The field of healthcare is considered to be the most promising application of intelligent sensor networks.However,the security and privacy protection ofmedical images collected by intelligent sensor networks is a hot ...The field of healthcare is considered to be the most promising application of intelligent sensor networks.However,the security and privacy protection ofmedical images collected by intelligent sensor networks is a hot problem that has attracted more and more attention.Fortunately,digital watermarking provides an effective method to solve this problem.In order to improve the robustness of the medical image watermarking scheme,in this paper,we propose a novel zero-watermarking algorithm with the integer wavelet transform(IWT),Schur decomposition and image block energy.Specifically,we first use IWT to extract low-frequency information and divide them into non-overlapping blocks,then we decompose the sub-blocks by Schur decomposition.After that,the feature matrix is constructed according to the relationship between the image block energy and the whole image energy.At the same time,we encrypt watermarking with the logistic chaotic position scrambling.Finally,the zero-watermarking is obtained by XOR operation with the encrypted watermarking.Three indexes of peak signal-to-noise ratio,normalization coefficient(NC)and the bit error rate(BER)are used to evaluate the robustness of the algorithm.According to the experimental results,most of the NC values are around 0.9 under various attacks,while the BER values are very close to 0.These experimental results show that the proposed algorithm is more robust than the existing zero-watermarking methods,which indicates it is more suitable for medical image privacy and security protection.展开更多
We study the ground states of attractive binary Bose-Einstein condensates with N particles,which are trapped in the steep potential wellsλV(x)inℝ2.We show that there exists a positive number N*such that if N>N*,th...We study the ground states of attractive binary Bose-Einstein condensates with N particles,which are trapped in the steep potential wellsλV(x)inℝ2.We show that there exists a positive number N*such that if N>N*,the system admits no ground state for anyλ>0.Moreover,there exist two positive numbers,M*andλ*(N),such that if N<M*,then for anyλ>λ*(N),the system admits at least one ground state.Asλ→∞,for any fixed N<M*,we give a detailed description for the limit behavior of both positive and semi-trivial ground states.展开更多
In order to solve the problem of patient information security protection in medical images,whilst also taking into consideration the unchangeable particularity of medical images to the lesion area and the need for med...In order to solve the problem of patient information security protection in medical images,whilst also taking into consideration the unchangeable particularity of medical images to the lesion area and the need for medical images themselves to be protected,a novel robust watermarking algorithm for encrypted medical images based on dual-tree complex wavelet transform and discrete cosine transform(DTCWT-DCT)and chaotic map is proposed in this paper.First,DTCWT-DCT transformation was performed on medical images,and dot product was per-formed in relation to the transformation matrix and logistic map.Inverse transformation was undertaken to obtain encrypted medical images.Then,in the low-frequency part of the DTCWT-DCT transformation coefficient of the encrypted medical image,a set of 32 bits visual feature vectors that can effectively resist geometric attacks are found to be the feature vector of the encrypted medical image by using perceptual hashing.After that,different logistic initial values and growth parameters were set to encrypt the watermark,and zero-watermark technology was used to embed and extract the encrypted medical images by combining cryptography and third-party concepts.The proposed watermarking algorithm does not change the region of interest of medical images thus it does not affect the judgment of doctors.Additionally,the security of the algorithm is enhanced by using chaotic mapping,which is sensitive to the initial value in order to encrypt the medical image and the watermark.The simulation results show that the pro-posed algorithm has good homomorphism,which can not only protect the original medical image and the watermark information,but can also embed and extract the watermark directly in the encrypted image,eliminating the potential risk of decrypting the embedded watermark and extracting watermark.Compared with the recent related research,the proposed algorithm solves the contradiction between robustness and invisibility of the watermarking algorithm for encrypted medical images,and it has good results against both conventional attacks and geometric attacks.Under geometric attacks in particular,the proposed algorithm performs much better than existing algorithms.展开更多
