BACKGROUND The gut microbiome interacts with the central nervous system through the gutbrain axis,and this interaction involves neuronal,endocrine,and immune mechanisms,among others,which allow the microbiota to influ...BACKGROUND The gut microbiome interacts with the central nervous system through the gutbrain axis,and this interaction involves neuronal,endocrine,and immune mechanisms,among others,which allow the microbiota to influence and respond to a variety of behavioral and mental conditions.AIM To explore the correlation between cognitive impairment and gut microbiota imbalance in patients with schizophrenia.METHODS A total of 498 untreated patients with schizophrenia admitted to our hospital from July 2020 to July 2022 were selected as the case group,while 498 healthy volunteers who underwent physical examinations at our hospital during the same period were selected as a control group.Fluorescence in situ hybridization was employed to determine the total number of bacteria in the feces of the two groups.The cognitive function test package was used to assess the score of cognitive function in each dimension.Then,the relationship between gut microbiota and cognitive function was analyzed.RESULTS There were statistically significant differences in the relative abundance of gut microbiota at both phylum and class levels between the case group and the control group.In addition,the scores of cognitive function,such as attention/alertness and learning ability,were significantly lower in the case group than in the control group(all P<0.05).The cognitive function was positively correlated with Actinomycetota,Bacteroidota,Euryarchaeota,Fusobacteria,Pseudomonadota,and Saccharibacteria,while negatively correlated with Bacillota,Tenericutes,and Verrucomicrobia at the phylum level.While at the class level,the cognitive function was positively correlated with Class Actinobacteria,Bacteroidia,Betaproteobacteria,Proteobacteria,Blastomycetes,and Gammaproteobacteria,while negatively correlated with Bacilli,Clostridia,Coriobacteriia,and Verrucomicrobiae.CONCLUSION There is a relationship between the metabolic results of gut microbiota and cognitive function in patients with schizophrenia.When imbalances occur in the gut microbiota of patients,it leads to more severe cognitive impairment.展开更多
A new Subjective Quality of Life (SQoL) Instrument for inpatient and community mental health settings was developed by the interRAI research collaborative to support evaluation of quality in mental health settings fro...A new Subjective Quality of Life (SQoL) Instrument for inpatient and community mental health settings was developed by the interRAI research collaborative to support evaluation of quality in mental health settings from the person’s perspective. Ratings of SQoL provide important information about the quality of service and patient experience with the care they receive. This information can help staff to improve approaches to each person’s plan of care in a manner that is meaningful to the individual. This study examined the reliability of the SQoL-MH. 83 inpatients from several clinical departments in a mental health center in South Western Ontario, Canada were randomly assigned to either be interviewed or complete the assessment on his or her own. Reliability was tested using Cronbach’s Alpha. A preliminary factor analysis points to four SQoL-MH subscales with very good internal consistency, ranging from 0.83 to 0.90. Once finalized, the Subjective Quality of Life instrument will be integral to the interRAI suite of instruments used to assess persons with mental health needs. A reliable and valid SQoL-MH instrument will allow mental health service providers to shape or modify care environments in order to enhance quality of life. In addition, the SQoL-MH instrument could also benefit advocacy groups who use reports on quality of life to influence social policy development and funding decisions.展开更多
To the Editor:Major depressive disorder(MDD)is a mood disorder characterized by complex patterns of emotional,cognitive,and behavioral symptomology and deficits in daily functioning.Genital symptoms,including a reduct...To the Editor:Major depressive disorder(MDD)is a mood disorder characterized by complex patterns of emotional,cognitive,and behavioral symptomology and deficits in daily functioning.Genital symptoms,including a reduction in libido and menstrual disturbances,have been considered to be a classic symptom of MDD for many decades.Previous evidence has reached a broad consensus that the incidence of genital symptoms is higher in patients with MDD than in the general population.A systematic review and meta-analysis found a bidirectional association between MDD and genital symptoms,with patients with MDD showing a 50–70%increased risk of developing genital symptoms,while individuals with genital symptoms had a 130–210%increased risk of developing MDD.^([1])As previously reported,50–70%of people with MDD experience sexual dysfunction.^([2])To date,few studies have focused on the comparison of clinical features between patients with MDD with and without genital symptoms,and the longitudinal prognosis.展开更多
Bipolar disorder (BD) is a chronic, recurrent, disabling disease, even when given currently-available pharmacological and psychological treatments. Currently, the etiology and pathogenesis of BD remain unclear. As a c...Bipolar disorder (BD) is a chronic, recurrent, disabling disease, even when given currently-available pharmacological and psychological treatments. Currently, the etiology and pathogenesis of BD remain unclear. As a consequence, patients with BD are frequently unrecognized, misdiagnosed, and inappropriately treated, which often yields a low treatment response and poor outcome.展开更多
