Nyquist pulses have wide applications in many areas,from electronics to optics.Mode-locked lasers are ideal platforms to generate such pulses.However,how to generate high-quality Nyquist pulses in mode-locked lasers r...Nyquist pulses have wide applications in many areas,from electronics to optics.Mode-locked lasers are ideal platforms to generate such pulses.However,how to generate high-quality Nyquist pulses in mode-locked lasers remains elusive.We address this problem by managing different physical effects in mode-locked fiber lasers through extensive numerical simulations.We find that net dispersion,linear loss,gain and filter shaping can affect the quality of Nyquist pulses significantly.We also demonstrate that Nyquist pulses experience similariton shaping due to the nonlinear attractor effect in the gain medium.Our work may contribute to the design of Nyquist pulse sources and enrich the understanding of pulse shaping dynamics in mode-locked lasers.展开更多
Besides the diverse investigations on the interactions between intense laser fields and molecular systems,extensive research has been recently dedicated to exploring the response of nanosystems excited by well-tailore...Besides the diverse investigations on the interactions between intense laser fields and molecular systems,extensive research has been recently dedicated to exploring the response of nanosystems excited by well-tailored femtosecond laser fields.Due to the fact that nanostructures hold peculiar effects when illuminated by laser pulses,the underlying mechanisms and the corresponding potential applications can make significant improvements in both fundamental research and development of novel techniques.In this review,we provide a summarization of the strong field ionization occurring on the surface of nanosystems.The molecules attached to the nanoparticle surface perform as the precursor in the ionization and excitation of the whole nanosystem,the fundamental processes of which are yet to be discovered.We discuss the influence on nanoparticle constituents,geometric shapes and sizes,as well as the specific waveforms of the excitation laser fields.The intriguing characteristics observed in surface ion emission reflect how enhanced near field affects the localized ionizations and nanoplasma expansions,thereby paving the way for further precision controls on the light-and-matter interactions in the extreme spatial temporal levels.展开更多
In this paper,we investigate the minimization of age of information(AoI),a metric that measures the information freshness,at the network edge with unreliable wireless communications.Particularly,we consider a set of u...In this paper,we investigate the minimization of age of information(AoI),a metric that measures the information freshness,at the network edge with unreliable wireless communications.Particularly,we consider a set of users transmitting status updates,which are collected by the user randomly over time,to an edge server through unreliable orthogonal channels.It begs a natural question:with random status update arrivals and obscure channel conditions,can we devise an intelligent scheduling policy that matches the users and channels to stabilize the queues of all users while minimizing the average AoI?To give an adequate answer,we define a bipartite graph and formulate a dynamic edge activation problem with stability constraints.Then,we propose an online matching while learning algorithm(MatL)and discuss its implementation for wireless scheduling.Finally,simulation results demonstrate that the MatL is reliable to learn the channel states and manage the users’buffers for fresher information at the edge.展开更多
Breakdown spectroscopy is a valuable tool for determining elements in solids,liquids,and gases.All materials in the breakdown region can be ionized and dissociated into highly excited fragments and emit characteristic...Breakdown spectroscopy is a valuable tool for determining elements in solids,liquids,and gases.All materials in the breakdown region can be ionized and dissociated into highly excited fragments and emit characteristic fluorescence spectra.In this sense,the elemental composition of materials can be evaluated by detecting the fluorescence spectrum.This paper reviews the recent developments in laser-induced breakdown spectroscopy.The traditional laser-induced breakdown spectroscopy,filament-induced breakdown spectroscopy,plasma grating,and multidimensional plasma grating-induced breakdown spectroscopy are introduced.There are also some proposals for applications of plasma gratings,such as laser ablation,laser deposition,and laser catalysis of chemical reactions in conjunction with research on the properties of plasma gratings.展开更多
