BACKGROUND Glycosylation,a commonly occurring post-translational modification,is highly expressed in several tumors,specifically in those of the digestive system,and plays a role in various cellular pathophysiological...BACKGROUND Glycosylation,a commonly occurring post-translational modification,is highly expressed in several tumors,specifically in those of the digestive system,and plays a role in various cellular pathophysiological mechanisms.Although the importance and detection methods of glycosylation in digestive system tumors have garnered increasing attention in recent years,bibliometric analysis of this field remains scarce.The present study aims to identify the developmental trends and research hotspots of glycosylation in digestive system tumors.AIM To find and identify the developmental trends and research hotspots of glycosylation in digestive system tumors.METHODS We obtained relevant literature from the Web of Science Core Collection and employed VOSviewer 1.6.19 and CiteSpace(version 6.1.R6)to perform bibliometric analysis.RESULTS A total of 2042 documents spanning from 1978 to the present were analyzed,with the research process divided into three phases:the period of obscurity(1978-1990),continuous development period(1991-2006),and the rapid outbreak period(2007-2023).These documents were authored by researchers from 66 countries or regions,with the United States and China leading in terms of publication output.Reis Celso A had the highest number of publications,while Pinho SS was the most cited author.Co-occurrence analysis revealed the most popular keywords in this field are glycosylation,expression,cancer,colorectal cancer,and pancreatic cancer.Furthermore,the Journal of Proteome Research was the most prolific journal in terms of publications,while the Journal of Biological Chemistry had the most citations.CONCLUSION The bibliometric analysis shows current research focus is primarily on basic research in this field.However,future research should aim to utilize glycosylation as a target for treating tumor patients.展开更多
This study aims to investigate characteristics of continental shelf wave(CSW)on the northwestern continental shelf of the South China Sea(SCS)induced by winter storms in 2021.Mooring and cruise observations,tidal gaug...This study aims to investigate characteristics of continental shelf wave(CSW)on the northwestern continental shelf of the South China Sea(SCS)induced by winter storms in 2021.Mooring and cruise observations,tidal gauge data at stations Hong Kong,Zhapo and Qinglan and sea surface wind data from January 1 to February 28,2021 are used to examine the relationship between along-shelf wind and sea level fluctuation.Two events of CSWs driven by the along-shelf sea surface wind are detected from wavelet spectra of tidal gauge data.The signals are triply peaked at periods of 56 h,94 h and 180 h,propagating along the coast with phase speed ranging from 6.9 m/s to18.9 m/s.The dispersion relation shows their property of the Kelvin mode of CSW.We develop a simple method to estimate amplitude of sea surface fluctuation by along-shelf wind.The results are comparable with the observation data,suggesting it is effective.The mode 2 CSWs fits very well with the mooring current velocity data.The results from rare current help to understand wave-current interaction in the northwestern SCS.展开更多
Background:This research focuses on herbal medicine,an ancient healthcare practice,exploring the antibacterial attributes of fresh and dried leaf extracts from Momordica charantia(commonly known as Bitter melon)and Ve...Background:This research focuses on herbal medicine,an ancient healthcare practice,exploring the antibacterial attributes of fresh and dried leaf extracts from Momordica charantia(commonly known as Bitter melon)and Vernonia amygdalina(Bitter leaf).The study specifically investigates their effects on different bacterial strains associated with gastroenteritis.Methods:Four enteric bacterial isolates-Klebsiella pneumoniae,Salmonella typhi,Escherichia coli,and Proteus mirabilis-were obtained from the Medical Laboratory Unit at Babcock University Teaching Hospital in Ilishan-Remo,Ogun State.Phytochemical screening and antibacterial testing were conducted using standard biochemical techniques and the Punch-hole agar diffusion method,respectively.Results:Qualitative phytochemical screening of the plant extracts revealed the presence of flavonoids,glycosides,and saponin in both plants,excluding terpenoids.Alkaloids were identified only in Vernonia amygdalina.Despite these phytochemicals,neither plant displayed inhibitory effects on the tested bacterial isolates(Escherichia coli,Proteus mirabilis,Klebsiella pneumoniae,and Salmonella typhi)when tested individually or in combination.Intriguingly,combining the fresh and dried leaf extracts of Momordica charantia and Vernonia amygdalina with a standard drug resulted in smaller mean zone diameters of inhibition(Escherichia coli range:14 mm–16 mm,Proteus mirabilis range:31 mm–35 mm,Klebsiella pneumoniae range:13 mm–22 mm,and Salmonella typhi range:35 mm–38 mm)compared to the drug tested alone(16 mm–45 mm).Conclusion:Despite previous indications of antibacterial properties in various extracts of V.amygdalina and M.charantia leaves,our study presents contradictory results,prompting the need for further investigation despite the presence of significant phytochemicals.展开更多
The recognition of the positive value of student diversity and their right to full participation are key aspects of inclusion as a means of managing heterogeneity of the school population from an equality perspective....The recognition of the positive value of student diversity and their right to full participation are key aspects of inclusion as a means of managing heterogeneity of the school population from an equality perspective.As the school cannot welcome the diversity of children without including their families,the same logic needs to apply to the relationship between the school and parents,particularly in the current environment where the school-family partnership appears as a privileged institutional leverage in the fight against inequalities at school.Based on an ethnographical study exploring how the relationship between the school and the families builds up in a Swiss school located in a context of strong cultural diversity,this paper interrogates how the school norm can be the main limitation to the inclusion of students and parents who are unfamiliar with the school.Derived from field observations and interviews,our results show how the teachers tend to approach their relationship with new students and their parents from the standpoint of narrowly defined expected models,leading them to engage in a vain attempt to conform the students and parents when they deviate from these models.The possibility of entering the school system for students and parents unfamiliar with school is hindered by the exclusive and excluding normativity on which the models of the child and the parent expected by the teachers are grounded.Based on these observations,we discuss how an inclusive approach seems to us to require in the first place a necessary process of decentering from the school and teachers,as a condition for recognition of the actual child and parent.展开更多