Purpose: We aim to create a model of consumer health information seeking behavior via social media, then to have a better understand of it. After that further efforts should be made to provide targeted recommendations...Purpose: We aim to create a model of consumer health information seeking behavior via social media, then to have a better understand of it. After that further efforts should be made to provide targeted recommendations for media managers to promote health communication via social media. Methods: Our custom model was derived from literature review, empirical research was tested by the use of questionnaire investigation, and then the collected data were analyzed by structural equation model tool SmartPLS. Finally, the custom model was modified according to the experimental results of SmartPLS. Results: A total of 239 (66.39%) of the respondents were female and 121 (33.61%) were male. The maximum of two stages of age were 18 - 29 (70.56%), 30 - 39 (13.89%). Wechat (60.28%), QQ Zone (55.22%), Micro-blog (48.89%) were the most commonly used social media to obtain health information. About 44.72% of respondents used social media to obtain health information multiple times a day. The whole numerical values of AVE, cronbach’s alpha, CR and square roots of AVE were above the benchmarks of themselves and showed great reliability and validity. All the 11 hypotheses had obvious statistical significance, the P-value of eight path coefficients exhibited <0.001, one path coefficient exhibited <0.01 and two path coefficients exhibited <0.05. Conclusions: A suitable model of consumer health information seeking behavior via social media was created and some inner relationships were found. Namely, gratification of health information and its platform had a positive effect on attitudes toward health information seeking behavior. Health information literacy and health status were proved to have a significant influence on attitudes toward health information seeking behavior, subject norms and perceived behavioral control respectively. In addition, attitudes toward the health information seeking behavior, subject norms and perceived behavioral control were proved to positively associate with health information seeking behavior intention.展开更多
Electroconvulsive therapy(ECT)uses a certain amount of electric current to pass through the head of the patient,causing convulsions throughout the body,to relieve the symptoms of the disease and achieve the purpose of...Electroconvulsive therapy(ECT)uses a certain amount of electric current to pass through the head of the patient,causing convulsions throughout the body,to relieve the symptoms of the disease and achieve the purpose of treatment.ECT can effectively improve the clinical symptoms of patients with major depression,but its therapeutic mechanism is still unclear.With the rapid development of neuroimaging technology,it is necessary to explore the neurobiological mechanism of major depression from the aspects of brain structure,brain function and brain metabolism,and to find that ECT can improve the brain function,metabolism and even brain structure of patients to a certain extent.Currently,an increasing number of neuroimaging studies adopt various neuroimaging techniques including functional magnetic resonance imaging(MRI),positron emission tomography,magnetic resonance spectroscopy,structural MRI,and diffusion tensor imaging to reveal the neural effects of ECT.This article reviews the recent progress in neuroimaging research on ECT for major depression.The results suggest that the neurobiological mechanism of ECT may be to modulate the functional activity and connectivity or neural structural plasticity in specific brain regions to the normal level,to achieve the therapeutic effect.展开更多
BACKGROUND Major depressive disorder(MDD)tends to have a high incidence and high suicide risk.Electroconvulsive therapy(ECT)is currently a relatively effective treatment for MDD.However,the mechanism of efficacy of EC...BACKGROUND Major depressive disorder(MDD)tends to have a high incidence and high suicide risk.Electroconvulsive therapy(ECT)is currently a relatively effective treatment for MDD.However,the mechanism of efficacy of ECT is still unclear.AIM To investigate the changes in the amplitude of low-frequency fluctuations in specific frequency bands in patients with MDD after ECT.METHODS Twenty-two MDD patients and fifteen healthy controls(HCs)were recruited to this study.MDD patients received 8 ECT sessions with bitemporal placement.Resting-state functional magnetic resonance imaging was adopted to examine regional cerebellar blood flow in both the MDD patients and HCs.The MDD patients were scanned twice(before the first ECT session and after the eighth ECT session)to acquire data.Then,the amplitude of low-frequency fluctuations(ALFF)was computed to characterize the intrinsic neural oscillations in different bands(typical frequency,slow-5,and slow-4 bands).RESULTS Compared to before ECT(pre-ECT),we found that MDD patients after the eighth ECT(post-ECT)session had a higher ALFF in the typical band in the right middle frontal gyrus,posterior cingulate,right supramarginal gyrus,left superior frontal gyrus,and left angular gyrus.There was a lower ALFF in the right superior temporal gyrus.Compared to pre-ECT values,the ALFF in the slow-5 band was significantly increased in the right limbic lobe,cerebellum posterior lobe,right middle orbitofrontal gyrus,and frontal lobe in post-ECT patients,whereas the ALFF in the slow-5 band in the left sublobar region,right angular gyrus,and right frontal lobe was lower.In contrast,significantly higher ALFF in the slow-4 band was observed in the frontal lobe,superior frontal gyrus,parietal lobe,right inferior parietal lobule,and left angular gyrus.CONCLUSION Our results suggest that the abnormal ALFF in pre-and post-ECT MDD patients may be associated with specific frequency bands.展开更多