Classical thermodynamics has been a great achievement in dealing with systems that are in equilibrium or near equilibrium.As an emerging field,nonequilibrium thermodynamics provides a general framework for understandi...Classical thermodynamics has been a great achievement in dealing with systems that are in equilibrium or near equilibrium.As an emerging field,nonequilibrium thermodynamics provides a general framework for understanding the nonequilibrium processes,particularly in small systems that are typically far-from-equilibrium and are dominated by thermal or quantum fluctuations.Cavity optomechanical systems hold great promise among the various experimental platforms for studying nonequilibrium thermodynamics owing to their high controllability,excellent mechanical performance,and ability to operate deep in the quantum regime.Here,we present an overview of the recent advances in nonequilibrium thermodynamics with cavity optomechanical systems.The experimental results in entropy production assessment,fluctuation theorems,heat transfer,and heat engines are highlighted.展开更多
Rabi oscillation is an elementary laser-driven physical process in atoms and artificial atoms from solid-state systems,while it is rarely demonstrated in molecules.Here,we investigate the bond-length-dependent Rabi os...Rabi oscillation is an elementary laser-driven physical process in atoms and artificial atoms from solid-state systems,while it is rarely demonstrated in molecules.Here,we investigate the bond-length-dependent Rabi oscillations with varying Rabi frequencies in strong-laser-field dissociation of H2+.The coupling of the bond stretching and Rabi oscillations makes the nuclei gain different kinetic energies while the electron is alternatively absorbing and emitting photons.The resulting proton kinetic energy spectra show rich structures beyond the prediction of the Floquet theorem and the well-accepted resonant one-photon dissociation pathway.Our study shows that the laser-driven Rabi oscillations accompanied by nuclear motions are essential to understanding the bond-breaking mechanism and provide a time-resolved perspective to manipulate rich dynamics of the strong-laser-field dissociation of molecules.展开更多
In this study,we present a method for free-space beam shaping and steering based on a silicon optical phased array,which addresses the theoretical limitation of traditional bulk optics.We theoretically analyze the bea...In this study,we present a method for free-space beam shaping and steering based on a silicon optical phased array,which addresses the theoretical limitation of traditional bulk optics.We theoretically analyze the beam propagation properties with changes in the applied phase.Different beam profiles can be shaped by varying the phase combination,while a high-order quasi-Bessel beam can be generated with a cubic change to the phase modulation.The simulated results are validated further experimentally,and they match one another well.Beam steering can be achieved with a field of view as large as 140°,which has potential benefits for practical applications.The presented method is expected to have broad application prospects for optical communications,free-space optical interconnects,and light detection and ranging.展开更多
Active mid-infrared(MIR)imagers capable of retrieving three-dimensional(3D)structure and reflectivity information are highly attractive in a wide range of biomedical and industrial applications.However,infrared 3D ima...Active mid-infrared(MIR)imagers capable of retrieving three-dimensional(3D)structure and reflectivity information are highly attractive in a wide range of biomedical and industrial applications.However,infrared 3D imaging at lowlight levels is still challenging due to the deficiency of sensitive and fast MiR sensors.Here we propose and implement a MiR time-of-flight imaging system that operates at single-photon sensitivity and femtosecond timing resolution.Specifically,back-scattered infrared photons from a scene are optically gated by delay-controlled ultrashort pump pulses through nonlinear frequency upconversion.The upconverted images with time stamps are then recorded by a silicon camera to facilitate the 3D reconstruction with high lateral and depth resolutions.Moreover,an effective numerical denoiser based on spatiotemporal correlation allows us to reveal the object profle and reflectivity under photon-starving conditions with a detected flux below 0.05 photons/pixel/second.The presented MIR 3D imager features high detection sensitivity,precise timing resolution,and wide-field operation,which may open new possibilities in life and material sciences.展开更多
