The Rural Minimum Living Standard Guarantee(Rural Dibao)is an important unconditional cash transfer program to alleviate poverty in rural China.Despite the importance of children’s nutrition in breaking poverty cycle...The Rural Minimum Living Standard Guarantee(Rural Dibao)is an important unconditional cash transfer program to alleviate poverty in rural China.Despite the importance of children’s nutrition in breaking poverty cycles,little is known about the impact of Rural Dibao on child nutrition outcomes.Using China Family Panel Studies(CFPS),this paper examines the effects of Rural Dibao on child nutrition outcomes and investigates potential pathways and heterogeneous effects.We exploit propensity score matching and difference-in-differences techniques to evaluate the effects of the Rural Dibao program on child nutrition outcomes.Our results suggest that Rural Dibao significantly impacts the nutrition outcomes of children up to 15 years of age.Specifically,our results suggest that Rural Dibao improves child height-to-age z-scores by 1.05 standard deviations and lowers the probability of stunting by 11.9 percentage points.Additional analyses suggest that increased protein intake is the main pathway through which Rural Dibao participation contributes to better nutrition outcomes.We also find that the effect of the program is more pronounced among girls,children who are non-left-behind or live with highly educated mothers,and those from low-income families and poor areas.Our findings suggest that Rural Dibao participation helps improve child nutrition outcomes through improving diet quality.展开更多
Objective:Paid sick leave(PSL)laws mandate employers give workers paid time off when they are sick or injured.This current study aims to examine whether access to PSL is associated with healthcare utilization and heal...Objective:Paid sick leave(PSL)laws mandate employers give workers paid time off when they are sick or injured.This current study aims to examine whether access to PSL is associated with healthcare utilization and health outcomes and to summarize the types of utilization and outcomes which have been reported to be associated with PSL.Methods:We conducted a rapid evidence review.Our search of seven databases,including Medline,Embase,PsycINFO,Cochrane Library,CINAHL,Scopus,and JSTOR,on September 21,2020,identified 757 studies,30 of which were retained.Results:Previous evidence is mostly provided by cross-sectional studies with survey data.In this study,evidence suggests that PSL is significantly associated with some types of healthcare utilization and health outcomes.In terms of healthcare utilization,findings indicate PSL is associated with an increase in the use of some preventive sendees and a decrease in the use of emergency care;while findings are mixed regarding associations of PSL with health provider visits and the use of mammograms and pap smears.As for health outcomes,findings suggest PSL is associated with improved mental and self-rated health,decreased incidence of influenza-like illness,and lower occupational injuries and mortality rates.Conclusion:PSL may be an effective tool in improving some healthcare utilization and health outcomes.Future research could help identify mechanisms through which PSL access works and identify what policy components lead to better outcomes.展开更多
BACKGROUND Within the normal range,elevated alanine aminotransferase(ALT)levels are associated with an increased risk of metabolic dysfunction-associated fatty liver disease(MAFLD).AIM To investigate the associations ...BACKGROUND Within the normal range,elevated alanine aminotransferase(ALT)levels are associated with an increased risk of metabolic dysfunction-associated fatty liver disease(MAFLD).AIM To investigate the associations between repeated high-normal ALT measurements and the risk of new-onset MAFLD prospectively.METHODS A cohort of 3553 participants followed for four consecutive health examinations over 4 years was selected.The incidence rate,cumulative times,and equally and unequally weighted cumulative effects of excess high-normal ALT levels(ehALT)were measured.Cox proportional hazards regression was used to analyse the association between the cumulative effects of ehALT and the risk of new-onset MAFLD.RESULTS A total of 83.13%of participants with MAFLD had normal ALT levels.The incidence rate of MAFLD showed a linear increasing trend in the cumulative ehALT group.Compared with those in the low-normal ALT group,the multivariate adjusted hazard ratios of the equally and unequally weighted cumulative effects of ehALT were 1.651[95%confidence interval(CI):1.199-2.273]and 1.535(95%CI:1.119-2.106)in the third quartile and 1.616(95%CI:1.162-2.246)and 1.580(95%CI:1.155-2.162)in the fourth quartile,respectively.CONCLUSION Most participants with MAFLD had normal ALT levels.Long-term high-normal ALT levels were associated with a cumulative increased risk of new-onset MAFLD.展开更多
Naphthalene, a constituent of coal tar, is a contaminant frequently found at former manufactured gas plants (MGP). Development at these sites has resulted in residential and commercial areas with potential exposures f...Naphthalene, a constituent of coal tar, is a contaminant frequently found at former manufactured gas plants (MGP). Development at these sites has resulted in residential and commercial areas with potential exposures from vapor intrusion adversely affecting indoor air of residences and buildings. Naphthalene is routinely analyzed in soil vapor intrusion assessments for properties overlying and surrounding former MGP sites. The United States Environmental Protection Agency (EPA) has a proposed unit risk factor and the State of California has promulgated a unit risk factor for naphthalene. Naphthalene exposure from vapor intrusion is potentially a public health risk. The purpose of this study was to evaluate three sites located in the northeast United States to determine the frequency of naphthalene detection in indoor air. A total of 79 properties were included in the study. A total of 546 indoor air samples were analyzed for naphthalene on 161 occasions. Naphthalene concentrations ranged from 0.26 to 51 μg/m3 of air. Only 3 of the 546 indoor air samples detected naphthalene above the ninety-fifth percentile background value of 12 μg/m3 of air. Risk analysis indicated naphthalene vapor intrusion was not a public health risk among the 79 properties built on or near the former MGP sites.展开更多
Objectives: Sexually Transmitted Infections (STIs) have a great public health impact globally. STIs are one of the most critical health problems in the United States of America (USA). Here, we present a mathematical m...Objectives: Sexually Transmitted Infections (STIs) have a great public health impact globally. STIs are one of the most critical health problems in the United States of America (USA). Here, we present a mathematical model for testing several interventions that are designed for various communities in order to control the Chlamydia epidemic. Study Design: Based on a community sexual behavior survey, we constructed and parameterized a mathematical disease transmission model to estimate the spread dynamics of Chlamydia in young adults in the northern part of Omaha, Nebraska. Methods: A differential equations based continuous time simulation model is run for various scenarios. The model considers only one age group i.e., 19 - 25 ages, which is considered as the highest risk group for this sexually transmitted disease. Our model assumes homogeneous mixing within this age group and use published estimates to model mixing rates between individuals. Results: The presented model quantified the potential value of screening and treatment programs for Chlamydia in reducing the burden of disease in this specific community. By increasing the screening and treatment rates from 35% to 85%, great public health benefit can be achieved in two years, i.e., total cases reduction around 9% just in this considered age group. Conclusions: Computational results show that behavioral change based interventions on prevention have some effect on reducing the prevalence in the targeted age group;however, more benefit can be obtained with frequent screening and treatment programs.展开更多