Learning mathematics requires an effective and strategic teaching approach.This study aimed to assess the mathematics performance of the learners with the implementation of the numeracy enhancement strategy QD2R(Quest...Learning mathematics requires an effective and strategic teaching approach.This study aimed to assess the mathematics performance of the learners with the implementation of the numeracy enhancement strategy QD2R(Questions,Drills,Repetition,and Recitation)and to propose a strategy implementation plan to elevate their performances.This study employed the use of a quasi-experimental research design,purposive sampling with 70 Grade 10 students of Lian National High School who were distributed equally to control and treatment groups.The pre-test and post-test results were statistically analyzed using independent and paired sample t-tests,and a survey questionnaire was examined by getting the mean and standard deviation.The results indicated that better performance was achieved by the students from the treatment group compared to the students from the control group,as revealed by the Mean Percentage Score(MPS)results,mean scores,and P values of their pre-test and post-test scores.The learners’perception of the implementation of this strategy was to a great extent,wherein it was perceived to be more helpful in concepts related to understanding the lesson compared to concepts related to developing their attitude and skills.Moreover,the proposed implementation plan of numeracy enhancement strategy QD2R had three expected outcomes:elevated understanding and performance in mathematics lessons;modified strategy to focus on the development of attitude and skills towards mathematics;and refined and well-implemented QD2R strategy in teaching mathematics.Relative to these expected outcomes,appropriate measures,timeframe,and resources of each were comprehensively formulated.展开更多
The western North Pacific summer monsoon(WNPSM)is an important subcomponent of the Asian summer monsoon.The equatorial zonal wind(EZW)in the lower troposphere over the western Pacific may play a critical role in the e...The western North Pacific summer monsoon(WNPSM)is an important subcomponent of the Asian summer monsoon.The equatorial zonal wind(EZW)in the lower troposphere over the western Pacific may play a critical role in the evolution of the El Niño-Southern Oscillation(ENSO).The possible linkage between the EZW over the western Pacific and the offequatorial monsoonal winds associated with the WNPSM and its decadal changes have not yet been fully understood.Here,we find a non-stationary relationship between the WNPSM and the western Pacific EZW,significantly strengthening their correlation around the late 1980s/early 1990s.This observed shift in the WNPSM–EZW relationship could be explained by the changes in the related sea surface temperature(SST)configurations across the tropical oceans.The enhanced influence from the springtime tropical North Atlantic,summertime tropical central Pacific,and maritime continent SST anomalies may be working together in contributing to the recent intensified WNPSM–EZW co-variability.The observed recent strengthening of the WNPSM–EZW relationship may profoundly impact the climate system,including prompting more effective feedback from the WNPSM on subsequent ENSO evolution and bolstering a stronger biennial tendency of the WNPSM–ENSO coupled system.The results obtained herein imply that the WNPSM,EZW,ENSO,and the tropical North Atlantic SST may be closely linked within a unified climate system with a quasi-biennial rhythm occurring during recent decades,accompanied by a reinforcement of the WNPSM–ENSO interplay quite possibly triggered by enhanced tropical Pacific–Atlantic cross-basin interactions.These results highlight the importance of the tropical Atlantic cross-basin influences in shaping the spatial structure of WNPSM-related wind anomalies and the WNPSM–ENSO interaction.展开更多
The construction of modern school system has a rich connotation,its essence is system innovation,and the core is the construction of school internal management system.It is also a dynamic improvement process.Shanghai ...The construction of modern school system has a rich connotation,its essence is system innovation,and the core is the construction of school internal management system.It is also a dynamic improvement process.Shanghai is one of the leading cities to run schools in collectivization in China.Through innovative collectivization of school running content,it has increasingly become an innovation mechanism of regional education governance,which not only complies with the construction of modern school system but also plays an important role in promoting modern school governance in reform and practice.This research believes that educational collectivization is a new exploration of modern school system construction and provides a reference for future research.展开更多
Future education is highly integrated with technology and highly open education.The rapid development of information technology urges education to embrace the change brought by technology enthusiastically.The alienati...Future education is highly integrated with technology and highly open education.The rapid development of information technology urges education to embrace the change brought by technology enthusiastically.The alienation of thinking under technology package must not be ignored and guard against the tendency of"technology determinism".Therefore,this paper interprets the irreplaceable life education from three angles:the reform trend,the basic pattern and the practice construction,and makes full use of technology to restore the meaning of life at the same time.展开更多
Adolescents’emotions and preferences are influenced by their childhood experiences.In today’s world,there is a pervasive eagerness for happiness.Happiness has been linked to feelings of self-strength,seeking help,and...Adolescents’emotions and preferences are influenced by their childhood experiences.In today’s world,there is a pervasive eagerness for happiness.Happiness has been linked to feelings of self-strength,seeking help,and psy-chological health.The current quantitative research was designed with a positive psychological perspective to compare Pakistani and Chines adolescents’self-strength,seeking help,and happiness.The research design of the study was causal-comparative.The study population consisted of 400 Pakistani and 409 Chinese adolescents studying in the elementary grades of both countries.The sample was selected by using a simple random sampling technique.It consisted of 413 boys(51%)and 396 girls(49%),319(39)of them were from the age group of 13–14 years,386(48%)of them were from the age group of 15–16 years,and 104(12.9%)were from the age group of 17–18 years.Three different scales were developed to collect study data.Independent sample t-test and simple linear regression were used to test study hypotheses.The analysis revealed that Pakistani adolescents have signifi-cantly higher self-strength,seeking help and happiness than their counterparts.It was also found that adolescents’self-strength and seeking help significant affect their happiness.Based on thefindings,it was suggested to inves-tigate the factors contributing to the improved self-strength,seeking help,and happiness of Pakistani adolescents.It was also recommended to investigate the mediating effect of adolescents’self-strength on the relationship between their happiness and seeking help.展开更多