We investigate the scaling of entanglement entropy for one spatial XXZ spin chain by using matrix product states to approximate ground states. The entanglement entropy scales logarithmically with a coefficient that is...We investigate the scaling of entanglement entropy for one spatial XXZ spin chain by using matrix product states to approximate ground states. The entanglement entropy scales logarithmically with a coefficient that is determined by the associated conformal field theory, the quantum phase transitions occurred between Large-D and Halde phase, Halde phase and Neel phase. The scaling relationship is given in this paper.展开更多
Big data has convincing merits in developing risk stratification strategies for diseases.The 6“V”s of big data,namely,volume,velocity,variety,veracity,value,and variability,have shown promise for real-world scenario...Big data has convincing merits in developing risk stratification strategies for diseases.The 6“V”s of big data,namely,volume,velocity,variety,veracity,value,and variability,have shown promise for real-world scenarios.Big data can be applied to analyze health data and advance research in preclinical biology,medicine,and especially disease initiation,development,and control.A study design comprises data selection,inclusion and exclusion criteria,standard confirmation and cohort establishment,follow-up strategy,and events of interest.The development and efficiency verification of a prognosis model consists of deciding the data source,taking previous models as references while selecting candidate predictors,assessing model performance,choosing appropriate statistical methods,and model optimization.The model should be able to inform disease development and outcomes,such as predicting variceal rebleeding in patients with cirrhosis.Our work has merits beyond those of other colleagues with respect to cirrhosis patient screening and data source regarding variceal bleeding.展开更多
The flexible wearable sensors with excellent stretchability,high sensitivity and good biocompatibility are significantly required for continuously physical condition tracking in health management and rehabilitation mo...The flexible wearable sensors with excellent stretchability,high sensitivity and good biocompatibility are significantly required for continuously physical condition tracking in health management and rehabilitation monitoring.Herein,we present a high-performance wearable sensor.The sensor is prepared with nanocomposite hydrogel by using silk fibroin(SF),polyacrylamide(PAM),polydopamine(PDA)and graphene oxide(GO).It can be used to monitor body motions(including large-scale and small-scale motions)as well as human electrophysiological(ECG)signals with high sensitivity,wide sensing range,and fast response time.Therefore,the proposed sensor is promising in the fields of rehabilitation,motion monitoring and disease diagnosis.展开更多
Based on the social network analysis methods and human network, this paper randomly selected 44 students (31 males and 13 females) as the research objects, and it used the UCINET software to analyze the friendship bet...Based on the social network analysis methods and human network, this paper randomly selected 44 students (31 males and 13 females) as the research objects, and it used the UCINET software to analyze the friendship between them of which 43 used WeChat and 44 used QQ, and it also used the tool Netdraw to visualize the network sociogram. By mining the four aspects of density, accessibility, centrality, block model, the results demonstrated that QQ social network and WeChat social network existed the phenomenon of small world, leaders and subgroups, and the key nodes of QQ human network were more than WeChat network. Through using the key nodes, it can push the precise and efficient information and improve the accuracy of information transmission and impact among network members.展开更多
The travelling solitary wave solutions to the higher order Korteweg-de Vries equation are obtained by using tanh-polynomial method. The method is effective and concise, which is also applied to various partial differe...The travelling solitary wave solutions to the higher order Korteweg-de Vries equation are obtained by using tanh-polynomial method. The method is effective and concise, which is also applied to various partial differential equations to obtain traveling wave solutions. The numerical simulation of the solutions is given for completeness. Numerical results show that the tanh-polynomial method works quite well.展开更多