Background: Anemia is the most common hematologic abnormality in HIV patients and is associated with disease progression and decreased survival. This study aims to describe the prevalence and predictors of anemia in H...Background: Anemia is the most common hematologic abnormality in HIV patients and is associated with disease progression and decreased survival. This study aims to describe the prevalence and predictors of anemia in HIV positive patients at the time of ART initiation at public health facilities of Arba Minch town, Southern Ethiopia. Methods: A total of 411 adults (?15 years) HIV positive patients with complete information on hemoglobin levels and CD4 count and clinical characteristics registered from 2006 to 2013 were assessed for anemia prevalence and risk factors at the ART clinic of the Arba Minch hospital and health center. The measurements of Hemoglobin and CD4 + T cell count were performed using standard methodology at baseline of ART initiation. Results: A total of 411 HIV positive patients (195 males and 216 females) with a mean ± SD age of 33.9 ± 9.0 years were assessed. Hemoglobin levels were between 6.0 and 16.5 mg/dL. The overall prevalence of anemia at the time of ART initiation was 52.3%;with 28.1%, 22.9% and 1.3% mild, moderate and severe anemia respectively. The overall prevalence of anemia was 62.4% among males and 46.7% among females (P < 0.001). An increased risk of anemia was seen in males (adjusted OR = 2.78, 95% CI = 1.77 - 4.35);low CD4 cell counts (adjusted OR = 3.48, 95% CI = 2.09 - 5.79);and history of TB (adjusted OR = 2.89, 95% CI = 1.28 - 6.54). Conclusions: Anemia in HIV-positive patients was highly prevalent at the time of ART initiation. Male gender, low CD4 count and history of TB were associated with higher risk of baseline anemia.展开更多
Township and Village Health Services Integration Management(TVHSIM) is an essential form of China's two-tiered health service integration plan at the township and village level. Its main purpose, also one of the t...Township and Village Health Services Integration Management(TVHSIM) is an essential form of China's two-tiered health service integration plan at the township and village level. Its main purpose, also one of the target goals in China's new healthcare reform, is to gradually integrate rural health services and appropriately allocate rural health resources. This study aims to assess the village doctors' satisfaction with the TVHSIM and provide scientific base to further improve TVHSIM. A cross-sectional study was carried out in which 162 village doctors from Qinghai, Inner Mongolia and Xinjiang in western China were interviewed. Descriptive analysis, independent t-test, one-way ANOVA, Spearman rank correlation and multiple linear regression were used to analyze the difference and relevance between village doctors' personal characteristics and their satisfaction with TVHSIM and six subscales. Village doctors with different years of practice, social insurance status and essential medical knowledge level showed statistically significant differences in their satisfaction levels(all P<0.05). Age(P<0.05) and years of practice(P<0.01) were negatively correlated with Drug and Medical Device Management and Financing Management. Essential medical knowledge level(P<0.05) was negatively correlated with Operations Management as well. However, social insurance status(P<0.05) was positively correlated with Human Resources Management and Drug and Medical Device management. Gender, age and years of practice respectively had significant influence on village doctors' satisfaction with TVHSIM(P<0.01). In conclusion, in order to further promote TVHSIM policy in rural China, a well-rounded social insurance model for village doctors is urgently needed. In addition, the development of TVHSIM is regionally imbalanced. Efficient and effective measures aiming at rationalizing gender and age structure and enhancing essential medical training should be carefully considered.展开更多
Health disparities between the western, central and eastern regions of rural China, and the impact of national health improvement policies and programming were assessed. A total of 400 counties were randomly sampled. ...Health disparities between the western, central and eastern regions of rural China, and the impact of national health improvement policies and programming were assessed. A total of 400 counties were randomly sampled. ANOVA and Logistic regression modeling were employed to estimate differences in health outcomes and determinants. Significant differences were found between the western, central and eastern rural regions in community infrastructure and health outcomes. From 2000 to 2010, health indicators in rural China were improved significantly, and the infant mortality rate(IMR), maternal mortality rate(MMR) and under 5 mortality rate(U5MR) had fallen by 62.79%, 71.74% and 61.92%, respectively. Central rural China had the greatest decrease in IMR(65.05%); whereas, western rural China had the greatest reduction in MMR(72.99%) but smallest reduction in U5MR(57.36%). Despite these improvements, Logistic regression analysis showed regional differences in key health outcome indicators(odds ratios): IMR(central: 2.13; western: 5.31), U5MR(central: 2.25; western: 5.69), MMR(central: 1.94; western: 3.31), and prevalence of infectious diseases(central: 1.62; western: 3.58). The community infrastructure and health outcomes of the western and central rural regions of China have been improved markedly during the first decade of the 21 st century. However, health disparities still exist across the three regions. National efforts to increase per capita income, community empowerment and mobilization, community infrastructure, capacity of rural health facilities, and health literacy would be effective policy options to attain health equity.展开更多
The focus of this paper is to investigate the role self-employment conceptualized as a lifestyle factor on health, access to health care, and health behaviors. We analyze rich data on 13,435 working adults in the US, ...The focus of this paper is to investigate the role self-employment conceptualized as a lifestyle factor on health, access to health care, and health behaviors. We analyze rich data on 13,435 working adults in the US, who are either selfemployed or salaried workers. Outcomes include physical and mental health perception, validated indexes of physical and mental health, and medical conditions;access-to-care measures such as a barrier to obtaining necessary health care;and health behaviors such as smoking, physical activity and body mass index. Instrumental variables methods are used to correct for selection into self-employment. We find that self-employment is positively associated with perceived physical health, and is negatively associated with having diabetes, high blood pressure, high cholesterol and arthritis. No mental health outcome is significantly associated with self-employment. There is no significant difference between self-employed and wage-earning individuals with regard to access to care. Self-employed individuals are less likely to smoke, and are more likely to participate in physical activity and have normal-weight. We conclude that despite lack of health insurance, self-employed persons in the US are as healthy as wage-earners, do not experience a greater barrier to access to care, and are more likely to engage in healthy behavior.展开更多
The purpose of this study was to investigate the differences in the sensory threshold between the paretic and nonparetic sides of hemiplegic patients. 28 patients who were hemiplegic post-stroke (14 men and 14 women) ...The purpose of this study was to investigate the differences in the sensory threshold between the paretic and nonparetic sides of hemiplegic patients. 28 patients who were hemiplegic post-stroke (14 men and 14 women) participated in the electrical sensory and pain thresholds study;22 patients who were hemiplegic post-stroke (13 men, 9 women) participated in a study measureing the sensory threshold with light touch. Electrical sensory and pain thresholds were measured in the forearm via transcutaneous electrical nerve stimulation. The light-touch threshold was measured in the forearm using monofilaments. The light-touch, electrical sensory, and pain thresholds for the paretic side were significantly higher than for the nonparetic side in our population, respectively. In both the nonparetic and paretic sides, the male group generally showed higher thresholds for pain and sensation than did the female group. These results suggest that the different evaluations of sensory thresholds performed in this study for healthy rehabilitation will be a valuable clinical tool in hemiplegic patients after stroke.展开更多
