable dust could reach over70%, showing a significant de-dusting effect.展开更多
By analyzing the form of pressure wave within automotive exhaust system and relationship between propagation process and working condition of engine, simulate a work cycle for purpose of timely diagnosing troubles, th...By analyzing the form of pressure wave within automotive exhaust system and relationship between propagation process and working condition of engine, simulate a work cycle for purpose of timely diagnosing troubles, thus presenting exhaust stroke of four cylinders through pressure wave;modifying of the speed of engine will affect the amplitude of pressure wave, harmonic components, phase position and other parameters;at the end of the exhaust stroke, exhaust pressure wave generates interference, superposition and negative effect, which is of great importance for analysis and diagnosis of engine troubles by using exhaust pressure wave.展开更多
Creep mechanics characteristics of large scale tectonic coal was studied under gas draingae and disturbance conditions by using the new self-developed coal gas cou- pling three axial creep equipment.The results show t...Creep mechanics characteristics of large scale tectonic coal was studied under gas draingae and disturbance conditions by using the new self-developed coal gas cou- pling three axial creep equipment.The results show that when σ_1 is smaller,σ_3 is larger, gas pressure and disturbance load are smaller,gassy coal has no disturbance to creep. When σ_3 is smaller,gas pressure and σ_1 are larger,disturbance load is constant,gassy coal has remarkable effects of disturbance to creep.The concepts of disturbance load sensitive domain and disturbance creep sensitive domain were put forward.Under same amplitude disturbance stress condition,blasting disturbance has a stronger influence on gassy coal deformation is related to frequency of disturbance load;gas drainage,blasting excavation and mining play an important role in coal-gas outbursting.The relationship of gassy coal creep and gas pressure gradient,the creep constitutive equation built with gas pressure gradient and disturbance load as independent variables within the framework of fluid-solid two phases coupling were established.展开更多
Pile foundation bearing-retaining wall combination structure is a new type of support structure developed in recent years.This article focuses on the characteristics,advantages,and application scope of the support str...Pile foundation bearing-retaining wall combination structure is a new type of support structure developed in recent years.This article focuses on the characteristics,advantages,and application scope of the support structure,while combining a variety of algorithms,according to different geological conditions and slope stability,as well as summarizes the pile foundation bearing-retaining wall combination structure force analysis and design methods,taking a high-fill road project in Chongqing as an example.The application of this support structure under special conditions,such as thicker soil layer,steeper sliding surface,weak foundation,and limited slope release conditions,is presented,which illustrates the technical advantages of this support structure and proving that it has several other advantages,including clear force mechanism as well as economic and reasonable structure,thus providing reference for similar projects.展开更多
Intensive farming is a primary cause of increased sediment and associated nitrogen(N)and phosphorus(P)loads in surface water systems.Determining their contributing sources,pathways and loads present major challenges i...Intensive farming is a primary cause of increased sediment and associated nitrogen(N)and phosphorus(P)loads in surface water systems.Determining their contributing sources,pathways and loads present major challenges in the high-intensity agricultural catchments.Herein,we quantify the sediment sources and magnitude of sediment total N and total P from different sources using a novel application of compound-specific stable isotope(CSSI)and fallout radionuclides(FRNs)of^(137)cs and^(210)pbex in an intensive agricultural catchment in North China.Sediment sources from surface and sub-surface soils were estimated from FRNs fingerprint and accounted for 62±7%and 38±7%respectively,while surface soil from land uses that originated from hillslope were identified by CssI fingerprint.Using a novel application of FRNs and CSSI sediment fingerprinting techniques,the dominant sediment source was derived from maize farmland(44±0.1%),followed by channel bank(38±7%).The sedimentation rate(13.55±0.30 t ha^(-1)yr^(-1))was quantifed by the^(137)cs cores(0-60 cm)at the outlet of this catchment.The total N and total P in sediment were both mostly derived from maize farmland and least from channel banks.The channel banks are significant sediment sources but contribute little to the input of sediment N and P for eutrophication.It implies that chemically-applied farmlands are the main hotspots for catchment erosion control and pollution prevention.The novel application of FRNs and CSSI techniques cost-effectively quantified sediment N and P loads from different sources with a single visit to the catchment,enabling rapid assessment for optimizing soil conservation strategies and land management practices.展开更多