The superfluorescence effect has received extensive attention due to the many-body physics of quantum correlation in dipole gas and the optical applications of ultrafast bright radiation field based on the cooperative...The superfluorescence effect has received extensive attention due to the many-body physics of quantum correlation in dipole gas and the optical applications of ultrafast bright radiation field based on the cooperative quantum state.Here,we demonstrate not only to observe the superfluorescence effect but also to control the cooperative state of the excitons ensemble by externally applying a regulatory dimension of coupling light fields.A new quasi-particle called cooperative exciton-polariton is revealed in a light-matter hybrid structure of a perovskite quantum dot thin film spin-coated on a Distributed Bragg Reflector.Above the nonlinear threshold,polaritonic condensation occurs at a nonzero momentum state on the lower polariton branch owning to the vital role of the synchronized excitons.The phase transition from superfluorescence to polariton condensation exhibits typical signatures of a decrease of the linewidth,an increase of the macroscopic coherence as well as an accelerated radiation decay rate.These findings are promising for opening new potential applications for super-brightness and unconventional coherent light sources and could enable the exploitation of cooperative effects for quantum optics.展开更多
We demonstrate a portable system integrated with time comparison,absolute distance ranging,and optical communication(TRC)to meet the requirements of space gravitational wave detection.A 1 km free-space asynchronous tw...We demonstrate a portable system integrated with time comparison,absolute distance ranging,and optical communication(TRC)to meet the requirements of space gravitational wave detection.A 1 km free-space asynchronous two-way optical link is performed.The TRC realizes optical communication with 7.7×10^(−5) bit error rate with a Si avalanche photodiode singlephoton detector,while the signal intensity is 1.4 photons per pulse with the background noise of 3×10^(4) counts per second.The distance measurement uncertainty is 48.3 mm,and time comparison precision is 162.4 ps.In this TRC system,a verticalcavity surface-emitting laser diode with a power of 9.1μW is used,and the equivalent receiving aperture is 0.5 mm.The TRC provides a miniaturization solution for ultra-long distance inter-satellite communication,time comparison,and ranging for space gravitational wave detectors.展开更多
Promoting the sensitivity of mid-infrared(MIR) spectroscopy to the single-photon level is a critical need for investigating photosensitive biological samples and chemical reactions. MIR spectroscopy based on frequency...Promoting the sensitivity of mid-infrared(MIR) spectroscopy to the single-photon level is a critical need for investigating photosensitive biological samples and chemical reactions. MIR spectroscopy based on frequency upconversion is a compelling pioneer allowing high-efficiency MIR spectral measurement with well-developed single-photon detectors, which overcomes the main limitations of high thermal noise of current MIR detectors.However, noise from other nonlinear processes caused by strong pump fields hinders the development of the upconversion-based MIR spectroscopy to reach the single-photon level. Here, a broadband MIR single-photon frequency upconversion spectroscopy is demonstrated based on the temporal-spectral quantum correlation of non-degenerate photon pairs, which is well preserved in the frequency upconversion process and is fully used in extracting the signals from tremendous noise caused by the strong pump. A correlation spectrum broader than660 nm is achieved and applied for the demonstration of sample identification under a low incident photon flux of 0.09 average photons per pulse. The system is featured with non-destructive and robust operation, which makes single-photon-level MIR spectroscopy an appealing option in biochemical applications. ? 2022 Chinese Laser Press.展开更多
A multi-channel laser interferometer(MCLI)is proposed to improve the coordinate measurement accuracy.A 780 nm external cavity laser is locked on the D2 line of ^(87)Rb atom by polarization spectroscopy,and a high freq...A multi-channel laser interferometer(MCLI)is proposed to improve the coordinate measurement accuracy.A 780 nm external cavity laser is locked on the D2 line of ^(87)Rb atom by polarization spectroscopy,and a high frequency stabilized laser source is obtained with a linewidth of 385.8 k Hz at root mean square(RMS).The interferometers share the stabilized source and individually install on 4 axes of a coordinate measuring system.As a result,the measurement uncertainty is reduced from 1.2μm to 0.2μm within the dynamic measurement range of 1.0 m.The MCLI is adept at integrate and flexible installation,which caters to various applications on precision measurement.展开更多