Noise is known that the physical risk factors defined as any unwanted sound. It can induce the health problems such as hearing loss or annoyance. The objective of this study was to assess the occupational noise exposu...Noise is known that the physical risk factors defined as any unwanted sound. It can induce the health problems such as hearing loss or annoyance. The objective of this study was to assess the occupational noise exposure of nine groups for twenty peoples according to job characteristics and to compare the noise level by different variables. Personal noise levels were measured for three times using by dosimeters for each participant in Korea. The mean time weighted average noise level (TWA) of total was 73.2 ± 11.5 dBA by American conference of governmental industrial hygienists (ACGIH) standard. Especially, Korean classical music students were highly exposed to 93.2 ± 6.2 dBA but, office workers were 63.2 ± 6.6 dBA. In case of peak sound pressure level (Lpeak), Korean classical music students and firefighters were exposed to the highest level of 151.8 dBC and 145.8 dBC during playing and dispatching, respectively. The analysis of noise level showed that Leq had positive correlations between TWA by ministry of employment and labour (MOEL) (r = 0.98, p < 0.01) and TWA by ACGIH (r = 0.98, p < 0.01). Unlikely other groups, the noise exposure level of the Korean classical music students were exceeded the ACGIH standard. These results suggest that Korean classical music students were exposed high noise level and some solutions are need to reduce the noise exposure level such as using hearing protect device.展开更多
Monitoring emissions from a former Manufactured Gas Plant (MGP) site during remediation was used to manage risks associated with inhalation of Volatile Organic Compounds (VOCs) and contaminated particulates acting as ...Monitoring emissions from a former Manufactured Gas Plant (MGP) site during remediation was used to manage risks associated with inhalation of Volatile Organic Compounds (VOCs) and contaminated particulates acting as an exposure conduit for Polycyclic Aromatic Hydrocarbons (PAHs) and heavy metals. This risk management case study presents a USEPA-approved air monitoring program implemented to manage public health risks during remediation at a former MGP site located in the southeast United States. Risk-based Acceptable Air Concentrations (AACs) were developed and a sampling regimen established to monitor potential emissions to maintain contaminant concentrations below the AACs. The exposure duration used was based on a twelve-month project duration and an exposure time of 24 hours per day;equations, toxicity values and sources were based on USEPA’s Regional Screening Levels. A total 535 twenty-four hour time weighted samples (269 VOC samples and 266 PAH samples) were collected over the project duration. Only minor levels of VOCs and PAHs were detected and no results were above the AACs. These timeweighted averages demonstrate that the real-time air monitoring and control measures implemented at the site effectively maintained concentrations below the AACs and were protective of public health.展开更多
The purpose of this study is to evaluate occupational risk factors for nurses and CNAs by analyzing the Florida workers’ compensation claims database. Risk factors for the cause of injury, nature of injury, body part...The purpose of this study is to evaluate occupational risk factors for nurses and CNAs by analyzing the Florida workers’ compensation claims database. Risk factors for the cause of injury, nature of injury, body part injured, and demographic and lifestyle factors were evaluated for a sample of CNAs, nurses, and restaurant servers. The results identified falls, lifting, being struck, and pushing and pulling as major causes for injury among nurses and CNAs as compared to servers. Regarding the nature of injury, sprains and strains constituted the majority of claims for nurses and CNAS with the lower back being the body part most commonly injured in a claim. The results of this study indicate that nurses and CNAs are at far greater risk for physical injury than injury or illness from chemical or biological exposures. It is recommended that emphasis must be placed on interventions for musculoskeletal injuries such as falls and lifting, taking into account environmental factors such as age and lifestyle factors that further exacerbate risk for injury.展开更多
Background: Patients and public are increasingly relying on Internet for health information. Health care providers are using internet for dissemination of health information. However, health information available on i...Background: Patients and public are increasingly relying on Internet for health information. Health care providers are using internet for dissemination of health information. However, health information available on internet is not well regulated, and information quality varies greatly. Malaria is the leading cause of death and disease in many developing countries and has serious health burden around the world. The Internet could become a major resource for malaria education and information in Africa. This may potentially save millions of lives. The purpose of this study is to evaluate the quality of malaria health and treatment information available on the internet provided by the Nigerian context. Methods: Two key terms (malaria & treatment) were entered into three search engines: Google, Yahoo! and Bing. In order to retrieve articles as if the searches were conducted in Nigeria, the Local Area Network (LAN) settings were changed to a Nigerian proxy server, with a local Internet Protocol address. Three raters evaluated the quality of information using the DISCERN [9] instrument criteria. Kendall’s concordance coefficient (W) was calculated to determine the level of agreement among the three raters. Results: Thirty-eight websites evaluated, and the highest inter-rater average score was attributed to the Patient.co.uk website, followed by Wikipedia web site and Malaria Site. The “Home Remedies for You” website received the lowest score. Most evaluated websites were .com domains. The highest average score was given to .co.uk domains while .int had the lowest score. Conclusions: Improving the quality of malaria-related health information could lead to empowering communities, engaging and assisting them to strengthen their health and social information sharing and support.展开更多
<strong>Background: </strong>Hepatitis-B (Hep-B) infection is a global public health problem of great concern which affects more than 5% of the local population in Sub-Saharan Africa. This study assessed s...<strong>Background: </strong>Hepatitis-B (Hep-B) infection is a global public health problem of great concern which affects more than 5% of the local population in Sub-Saharan Africa. This study assessed students’ knowledge, attitude and practices towards Hepatitis B infection and vaccination at the University of Health and Allied Sciences, Ghana. <strong>Methods:</strong> A cross-sectional quantitative descriptive survey was conducted among 262 Public Health students of the University of Health and Allied Science of the Volta region of Ghana, using a multi-stage sampling technique in selecting participants. A structured questionnaire was used to collect data from the participants. Data was analyzed using SPSS Version 20.1. <strong>Results: </strong>Study respondents were mostly males, forming 69.8% as against 30.2% of their female counterparts. All (262) respondents had knowledge on Hep-B infection and the availability of a vaccine for preventing Hepatitis infection. However, despite their knowledge of existence, the majority (56.9%) of the respondents felt they did not need to be protected from Hep-B infection. Majority (58.8%) of the total respondents have been vaccinated against Hep-B infection. The study identified the cost of vaccines as a major setback to non-vaccination. However, out of the 41.2% respondents who were not vaccinated against Hep B infection, majority (50.9%) of them were not willing to be vaccinated even if it was offered to them at no cost. <strong>Conclusion:</strong> There was a significantly high level of knowledge on Hep-B infection and the availability of vaccine for Hep-B infection among students. However, the majority of the respondents felt they did not need to be protected from Hep-B infection. More education is needed on the importance of vaccination as an effective measure for controlling Hepatitis infection.展开更多