Uveitis,a vision-threatening inflammatory disease worldwide,is closely related to resident microglia.Retinal microglia are the main immune effector cells with strong plasticity,but their role in uveitis remains unclea...Uveitis,a vision-threatening inflammatory disease worldwide,is closely related to resident microglia.Retinal microglia are the main immune effector cells with strong plasticity,but their role in uveitis remains unclear.N6-methyladenosine(m^(6)A)modification has been proven to be involved in the immune response.Therefore,we in this work aimed to identify the potentially crucial m^(6)A regulators of microglia in uveitis.Through the single-cell sequencing(scRNA-seq)analysis and experimental verification,we found a significant decrease in the expression of fat mass and obesity-associated protein(FTO)in retinal microglia of uveitis mice and human microglia clone 3(HMC3)cells with inflammation.Additionally,FTO knockdown was found to aggravate the secretion of inflammatory factors and the mobility/chemotaxis of microglia.Mechanistically,the RNA-seq data and rescue experiments showed that glypican 4(GPC4)was the target of FTO,which regulated microglial inflammation mediated by the TLR4/NF-κB pathway.Moreover,RNA stability assays indicated that GPC4 upregulation was mainly regulated by the downregulation of the m^(6)A“reader”YTH domain family protein 3(YTHDF3).Finally,the FTO inhibitor FB23-2 further exacerbated experimental autoimmune uveitis(EAU)inflammation by promoting the GPC4/TLR4/NF-κB signaling axis,and this could be attenuated by the TLR4 inhibitor TAK-242.Collectively,a decreased FTO could facilitate microglial inflammation in EAU,suggesting that the restoration or activation of FTO function may be a potential therapeutic strategy for uveitis.展开更多
The compression and creep characteristics of moraine soil are important mechanical properties of geomaterials to be analyzed during the construction process of engineering projects.However,related references about the...The compression and creep characteristics of moraine soil are important mechanical properties of geomaterials to be analyzed during the construction process of engineering projects.However,related references about these characteristics through large-size in-situ tests have rarely been reported.In this study,in-situ tests of particle size distribution,compression deformation,and compression creep were conducted at the Xingkang Bridge,West Sichuan,China.The results show that the uniformity coefficient of moraine soil ranges from 12.1 to 183.3,and gradation coefficient ranges from 0.4 to 2.8.The total compression deformations of moraine samples during the conventional compression deformation test are 4.70,4.07,and 0.47 mm,and their residual deformations are 2.81,2.45,and 0.22 mm,respectively.The deformation modulus ranges from 127.3 to 676.4 MPa,and elastic modulus ranges from 316.3 to 765.7 MPa.During compression creep tests,moraine soil enters the steady creep stage after 3.8 h of loading pressure at 445 k Pa,and it keeps steady after 14 h of loading pressure at 900 k Pa.The Burgers model and generalized Kelvin model predict the deformation well in transient,deceleration and steady creep stages.Results provide a valuable reference for the analysis of the compression deformation and creep behavior of moraine soil during engineering construction and management.展开更多
This paper reports a series of studies on the lubricant properties,elastohydrodynamic film thickness,and coefficients of friction of several commercially available ester base stocks,i.e.,diisooctyl phthalate(DIOP),dii...This paper reports a series of studies on the lubricant properties,elastohydrodynamic film thickness,and coefficients of friction of several commercially available ester base stocks,i.e.,diisooctyl phthalate(DIOP),diisodecyl phthalate(DIDP),diisotridecyl phthalate(DITDP),diisooctyl sebacate(DOS),diisotridecyl sebacate(DTDS),trihydroxymethylpropyl trioleate(TMPTO),and pentaerythritol tetraoleate(PETO).The results include densities and viscosities from 303 to 398 K,and elastohydrodynamic lubricant film thicknesses and friction in the boundary,mixed and full-film lubrication regimes measured at several temperatures,loads,and speeds.These ester base stocks have different lubrication abilities owing to their chain lengths,geometric configurations,and molecular rigidity.This study provides quantitative insight into the use of ester-based lubricants for low friction through the entire lubrication regime(boundary to full film)by utilization of suitable type and size of the ester base stocks.展开更多
基金the Project of Jiangxi Meteorological Bureau"Spatial and Temporal Distribution Characteristics and Classification of Heavy Rainstorm in Nanchang City".