Obtaining the new solutions for the nonlinear evolution equation is a hot topic. Benjamin<span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-...Obtaining the new solutions for the nonlinear evolution equation is a hot topic. Benjamin<span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">-</span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">Bona</span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">-</span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">Mahony</span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">-</span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">Burgers equation is this kind of equation,</span></span></span><span><span><b><span style="font-family:""> </span></b></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">t</span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">he solutions are very interest. Several new exact solutions for the nonlinear equation are obtained by using truncated expansion method in this paper. The numerical simulations with different parameters for the new exact solutions of Benjamin</span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">-</span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">Bona</span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">-</span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">Mahony</span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">-</span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">Burgers equation are given.</span></span></span>展开更多
The quantum phase transitions for one-dimensional spin-1 XXZ model with uniaxial single-ion-type anisotropy are investigated by numerical simulation. The Gaussion transition occurred between the Larged-D phase and Nee...The quantum phase transitions for one-dimensional spin-1 XXZ model with uniaxial single-ion-type anisotropy are investigated by numerical simulation. The Gaussion transition occurred between the Larged-D phase and Neel phase, which is a gapped phase. The results of ground state energy, local order parameter and entanglement entropy agree with each other. The figures for all of the physical observable are shown in the text.展开更多
We study the ground-state information of one-dimensional Heisenberg chain with alternating D-term. Given the ground-state phase diagram, the ground-state energy and the entanglement entropy are obtained by tensor-net ...We study the ground-state information of one-dimensional Heisenberg chain with alternating D-term. Given the ground-state phase diagram, the ground-state energy and the entanglement entropy are obtained by tensor-net work algorithm. The phase transition points are shown in the entanglement entropy figure. The results are agreed with the phase diagram.展开更多
The one-dimensional 3-spin couplings and 2-spin competing many-body interactions with magnetic fields are an interesting field in quantum system, which is theoretically analysed in an experimental configuration. In th...The one-dimensional 3-spin couplings and 2-spin competing many-body interactions with magnetic fields are an interesting field in quantum system, which is theoretically analysed in an experimental configuration. In this paper, we study the physical observable information for one-dimensional competing many-body interactions. The figure for symmetry broken state density, local order parameter, scaling of entanglement entropy is shown. The results agree with the phase diagram.展开更多
Intra-articular injection of mesenchymal stem cells(MSCs)is a promising strategy for osteoarthritis(OA)treatment.However,more and more studies reveal that the injected MSCs have poor adhesion,migration,and survival in...Intra-articular injection of mesenchymal stem cells(MSCs)is a promising strategy for osteoarthritis(OA)treatment.However,more and more studies reveal that the injected MSCs have poor adhesion,migration,and survival in the joint cavity.A recent study shows that tropoelastin(TE)regulates adhesion,proliferation and phenotypic maintenance of MSCs as a soluble additive,indicating that TE could promote MSCs-homing in regenerative medicine.In this study,we used TE as injection medium,and compared it with classic media in MSCs intra-articular injection such as normal saline(NS),hyaluronic acid(HA),and platelet-rich plasma(PRP).We found that TE could effectively improve adhesion,migration,chondrogenic differentiation of infrapatellar fat pad MSCs(IPFP-MSCs)and enhance matrix synthesis of osteoarthritic chondrocytes(OACs)in indirect-coculture system.Moreover,TE could significantly enhance IPFP-MSCs adhesion via activation of integrin β1,ERK1/2 and vinculin(VCL)in vitro.In addition,intra-articular injection of TE-IPFP MSCs suspension resulted in a short-term increase in survival rate of IPFP-MSCs and better histology scores of rat joint tissues.Inhibition of integrin β1 or ERK1/2 attenuated the protective effect of TE-IPFP MSCs suspension in vivo.In conclusion,TE promotes performance of IPFP-MSCs and protects knee cartilage from damage in OA through enhancement of cell adhesion and activation of integrin β1/ERK/VCL pathway.Our findings may provide new insights in MSCs intra-articular injection for OA treatment.展开更多
基金supported in part by the Hainan Provincial Natural Science Foundation of China (No.620MS067)the Intelligent Medical Project of Chongqing Medical University (ZHYXQNRC202101)the Student Scientific Research and Innovation Experiment Project of the Medical Information College of Chongqing Medical University (No.2020C006).