We examined the changes in numerous skin conditions before and after the ap-plication of interferential current therapy to various regions of healthy male bodies. In this study, we assessed the differences in the skin...We examined the changes in numerous skin conditions before and after the ap-plication of interferential current therapy to various regions of healthy male bodies. In this study, we assessed the differences in the skin’s sebum, moisture levels, pores, wrinkles, pigmentation, and elasticity on the shoulders, lower back, and the knees of Korean males in their 20s. A total of 30 healthy males were in-cluded in the study. We used a skin diagnosis meter as a device for measuring the state of the skin. A statistical difference was found when comparing the pre- and post-measurement values in regards to the moisture levels, wrinkles, and pig-mentation. In the correlation analysis results, the sebum and pigmentation, moisture levels and wrinkles, moisture levels and pigmentation, and moisture levels and elasticity were all positively correlated, respectively. The results of this study partially suggest that a change in skin condition is associated with ex-ternal stimulation. The study also found that the effects of the application of in-terferential current therapy on the various skin conditions may differ depending on the region of the body that the application is conducted as well.展开更多
Background: The coronavirus disease 2019 (COVID-19) is a public health problem that has caused harm to the mental health of healthcare workers. In Africa, the COVID-19 pandemic has led healthcare workers to experience...Background: The coronavirus disease 2019 (COVID-19) is a public health problem that has caused harm to the mental health of healthcare workers. In Africa, the COVID-19 pandemic has led healthcare workers to experience mental health disorders such as anxiety, depression, stress, insomnia and burnout. This study aimed to review published studies on the effect of COVID-19 on the mental health of healthcare workers, associated factors and coping strategies that have been employed in Africa. Methods: This was a systematic review that was conducted through searching databases including;PubMed/Medline and Google Scholar. The study included published literature from January 2020 to May 2022 that met the inclusion criteria. The selection of articles was conducted following the 2020 PRISMA guidelines. Results: A total of 39 articles were retrieved, of which only 18 met the inclusion criteria and were used in this study. Our review revealed that healthcare workers experienced mental health disorders such as anxiety, depression, insomnia, stress and burnout that were associated with the COVID-19 pandemic. Coping strategies such as religious practices, support from family members and colleagues and avoiding listening to social media about COVID-19 were used to minimize mental health problems. Conclusion: The COVID-19 pandemic has caused increased mental health disorders among healthcare workers in Africa. Identification of factors associated with mental health problems is cardinal in developing coping mechanisms against the psychological impact of COVID-19. Therefore, there is a need for governments to develop and implement strategies for protecting the mental health of healthcare workers during crises such as the COVID-19 pandemic.展开更多
A highly acidic spill from one of the most important copper mines in the Americas (Buenavista del Cobre) occurred in Sonora, Mexico in August, 2014. 40,000 m3 of metals-enriched sulphate solution escaped into the Sono...A highly acidic spill from one of the most important copper mines in the Americas (Buenavista del Cobre) occurred in Sonora, Mexico in August, 2014. 40,000 m3 of metals-enriched sulphate solution escaped into the Sonora River representing the worst ecological disaster in Mexican history. The spill affected the economy, water accessibility and the health of residents near the river. Despite the economic importance of mining in this area, no environmental assessment was undertaken. There is no information about the health impact of this event on the local population. The study assesses the health risk among children exposed to arsenic and mercury via groundwater in five communities located in a mining area into the Sonora River Basin, Mexico. Local drinking water from the localities was sampled one year after the spill and it was analyzed for arsenic and mercury by Atomic Absorption Spectrometry coupled with Hydride Generation (AAS/HG). Further, some of the traditional local foods were sampled and analyzed for the same elements. Results indicate that levels of arsenic in drinking water did not exceed the Mexican Norm (25 μg As/L) or the EPA Guideline (10 μg As/L). The concentrations of mercury exceeded the WHO and Mexican Legislation value (1.0 μg Hg/L). The Hazard Quotient (HQ) values for arsenic were >1 in 42% of children exposed and for mercury in 67% of the children. Foods concentrations contained in the ranges of 9.2 to 62.0 μg As/Kg and 0.28 to 42 μg Hg/Kg for arsenic and mercury respectively. These values are below the Codex Alimentarius limits. Children affected by mining activities are at risk of developing chronic diseases associated with low arsenic and mercury exposure via groundwater consumption, without consideration of the contribution from these metals by other important exposures routes.展开更多
The aim of our study was to recognize different skin conditions of the face and neck using six biophysical parameters and to show the changes after the application of ultrasonic stimulation (US). We assessed the diffe...The aim of our study was to recognize different skin conditions of the face and neck using six biophysical parameters and to show the changes after the application of ultrasonic stimulation (US). We assessed the differences in the sebum, moisture, pores, wrinkles, pigmentation, and elasticity of the skin in the face and neck regions. A total of 30 healthy men in their 20s were enrolled. We used a skin diagnosis meter to assess the state of the skin. The sebum and pores of the face were more significant than in the neck. The amount of moisture in the U-zone was significantly higher than in other areas. Statistical differences were found between the pre-and post-measure-ment values in the sebum, moisture, wrinkles and pigmentation. Wrinkles and pigmentation were positively correlated. Our data showed that the changes in skin condition are associated with external stimulants. The effect of US on skin may differ depending on the part of the body, and some biophysical properties of skin vary depending on the location on the body.展开更多
Objective To explore whether the protein Deglycase protein 1(DJ1)can ameliorate Alzheimer’s disease(AD)-like pathology in Amyloid Precursor Protein/Presenilin 1(APP/PS1)double transgenic mice and its possible mechani...Objective To explore whether the protein Deglycase protein 1(DJ1)can ameliorate Alzheimer’s disease(AD)-like pathology in Amyloid Precursor Protein/Presenilin 1(APP/PS1)double transgenic mice and its possible mechanism to provide a theoretical basis for exploring the pathogenesis of AD.Methods Adeno-associated viral vectors(AAV)of DJ1-overexpression or DJ1-knockdown were injected into the hippocampus of 7-month-old APP/PS1 mice to construct models of overexpression or knockdown.Mice were divided into the AD model control group(MC),AAV vector control group(NC),DJ1-overexpression group(DJ1+),and DJ1-knockdown group(DJ1-).After 21 days,the Morris water maze test,immunohistochemistry,immunofluorescence,and western blotting were used to evaluate the effects of DJ1 on mice.Results DJ1+overexpression decreased the latency and increased the number of platform traversals in the water maze test.DJ1-cells were cured and atrophied,and the intercellular structure was relaxed;the number of age spots and the expression of AD-related proteins were significantly increased.DJ1+increased the protein expression of Nuclear factor erythroid 2-related factor 2(NRF2),heme oxygenase-1(HO-1),light chain 3(LC3),phosphorylated AMPK(p-AMPK),and B cell lymphoma-2(BCL-2),as well as the antioxidant levels of total superoxide dismutase(T-SOD),total antioxidant capacity(T-AOC),and Glutathione peroxidase(GSH-PX),while decreasing the levels of Kelch-like hydrates-associated protein 1(Keap1),mammalian target of rapamycin(mTOR),p62/sequestosome1(p62/SQSTM1),Caspase3,and malondialdehyde(MDA).Conclusion DJ1-overexpression can ameliorate learning,memory,and AD-like pathology in APP/PS1 mice,which may be related to the activation of the NRF2/HO-1 and AMPK/mTOR pathways by DJ1.展开更多
基金The authors are grateful for support from the National Social Science Fund of China(21AJL015).