文摘Based on the conventional observation data,dual polarization radar data and NCEP reanalysis data,the large-scale circulation background field,mesoscale conditions and formation causes of a heavy rainstorm in Nanchang on July 7,2020 were studied.It was found that this heavy rainstorm occurred under the weather background of the confrontation between the northward air flow behind the trough and the strong southwest warm and humid air flow to the northwest of the subtropical high.The divergence at the upper level,the shear in the middle and low levels,the southward movement of cold air at the low level,unusually abundant water vapor and high unstable energy caused the heavy rainstorm weather.In this process,under the influence of continuous eastward movement of several strong echo cells,an obvious"train effect"was formed in Nanchang,so that the local rainfall was continuous and intense.Moreover,the average of VIL was about 17 kg/m 2,and its variation characteristics were consistent with the variation trend of 5-min rainfall intensity,which had a certain indicator effect on short-term heavy precipitation.The topography of the Meiling Mountain in the west of Nanchang had a great influence on the formation and precipitation distribution of the heavy rain process.There was a strong rainstorm center near the mountain,and the precipitation was obviously larger than that in the plain area.
基金Supported by the National Natural Science Foundation of China(No.81970832No.81870650)+2 种基金the Key Project of the Chongqing Health Commission(No.2018MSXM003No.2018GDRC008)Natural Science Foundation of Chongqing Science and Technology Bureau(No.cstc2021jcyj-msxmX0967).
文摘AIM:To evaluate the safety,effectiveness,and predictability of small incision lenticule extraction(SMILE)for the treatment of anisometropia,and to explore the personalized design scheme of SMILE in correcting adult myopia anisometropia based on the nomogram.METHODS:It’s a prospective cohort study.Patients with anisometropic myopia of refractive difference≥2.0 diopters(D)who underwent SMILE between September 2020 and March 2021 were enrolled.Clinical features and visual function were assessed preoperatively and at 1wk,1,3,and 6mo after the operation.The examination included tests for uncorrected distance visual acuity(UDVA),corrected distance visual acuity(CDVA),refractive errors,effectiveness index(preoperative CDVA/postoperative UDVA),safety index(postoperative CDVA/preoperative CDVA),nomogram and stereoscopic function.Paired t-test,Wilcoxon signed-rank test and repeated-measures analyses of variance were used for continuous variables,and Pearson Chi-squared test was used for categorical variables.RESULTS:The study involved 45 consecutive patients(average age:25.0±6.9y;82 out of 90 eyes underwent SMILE,while 8 eyes were not operated).The average preoperative spherical equivalent(SE)was-4.74±0.22 D.Six months after surgery,the effectiveness index was 1.05±0.12,and the safety index was 1.09±0.11.Seventy eyes(85.4%)exhibited SE correction error within±0.5 D.The percentage of eyes with Titmus stereoscopic function equal to or less than 200”significantly increased from 55.6%preoperatively to 88.9%postoperatively(P<0.05).There was statistically significant difference between higher myopia eyes and contralateral eyes in average nomogram value/spherical refraction ratio.CONCLUSION:SMILE is safe,effective and predictable in correcting myopic anisometropia,and it improves stereoscopic visual function of anisometropia patients.The precise and individualized design of the nomogram is a vital element to ensure the balance of both eyes after SMILE.
基金supported by the National Natural Science Foundation of China(No.51074004)the Open Project of State Key Laboratory Breeding Base for Mining Disaster Prevention and Control of Shandong University of Science and Technology of China(No.MDPC2012KF06)+1 种基金the Natural Science Foundation of Anhui Province of China(No.11040606M102)Young Teachers Science Foundation of Anhui University of Science&Technology of China(No.2012QNZ14)
文摘According to the distribution of abutment stress in a stope,this research established the mechanical model of mining abutment pressure transmission in floor base on the theory of semi-infnite plate body in elasticity.This study takes the 762 working face of Haizi Coal Mine as a case in point,and analyzed the dynamic evolution law of seam floor stress during the mining process.With an organic combination of the mining floor stress and surrounding rock stress,the study obtained the change laws of the maximum principle stress and the minimum one for the floor roadway surrounding rock when mining the upper working face.Considering the non-constant pressure force state and the cracks revolution mechanisms of floor roadway surrounding rock,the research built the mechanical model of roadway stress.Simulation results verify the reliability of the above conclusions.Moreover,this model could provide the theoretical basis and technical support for controlling floor roadway surrounding rock.
