Objective:The aim of this study is to compare the effect of Vitamin D and Vitamin E supplementations,alone,and in combination,on reducing the intensity and duration of dysmenorrhea in women who were referred to the Ko...Objective:The aim of this study is to compare the effect of Vitamin D and Vitamin E supplementations,alone,and in combination,on reducing the intensity and duration of dysmenorrhea in women who were referred to the Kowsar gynecological clinics of Shahid Motahari Hospital of Urmia University of Medical Sciences.Materials and Methods:A double-blinded clinical trial was conducted on 112 women with dysmenorrhea who were randomly allocated into the four study groups.Finally,100 women complete the study and received capsules containing a placebo(n=25),1000 IU of Vitamin D(n=25),400 mg of Vitamin E(n=25),and 1000 IU of Vitamin D+400 mg of Vitamin E(n=25)every 24 h for 2 consecutive months at the beginning of the menstrual period.The pain intensity and duration among groups were compared before and after the intervention.Results:The mean menstrual pain duration in all three experimental groups(Vitamin E,Vitamin D,and the combination of them)was lower than the placebo group(all P<0.05),and the mean pain intensity scores in all three experimental groups were significantly lower than the placebo group(all P<0.05).The results(means)for all of the drugs administered at the end of the 2nd month were better than the 1st month(all P<0.01).Conclusions:Vitamin E and Vitamin D,as well as their combination,are recommended as an effective and safe treatment for the management of the complications of dysmenorrhea.展开更多
Adequate calcium and vitamin D intake is advocated in guidelines of osteoporosis. However, the dosage needed to achieve an optimal calcium intake and vitamin D status is still a point of debate. Of 902 consecutive pat...Adequate calcium and vitamin D intake is advocated in guidelines of osteoporosis. However, the dosage needed to achieve an optimal calcium intake and vitamin D status is still a point of debate. Of 902 consecutive patients older than 50 years presenting at the time of fracture, 502 were evaluable for measurement of calcium intake and serum 25(OH)D concentration. We calculated the percentage of patients who needed calcium supplements to achieve intake of ?1000 mg/d and who needed cholecalciferol supplementation to achieve serum levels of ?50 nmol/l. Calcium intake ranged between 250 and 2050 mg/d and serum 25(OH)D between <10 and 130 nmol/l. A combination of calcium intake of ≥1000 mg/d and serum 25(OH)D concentration of ?50 nmol/l was present in 11% of patients. To achieve 1000 mg/d of calcium, 57% of patients needed supplementation of 500 mg/d and 12% needed 1000 mg/d. Systematic calcium supplements of 500 mg/d would achieve an intake of 1000 mg/d in 88%. To achieve serum 25(OH)D concentrations of 50 nmol/l, 41% of patients needed a supplement of 800 IU D3/d and 25% needed higher doses. Systematic supplementation of 800 IU/d would achieve 50 nmol/l in 75% of patients. Calcium intake and vitamin D status vary considerably between fracture patients. Conclusion: calcium supplements need to be titrated individually to achieve desirable levels. Most patients achieved 50 nmol/l of 25(OH)D with 800 IU D3/d. Prospective studies are needed to study how to achieve and maintain optimal serum vitamin D levels and adequate calcium intake.展开更多
The deficiency of Vitamin D (VD) is widely prevalent worldwide in adults, but many studies show that this deficiency also affects adolescents and may be considered a global public health problem. The VD levels are par...The deficiency of Vitamin D (VD) is widely prevalent worldwide in adults, but many studies show that this deficiency also affects adolescents and may be considered a global public health problem. The VD levels are particularly significant in adolescents since it influences several aspects of growth, development, and puberty. During this phase of life, both girls and boys develop reproductive aspects, and secondary sexual characteristics and the adequate nutritional status appear to be the prerequisite for normal pubertal development. Due to the importance of VD in adolescents, the objective of this study was to investigate the association of the levels of this vitamin with glycemic, lipid, and anthropometric profile and sexual maturation stages of adolescents. Anthropometric (weight and height) and biochemical (fasting glycemia, total cholesterol, HDL-c, LDL-c, and triglycerides) data and VD levels were collected in 67 adolescents. 66% of the adolescents showed VD sufficiency, 28% insufficiency, and 6% showed the deficiency. There was a significant difference in VD levels between the stages of sexual maturation for boys and girls. Overweight patients had lower serum VD levels. The correlation analysis indicated a positive correlation between VD and fasting glycemia and HDL-c, but with no significant difference. A negative correlation was observed between VD and cholesterol, LDL-c and triglycerides, but also with no significant difference. Once VD is crucial for bone health, and as it seems it is necessary to the homeostasis of glycemia, lipids, and body weight, we suggest that more studies should be conducted to confirm the precise role of this vitamin in the promotion and maintenance of health in this population.展开更多