Diabetes treatment and rehabilitation are usually a lifetime process.Optogenetic engineered designer cell-therapy holds great promise in regulating blood glucose homeostasis.However,portable,sustainable,and long-term ...Diabetes treatment and rehabilitation are usually a lifetime process.Optogenetic engineered designer cell-therapy holds great promise in regulating blood glucose homeostasis.However,portable,sustainable,and long-term energy supplementation has previously presented a challenge for the use of optogenetic stimulation in vivo.Herein,we_purpose a self-powered optogenetic system(SOS)for implantable blood glucose control.The SOS consists of a biocompatible far-red light(FRL)source,FRL-triggered transgene-expressing cells,a power management unit,and a flexible implantable piezoelectric nanogenerator(i-PENG)to supply long-term energy by converting biomechanical energy into electricity.Our results show that this system can harvest energy from body movement and power the FRL source,which then significantly enhanced production of a short variant of human glucagon-like peptide 1(shGLP-1)in vitro and in vivo.Indeed,diabetic mice equipped with the SOS showed rapid restoration of blood glucose homeostasis,improved glucose,and insulin tolerance.Our results suggest that the SOs is sufficiently effective in self-powering the modulation of therapeutic outputs to control glucose homeostasis and,furthermore,present a new strategy for providing energy in optogenetic-based cell therapy.展开更多
基金Project supported by the National Natural Science Foundation of China(Grant Nos.11621404,11561121003,11727812,61775059,12074122,62022033,and 11704123)Shanghai Rising-Star Program,the Sustainedly Supported Foundation by the National Key Laboratory of Science and Technology on Space Microwave(Grant No.HTKT2022KL504008)+1 种基金Shanghai Natural Science Foundation(Grant No.23ZR1419000)the National Key Laboratory Foundation of China(Grant No.6142411196307).
文摘Nyquist pulses have wide applications in many areas,from electronics to optics.Mode-locked lasers are ideal platforms to generate such pulses.However,how to generate high-quality Nyquist pulses in mode-locked lasers remains elusive.We address this problem by managing different physical effects in mode-locked fiber lasers through extensive numerical simulations.We find that net dispersion,linear loss,gain and filter shaping can affect the quality of Nyquist pulses significantly.We also demonstrate that Nyquist pulses experience similariton shaping due to the nonlinear attractor effect in the gain medium.Our work may contribute to the design of Nyquist pulse sources and enrich the understanding of pulse shaping dynamics in mode-locked lasers.
基金Project supported by the National Natural Science Fundation of China (Grant Nos.92050105,92250301,and 12227807)。
文摘Besides the diverse investigations on the interactions between intense laser fields and molecular systems,extensive research has been recently dedicated to exploring the response of nanosystems excited by well-tailored femtosecond laser fields.Due to the fact that nanostructures hold peculiar effects when illuminated by laser pulses,the underlying mechanisms and the corresponding potential applications can make significant improvements in both fundamental research and development of novel techniques.In this review,we provide a summarization of the strong field ionization occurring on the surface of nanosystems.The molecules attached to the nanoparticle surface perform as the precursor in the ionization and excitation of the whole nanosystem,the fundamental processes of which are yet to be discovered.We discuss the influence on nanoparticle constituents,geometric shapes and sizes,as well as the specific waveforms of the excitation laser fields.The intriguing characteristics observed in surface ion emission reflect how enhanced near field affects the localized ionizations and nanoplasma expansions,thereby paving the way for further precision controls on the light-and-matter interactions in the extreme spatial temporal levels.
基金supported in part by Shanghai Pujiang Program under Grant No.21PJ1402600in part by Natural Science Foundation of Chongqing,China under Grant No.CSTB2022NSCQ-MSX0375+4 种基金in part by Song Shan Laboratory Foundation,under Grant No.YYJC022022007in part by Zhejiang Provincial Natural Science Foundation of China under Grant LGJ22F010001in part by National Key Research and Development Program of China under Grant 2020YFA0711301in part by National Natural Science Foundation of China under Grant 61922049。
文摘In this paper,we investigate the minimization of age of information(AoI),a metric that measures the information freshness,at the network edge with unreliable wireless communications.Particularly,we consider a set of users transmitting status updates,which are collected by the user randomly over time,to an edge server through unreliable orthogonal channels.It begs a natural question:with random status update arrivals and obscure channel conditions,can we devise an intelligent scheduling policy that matches the users and channels to stabilize the queues of all users while minimizing the average AoI?To give an adequate answer,we define a bipartite graph and formulate a dynamic edge activation problem with stability constraints.Then,we propose an online matching while learning algorithm(MatL)and discuss its implementation for wireless scheduling.Finally,simulation results demonstrate that the MatL is reliable to learn the channel states and manage the users’buffers for fresher information at the edge.