基金partially the Chongqing Municipality’s Major Theme Project “R & D and Application of 5G terminal simulation equipment” (Grant No. Cstc2017zdcy-zdzx0030)
文摘The initial cell search plays an important role during the process of downlink synchronization establishment between the User Equipment(UE) and the base station. In particular, the uncertainty of the synchronization signals on the frequency domain and the flexibility of frame structure configuration have brought great challenges to the initial cell search for the fifth-generation(5G) new radio(NR). To solve this problem, firstly, we analyze the physical layer frame structure of 5G NR systems. Then, by focusing on the knowledge of synchronization signals, the 5G NR cell search process is designed, and the primary synchronization signal(PSS) timing synchronization algorithm is proposed, including a 5G-based coarse synchronization algorithm and conjugate symmetry-based fine synchronization algorithm. Finally, the performance of the proposed cell search algorithm in 5G NR systems is verified through the combination of Digital Signal Processing(DSP) and personal computer(PC). And the MATLAB simulation proves that the proposed algorithm has better performance than the conventional cross-correlation algorithm when a certain frequency offset exists.
基金support from the National Natural Science Foundation of China (Nos.U1261205, 51474139 and 51204103)the Science and Technology Development Plan of Shandong Province (No.2013GSF12004)the Excellent Young Scientific Talents Project of Shandong University of Science and Technology (No.2014JQJH106)
文摘In order to obtain appropriate spray pressure and enhance the spraying and dust removal efficiency, various factors including the dust characteristics, nozzle spraying angle, effective spraying range, water consumption and droplet size are taken into account. The dust characteristics from different mines and atomization parameters of different pressure nozzles were measured. It was found that the internal pressure of coal cutters and roadheaders should be kept at 2 MPa, which could ensure large droplet size, large spraying angle and low water consumption and hence realizing a large-area covering and capture for large particle dusts. However, the external spray pressure should be kept at 4 MPa for smaller droplet size and longer effective spraying range, leading to effective dust removal in the operator zone. The spray pressure of support moving, drawing opening, and stage loader on a fully mechanized caving face and stage loader on a fully mechanized driving face should be kept at 8 MPa, under which the nozzles have long effective spraying range, high water flow and small droplet size for the rapid capture of instantaneous, high-concentration and small size dust groups. From the applications on the caving and driving faces in the coal mines, it is indicated that the optimization of spray pressure in different spraying positions could effectively enhance dust removal efficiency. Selecting appropriate nozzles according to the dust characteristics at different positions is also favorable for dust removal efficiency. With the selected nozzles under optimal pressures, the removal rates of both total dust and respirable dust could reach over70%, showing a significant de-dusting effect.
基金Supported by the Key Program of＂National Basic Research Program of China （973 Program）＂ （2005CB221504） the Key Program of＂National Natural Science Foundation of China＂ （50534080）
基金Supported by the National Natural Science Foundation of China（50534080） the National Basic Research Program of China（2005CB221504） Taishan Scholar Engineering Construction Foundation of Shandong Province
文摘By analyzing the form of pressure wave within automotive exhaust system and relationship between propagation process and working condition of engine, simulate a work cycle for purpose of timely diagnosing troubles, thus presenting exhaust stroke of four cylinders through pressure wave;modifying of the speed of engine will affect the amplitude of pressure wave, harmonic components, phase position and other parameters;at the end of the exhaust stroke, exhaust pressure wave generates interference, superposition and negative effect, which is of great importance for analysis and diagnosis of engine troubles by using exhaust pressure wave.