文摘The field of healthcare is considered to be the most promising application of intelligent sensor networks.However,the security and privacy protection ofmedical images collected by intelligent sensor networks is a hot problem that has attracted more and more attention.Fortunately,digital watermarking provides an effective method to solve this problem.In order to improve the robustness of the medical image watermarking scheme,in this paper,we propose a novel zero-watermarking algorithm with the integer wavelet transform(IWT),Schur decomposition and image block energy.Specifically,we first use IWT to extract low-frequency information and divide them into non-overlapping blocks,then we decompose the sub-blocks by Schur decomposition.After that,the feature matrix is constructed according to the relationship between the image block energy and the whole image energy.At the same time,we encrypt watermarking with the logistic chaotic position scrambling.Finally,the zero-watermarking is obtained by XOR operation with the encrypted watermarking.Three indexes of peak signal-to-noise ratio,normalization coefficient(NC)and the bit error rate(BER)are used to evaluate the robustness of the algorithm.According to the experimental results,most of the NC values are around 0.9 under various attacks,while the BER values are very close to 0.These experimental results show that the proposed algorithm is more robust than the existing zero-watermarking methods,which indicates it is more suitable for medical image privacy and security protection.
基金supported by NSFC(12075102 and 11971212)the Fundamental Research Funds for the Central Universities(lzujbky-2020-pd01)。
文摘We study the ground states of attractive binary Bose-Einstein condensates with N particles,which are trapped in the steep potential wellsλV(x)inℝ2.We show that there exists a positive number N*such that if N>N*,the system admits no ground state for anyλ>0.Moreover,there exist two positive numbers,M*andλ*(N),such that if N<M*,then for anyλ>λ*(N),the system admits at least one ground state.Asλ→∞,for any fixed N<M*,we give a detailed description for the limit behavior of both positive and semi-trivial ground states.
基金supported by the Key Research Project of Hainan Province[ZDYF2018129]the Higher Education Research Project of Hainan Province(Hnky2019-73)+3 种基金the National Natural Science Foundation of China[61762033]the Natural Science Foundation of Hainan[617175]the Special Scientific Research Project of Philosophy and Social Sciences of Chongqing Medical University[201703]the Key Research Project of Haikou College of Economics[HJKZ18-01].