In this study,different molar of methylolureas(MMU)were used to improve the properties and drying speed of the raw lacquer(RL).The drying time,gloss,pencil hardness and impact resistance of the lacquer film were teste...In this study,different molar of methylolureas(MMU)were used to improve the properties and drying speed of the raw lacquer(RL).The drying time,gloss,pencil hardness and impact resistance of the lacquer film were tested.The thermal behaviors and chemical structures of the lacquer membrane were also discussed by thermal gravimetric analysis(TGA),fourier infrared spectrometer(FT-IR)and nuclear magnetic resonance(NMR)analysis,respectively.The results demonstrated that lower molar ratio MMU can significantly improve the properties of lacquer.The TGA analysis showed that the modified lacquer had high thermal stability than that of the control.The FT-IR and 13C NMR analysis revealed that the structures of the modified lacquer were significantly improved by cross-linking with the hydroxymethyl groups and methylene methyl ethers of MMU.In addition,through scanning electron microscopy(SEM)characterization,it was found that the introduction of MMU can effectively improve the surface smoothness of the lacquer film.展开更多
The traditional tenon and mortise joint has low processing efficiency and a weak theoretical basis,making the structure easy to deform and damage,reducing the safety,and increasing waste of resources.This study aims t...The traditional tenon and mortise joint has low processing efficiency and a weak theoretical basis,making the structure easy to deform and damage,reducing the safety,and increasing waste of resources.This study aims to determine the optimum dowel center spacing parameter for chamfered-joint components and the maximum value of the strength of joints loaded into bending strength and tensile strength.In this study,an integrated opti-mization method combining the single-factor test and one-way ANOVA analysis was proposed to study the influ-ence of the dowel center spacing on the bending strength and the tensile strength of chamfered-joint components made by Cupressus funebris wood.The results revealed that the bending strength of chamfered-joint components decreases linearly with the increase of the dowel center spacing.In addition,the tensile strength of chamfered-joint components increases first and then decreases with the increase of the dowel center spacing,showing para-bola change.The relational expression between dowel center spacing,the bending strength,dowel center spacing and the tensile strength were obtained.展开更多
The COVID-19 pandemic has struck nations worldwide,pushing worldwide health and socioeconomic systems to extreme limits.Various factors,such as drastic alterations in public environments,prolonged quarantine,revenue l...The COVID-19 pandemic has struck nations worldwide,pushing worldwide health and socioeconomic systems to extreme limits.Various factors,such as drastic alterations in public environments,prolonged quarantine,revenue loss,and anxiety of disease contraction,have caused mental turmoil.Although there was a need to cope with an excess of psychological strain among the public,post-COVID patients,and those with a previously diagnosed psychiatric condition,mental health programs faced a substantial decline in services,mirroring the dramatic rise in psychological issues.Interestingly,certain coping strategies play protective or deleterious effects on mental health outcomes.Moreover,social media exposure has played a double-edged role in the mental health of the public during the pandemic,leaving grounds for further debates.Protean cultural themes have taken center stage in the discussion on social resilience and compliance to COVID-19 measures,driving their impact through cer-tain work ethics,social capital,and public attitudes in different societies.On the other hand,exceedingly rising poverty rates cemented the deleterious economic impact of the pandemic.Attention has been called to the racial implications of the pandemic,driving millions of individuals with low socioeconomic position(SEP)and belong-ing to minority groups out of the paid workforce.Interestingly,we turn attention to an array of elements impli-cated in this dramatic effect,such as public transport,living arrangements,and health insurance coverage among these vulnerable groups.We attempt to address the mechanisms COVID-19 channeled its mental health and socioeconomic impacts by explaining the risk factors and pave the way for stronger crisis management in the future by evaluating the socioeconomic and psychological effects in stark detail.展开更多
Objectives The aim of this study was to analyze the psychometric properties(reliability and validity)of the Social Isolation Scale(SIS)in a sample of Portuguese community-dwelling older adults.Methods A transversal de...Objectives The aim of this study was to analyze the psychometric properties(reliability and validity)of the Social Isolation Scale(SIS)in a sample of Portuguese community-dwelling older adults.Methods A transversal descriptive study was carried out with a convenience sample of 250 community-dwelling older adults(≥65 years).The survey comprised a sociodemographic questionnaire,SIS,Geriatric Depression Scale-4(GDS-4),6-item Lubben Social Network Scale(LSNS-6),a loneliness self-assessment question,and Satisfaction with Life Scale(SWLS).Construct validity(confirmatory factor analysis)and convergent validity were analyzed,and ISI internal reliability(composite reliability),external reliability(test-retest,intraclass correlation coefficient)and inter-rater reliability(Cohen’s kappa coefficient)were evaluated.Results Confirmatory factor analysis showed a two-factor model with an excellent index of fit.The SIS showed significant correlations with LSNS-6(rs=0.47),SWLS(rs=0.26),the loneliness self-assessment question(rs=0.35),and GDS-4(rs=−0.16).SIS composite reliability was good(0.708).The inter-class correlation coefficient varied from 0.84 to 0.98.The Cohen’s kappa coefficient ranged from 0.936 to 1.Conclusions SIS has been shown to be a valid and reliable instrument for assessing social isolation among Portuguese community-dwelling older adults.Healthcare professionals,particularly nurses working in community settings,can use SIS to assess social isolation in older adults to design,implement,and evaluate interventions.展开更多
Past hydroclimatic conditions in southern China are poorly constrained owing to the lack of high-resolution marine-sediment records. In this study, we present high-resolution geochemical and grain-size records of mari...Past hydroclimatic conditions in southern China are poorly constrained owing to the lack of high-resolution marine-sediment records. In this study, we present high-resolution geochemical and grain-size records of marine sediments from the coastal shelf of the northern South China Sea to investigate regional hydrological variations.Results suggest a warm and humid climate during the interval 9 200–7 600 cal a BP, followed by a cold and dry climate from 7 600 cal a BP to 6 500 cal a BP, and progressive humidification during the period 6 500–6 200 cal a BP.A prominent hydrological anomaly occurred during 7 600–6 500 cal a BP. This abrupt event corresponds closely to tropical Pacific and interhemispheric temperature gradients, suggesting that moisture variations in southern China may have been driven by interhemispheric and zonal Pacific temperature gradients via modulation of the intensity and location of the West Pacific subtropical high.展开更多