文摘The Rural Minimum Living Standard Guarantee(Rural Dibao)is an important unconditional cash transfer program to alleviate poverty in rural China.Despite the importance of children’s nutrition in breaking poverty cycles,little is known about the impact of Rural Dibao on child nutrition outcomes.Using China Family Panel Studies(CFPS),this paper examines the effects of Rural Dibao on child nutrition outcomes and investigates potential pathways and heterogeneous effects.We exploit propensity score matching and difference-in-differences techniques to evaluate the effects of the Rural Dibao program on child nutrition outcomes.Our results suggest that Rural Dibao significantly impacts the nutrition outcomes of children up to 15 years of age.Specifically,our results suggest that Rural Dibao improves child height-to-age z-scores by 1.05 standard deviations and lowers the probability of stunting by 11.9 percentage points.Additional analyses suggest that increased protein intake is the main pathway through which Rural Dibao participation contributes to better nutrition outcomes.We also find that the effect of the program is more pronounced among girls,children who are non-left-behind or live with highly educated mothers,and those from low-income families and poor areas.Our findings suggest that Rural Dibao participation helps improve child nutrition outcomes through improving diet quality.
文摘Objective:Paid sick leave(PSL)laws mandate employers give workers paid time off when they are sick or injured.This current study aims to examine whether access to PSL is associated with healthcare utilization and health outcomes and to summarize the types of utilization and outcomes which have been reported to be associated with PSL.Methods:We conducted a rapid evidence review.Our search of seven databases,including Medline,Embase,PsycINFO,Cochrane Library,CINAHL,Scopus,and JSTOR,on September 21,2020,identified 757 studies,30 of which were retained.Results:Previous evidence is mostly provided by cross-sectional studies with survey data.In this study,evidence suggests that PSL is significantly associated with some types of healthcare utilization and health outcomes.In terms of healthcare utilization,findings indicate PSL is associated with an increase in the use of some preventive sendees and a decrease in the use of emergency care;while findings are mixed regarding associations of PSL with health provider visits and the use of mammograms and pap smears.As for health outcomes,findings suggest PSL is associated with improved mental and self-rated health,decreased incidence of influenza-like illness,and lower occupational injuries and mortality rates.Conclusion:PSL may be an effective tool in improving some healthcare utilization and health outcomes.Future research could help identify mechanisms through which PSL access works and identify what policy components lead to better outcomes.
基金National Natural Science Foundation of China,No.72101236China Postdoctoral Science Foundation,No.2022M722900+1 种基金Collaborative Innovation Project of Zhengzhou City,No.XTCX2023006Nursing Team Project of the First Affiliated Hospital of Zhengzhou University,No.HLKY2023005.
文摘BACKGROUND Within the normal range,elevated alanine aminotransferase(ALT)levels are associated with an increased risk of metabolic dysfunction-associated fatty liver disease(MAFLD).AIM To investigate the associations between repeated high-normal ALT measurements and the risk of new-onset MAFLD prospectively.METHODS A cohort of 3553 participants followed for four consecutive health examinations over 4 years was selected.The incidence rate,cumulative times,and equally and unequally weighted cumulative effects of excess high-normal ALT levels(ehALT)were measured.Cox proportional hazards regression was used to analyse the association between the cumulative effects of ehALT and the risk of new-onset MAFLD.RESULTS A total of 83.13%of participants with MAFLD had normal ALT levels.The incidence rate of MAFLD showed a linear increasing trend in the cumulative ehALT group.Compared with those in the low-normal ALT group,the multivariate adjusted hazard ratios of the equally and unequally weighted cumulative effects of ehALT were 1.651[95%confidence interval(CI):1.199-2.273]and 1.535(95%CI:1.119-2.106)in the third quartile and 1.616(95%CI:1.162-2.246)and 1.580(95%CI:1.155-2.162)in the fourth quartile,respectively.CONCLUSION Most participants with MAFLD had normal ALT levels.Long-term high-normal ALT levels were associated with a cumulative increased risk of new-onset MAFLD.
文摘Naphthalene, a constituent of coal tar, is a contaminant frequently found at former manufactured gas plants (MGP). Development at these sites has resulted in residential and commercial areas with potential exposures from vapor intrusion adversely affecting indoor air of residences and buildings. Naphthalene is routinely analyzed in soil vapor intrusion assessments for properties overlying and surrounding former MGP sites. The United States Environmental Protection Agency (EPA) has a proposed unit risk factor and the State of California has promulgated a unit risk factor for naphthalene. Naphthalene exposure from vapor intrusion is potentially a public health risk. The purpose of this study was to evaluate three sites located in the northeast United States to determine the frequency of naphthalene detection in indoor air. A total of 79 properties were included in the study. A total of 546 indoor air samples were analyzed for naphthalene on 161 occasions. Naphthalene concentrations ranged from 0.26 to 51 μg/m3 of air. Only 3 of the 546 indoor air samples detected naphthalene above the ninety-fifth percentile background value of 12 μg/m3 of air. Risk analysis indicated naphthalene vapor intrusion was not a public health risk among the 79 properties built on or near the former MGP sites.