文摘In order to solve the problem of patient information security protection in medical images,whilst also taking into consideration the unchangeable particularity of medical images to the lesion area and the need for medical images themselves to be protected,a novel robust watermarking algorithm for encrypted medical images based on dual-tree complex wavelet transform and discrete cosine transform(DTCWT-DCT)and chaotic map is proposed in this paper.First,DTCWT-DCT transformation was performed on medical images,and dot product was per-formed in relation to the transformation matrix and logistic map.Inverse transformation was undertaken to obtain encrypted medical images.Then,in the low-frequency part of the DTCWT-DCT transformation coefficient of the encrypted medical image,a set of 32 bits visual feature vectors that can effectively resist geometric attacks are found to be the feature vector of the encrypted medical image by using perceptual hashing.After that,different logistic initial values and growth parameters were set to encrypt the watermark,and zero-watermark technology was used to embed and extract the encrypted medical images by combining cryptography and third-party concepts.The proposed watermarking algorithm does not change the region of interest of medical images thus it does not affect the judgment of doctors.Additionally,the security of the algorithm is enhanced by using chaotic mapping,which is sensitive to the initial value in order to encrypt the medical image and the watermark.The simulation results show that the pro-posed algorithm has good homomorphism,which can not only protect the original medical image and the watermark information,but can also embed and extract the watermark directly in the encrypted image,eliminating the potential risk of decrypting the embedded watermark and extracting watermark.Compared with the recent related research,the proposed algorithm solves the contradiction between robustness and invisibility of the watermarking algorithm for encrypted medical images,and it has good results against both conventional attacks and geometric attacks.Under geometric attacks in particular,the proposed algorithm performs much better than existing algorithms.
文摘Purpose: We aim to create a model of consumer health information seeking behavior via social media, then to have a better understand of it. After that further efforts should be made to provide targeted recommendations for media managers to promote health communication via social media. Methods: Our custom model was derived from literature review, empirical research was tested by the use of questionnaire investigation, and then the collected data were analyzed by structural equation model tool SmartPLS. Finally, the custom model was modified according to the experimental results of SmartPLS. Results: A total of 239 (66.39%) of the respondents were female and 121 (33.61%) were male. The maximum of two stages of age were 18 - 29 (70.56%), 30 - 39 (13.89%). Wechat (60.28%), QQ Zone (55.22%), Micro-blog (48.89%) were the most commonly used social media to obtain health information. About 44.72% of respondents used social media to obtain health information multiple times a day. The whole numerical values of AVE, cronbach’s alpha, CR and square roots of AVE were above the benchmarks of themselves and showed great reliability and validity. All the 11 hypotheses had obvious statistical significance, the P-value of eight path coefficients exhibited <0.001, one path coefficient exhibited <0.01 and two path coefficients exhibited <0.05. Conclusions: A suitable model of consumer health information seeking behavior via social media was created and some inner relationships were found. Namely, gratification of health information and its platform had a positive effect on attitudes toward health information seeking behavior. Health information literacy and health status were proved to have a significant influence on attitudes toward health information seeking behavior, subject norms and perceived behavioral control respectively. In addition, attitudes toward the health information seeking behavior, subject norms and perceived behavioral control were proved to positively associate with health information seeking behavior intention.
基金Supported by the Natural Science Foundation of ChinaNo.81901373。
文摘Electroconvulsive therapy(ECT)uses a certain amount of electric current to pass through the head of the patient,causing convulsions throughout the body,to relieve the symptoms of the disease and achieve the purpose of treatment.ECT can effectively improve the clinical symptoms of patients with major depression,but its therapeutic mechanism is still unclear.With the rapid development of neuroimaging technology,it is necessary to explore the neurobiological mechanism of major depression from the aspects of brain structure,brain function and brain metabolism,and to find that ECT can improve the brain function,metabolism and even brain structure of patients to a certain extent.Currently,an increasing number of neuroimaging studies adopt various neuroimaging techniques including functional magnetic resonance imaging(MRI),positron emission tomography,magnetic resonance spectroscopy,structural MRI,and diffusion tensor imaging to reveal the neural effects of ECT.This article reviews the recent progress in neuroimaging research on ECT for major depression.The results suggest that the neurobiological mechanism of ECT may be to modulate the functional activity and connectivity or neural structural plasticity in specific brain regions to the normal level,to achieve the therapeutic effect.
基金Supported by the Natural Science Foundation of China,No.81901373the Intelligent Medicine Research Project of Chongqing Medical University,No.ZHYX202126.