This study aimed to determine the association and predictive capacities of job satisfaction,workplace stress,work motivation,and self-esteem on state of mental health of caregivers of children with disabilities in Sou...This study aimed to determine the association and predictive capacities of job satisfaction,workplace stress,work motivation,and self-esteem on state of mental health of caregivers of children with disabilities in South-West Nigeria.The self-determination theory provided a theoretical framework for the study.A closed-ended paper-pencil questionnaire tagged‘Mental Healthiness Scale for Caregivers’was used for data collection from 241 care-givers of children with disabilities.Data collected was analyzed using descriptive of frequency count,simple per-centage and mean as well as inferential statistics involving Pearson product moment correlation and Binary Logistic Regression at 95%confidence interval.Findings revealed a significant but inverse association between self-esteem,workplace stress and mental health.Work motivation had a direct association with mental health while job satisfaction had no significant association with mental health of caregivers of children with disabilities.Caregivers(18–40 years)had the highest odds for mental health concerns.Lowered self-esteem and workplace stress increased mental health concerns while job satisfaction significantly predicted a higher likelihood for posi-tive state of mental health among caregivers of children with disabilities.展开更多
The present study evaluated the stabilizing effect of starch produced from corns and cassava on the stability of cow milk yogurt. A sample of both corn and cassava starch was selected and used in the yogurt making as ...The present study evaluated the stabilizing effect of starch produced from corns and cassava on the stability of cow milk yogurt. A sample of both corn and cassava starch was selected and used in the yogurt making as stabilizers. The yogurt samples have been analyzed for their WHC, syneresis and protein content. The yogurt with no added starch has found to have very low WHC and high syneresis compared to other samples. The yogurt made with the addition of corn starch as a stabilizer was highly accepted than the yogurt with cassava starch and the yogurt without starch. The findings from this study provide an alternative to add the value of local corns and cassava.展开更多
Today, the most urgent problem of the existing and future nuclear power industry is to ensure the nuclear and environmental safety of the operation of nuclear power reactor units (NPPs) and nuclear power plants (NPPs)...Today, the most urgent problem of the existing and future nuclear power industry is to ensure the nuclear and environmental safety of the operation of nuclear power reactor units (NPPs) and nuclear power plants (NPPs). It is solved thanks to the application of deeply echeloned protection and an anti-accident complex of methods and means for effective control of the operation of active reactor zones (AZR). However, the danger of existing NPPs in the world from time to time manifests itself in the form of severe post-project accidents and catastrophes with the release into the environment of a significant amount of radioactive materials dangerous for all living things. The results of the analysis show that the unconditional fulfillment of the main requirements of nuclear environmental safety and biocompatibility is possible only in the so-called wave nuclear reactor of the G-V generation, which, unlike reactors of the previous generations III, II+ and IV, does not require supercritical loading of the core with nuclear fuel. In the active zone of this reactor, nuclear-physical processes governed by physical law are implemented, which exclude the operator’s participation in regulating the reactivity of the reactor’s active zone, which makes it the reactor with the highest level of nuclear and environmental safety today, which is based on the principles of so-called internal safety, free from the human factor. The possibility of burning nuclear fuel based on U238 and Th232 in it expands the reserves of energetic nuclear fuel almost to inexhaustibility. The technology of nuclear reactors of the G5 generation through the secondary use of spent irradiated nuclear fuel (SNF) for the production of energy and energy raw materials with simultaneous burning of it to an environmentally safe state is able to quickly reduce the available stocks and further production of dangerous SNF, guarantee the nuclear and environmental safety of NPPs with reactors G5 and to technologically make nuclear post-project accidents and disasters impossible at the level of physical law with the complete elimination of the human factor.展开更多
Numeracy is the capacity to use mathematical ideas in all facets of life.It involves activities such as adding and subtracting numbers,counting,number recognition,solving number problems involving various operations,s...Numeracy is the capacity to use mathematical ideas in all facets of life.It involves activities such as adding and subtracting numbers,counting,number recognition,solving number problems involving various operations,sorting,observing,identifying,and establishing patterns.It is one of the fundamental skills that students should have mastered by the end of their primary schooling.With the notable importance of mastery of numeracy skills,low achievement and performance of the learners were observed in this aspect.This study aimed in enhancing the numeracy skills of Grade 3 learners through authentic performance tasks.The variable in numeracy skills includes the four fundamental operations and problem solving.The quasi-experimental design was utilized wherein purposive sampling or non-randomized sampling was used.In this study,33 Grade 3 learners of Rizal Elementary School were selected to participate in the tests.Pre-test and post-test crafted by the teacher were the main instrument in the study.The result revealed that in the pre-test the learners obtained a mean percentage score(MPS)of 38.20%in four fundamental operations,which implied a non-numerate level.While in terms of problem solving,the learners obtained a MPS of 20.60%which is also in the non-numerate level.It has a grand mean of 29.40%with an interpretation of non-numerate level.In the post-test,it was observed that four fundamental operations have a MPS of 81.10%which is in average numerate level,while problem solving has a MPS of 76.30%with a grand mean of 78.70%with an interpretation of average numerate level.This implied that there is a significant difference between the pre-test and post-test in the four fundamental operations and problem solving.Thus,it can be concluded that the application of authentic performance tasks was effective to bridge the gap on numeracy skills.展开更多
The cultural ecology of university classroom has been influenced by postmodernism and has shown complex and variable characteristics.Specifically speaking,it tends to be both conflicting and interactive in terms of su...The cultural ecology of university classroom has been influenced by postmodernism and has shown complex and variable characteristics.Specifically speaking,it tends to be both conflicting and interactive in terms of subject relations in the classroom,fragmented and diversified in terms of classroom teaching,and redundant and dynamic in terms of classroom assessment.In order to further harmonize and develop the cultural ecology of university classrooms,it is necessary to expand the space for communication and interaction between teachers and students,improve the overall professional quality of faculty members,and perfect the management and assessment system for university teachers and students.展开更多
基金the National Natural Science Foundation of China,No.82072662Shanghai Municipal Education Commission-Gaofeng Clinical Medicine Grant Support,No.2019142+1 种基金Shanghai Three-year Action Plan to Promote Clinical Skills and Clinical Innovation in Municipal Hospitals,No.SHDC2020CR4022the 2021 Shanghai“Rising Stars of Medical Talent”Youth Development Program:Outstanding Youth Medical Talents.