文摘BACKGROUND The gut microbiome interacts with the central nervous system through the gutbrain axis,and this interaction involves neuronal,endocrine,and immune mechanisms,among others,which allow the microbiota to influence and respond to a variety of behavioral and mental conditions.AIM To explore the correlation between cognitive impairment and gut microbiota imbalance in patients with schizophrenia.METHODS A total of 498 untreated patients with schizophrenia admitted to our hospital from July 2020 to July 2022 were selected as the case group,while 498 healthy volunteers who underwent physical examinations at our hospital during the same period were selected as a control group.Fluorescence in situ hybridization was employed to determine the total number of bacteria in the feces of the two groups.The cognitive function test package was used to assess the score of cognitive function in each dimension.Then,the relationship between gut microbiota and cognitive function was analyzed.RESULTS There were statistically significant differences in the relative abundance of gut microbiota at both phylum and class levels between the case group and the control group.In addition,the scores of cognitive function,such as attention/alertness and learning ability,were significantly lower in the case group than in the control group(all P<0.05).The cognitive function was positively correlated with Actinomycetota,Bacteroidota,Euryarchaeota,Fusobacteria,Pseudomonadota,and Saccharibacteria,while negatively correlated with Bacillota,Tenericutes,and Verrucomicrobia at the phylum level.While at the class level,the cognitive function was positively correlated with Class Actinobacteria,Bacteroidia,Betaproteobacteria,Proteobacteria,Blastomycetes,and Gammaproteobacteria,while negatively correlated with Bacilli,Clostridia,Coriobacteriia,and Verrucomicrobiae.CONCLUSION There is a relationship between the metabolic results of gut microbiota and cognitive function in patients with schizophrenia.When imbalances occur in the gut microbiota of patients,it leads to more severe cognitive impairment.
文摘A new Subjective Quality of Life (SQoL) Instrument for inpatient and community mental health settings was developed by the interRAI research collaborative to support evaluation of quality in mental health settings from the person’s perspective. Ratings of SQoL provide important information about the quality of service and patient experience with the care they receive. This information can help staff to improve approaches to each person’s plan of care in a manner that is meaningful to the individual. This study examined the reliability of the SQoL-MH. 83 inpatients from several clinical departments in a mental health center in South Western Ontario, Canada were randomly assigned to either be interviewed or complete the assessment on his or her own. Reliability was tested using Cronbach’s Alpha. A preliminary factor analysis points to four SQoL-MH subscales with very good internal consistency, ranging from 0.83 to 0.90. Once finalized, the Subjective Quality of Life instrument will be integral to the interRAI suite of instruments used to assess persons with mental health needs. A reliable and valid SQoL-MH instrument will allow mental health service providers to shape or modify care environments in order to enhance quality of life. In addition, the SQoL-MH instrument could also benefit advocacy groups who use reports on quality of life to influence social policy development and funding decisions.
文摘To the Editor:Major depressive disorder(MDD)is a mood disorder characterized by complex patterns of emotional,cognitive,and behavioral symptomology and deficits in daily functioning.Genital symptoms,including a reduction in libido and menstrual disturbances,have been considered to be a classic symptom of MDD for many decades.Previous evidence has reached a broad consensus that the incidence of genital symptoms is higher in patients with MDD than in the general population.A systematic review and meta-analysis found a bidirectional association between MDD and genital symptoms,with patients with MDD showing a 50–70%increased risk of developing genital symptoms,while individuals with genital symptoms had a 130–210%increased risk of developing MDD.^([1])As previously reported,50–70%of people with MDD experience sexual dysfunction.^([2])To date,few studies have focused on the comparison of clinical features between patients with MDD with and without genital symptoms,and the longitudinal prognosis.
基金supported by the National Key Research and Development Program of China (2016YFC1307100 and 2016YFC1307105)the Shanghai Key Medicine Specialties Program (ZK2015A06)+1 种基金Projects of International Cooperation and Exchanges National Natural Science Foundation of China (81761128032)the Sanming Project of Medicine in Shenzhen, China (SZSM201612006)
文摘Bipolar disorder (BD) is a chronic, recurrent, disabling disease, even when given currently-available pharmacological and psychological treatments. Currently, the etiology and pathogenesis of BD remain unclear. As a consequence, patients with BD are frequently unrecognized, misdiagnosed, and inappropriately treated, which often yields a low treatment response and poor outcome.