基金sponsored by Shanghai Rising-Star Program(22QC1401000)National Defense Administration of Science,Technology and Industry(HTKJ2021KL504014)+2 种基金National Key Research and Development Program(2018YFB0504400)National Natural Science Foundation ofChina(11621404,11727812,and 62035005)Shanghai Municipal Science and Technology Major Project(2019SHZDZX01-ZX05).
文摘Breakdown spectroscopy is a valuable tool for determining elements in solids,liquids,and gases.All materials in the breakdown region can be ionized and dissociated into highly excited fragments and emit characteristic fluorescence spectra.In this sense,the elemental composition of materials can be evaluated by detecting the fluorescence spectrum.This paper reviews the recent developments in laser-induced breakdown spectroscopy.The traditional laser-induced breakdown spectroscopy,filament-induced breakdown spectroscopy,plasma grating,and multidimensional plasma grating-induced breakdown spectroscopy are introduced.There are also some proposals for applications of plasma gratings,such as laser ablation,laser deposition,and laser catalysis of chemical reactions in conjunction with research on the properties of plasma gratings.
基金supported by the National Key R&D Program of China(2022YFA1404202)the National Natural Science Foundation of China(11925401,12234008,11734008,12222404,11974115)+2 种基金the Shanghai Municipal Science and Technology Major Project(2019SHZDZX01)Natural Science Foundation Project of CQ(cstc2021jcyj-msxmX0914)Equipment Development Department Rapid Support Project(80917020109)。
文摘Classical thermodynamics has been a great achievement in dealing with systems that are in equilibrium or near equilibrium.As an emerging field,nonequilibrium thermodynamics provides a general framework for understanding the nonequilibrium processes,particularly in small systems that are typically far-from-equilibrium and are dominated by thermal or quantum fluctuations.Cavity optomechanical systems hold great promise among the various experimental platforms for studying nonequilibrium thermodynamics owing to their high controllability,excellent mechanical performance,and ability to operate deep in the quantum regime.Here,we present an overview of the recent advances in nonequilibrium thermodynamics with cavity optomechanical systems.The experimental results in entropy production assessment,fluctuation theorems,heat transfer,and heat engines are highlighted.
基金This work was supported by the National Key R&D Program of China(Grants Nos.2018YFA0306303 and 2018YFA0404802)the National Natural Science Fund(Grants Nos.11834004,11925405,12241407,12227807 and 91850203)+1 种基金Innovation Program of Shanghai Municipal Education Commission(Grant No.2017-01-07-00-02-E00034)S.P.acknowledges the support from the Academic Innovation Ability Enhancement Program for Excellent Doctoral Students of East China Normal University in 2021(Grant No.40600-30302-515100/141).
文摘Rabi oscillation is an elementary laser-driven physical process in atoms and artificial atoms from solid-state systems,while it is rarely demonstrated in molecules.Here,we investigate the bond-length-dependent Rabi oscillations with varying Rabi frequencies in strong-laser-field dissociation of H2+.The coupling of the bond stretching and Rabi oscillations makes the nuclei gain different kinetic energies while the electron is alternatively absorbing and emitting photons.The resulting proton kinetic energy spectra show rich structures beyond the prediction of the Floquet theorem and the well-accepted resonant one-photon dissociation pathway.Our study shows that the laser-driven Rabi oscillations accompanied by nuclear motions are essential to understanding the bond-breaking mechanism and provide a time-resolved perspective to manipulate rich dynamics of the strong-laser-field dissociation of molecules.