文摘BACKGROUND Glycosylation,a commonly occurring post-translational modification,is highly expressed in several tumors,specifically in those of the digestive system,and plays a role in various cellular pathophysiological mechanisms.Although the importance and detection methods of glycosylation in digestive system tumors have garnered increasing attention in recent years,bibliometric analysis of this field remains scarce.The present study aims to identify the developmental trends and research hotspots of glycosylation in digestive system tumors.AIM To find and identify the developmental trends and research hotspots of glycosylation in digestive system tumors.METHODS We obtained relevant literature from the Web of Science Core Collection and employed VOSviewer 1.6.19 and CiteSpace(version 6.1.R6)to perform bibliometric analysis.RESULTS A total of 2042 documents spanning from 1978 to the present were analyzed,with the research process divided into three phases:the period of obscurity(1978-1990),continuous development period(1991-2006),and the rapid outbreak period(2007-2023).These documents were authored by researchers from 66 countries or regions,with the United States and China leading in terms of publication output.Reis Celso A had the highest number of publications,while Pinho SS was the most cited author.Co-occurrence analysis revealed the most popular keywords in this field are glycosylation,expression,cancer,colorectal cancer,and pancreatic cancer.Furthermore,the Journal of Proteome Research was the most prolific journal in terms of publications,while the Journal of Biological Chemistry had the most citations.CONCLUSION The bibliometric analysis shows current research focus is primarily on basic research in this field.However,future research should aim to utilize glycosylation as a target for treating tumor patients.
基金The National Key R&D Program of China under contract No.2022YFC3104805the National Natural Science Foundation of China under contract Nos 42276019,41706025 and 41976200+4 种基金the Innovation Team Plan for Universities in Guangdong Province under contract No.2019KCXTF021the First-class Discipline Plan of Guangdong Province under contract Nos 080503032101and 231420003the Program for Scientific Research Start-up Funds of Guangdong Ocean University under contract No.060302032106the Open Fund Project of Key Laboratory of Marine Environmental Information Technology(2019)Ministry of Natural Resources。
文摘This study aims to investigate characteristics of continental shelf wave(CSW)on the northwestern continental shelf of the South China Sea(SCS)induced by winter storms in 2021.Mooring and cruise observations,tidal gauge data at stations Hong Kong,Zhapo and Qinglan and sea surface wind data from January 1 to February 28,2021 are used to examine the relationship between along-shelf wind and sea level fluctuation.Two events of CSWs driven by the along-shelf sea surface wind are detected from wavelet spectra of tidal gauge data.The signals are triply peaked at periods of 56 h,94 h and 180 h,propagating along the coast with phase speed ranging from 6.9 m/s to18.9 m/s.The dispersion relation shows their property of the Kelvin mode of CSW.We develop a simple method to estimate amplitude of sea surface fluctuation by along-shelf wind.The results are comparable with the observation data,suggesting it is effective.The mode 2 CSWs fits very well with the mooring current velocity data.The results from rare current help to understand wave-current interaction in the northwestern SCS.
文摘Background:This research focuses on herbal medicine,an ancient healthcare practice,exploring the antibacterial attributes of fresh and dried leaf extracts from Momordica charantia(commonly known as Bitter melon)and Vernonia amygdalina(Bitter leaf).The study specifically investigates their effects on different bacterial strains associated with gastroenteritis.Methods:Four enteric bacterial isolates-Klebsiella pneumoniae,Salmonella typhi,Escherichia coli,and Proteus mirabilis-were obtained from the Medical Laboratory Unit at Babcock University Teaching Hospital in Ilishan-Remo,Ogun State.Phytochemical screening and antibacterial testing were conducted using standard biochemical techniques and the Punch-hole agar diffusion method,respectively.Results:Qualitative phytochemical screening of the plant extracts revealed the presence of flavonoids,glycosides,and saponin in both plants,excluding terpenoids.Alkaloids were identified only in Vernonia amygdalina.Despite these phytochemicals,neither plant displayed inhibitory effects on the tested bacterial isolates(Escherichia coli,Proteus mirabilis,Klebsiella pneumoniae,and Salmonella typhi)when tested individually or in combination.Intriguingly,combining the fresh and dried leaf extracts of Momordica charantia and Vernonia amygdalina with a standard drug resulted in smaller mean zone diameters of inhibition(Escherichia coli range:14 mm–16 mm,Proteus mirabilis range:31 mm–35 mm,Klebsiella pneumoniae range:13 mm–22 mm,and Salmonella typhi range:35 mm–38 mm)compared to the drug tested alone(16 mm–45 mm).Conclusion:Despite previous indications of antibacterial properties in various extracts of V.amygdalina and M.charantia leaves,our study presents contradictory results,prompting the need for further investigation despite the presence of significant phytochemicals.
文摘The recognition of the positive value of student diversity and their right to full participation are key aspects of inclusion as a means of managing heterogeneity of the school population from an equality perspective.As the school cannot welcome the diversity of children without including their families,the same logic needs to apply to the relationship between the school and parents,particularly in the current environment where the school-family partnership appears as a privileged institutional leverage in the fight against inequalities at school.Based on an ethnographical study exploring how the relationship between the school and the families builds up in a Swiss school located in a context of strong cultural diversity,this paper interrogates how the school norm can be the main limitation to the inclusion of students and parents who are unfamiliar with the school.Derived from field observations and interviews,our results show how the teachers tend to approach their relationship with new students and their parents from the standpoint of narrowly defined expected models,leading them to engage in a vain attempt to conform the students and parents when they deviate from these models.The possibility of entering the school system for students and parents unfamiliar with school is hindered by the exclusive and excluding normativity on which the models of the child and the parent expected by the teachers are grounded.Based on these observations,we discuss how an inclusive approach seems to us to require in the first place a necessary process of decentering from the school and teachers,as a condition for recognition of the actual child and parent.