文摘Objectives: Sexually Transmitted Infections (STIs) have a great public health impact globally. STIs are one of the most critical health problems in the United States of America (USA). Here, we present a mathematical model for testing several interventions that are designed for various communities in order to control the Chlamydia epidemic. Study Design: Based on a community sexual behavior survey, we constructed and parameterized a mathematical disease transmission model to estimate the spread dynamics of Chlamydia in young adults in the northern part of Omaha, Nebraska. Methods: A differential equations based continuous time simulation model is run for various scenarios. The model considers only one age group i.e., 19 - 25 ages, which is considered as the highest risk group for this sexually transmitted disease. Our model assumes homogeneous mixing within this age group and use published estimates to model mixing rates between individuals. Results: The presented model quantified the potential value of screening and treatment programs for Chlamydia in reducing the burden of disease in this specific community. By increasing the screening and treatment rates from 35% to 85%, great public health benefit can be achieved in two years, i.e., total cases reduction around 9% just in this considered age group. Conclusions: Computational results show that behavioral change based interventions on prevention have some effect on reducing the prevalence in the targeted age group;however, more benefit can be obtained with frequent screening and treatment programs.
文摘Background: Anemia is the most common hematologic abnormality in HIV patients and is associated with disease progression and decreased survival. This study aims to describe the prevalence and predictors of anemia in HIV positive patients at the time of ART initiation at public health facilities of Arba Minch town, Southern Ethiopia. Methods: A total of 411 adults (?15 years) HIV positive patients with complete information on hemoglobin levels and CD4 count and clinical characteristics registered from 2006 to 2013 were assessed for anemia prevalence and risk factors at the ART clinic of the Arba Minch hospital and health center. The measurements of Hemoglobin and CD4 + T cell count were performed using standard methodology at baseline of ART initiation. Results: A total of 411 HIV positive patients (195 males and 216 females) with a mean ± SD age of 33.9 ± 9.0 years were assessed. Hemoglobin levels were between 6.0 and 16.5 mg/dL. The overall prevalence of anemia at the time of ART initiation was 52.3%;with 28.1%, 22.9% and 1.3% mild, moderate and severe anemia respectively. The overall prevalence of anemia was 62.4% among males and 46.7% among females (P < 0.001). An increased risk of anemia was seen in males (adjusted OR = 2.78, 95% CI = 1.77 - 4.35);low CD4 cell counts (adjusted OR = 3.48, 95% CI = 2.09 - 5.79);and history of TB (adjusted OR = 2.89, 95% CI = 1.28 - 6.54). Conclusions: Anemia in HIV-positive patients was highly prevalent at the time of ART initiation. Male gender, low CD4 count and history of TB were associated with higher risk of baseline anemia.
基金supported by the National Natural Science Foundation of China(No.71273097)
文摘Township and Village Health Services Integration Management(TVHSIM) is an essential form of China's two-tiered health service integration plan at the township and village level. Its main purpose, also one of the target goals in China's new healthcare reform, is to gradually integrate rural health services and appropriately allocate rural health resources. This study aims to assess the village doctors' satisfaction with the TVHSIM and provide scientific base to further improve TVHSIM. A cross-sectional study was carried out in which 162 village doctors from Qinghai, Inner Mongolia and Xinjiang in western China were interviewed. Descriptive analysis, independent t-test, one-way ANOVA, Spearman rank correlation and multiple linear regression were used to analyze the difference and relevance between village doctors' personal characteristics and their satisfaction with TVHSIM and six subscales. Village doctors with different years of practice, social insurance status and essential medical knowledge level showed statistically significant differences in their satisfaction levels(all P<0.05). Age(P<0.05) and years of practice(P<0.01) were negatively correlated with Drug and Medical Device Management and Financing Management. Essential medical knowledge level(P<0.05) was negatively correlated with Operations Management as well. However, social insurance status(P<0.05) was positively correlated with Human Resources Management and Drug and Medical Device management. Gender, age and years of practice respectively had significant influence on village doctors' satisfaction with TVHSIM(P<0.01). In conclusion, in order to further promote TVHSIM policy in rural China, a well-rounded social insurance model for village doctors is urgently needed. In addition, the development of TVHSIM is regionally imbalanced. Efficient and effective measures aiming at rationalizing gender and age structure and enhancing essential medical training should be carefully considered.
文摘Health disparities between the western, central and eastern regions of rural China, and the impact of national health improvement policies and programming were assessed. A total of 400 counties were randomly sampled. ANOVA and Logistic regression modeling were employed to estimate differences in health outcomes and determinants. Significant differences were found between the western, central and eastern rural regions in community infrastructure and health outcomes. From 2000 to 2010, health indicators in rural China were improved significantly, and the infant mortality rate(IMR), maternal mortality rate(MMR) and under 5 mortality rate(U5MR) had fallen by 62.79%, 71.74% and 61.92%, respectively. Central rural China had the greatest decrease in IMR(65.05%); whereas, western rural China had the greatest reduction in MMR(72.99%) but smallest reduction in U5MR(57.36%). Despite these improvements, Logistic regression analysis showed regional differences in key health outcome indicators(odds ratios): IMR(central: 2.13; western: 5.31), U5MR(central: 2.25; western: 5.69), MMR(central: 1.94; western: 3.31), and prevalence of infectious diseases(central: 1.62; western: 3.58). The community infrastructure and health outcomes of the western and central rural regions of China have been improved markedly during the first decade of the 21 st century. However, health disparities still exist across the three regions. National efforts to increase per capita income, community empowerment and mobilization, community infrastructure, capacity of rural health facilities, and health literacy would be effective policy options to attain health equity.
文摘The focus of this paper is to investigate the role self-employment conceptualized as a lifestyle factor on health, access to health care, and health behaviors. We analyze rich data on 13,435 working adults in the US, who are either selfemployed or salaried workers. Outcomes include physical and mental health perception, validated indexes of physical and mental health, and medical conditions;access-to-care measures such as a barrier to obtaining necessary health care;and health behaviors such as smoking, physical activity and body mass index. Instrumental variables methods are used to correct for selection into self-employment. We find that self-employment is positively associated with perceived physical health, and is negatively associated with having diabetes, high blood pressure, high cholesterol and arthritis. No mental health outcome is significantly associated with self-employment. There is no significant difference between self-employed and wage-earning individuals with regard to access to care. Self-employed individuals are less likely to smoke, and are more likely to participate in physical activity and have normal-weight. We conclude that despite lack of health insurance, self-employed persons in the US are as healthy as wage-earners, do not experience a greater barrier to access to care, and are more likely to engage in healthy behavior.