文摘BACKGROUND Major depressive disorder(MDD)tends to have a high incidence and high suicide risk.Electroconvulsive therapy(ECT)is currently a relatively effective treatment for MDD.However,the mechanism of efficacy of ECT is still unclear.AIM To investigate the changes in the amplitude of low-frequency fluctuations in specific frequency bands in patients with MDD after ECT.METHODS Twenty-two MDD patients and fifteen healthy controls(HCs)were recruited to this study.MDD patients received 8 ECT sessions with bitemporal placement.Resting-state functional magnetic resonance imaging was adopted to examine regional cerebellar blood flow in both the MDD patients and HCs.The MDD patients were scanned twice(before the first ECT session and after the eighth ECT session)to acquire data.Then,the amplitude of low-frequency fluctuations(ALFF)was computed to characterize the intrinsic neural oscillations in different bands(typical frequency,slow-5,and slow-4 bands).RESULTS Compared to before ECT(pre-ECT),we found that MDD patients after the eighth ECT(post-ECT)session had a higher ALFF in the typical band in the right middle frontal gyrus,posterior cingulate,right supramarginal gyrus,left superior frontal gyrus,and left angular gyrus.There was a lower ALFF in the right superior temporal gyrus.Compared to pre-ECT values,the ALFF in the slow-5 band was significantly increased in the right limbic lobe,cerebellum posterior lobe,right middle orbitofrontal gyrus,and frontal lobe in post-ECT patients,whereas the ALFF in the slow-5 band in the left sublobar region,right angular gyrus,and right frontal lobe was lower.In contrast,significantly higher ALFF in the slow-4 band was observed in the frontal lobe,superior frontal gyrus,parietal lobe,right inferior parietal lobule,and left angular gyrus.CONCLUSION Our results suggest that the abnormal ALFF in pre-and post-ECT MDD patients may be associated with specific frequency bands.
文摘We investigate the scaling of entanglement entropy for one spatial XXZ spin chain by using matrix product states to approximate ground states. The entanglement entropy scales logarithmically with a coefficient that is determined by the associated conformal field theory, the quantum phase transitions occurred between Large-D and Halde phase, Halde phase and Neel phase. The scaling relationship is given in this paper.
文摘Big data has convincing merits in developing risk stratification strategies for diseases.The 6“V”s of big data,namely,volume,velocity,variety,veracity,value,and variability,have shown promise for real-world scenarios.Big data can be applied to analyze health data and advance research in preclinical biology,medicine,and especially disease initiation,development,and control.A study design comprises data selection,inclusion and exclusion criteria,standard confirmation and cohort establishment,follow-up strategy,and events of interest.The development and efficiency verification of a prognosis model consists of deciding the data source,taking previous models as references while selecting candidate predictors,assessing model performance,choosing appropriate statistical methods,and model optimization.The model should be able to inform disease development and outcomes,such as predicting variceal rebleeding in patients with cirrhosis.Our work has merits beyond those of other colleagues with respect to cirrhosis patient screening and data source regarding variceal bleeding.
基金Smart Medicine Research Project of Chongqing Medical University in 2020(YJSZHYX202022)Smart Medicine Research Project of Chongqing Medical University(ZHYX2019019)Chongqing Research Program of Basic Research and Frontier Technology(cstc2018jcyjAX0165).
文摘The flexible wearable sensors with excellent stretchability,high sensitivity and good biocompatibility are significantly required for continuously physical condition tracking in health management and rehabilitation monitoring.Herein,we present a high-performance wearable sensor.The sensor is prepared with nanocomposite hydrogel by using silk fibroin(SF),polyacrylamide(PAM),polydopamine(PDA)and graphene oxide(GO).It can be used to monitor body motions(including large-scale and small-scale motions)as well as human electrophysiological(ECG)signals with high sensitivity,wide sensing range,and fast response time.Therefore,the proposed sensor is promising in the fields of rehabilitation,motion monitoring and disease diagnosis.