基金the National Natural Science Foundation(50474029)the China Natural Science Foundation(50534080)+1 种基金the Innovative Research Group(50221402)the Anhui University of Science &Technology Doctor's Fund Project(11142)
文摘Creep mechanics characteristics of large scale tectonic coal was studied under gas draingae and disturbance conditions by using the new self-developed coal gas cou- pling three axial creep equipment.The results show that when σ_1 is smaller,σ_3 is larger, gas pressure and disturbance load are smaller,gassy coal has no disturbance to creep. When σ_3 is smaller,gas pressure and σ_1 are larger,disturbance load is constant,gassy coal has remarkable effects of disturbance to creep.The concepts of disturbance load sensitive domain and disturbance creep sensitive domain were put forward.Under same amplitude disturbance stress condition,blasting disturbance has a stronger influence on gassy coal deformation is related to frequency of disturbance load;gas drainage,blasting excavation and mining play an important role in coal-gas outbursting.The relationship of gassy coal creep and gas pressure gradient,the creep constitutive equation built with gas pressure gradient and disturbance load as independent variables within the framework of fluid-solid two phases coupling were established.
基金Youth Project of Science and Technology Research of Chongqing Municipal Education Commission“Research on the Promotion of Pile Foundation Bearing-Retaining Wall Combined Structure Technology”(Project Number:KJQN201905601)Youth Project of Science and Technology Research of Chongqing Education Commission“Research on Construction Monitoring and Risk Warning of Deep Foundation Pit Project Based on BIM+Internet of Things”(Project Number:KJQN201904306)。
文摘Pile foundation bearing-retaining wall combination structure is a new type of support structure developed in recent years.This article focuses on the characteristics,advantages,and application scope of the support structure,while combining a variety of algorithms,according to different geological conditions and slope stability,as well as summarizes the pile foundation bearing-retaining wall combination structure force analysis and design methods,taking a high-fill road project in Chongqing as an example.The application of this support structure under special conditions,such as thicker soil layer,steeper sliding surface,weak foundation,and limited slope release conditions,is presented,which illustrates the technical advantages of this support structure and proving that it has several other advantages,including clear force mechanism as well as economic and reasonable structure,thus providing reference for similar projects.
基金supported by the International Atomic Energy Agency through coordination research projects(CRP)under Research Contract No.23008 and technical cooperation project(TCP)RAS 5084,and the Central Public-interest Scientific Institution Basal Research Fund(No.BSRF202004)Funding for AC to collaborate on this work was provided by the High-end Foreign Experts Recruitment Program from State of Administration of Foreign Experts Affairs of ChinaThis work was partly supported by the Science and Technology Major Project of Guangxi(Guike AA17204078).
文摘Intensive farming is a primary cause of increased sediment and associated nitrogen(N)and phosphorus(P)loads in surface water systems.Determining their contributing sources,pathways and loads present major challenges in the high-intensity agricultural catchments.Herein,we quantify the sediment sources and magnitude of sediment total N and total P from different sources using a novel application of compound-specific stable isotope(CSSI)and fallout radionuclides(FRNs)of^(137)cs and^(210)pbex in an intensive agricultural catchment in North China.Sediment sources from surface and sub-surface soils were estimated from FRNs fingerprint and accounted for 62±7%and 38±7%respectively,while surface soil from land uses that originated from hillslope were identified by CssI fingerprint.Using a novel application of FRNs and CSSI sediment fingerprinting techniques,the dominant sediment source was derived from maize farmland(44±0.1%),followed by channel bank(38±7%).The sedimentation rate(13.55±0.30 t ha^(-1)yr^(-1))was quantifed by the^(137)cs cores(0-60 cm)at the outlet of this catchment.The total N and total P in sediment were both mostly derived from maize farmland and least from channel banks.The channel banks are significant sediment sources but contribute little to the input of sediment N and P for eutrophication.It implies that chemically-applied farmlands are the main hotspots for catchment erosion control and pollution prevention.The novel application of FRNs and CSSI techniques cost-effectively quantified sediment N and P loads from different sources with a single visit to the catchment,enabling rapid assessment for optimizing soil conservation strategies and land management practices.
基金supported by the National Natural Science Foundation Project of China(No.82070951,82271078 and 81873678)the Innovative Research Group Project of Chongqing Education Commission(China)(No.CXQT19015)+5 种基金the Natural Science Foundation Project of Chongqing,China(No.cstc2019jcyjmsxmx0120)the Innovation Supporting Plan of Overseas Study of Chongqing,China(No.cx2018010)the Chongqing Education Commission(China)(No.KJQN202000406)the National Key Clinical Specialties Construction Program of China,Chongqing Branch of National Clinical Research Center for Ocular Diseasesthe Chongqing Key Laboratory of Ophthalmology(China)(CSTC,No.2008CA5003)Natural Science Foundation Project of Chongqing Medical University(China)(No.W0047).