文摘The purpose of this study was to investigate the differences in the sensory threshold between the paretic and nonparetic sides of hemiplegic patients. 28 patients who were hemiplegic post-stroke (14 men and 14 women) participated in the electrical sensory and pain thresholds study;22 patients who were hemiplegic post-stroke (13 men, 9 women) participated in a study measureing the sensory threshold with light touch. Electrical sensory and pain thresholds were measured in the forearm via transcutaneous electrical nerve stimulation. The light-touch threshold was measured in the forearm using monofilaments. The light-touch, electrical sensory, and pain thresholds for the paretic side were significantly higher than for the nonparetic side in our population, respectively. In both the nonparetic and paretic sides, the male group generally showed higher thresholds for pain and sensation than did the female group. These results suggest that the different evaluations of sensory thresholds performed in this study for healthy rehabilitation will be a valuable clinical tool in hemiplegic patients after stroke.
文摘Noise is known that the physical risk factors defined as any unwanted sound. It can induce the health problems such as hearing loss or annoyance. The objective of this study was to assess the occupational noise exposure of nine groups for twenty peoples according to job characteristics and to compare the noise level by different variables. Personal noise levels were measured for three times using by dosimeters for each participant in Korea. The mean time weighted average noise level (TWA) of total was 73.2 ± 11.5 dBA by American conference of governmental industrial hygienists (ACGIH) standard. Especially, Korean classical music students were highly exposed to 93.2 ± 6.2 dBA but, office workers were 63.2 ± 6.6 dBA. In case of peak sound pressure level (Lpeak), Korean classical music students and firefighters were exposed to the highest level of 151.8 dBC and 145.8 dBC during playing and dispatching, respectively. The analysis of noise level showed that Leq had positive correlations between TWA by ministry of employment and labour (MOEL) (r = 0.98, p < 0.01) and TWA by ACGIH (r = 0.98, p < 0.01). Unlikely other groups, the noise exposure level of the Korean classical music students were exceeded the ACGIH standard. These results suggest that Korean classical music students were exposed high noise level and some solutions are need to reduce the noise exposure level such as using hearing protect device.
文摘Monitoring emissions from a former Manufactured Gas Plant (MGP) site during remediation was used to manage risks associated with inhalation of Volatile Organic Compounds (VOCs) and contaminated particulates acting as an exposure conduit for Polycyclic Aromatic Hydrocarbons (PAHs) and heavy metals. This risk management case study presents a USEPA-approved air monitoring program implemented to manage public health risks during remediation at a former MGP site located in the southeast United States. Risk-based Acceptable Air Concentrations (AACs) were developed and a sampling regimen established to monitor potential emissions to maintain contaminant concentrations below the AACs. The exposure duration used was based on a twelve-month project duration and an exposure time of 24 hours per day;equations, toxicity values and sources were based on USEPA’s Regional Screening Levels. A total 535 twenty-four hour time weighted samples (269 VOC samples and 266 PAH samples) were collected over the project duration. Only minor levels of VOCs and PAHs were detected and no results were above the AACs. These timeweighted averages demonstrate that the real-time air monitoring and control measures implemented at the site effectively maintained concentrations below the AACs and were protective of public health.
文摘The purpose of this study is to evaluate occupational risk factors for nurses and CNAs by analyzing the Florida workers’ compensation claims database. Risk factors for the cause of injury, nature of injury, body part injured, and demographic and lifestyle factors were evaluated for a sample of CNAs, nurses, and restaurant servers. The results identified falls, lifting, being struck, and pushing and pulling as major causes for injury among nurses and CNAs as compared to servers. Regarding the nature of injury, sprains and strains constituted the majority of claims for nurses and CNAS with the lower back being the body part most commonly injured in a claim. The results of this study indicate that nurses and CNAs are at far greater risk for physical injury than injury or illness from chemical or biological exposures. It is recommended that emphasis must be placed on interventions for musculoskeletal injuries such as falls and lifting, taking into account environmental factors such as age and lifestyle factors that further exacerbate risk for injury.
文摘Background: Patients and public are increasingly relying on Internet for health information. Health care providers are using internet for dissemination of health information. However, health information available on internet is not well regulated, and information quality varies greatly. Malaria is the leading cause of death and disease in many developing countries and has serious health burden around the world. The Internet could become a major resource for malaria education and information in Africa. This may potentially save millions of lives. The purpose of this study is to evaluate the quality of malaria health and treatment information available on the internet provided by the Nigerian context. Methods: Two key terms (malaria & treatment) were entered into three search engines: Google, Yahoo! and Bing. In order to retrieve articles as if the searches were conducted in Nigeria, the Local Area Network (LAN) settings were changed to a Nigerian proxy server, with a local Internet Protocol address. Three raters evaluated the quality of information using the DISCERN [9] instrument criteria. Kendall’s concordance coefficient (W) was calculated to determine the level of agreement among the three raters. Results: Thirty-eight websites evaluated, and the highest inter-rater average score was attributed to the Patient.co.uk website, followed by Wikipedia web site and Malaria Site. The “Home Remedies for You” website received the lowest score. Most evaluated websites were .com domains. The highest average score was given to .co.uk domains while .int had the lowest score. Conclusions: Improving the quality of malaria-related health information could lead to empowering communities, engaging and assisting them to strengthen their health and social information sharing and support.
文摘<strong>Background: </strong>Hepatitis-B (Hep-B) infection is a global public health problem of great concern which affects more than 5% of the local population in Sub-Saharan Africa. This study assessed students’ knowledge, attitude and practices towards Hepatitis B infection and vaccination at the University of Health and Allied Sciences, Ghana. <strong>Methods:</strong> A cross-sectional quantitative descriptive survey was conducted among 262 Public Health students of the University of Health and Allied Science of the Volta region of Ghana, using a multi-stage sampling technique in selecting participants. A structured questionnaire was used to collect data from the participants. Data was analyzed using SPSS Version 20.1. <strong>Results: </strong>Study respondents were mostly males, forming 69.8% as against 30.2% of their female counterparts. All (262) respondents had knowledge on Hep-B infection and the availability of a vaccine for preventing Hepatitis infection. However, despite their knowledge of existence, the majority (56.9%) of the respondents felt they did not need to be protected from Hep-B infection. Majority (58.8%) of the total respondents have been vaccinated against Hep-B infection. The study identified the cost of vaccines as a major setback to non-vaccination. However, out of the 41.2% respondents who were not vaccinated against Hep B infection, majority (50.9%) of them were not willing to be vaccinated even if it was offered to them at no cost. <strong>Conclusion:</strong> There was a significantly high level of knowledge on Hep-B infection and the availability of vaccine for Hep-B infection among students. However, the majority of the respondents felt they did not need to be protected from Hep-B infection. More education is needed on the importance of vaccination as an effective measure for controlling Hepatitis infection.