文摘Learning mathematics requires an effective and strategic teaching approach.This study aimed to assess the mathematics performance of the learners with the implementation of the numeracy enhancement strategy QD2R(Questions,Drills,Repetition,and Recitation)and to propose a strategy implementation plan to elevate their performances.This study employed the use of a quasi-experimental research design,purposive sampling with 70 Grade 10 students of Lian National High School who were distributed equally to control and treatment groups.The pre-test and post-test results were statistically analyzed using independent and paired sample t-tests,and a survey questionnaire was examined by getting the mean and standard deviation.The results indicated that better performance was achieved by the students from the treatment group compared to the students from the control group,as revealed by the Mean Percentage Score(MPS)results,mean scores,and P values of their pre-test and post-test scores.The learners’perception of the implementation of this strategy was to a great extent,wherein it was perceived to be more helpful in concepts related to understanding the lesson compared to concepts related to developing their attitude and skills.Moreover,the proposed implementation plan of numeracy enhancement strategy QD2R had three expected outcomes:elevated understanding and performance in mathematics lessons;modified strategy to focus on the development of attitude and skills towards mathematics;and refined and well-implemented QD2R strategy in teaching mathematics.Relative to these expected outcomes,appropriate measures,timeframe,and resources of each were comprehensively formulated.
基金This work was supported by the National Natural Science Foundation of China(Grant No:41776031)the National Key Research and Development Program of China(Grant 2018YFC1506903)+1 种基金the team project funding of scientific research innovation for universities in Guangdong province(Grant 2019KCXTF021)the program for scientific research start-up funds of Guangdong Ocean University(Grant R17051).
文摘The western North Pacific summer monsoon(WNPSM)is an important subcomponent of the Asian summer monsoon.The equatorial zonal wind(EZW)in the lower troposphere over the western Pacific may play a critical role in the evolution of the El Niño-Southern Oscillation(ENSO).The possible linkage between the EZW over the western Pacific and the offequatorial monsoonal winds associated with the WNPSM and its decadal changes have not yet been fully understood.Here,we find a non-stationary relationship between the WNPSM and the western Pacific EZW,significantly strengthening their correlation around the late 1980s/early 1990s.This observed shift in the WNPSM–EZW relationship could be explained by the changes in the related sea surface temperature(SST)configurations across the tropical oceans.The enhanced influence from the springtime tropical North Atlantic,summertime tropical central Pacific,and maritime continent SST anomalies may be working together in contributing to the recent intensified WNPSM–EZW co-variability.The observed recent strengthening of the WNPSM–EZW relationship may profoundly impact the climate system,including prompting more effective feedback from the WNPSM on subsequent ENSO evolution and bolstering a stronger biennial tendency of the WNPSM–ENSO coupled system.The results obtained herein imply that the WNPSM,EZW,ENSO,and the tropical North Atlantic SST may be closely linked within a unified climate system with a quasi-biennial rhythm occurring during recent decades,accompanied by a reinforcement of the WNPSM–ENSO interplay quite possibly triggered by enhanced tropical Pacific–Atlantic cross-basin interactions.These results highlight the importance of the tropical Atlantic cross-basin influences in shaping the spatial structure of WNPSM-related wind anomalies and the WNPSM–ENSO interaction.
文摘The construction of modern school system has a rich connotation,its essence is system innovation,and the core is the construction of school internal management system.It is also a dynamic improvement process.Shanghai is one of the leading cities to run schools in collectivization in China.Through innovative collectivization of school running content,it has increasingly become an innovation mechanism of regional education governance,which not only complies with the construction of modern school system but also plays an important role in promoting modern school governance in reform and practice.This research believes that educational collectivization is a new exploration of modern school system construction and provides a reference for future research.
文摘Future education is highly integrated with technology and highly open education.The rapid development of information technology urges education to embrace the change brought by technology enthusiastically.The alienation of thinking under technology package must not be ignored and guard against the tendency of"technology determinism".Therefore,this paper interprets the irreplaceable life education from three angles:the reform trend,the basic pattern and the practice construction,and makes full use of technology to restore the meaning of life at the same time.
基金funded by“13th Five-Year Plan”of National Education Science in China(No.BBA200033).
文摘Adolescents’emotions and preferences are influenced by their childhood experiences.In today’s world,there is a pervasive eagerness for happiness.Happiness has been linked to feelings of self-strength,seeking help,and psy-chological health.The current quantitative research was designed with a positive psychological perspective to compare Pakistani and Chines adolescents’self-strength,seeking help,and happiness.The research design of the study was causal-comparative.The study population consisted of 400 Pakistani and 409 Chinese adolescents studying in the elementary grades of both countries.The sample was selected by using a simple random sampling technique.It consisted of 413 boys(51%)and 396 girls(49%),319(39)of them were from the age group of 13–14 years,386(48%)of them were from the age group of 15–16 years,and 104(12.9%)were from the age group of 17–18 years.Three different scales were developed to collect study data.Independent sample t-test and simple linear regression were used to test study hypotheses.The analysis revealed that Pakistani adolescents have signifi-cantly higher self-strength,seeking help and happiness than their counterparts.It was also found that adolescents’self-strength and seeking help significant affect their happiness.Based on thefindings,it was suggested to inves-tigate the factors contributing to the improved self-strength,seeking help,and happiness of Pakistani adolescents.It was also recommended to investigate the mediating effect of adolescents’self-strength on the relationship between their happiness and seeking help.