文摘Uveitis,a vision-threatening inflammatory disease worldwide,is closely related to resident microglia.Retinal microglia are the main immune effector cells with strong plasticity,but their role in uveitis remains unclear.N6-methyladenosine(m^(6)A)modification has been proven to be involved in the immune response.Therefore,we in this work aimed to identify the potentially crucial m^(6)A regulators of microglia in uveitis.Through the single-cell sequencing(scRNA-seq)analysis and experimental verification,we found a significant decrease in the expression of fat mass and obesity-associated protein(FTO)in retinal microglia of uveitis mice and human microglia clone 3(HMC3)cells with inflammation.Additionally,FTO knockdown was found to aggravate the secretion of inflammatory factors and the mobility/chemotaxis of microglia.Mechanistically,the RNA-seq data and rescue experiments showed that glypican 4(GPC4)was the target of FTO,which regulated microglial inflammation mediated by the TLR4/NF-κB pathway.Moreover,RNA stability assays indicated that GPC4 upregulation was mainly regulated by the downregulation of the m^(6)A“reader”YTH domain family protein 3(YTHDF3).Finally,the FTO inhibitor FB23-2 further exacerbated experimental autoimmune uveitis(EAU)inflammation by promoting the GPC4/TLR4/NF-κB signaling axis,and this could be attenuated by the TLR4 inhibitor TAK-242.Collectively,a decreased FTO could facilitate microglial inflammation in EAU,suggesting that the restoration or activation of FTO function may be a potential therapeutic strategy for uveitis.
基金supported by the Engineering Research Center of Rock-Soil Drilling&Excavation and Protection,Ministry of Education (No.202202)the National Natural Science Foundation of China (Nos.42107180,42162023 and 42162025)the Construction S&T Project of Department of Transportation of Sichuan Province of China (No.2020A01)。
文摘The compression and creep characteristics of moraine soil are important mechanical properties of geomaterials to be analyzed during the construction process of engineering projects.However,related references about these characteristics through large-size in-situ tests have rarely been reported.In this study,in-situ tests of particle size distribution,compression deformation,and compression creep were conducted at the Xingkang Bridge,West Sichuan,China.The results show that the uniformity coefficient of moraine soil ranges from 12.1 to 183.3,and gradation coefficient ranges from 0.4 to 2.8.The total compression deformations of moraine samples during the conventional compression deformation test are 4.70,4.07,and 0.47 mm,and their residual deformations are 2.81,2.45,and 0.22 mm,respectively.The deformation modulus ranges from 127.3 to 676.4 MPa,and elastic modulus ranges from 316.3 to 765.7 MPa.During compression creep tests,moraine soil enters the steady creep stage after 3.8 h of loading pressure at 445 k Pa,and it keeps steady after 14 h of loading pressure at 900 k Pa.The Burgers model and generalized Kelvin model predict the deformation well in transient,deceleration and steady creep stages.Results provide a valuable reference for the analysis of the compression deformation and creep behavior of moraine soil during engineering construction and management.
基金The Northwestern authors would also like to acknowledge the support from US Department of Energy(DE-EE0006449).
文摘This paper reports a series of studies on the lubricant properties,elastohydrodynamic film thickness,and coefficients of friction of several commercially available ester base stocks,i.e.,diisooctyl phthalate(DIOP),diisodecyl phthalate(DIDP),diisotridecyl phthalate(DITDP),diisooctyl sebacate(DOS),diisotridecyl sebacate(DTDS),trihydroxymethylpropyl trioleate(TMPTO),and pentaerythritol tetraoleate(PETO).The results include densities and viscosities from 303 to 398 K,and elastohydrodynamic lubricant film thicknesses and friction in the boundary,mixed and full-film lubrication regimes measured at several temperatures,loads,and speeds.These ester base stocks have different lubrication abilities owing to their chain lengths,geometric configurations,and molecular rigidity.This study provides quantitative insight into the use of ester-based lubricants for low friction through the entire lubrication regime(boundary to full film)by utilization of suitable type and size of the ester base stocks.