文摘We examined the changes in numerous skin conditions before and after the ap-plication of interferential current therapy to various regions of healthy male bodies. In this study, we assessed the differences in the skin’s sebum, moisture levels, pores, wrinkles, pigmentation, and elasticity on the shoulders, lower back, and the knees of Korean males in their 20s. A total of 30 healthy males were in-cluded in the study. We used a skin diagnosis meter as a device for measuring the state of the skin. A statistical difference was found when comparing the pre- and post-measurement values in regards to the moisture levels, wrinkles, and pig-mentation. In the correlation analysis results, the sebum and pigmentation, moisture levels and wrinkles, moisture levels and pigmentation, and moisture levels and elasticity were all positively correlated, respectively. The results of this study partially suggest that a change in skin condition is associated with ex-ternal stimulation. The study also found that the effects of the application of in-terferential current therapy on the various skin conditions may differ depending on the region of the body that the application is conducted as well.
文摘Background: The coronavirus disease 2019 (COVID-19) is a public health problem that has caused harm to the mental health of healthcare workers. In Africa, the COVID-19 pandemic has led healthcare workers to experience mental health disorders such as anxiety, depression, stress, insomnia and burnout. This study aimed to review published studies on the effect of COVID-19 on the mental health of healthcare workers, associated factors and coping strategies that have been employed in Africa. Methods: This was a systematic review that was conducted through searching databases including;PubMed/Medline and Google Scholar. The study included published literature from January 2020 to May 2022 that met the inclusion criteria. The selection of articles was conducted following the 2020 PRISMA guidelines. Results: A total of 39 articles were retrieved, of which only 18 met the inclusion criteria and were used in this study. Our review revealed that healthcare workers experienced mental health disorders such as anxiety, depression, insomnia, stress and burnout that were associated with the COVID-19 pandemic. Coping strategies such as religious practices, support from family members and colleagues and avoiding listening to social media about COVID-19 were used to minimize mental health problems. Conclusion: The COVID-19 pandemic has caused increased mental health disorders among healthcare workers in Africa. Identification of factors associated with mental health problems is cardinal in developing coping mechanisms against the psychological impact of COVID-19. Therefore, there is a need for governments to develop and implement strategies for protecting the mental health of healthcare workers during crises such as the COVID-19 pandemic.
文摘A highly acidic spill from one of the most important copper mines in the Americas (Buenavista del Cobre) occurred in Sonora, Mexico in August, 2014. 40,000 m3 of metals-enriched sulphate solution escaped into the Sonora River representing the worst ecological disaster in Mexican history. The spill affected the economy, water accessibility and the health of residents near the river. Despite the economic importance of mining in this area, no environmental assessment was undertaken. There is no information about the health impact of this event on the local population. The study assesses the health risk among children exposed to arsenic and mercury via groundwater in five communities located in a mining area into the Sonora River Basin, Mexico. Local drinking water from the localities was sampled one year after the spill and it was analyzed for arsenic and mercury by Atomic Absorption Spectrometry coupled with Hydride Generation (AAS/HG). Further, some of the traditional local foods were sampled and analyzed for the same elements. Results indicate that levels of arsenic in drinking water did not exceed the Mexican Norm (25 μg As/L) or the EPA Guideline (10 μg As/L). The concentrations of mercury exceeded the WHO and Mexican Legislation value (1.0 μg Hg/L). The Hazard Quotient (HQ) values for arsenic were >1 in 42% of children exposed and for mercury in 67% of the children. Foods concentrations contained in the ranges of 9.2 to 62.0 μg As/Kg and 0.28 to 42 μg Hg/Kg for arsenic and mercury respectively. These values are below the Codex Alimentarius limits. Children affected by mining activities are at risk of developing chronic diseases associated with low arsenic and mercury exposure via groundwater consumption, without consideration of the contribution from these metals by other important exposures routes.
文摘The aim of our study was to recognize different skin conditions of the face and neck using six biophysical parameters and to show the changes after the application of ultrasonic stimulation (US). We assessed the differences in the sebum, moisture, pores, wrinkles, pigmentation, and elasticity of the skin in the face and neck regions. A total of 30 healthy men in their 20s were enrolled. We used a skin diagnosis meter to assess the state of the skin. The sebum and pores of the face were more significant than in the neck. The amount of moisture in the U-zone was significantly higher than in other areas. Statistical differences were found between the pre-and post-measure-ment values in the sebum, moisture, wrinkles and pigmentation. Wrinkles and pigmentation were positively correlated. Our data showed that the changes in skin condition are associated with external stimulants. The effect of US on skin may differ depending on the part of the body, and some biophysical properties of skin vary depending on the location on the body.
基金supported by the National Natural Science Foundation of China[grant numbers 81872626 and 82003454]Chinese Nutrition Society-Bright Moon Seaweed Group Nutrition and Health Research Fund[grant number CNS-BMSG2020A63]Key R&D and promotion projects in Henan Province[grant number 212102310219 and 212102310110]。
文摘Objective To explore whether the protein Deglycase protein 1(DJ1)can ameliorate Alzheimer’s disease(AD)-like pathology in Amyloid Precursor Protein/Presenilin 1(APP/PS1)double transgenic mice and its possible mechanism to provide a theoretical basis for exploring the pathogenesis of AD.Methods Adeno-associated viral vectors(AAV)of DJ1-overexpression or DJ1-knockdown were injected into the hippocampus of 7-month-old APP/PS1 mice to construct models of overexpression or knockdown.Mice were divided into the AD model control group(MC),AAV vector control group(NC),DJ1-overexpression group(DJ1+),and DJ1-knockdown group(DJ1-).After 21 days,the Morris water maze test,immunohistochemistry,immunofluorescence,and western blotting were used to evaluate the effects of DJ1 on mice.Results DJ1+overexpression decreased the latency and increased the number of platform traversals in the water maze test.DJ1-cells were cured and atrophied,and the intercellular structure was relaxed;the number of age spots and the expression of AD-related proteins were significantly increased.DJ1+increased the protein expression of Nuclear factor erythroid 2-related factor 2(NRF2),heme oxygenase-1(HO-1),light chain 3(LC3),phosphorylated AMPK(p-AMPK),and B cell lymphoma-2(BCL-2),as well as the antioxidant levels of total superoxide dismutase(T-SOD),total antioxidant capacity(T-AOC),and Glutathione peroxidase(GSH-PX),while decreasing the levels of Kelch-like hydrates-associated protein 1(Keap1),mammalian target of rapamycin(mTOR),p62/sequestosome1(p62/SQSTM1),Caspase3,and malondialdehyde(MDA).Conclusion DJ1-overexpression can ameliorate learning,memory,and AD-like pathology in APP/PS1 mice,which may be related to the activation of the NRF2/HO-1 and AMPK/mTOR pathways by DJ1.
