期刊文献+
共找到1篇文章
< 1 >
每页显示 20 50 100
Appendix is a priming site in the development of ulcerative colitis 被引量:10
1
作者 Mitsunobu Matsushita Hiroshi Takakuwa +3 位作者 Yuji Matsubayashi Akiyoshi Nishio Susumu Ikehara Kazuichi Okazaki 《World Journal of Gastroenterology》 SCIE CAS CSCD 2005年第31期4869-4874,共6页
AIM: The role of the appendix has been highlighted in the pathogenesis of ulcerative colitis (UC). The aims of this study were to elucidate the immuno-imbalances in the appendix of UC patients, and to clarify the r... AIM: The role of the appendix has been highlighted in the pathogenesis of ulcerative colitis (UC). The aims of this study were to elucidate the immuno-imbalances in the appendix of UC patients, and to clarify the role of the appendix in the development of UC. METHODS: Colonoscopic biopsy specimens of the appendix, transverse colon, and rectum were obtained from 86 patients with UC: active pancolitis (A-Pan; n = 15), active letf-sided colitis (A-Lt; n = 25), A-Lt with appendiceal involvement (A-Lt/Ap; n = 10), inactive pancolitis (I-Pan; n = 14), and inactive left-sided colitis (I-Lt; n = 22), and from controls. In the isolated mucosal T cells, the CD4/CD8 ratio and proportion of activated CD4+ T ceils were investigated, and compared with controls. RESULTS: in the appendix, the CD4/CD8 ratio significantly increased in A-Lt and A-Lt/Ap. The ratio in the appendix also tended to increase in A-Pan. In the rectum, the ratio significantly increased in all UC groups. In the appendix, the proportion of CD4+CD69+ (early activation antigen) T cells significantly increased in all UC groups. In the rectum, the proportion of CD4+CD69+ T cells significantly increased only in A-Pan. The proportion of CD4+HLADR+ (mature activation antigen) T cells significantly increased only in the rectum of A-Pan, but not in the otherareas of any groups. CONCLUSION: The increased CD4/CD8 ratio and predominant infiltration of CD4+CD69+ T cells in the appendix suggest that the appendix is a priming site in the development of UC. 展开更多
关键词 APPENDIX APPENDECTOMY Ulcerative colitis Activated T cell CD4+ T cell
下载PDF
上一页 1 下一页 到第
使用帮助 返回顶部