基金National Key Research and Development Program of China(2022YFE0107400)National Natural Science Foundation of China(11727812,11774235,11904232,11933005,61705130)+1 种基金Science and Technology Commission of Shanghai Municipality(23010503600,23530730500)Program for Professor of Special Appointment(Eastern Scholar)at Shanghai Institutions of Higher Learning(GZ2020015)。
文摘In this study,we present a method for free-space beam shaping and steering based on a silicon optical phased array,which addresses the theoretical limitation of traditional bulk optics.We theoretically analyze the beam propagation properties with changes in the applied phase.Different beam profiles can be shaped by varying the phase combination,while a high-order quasi-Bessel beam can be generated with a cubic change to the phase modulation.The simulated results are validated further experimentally,and they match one another well.Beam steering can be achieved with a field of view as large as 140°,which has potential benefits for practical applications.The presented method is expected to have broad application prospects for optical communications,free-space optical interconnects,and light detection and ranging.
基金supported by the National Natural Science Foundation of China(Nos.62175064,62235019,62035005)Shanghai Pilot Program for Basic Research(TQ20220104)+1 种基金Shanghai Municipal Science and Technology Major Project(2019SHZDZX01)Fundamental Research Funds for the Central Universities.
文摘Active mid-infrared(MIR)imagers capable of retrieving three-dimensional(3D)structure and reflectivity information are highly attractive in a wide range of biomedical and industrial applications.However,infrared 3D imaging at lowlight levels is still challenging due to the deficiency of sensitive and fast MiR sensors.Here we propose and implement a MiR time-of-flight imaging system that operates at single-photon sensitivity and femtosecond timing resolution.Specifically,back-scattered infrared photons from a scene are optically gated by delay-controlled ultrashort pump pulses through nonlinear frequency upconversion.The upconverted images with time stamps are then recorded by a silicon camera to facilitate the 3D reconstruction with high lateral and depth resolutions.Moreover,an effective numerical denoiser based on spatiotemporal correlation allows us to reveal the object profle and reflectivity under photon-starving conditions with a detected flux below 0.05 photons/pixel/second.The presented MIR 3D imager features high detection sensitivity,precise timing resolution,and wide-field operation,which may open new possibilities in life and material sciences.
基金The work was supported by the National Natural Science Foundation of China(12174111,12004115,1674097,61675219,61875256,12174112,61925506,12374297,62305078)the National Key Research and Development Program of China(2021YFA1200803)+2 种基金the Natural Science Foundation of Shanghai(23ZR1419800,20JC1414605)Chongqing and Zhejiang Province(2023NSCQ-MSX1489 and TD2020002)Shanghai Sailing Program(20YF1411600).
文摘The superfluorescence effect has received extensive attention due to the many-body physics of quantum correlation in dipole gas and the optical applications of ultrafast bright radiation field based on the cooperative quantum state.Here,we demonstrate not only to observe the superfluorescence effect but also to control the cooperative state of the excitons ensemble by externally applying a regulatory dimension of coupling light fields.A new quasi-particle called cooperative exciton-polariton is revealed in a light-matter hybrid structure of a perovskite quantum dot thin film spin-coated on a Distributed Bragg Reflector.Above the nonlinear threshold,polaritonic condensation occurs at a nonzero momentum state on the lower polariton branch owning to the vital role of the synchronized excitons.The phase transition from superfluorescence to polariton condensation exhibits typical signatures of a decrease of the linewidth,an increase of the macroscopic coherence as well as an accelerated radiation decay rate.These findings are promising for opening new potential applications for super-brightness and unconventional coherent light sources and could enable the exploitation of cooperative effects for quantum optics.
基金supported by the National Natural Science Foundation of China(Nos.11804099,62075062,62175067,and 11621404)Research Funds of Happiness Flower ECNU(No.2021ST2110).
文摘We demonstrate a portable system integrated with time comparison,absolute distance ranging,and optical communication(TRC)to meet the requirements of space gravitational wave detection.A 1 km free-space asynchronous two-way optical link is performed.The TRC realizes optical communication with 7.7×10^(−5) bit error rate with a Si avalanche photodiode singlephoton detector,while the signal intensity is 1.4 photons per pulse with the background noise of 3×10^(4) counts per second.The distance measurement uncertainty is 48.3 mm,and time comparison precision is 162.4 ps.In this TRC system,a verticalcavity surface-emitting laser diode with a power of 9.1μW is used,and the equivalent receiving aperture is 0.5 mm.The TRC provides a miniaturization solution for ultra-long distance inter-satellite communication,time comparison,and ranging for space gravitational wave detectors.