基金support by Key Research and Development Project of Sichuan Science and Technology Plan Projects(Grant No.2020YFS0357)Ministry of Education Humanities and Social Sciences Research Project of China(Grant No.19YJC760009)+1 种基金Research Program of Science and Technology Agency of Sichuan of China(Project No.2012129068)Research Interest in Training Program of Sichuan Agricultural University(Project No.2021182)。
文摘In this study,different molar of methylolureas(MMU)were used to improve the properties and drying speed of the raw lacquer(RL).The drying time,gloss,pencil hardness and impact resistance of the lacquer film were tested.The thermal behaviors and chemical structures of the lacquer membrane were also discussed by thermal gravimetric analysis(TGA),fourier infrared spectrometer(FT-IR)and nuclear magnetic resonance(NMR)analysis,respectively.The results demonstrated that lower molar ratio MMU can significantly improve the properties of lacquer.The TGA analysis showed that the modified lacquer had high thermal stability than that of the control.The FT-IR and 13C NMR analysis revealed that the structures of the modified lacquer were significantly improved by cross-linking with the hydroxymethyl groups and methylene methyl ethers of MMU.In addition,through scanning electron microscopy(SEM)characterization,it was found that the introduction of MMU can effectively improve the surface smoothness of the lacquer film.
基金support of the Ministry of Education Humanities and Social Sciences Research Project of China(Grant No.19YJC760009)the Key Research and Development Project of Sichuan Science and Technology Plan Projects(Grant No.2020YFS0357)the Project of Modern Design and Culture Research Centre(Grant No.MD18Z002)。
文摘The traditional tenon and mortise joint has low processing efficiency and a weak theoretical basis,making the structure easy to deform and damage,reducing the safety,and increasing waste of resources.This study aims to determine the optimum dowel center spacing parameter for chamfered-joint components and the maximum value of the strength of joints loaded into bending strength and tensile strength.In this study,an integrated opti-mization method combining the single-factor test and one-way ANOVA analysis was proposed to study the influ-ence of the dowel center spacing on the bending strength and the tensile strength of chamfered-joint components made by Cupressus funebris wood.The results revealed that the bending strength of chamfered-joint components decreases linearly with the increase of the dowel center spacing.In addition,the tensile strength of chamfered-joint components increases first and then decreases with the increase of the dowel center spacing,showing para-bola change.The relational expression between dowel center spacing,the bending strength,dowel center spacing and the tensile strength were obtained.
基金supported by the Social Science Program of Hainan Province(HNSK(Y.B.)19-10)the Program of the Ministry of Culture and Tourism(TYETP201552).
文摘The COVID-19 pandemic has struck nations worldwide,pushing worldwide health and socioeconomic systems to extreme limits.Various factors,such as drastic alterations in public environments,prolonged quarantine,revenue loss,and anxiety of disease contraction,have caused mental turmoil.Although there was a need to cope with an excess of psychological strain among the public,post-COVID patients,and those with a previously diagnosed psychiatric condition,mental health programs faced a substantial decline in services,mirroring the dramatic rise in psychological issues.Interestingly,certain coping strategies play protective or deleterious effects on mental health outcomes.Moreover,social media exposure has played a double-edged role in the mental health of the public during the pandemic,leaving grounds for further debates.Protean cultural themes have taken center stage in the discussion on social resilience and compliance to COVID-19 measures,driving their impact through cer-tain work ethics,social capital,and public attitudes in different societies.On the other hand,exceedingly rising poverty rates cemented the deleterious economic impact of the pandemic.Attention has been called to the racial implications of the pandemic,driving millions of individuals with low socioeconomic position(SEP)and belong-ing to minority groups out of the paid workforce.Interestingly,we turn attention to an array of elements impli-cated in this dramatic effect,such as public transport,living arrangements,and health insurance coverage among these vulnerable groups.We attempt to address the mechanisms COVID-19 channeled its mental health and socioeconomic impacts by explaining the risk factors and pave the way for stronger crisis management in the future by evaluating the socioeconomic and psychological effects in stark detail.
基金supported by national funds through FCT-Fundaçao para a Ciencia e a Tecnologia,I.P.,within CINTESIS R&D Unit(UIDB/4255/2020 and UIDP/4255/2020)within the scope of the project RISE(LA/P/0053/2020).
文摘Objectives The aim of this study was to analyze the psychometric properties(reliability and validity)of the Social Isolation Scale(SIS)in a sample of Portuguese community-dwelling older adults.Methods A transversal descriptive study was carried out with a convenience sample of 250 community-dwelling older adults(≥65 years).The survey comprised a sociodemographic questionnaire,SIS,Geriatric Depression Scale-4(GDS-4),6-item Lubben Social Network Scale(LSNS-6),a loneliness self-assessment question,and Satisfaction with Life Scale(SWLS).Construct validity(confirmatory factor analysis)and convergent validity were analyzed,and ISI internal reliability(composite reliability),external reliability(test-retest,intraclass correlation coefficient)and inter-rater reliability(Cohen’s kappa coefficient)were evaluated.Results Confirmatory factor analysis showed a two-factor model with an excellent index of fit.The SIS showed significant correlations with LSNS-6(rs=0.47),SWLS(rs=0.26),the loneliness self-assessment question(rs=0.35),and GDS-4(rs=−0.16).SIS composite reliability was good(0.708).The inter-class correlation coefficient varied from 0.84 to 0.98.The Cohen’s kappa coefficient ranged from 0.936 to 1.Conclusions SIS has been shown to be a valid and reliable instrument for assessing social isolation among Portuguese community-dwelling older adults.Healthcare professionals,particularly nurses working in community settings,can use SIS to assess social isolation in older adults to design,implement,and evaluate interventions.
