Microbial pathogens,including bacteria,fungi and viruses,greatly threaten the global public health.For pathogen infections,early diagnosis and precise treatment are essential to cut the mortality rate.The emergence of...Microbial pathogens,including bacteria,fungi and viruses,greatly threaten the global public health.For pathogen infections,early diagnosis and precise treatment are essential to cut the mortality rate.The emergence of aggregation‐induced emission(AIE)biomaterials provides an effective and promising tool for the theranostics of pathogen infections.In this review,the recent advances about AIE biomaterials for anti-pathogen theranostics are summarized.With the excellent sensitivity and photostability,AIE biomaterials have been widely applied for precise diagnosis of pathogens.Besides,different types of anti-pathogen methods based on AIE biomaterials will be presented in detail,including chemotherapy and phototherapy.Finally,the existing deficiencies and future development of AIE biomaterials for anti-pathogen applications will be discussed.展开更多
Efficient strategies for transforming Bacillus subtilis vegetative cells into spores(BtS transformation)are still limited,although they show promise for the treatment of inflammatory bowel disease(IBD).A novel,simple,an...Efficient strategies for transforming Bacillus subtilis vegetative cells into spores(BtS transformation)are still limited,although they show promise for the treatment of inflammatory bowel disease(IBD).A novel,simple,and rapid photo-induced BtS transformation mechanism is now presented that utilizes a novel aggregation-induced emission luminogen(AIEgen)photosensitizer,triphenylamine-benzothiadiazole-pyridine-p-tolylboronic acid bromine salt(TBPBB),that generates reactive oxygen species(ROS)when exposed to light.The ROS selectively target and damage the membranes of Bacillus subtilis and trigger their transformation into spores.These spores demonstrate considerable promise for the effective treatment of IBD in a mouse disease model.Furthermore,thefluorescence signal generated by TBPBB can be used to directly visualize the recovery of damaged intestinal tis-sue.This is a valuable tool for monitoring the healing process and gaining insights into therapeutic efficacy.This study highlights the remarkable practical value of AIEgen-induced BtS transformation for identifying,localizing,and visualizing the therapeutic outcomes of IBD treatments.展开更多
基金supported by NSFC(52003228,52273197 and 21788102)Shenzhen Key Laboratory of Functional Aggregate Materials(ZDSYS20211021111400001)the Science Technology Innovation Commission of Shenzhen Municipality(JCYJ2021324134613038,KQTD20210811090142053,JSGG20220606141800001 and GJHZ20210705141810031).
文摘Microbial pathogens,including bacteria,fungi and viruses,greatly threaten the global public health.For pathogen infections,early diagnosis and precise treatment are essential to cut the mortality rate.The emergence of aggregation‐induced emission(AIE)biomaterials provides an effective and promising tool for the theranostics of pathogen infections.In this review,the recent advances about AIE biomaterials for anti-pathogen theranostics are summarized.With the excellent sensitivity and photostability,AIE biomaterials have been widely applied for precise diagnosis of pathogens.Besides,different types of anti-pathogen methods based on AIE biomaterials will be presented in detail,including chemotherapy and phototherapy.Finally,the existing deficiencies and future development of AIE biomaterials for anti-pathogen applications will be discussed.
基金National Science Foundation of China,Grant/Award Numbers:52003228,52273197Shenzhen Key Laboratory of Functional Aggregate Materials,Grant/Award Number:DSYS20211021111400001Science Technology Innovation Commission of Shenzhen Municipality,Grant/Award Numbers:KQTD20210811090142053,JCYJ20220818103007014,JSGG20220606141800001。
文摘Efficient strategies for transforming Bacillus subtilis vegetative cells into spores(BtS transformation)are still limited,although they show promise for the treatment of inflammatory bowel disease(IBD).A novel,simple,and rapid photo-induced BtS transformation mechanism is now presented that utilizes a novel aggregation-induced emission luminogen(AIEgen)photosensitizer,triphenylamine-benzothiadiazole-pyridine-p-tolylboronic acid bromine salt(TBPBB),that generates reactive oxygen species(ROS)when exposed to light.The ROS selectively target and damage the membranes of Bacillus subtilis and trigger their transformation into spores.These spores demonstrate considerable promise for the effective treatment of IBD in a mouse disease model.Furthermore,thefluorescence signal generated by TBPBB can be used to directly visualize the recovery of damaged intestinal tis-sue.This is a valuable tool for monitoring the healing process and gaining insights into therapeutic efficacy.This study highlights the remarkable practical value of AIEgen-induced BtS transformation for identifying,localizing,and visualizing the therapeutic outcomes of IBD treatments.