基金National Key Research and Development Program of China(2021YFA1201503)National Natural Science Foundation of China(11621404,12204174,62175064)+2 种基金Natural Scienceof CQ CSTC2021JCYJ-MAXMX0356Research Funds of Happiness Flower ECNU(2021ST2110)Fundamental Research Funds for the Central Universities。
文摘Promoting the sensitivity of mid-infrared(MIR) spectroscopy to the single-photon level is a critical need for investigating photosensitive biological samples and chemical reactions. MIR spectroscopy based on frequency upconversion is a compelling pioneer allowing high-efficiency MIR spectral measurement with well-developed single-photon detectors, which overcomes the main limitations of high thermal noise of current MIR detectors.However, noise from other nonlinear processes caused by strong pump fields hinders the development of the upconversion-based MIR spectroscopy to reach the single-photon level. Here, a broadband MIR single-photon frequency upconversion spectroscopy is demonstrated based on the temporal-spectral quantum correlation of non-degenerate photon pairs, which is well preserved in the frequency upconversion process and is fully used in extracting the signals from tremendous noise caused by the strong pump. A correlation spectrum broader than660 nm is achieved and applied for the demonstration of sample identification under a low incident photon flux of 0.09 average photons per pulse. The system is featured with non-destructive and robust operation, which makes single-photon-level MIR spectroscopy an appealing option in biochemical applications. ? 2022 Chinese Laser Press.
基金supported by the National Natural Science Foundation of China(Nos.11774095,11804099,and 11621404)the Research Funds of Happiness Flower ECNU(No.2021ST2110).
文摘A multi-channel laser interferometer(MCLI)is proposed to improve the coordinate measurement accuracy.A 780 nm external cavity laser is locked on the D2 line of ^(87)Rb atom by polarization spectroscopy,and a high frequency stabilized laser source is obtained with a linewidth of 385.8 k Hz at root mean square(RMS).The interferometers share the stabilized source and individually install on 4 axes of a coordinate measuring system.As a result,the measurement uncertainty is reduced from 1.2μm to 0.2μm within the dynamic measurement range of 1.0 m.The MCLI is adept at integrate and flexible installation,which caters to various applications on precision measurement.
基金We are grateful to all the laboratory members for their cooperation in this study.This work was financially supported by grants from the National Key R&D Program of China,Synthetic Biology Research(no.2019YFA0904500)the National Natural Science Foundation of China(nos.82102231,31971346,61875015,31861143016,U20A20390,11827803,and T2125003)+4 种基金the Science and Technology Commission of Shanghai Municipality(no.22N31900300)Beijing Natural Science Foundation(JQ20038,L212010)China Postdoctoral Science Foundation(2020M680302,2021T140041)the Strategic Priority Research Program of the Chinese Academy of Sciences(XDA16021101)We also thank the ECNU Multifunctional Platform for Innovation(011)for supporting the murine experiments and the Instruments Sharing Platform of the School of Life Sciences,ECNU.
文摘Diabetes treatment and rehabilitation are usually a lifetime process.Optogenetic engineered designer cell-therapy holds great promise in regulating blood glucose homeostasis.However,portable,sustainable,and long-term energy supplementation has previously presented a challenge for the use of optogenetic stimulation in vivo.Herein,we_purpose a self-powered optogenetic system(SOS)for implantable blood glucose control.The SOS consists of a biocompatible far-red light(FRL)source,FRL-triggered transgene-expressing cells,a power management unit,and a flexible implantable piezoelectric nanogenerator(i-PENG)to supply long-term energy by converting biomechanical energy into electricity.Our results show that this system can harvest energy from body movement and power the FRL source,which then significantly enhanced production of a short variant of human glucagon-like peptide 1(shGLP-1)in vitro and in vivo.Indeed,diabetic mice equipped with the SOS showed rapid restoration of blood glucose homeostasis,improved glucose,and insulin tolerance.Our results suggest that the SOs is sufficiently effective in self-powering the modulation of therapeutic outputs to control glucose homeostasis and,furthermore,present a new strategy for providing energy in optogenetic-based cell therapy.