基金The National Natural Science Foundation of China under contract No. 42001078the College Student Innovation and Training Project of Guangdong Ocean University under contract No. S20211056601+3 种基金the Guangdong Natural Science Foundation of China under contract No. 2021A1515011157the Innovative Team Project of Guangdong Universities under contract No.2019KCXTF021the First-class Discipline Plan of Guangdong Province under contract Nos 080503032101 and 231420003the Marine Science Research Team Project of Guangdong Ocean University under contract No. 002026002004。
文摘Past hydroclimatic conditions in southern China are poorly constrained owing to the lack of high-resolution marine-sediment records. In this study, we present high-resolution geochemical and grain-size records of marine sediments from the coastal shelf of the northern South China Sea to investigate regional hydrological variations.Results suggest a warm and humid climate during the interval 9 200–7 600 cal a BP, followed by a cold and dry climate from 7 600 cal a BP to 6 500 cal a BP, and progressive humidification during the period 6 500–6 200 cal a BP.A prominent hydrological anomaly occurred during 7 600–6 500 cal a BP. This abrupt event corresponds closely to tropical Pacific and interhemispheric temperature gradients, suggesting that moisture variations in southern China may have been driven by interhemispheric and zonal Pacific temperature gradients via modulation of the intensity and location of the West Pacific subtropical high.
文摘This study aimed to determine the association and predictive capacities of job satisfaction,workplace stress,work motivation,and self-esteem on state of mental health of caregivers of children with disabilities in South-West Nigeria.The self-determination theory provided a theoretical framework for the study.A closed-ended paper-pencil questionnaire tagged‘Mental Healthiness Scale for Caregivers’was used for data collection from 241 care-givers of children with disabilities.Data collected was analyzed using descriptive of frequency count,simple per-centage and mean as well as inferential statistics involving Pearson product moment correlation and Binary Logistic Regression at 95%confidence interval.Findings revealed a significant but inverse association between self-esteem,workplace stress and mental health.Work motivation had a direct association with mental health while job satisfaction had no significant association with mental health of caregivers of children with disabilities.Caregivers(18–40 years)had the highest odds for mental health concerns.Lowered self-esteem and workplace stress increased mental health concerns while job satisfaction significantly predicted a higher likelihood for posi-tive state of mental health among caregivers of children with disabilities.
文摘The present study evaluated the stabilizing effect of starch produced from corns and cassava on the stability of cow milk yogurt. A sample of both corn and cassava starch was selected and used in the yogurt making as stabilizers. The yogurt samples have been analyzed for their WHC, syneresis and protein content. The yogurt with no added starch has found to have very low WHC and high syneresis compared to other samples. The yogurt made with the addition of corn starch as a stabilizer was highly accepted than the yogurt with cassava starch and the yogurt without starch. The findings from this study provide an alternative to add the value of local corns and cassava.
文摘Today, the most urgent problem of the existing and future nuclear power industry is to ensure the nuclear and environmental safety of the operation of nuclear power reactor units (NPPs) and nuclear power plants (NPPs). It is solved thanks to the application of deeply echeloned protection and an anti-accident complex of methods and means for effective control of the operation of active reactor zones (AZR). However, the danger of existing NPPs in the world from time to time manifests itself in the form of severe post-project accidents and catastrophes with the release into the environment of a significant amount of radioactive materials dangerous for all living things. The results of the analysis show that the unconditional fulfillment of the main requirements of nuclear environmental safety and biocompatibility is possible only in the so-called wave nuclear reactor of the G-V generation, which, unlike reactors of the previous generations III, II+ and IV, does not require supercritical loading of the core with nuclear fuel. In the active zone of this reactor, nuclear-physical processes governed by physical law are implemented, which exclude the operator’s participation in regulating the reactivity of the reactor’s active zone, which makes it the reactor with the highest level of nuclear and environmental safety today, which is based on the principles of so-called internal safety, free from the human factor. The possibility of burning nuclear fuel based on U238 and Th232 in it expands the reserves of energetic nuclear fuel almost to inexhaustibility. The technology of nuclear reactors of the G5 generation through the secondary use of spent irradiated nuclear fuel (SNF) for the production of energy and energy raw materials with simultaneous burning of it to an environmentally safe state is able to quickly reduce the available stocks and further production of dangerous SNF, guarantee the nuclear and environmental safety of NPPs with reactors G5 and to technologically make nuclear post-project accidents and disasters impossible at the level of physical law with the complete elimination of the human factor.
文摘Numeracy is the capacity to use mathematical ideas in all facets of life.It involves activities such as adding and subtracting numbers,counting,number recognition,solving number problems involving various operations,sorting,observing,identifying,and establishing patterns.It is one of the fundamental skills that students should have mastered by the end of their primary schooling.With the notable importance of mastery of numeracy skills,low achievement and performance of the learners were observed in this aspect.This study aimed in enhancing the numeracy skills of Grade 3 learners through authentic performance tasks.The variable in numeracy skills includes the four fundamental operations and problem solving.The quasi-experimental design was utilized wherein purposive sampling or non-randomized sampling was used.In this study,33 Grade 3 learners of Rizal Elementary School were selected to participate in the tests.Pre-test and post-test crafted by the teacher were the main instrument in the study.The result revealed that in the pre-test the learners obtained a mean percentage score(MPS)of 38.20%in four fundamental operations,which implied a non-numerate level.While in terms of problem solving,the learners obtained a MPS of 20.60%which is also in the non-numerate level.It has a grand mean of 29.40%with an interpretation of non-numerate level.In the post-test,it was observed that four fundamental operations have a MPS of 81.10%which is in average numerate level,while problem solving has a MPS of 76.30%with a grand mean of 78.70%with an interpretation of average numerate level.This implied that there is a significant difference between the pre-test and post-test in the four fundamental operations and problem solving.Thus,it can be concluded that the application of authentic performance tasks was effective to bridge the gap on numeracy skills.
文摘The cultural ecology of university classroom has been influenced by postmodernism and has shown complex and variable characteristics.Specifically speaking,it tends to be both conflicting and interactive in terms of subject relations in the classroom,fragmented and diversified in terms of classroom teaching,and redundant and dynamic in terms of classroom assessment.In order to further harmonize and develop the cultural ecology of university classrooms,it is necessary to expand the space for communication and interaction between teachers and students,improve the overall professional quality of faculty members,and perfect the management and assessment system for university teachers and students.