文摘Based on the social network analysis methods and human network, this paper randomly selected 44 students (31 males and 13 females) as the research objects, and it used the UCINET software to analyze the friendship between them of which 43 used WeChat and 44 used QQ, and it also used the tool Netdraw to visualize the network sociogram. By mining the four aspects of density, accessibility, centrality, block model, the results demonstrated that QQ social network and WeChat social network existed the phenomenon of small world, leaders and subgroups, and the key nodes of QQ human network were more than WeChat network. Through using the key nodes, it can push the precise and efficient information and improve the accuracy of information transmission and impact among network members.
文摘The travelling solitary wave solutions to the higher order Korteweg-de Vries equation are obtained by using tanh-polynomial method. The method is effective and concise, which is also applied to various partial differential equations to obtain traveling wave solutions. The numerical simulation of the solutions is given for completeness. Numerical results show that the tanh-polynomial method works quite well.
文摘Obtaining the new solutions for the nonlinear evolution equation is a hot topic. Benjamin<span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">-</span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">Bona</span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">-</span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">Mahony</span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">-</span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">Burgers equation is this kind of equation,</span></span></span><span><span><b><span style="font-family:""> </span></b></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">t</span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">he solutions are very interest. Several new exact solutions for the nonlinear equation are obtained by using truncated expansion method in this paper. The numerical simulations with different parameters for the new exact solutions of Benjamin</span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">-</span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">Bona</span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">-</span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">Mahony</span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">-</span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">Burgers equation are given.</span></span></span>
文摘The quantum phase transitions for one-dimensional spin-1 XXZ model with uniaxial single-ion-type anisotropy are investigated by numerical simulation. The Gaussion transition occurred between the Larged-D phase and Neel phase, which is a gapped phase. The results of ground state energy, local order parameter and entanglement entropy agree with each other. The figures for all of the physical observable are shown in the text.
文摘We study the ground-state information of one-dimensional Heisenberg chain with alternating D-term. Given the ground-state phase diagram, the ground-state energy and the entanglement entropy are obtained by tensor-net work algorithm. The phase transition points are shown in the entanglement entropy figure. The results are agreed with the phase diagram.
文摘The one-dimensional 3-spin couplings and 2-spin competing many-body interactions with magnetic fields are an interesting field in quantum system, which is theoretically analysed in an experimental configuration. In this paper, we study the physical observable information for one-dimensional competing many-body interactions. The figure for symmetry broken state density, local order parameter, scaling of entanglement entropy is shown. The results agree with the phase diagram.
基金supported by CHONGQING TALENTS PROJECT(4246ZJ1)Science and technology projects of Chongqing Education Commission(KJQN202000427).
文摘Intra-articular injection of mesenchymal stem cells(MSCs)is a promising strategy for osteoarthritis(OA)treatment.However,more and more studies reveal that the injected MSCs have poor adhesion,migration,and survival in the joint cavity.A recent study shows that tropoelastin(TE)regulates adhesion,proliferation and phenotypic maintenance of MSCs as a soluble additive,indicating that TE could promote MSCs-homing in regenerative medicine.In this study,we used TE as injection medium,and compared it with classic media in MSCs intra-articular injection such as normal saline(NS),hyaluronic acid(HA),and platelet-rich plasma(PRP).We found that TE could effectively improve adhesion,migration,chondrogenic differentiation of infrapatellar fat pad MSCs(IPFP-MSCs)and enhance matrix synthesis of osteoarthritic chondrocytes(OACs)in indirect-coculture system.Moreover,TE could significantly enhance IPFP-MSCs adhesion via activation of integrin β1,ERK1/2 and vinculin(VCL)in vitro.In addition,intra-articular injection of TE-IPFP MSCs suspension resulted in a short-term increase in survival rate of IPFP-MSCs and better histology scores of rat joint tissues.Inhibition of integrin β1 or ERK1/2 attenuated the protective effect of TE-IPFP MSCs suspension in vivo.In conclusion,TE promotes performance of IPFP-MSCs and protects knee cartilage from damage in OA through enhancement of cell adhesion and activation of integrin β1/ERK/VCL pathway.Our findings may provide new insights in MSCs intra-articular injection for OA treatment.