Background Visfatin, a visceral fat-derived adipocytokine, plays a significant physiological function in lipid metabolism. However, the precise function of visfatin and its regulation by thyroid hormones are still unk...Background Visfatin, a visceral fat-derived adipocytokine, plays a significant physiological function in lipid metabolism. However, the precise function of visfatin and its regulation by thyroid hormones are still unknown. This study observed the plasma visfatin concentrations in subjects with hyperthyroidism and hypothyroidism in vivo, and investigated the possible reaulation mechanism between visfatin and tri-iodothvronine （T3） in vitro as a further interpretation.展开更多
文摘Objective:The aim of this study is to compare the effect of Vitamin D and Vitamin E supplementations,alone,and in combination,on reducing the intensity and duration of dysmenorrhea in women who were referred to the Kowsar gynecological clinics of Shahid Motahari Hospital of Urmia University of Medical Sciences.Materials and Methods:A double-blinded clinical trial was conducted on 112 women with dysmenorrhea who were randomly allocated into the four study groups.Finally,100 women complete the study and received capsules containing a placebo(n=25),1000 IU of Vitamin D(n=25),400 mg of Vitamin E(n=25),and 1000 IU of Vitamin D+400 mg of Vitamin E(n=25)every 24 h for 2 consecutive months at the beginning of the menstrual period.The pain intensity and duration among groups were compared before and after the intervention.Results:The mean menstrual pain duration in all three experimental groups(Vitamin E,Vitamin D,and the combination of them)was lower than the placebo group(all P<0.05),and the mean pain intensity scores in all three experimental groups were significantly lower than the placebo group(all P<0.05).The results(means)for all of the drugs administered at the end of the 2nd month were better than the 1st month(all P<0.01).Conclusions:Vitamin E and Vitamin D,as well as their combination,are recommended as an effective and safe treatment for the management of the complications of dysmenorrhea.
文摘Adequate calcium and vitamin D intake is advocated in guidelines of osteoporosis. However, the dosage needed to achieve an optimal calcium intake and vitamin D status is still a point of debate. Of 902 consecutive patients older than 50 years presenting at the time of fracture, 502 were evaluable for measurement of calcium intake and serum 25(OH)D concentration. We calculated the percentage of patients who needed calcium supplements to achieve intake of ?1000 mg/d and who needed cholecalciferol supplementation to achieve serum levels of ?50 nmol/l. Calcium intake ranged between 250 and 2050 mg/d and serum 25(OH)D between <10 and 130 nmol/l. A combination of calcium intake of ≥1000 mg/d and serum 25(OH)D concentration of ?50 nmol/l was present in 11% of patients. To achieve 1000 mg/d of calcium, 57% of patients needed supplementation of 500 mg/d and 12% needed 1000 mg/d. Systematic calcium supplements of 500 mg/d would achieve an intake of 1000 mg/d in 88%. To achieve serum 25(OH)D concentrations of 50 nmol/l, 41% of patients needed a supplement of 800 IU D3/d and 25% needed higher doses. Systematic supplementation of 800 IU/d would achieve 50 nmol/l in 75% of patients. Calcium intake and vitamin D status vary considerably between fracture patients. Conclusion: calcium supplements need to be titrated individually to achieve desirable levels. Most patients achieved 50 nmol/l of 25(OH)D with 800 IU D3/d. Prospective studies are needed to study how to achieve and maintain optimal serum vitamin D levels and adequate calcium intake.
文摘The deficiency of Vitamin D (VD) is widely prevalent worldwide in adults, but many studies show that this deficiency also affects adolescents and may be considered a global public health problem. The VD levels are particularly significant in adolescents since it influences several aspects of growth, development, and puberty. During this phase of life, both girls and boys develop reproductive aspects, and secondary sexual characteristics and the adequate nutritional status appear to be the prerequisite for normal pubertal development. Due to the importance of VD in adolescents, the objective of this study was to investigate the association of the levels of this vitamin with glycemic, lipid, and anthropometric profile and sexual maturation stages of adolescents. Anthropometric (weight and height) and biochemical (fasting glycemia, total cholesterol, HDL-c, LDL-c, and triglycerides) data and VD levels were collected in 67 adolescents. 66% of the adolescents showed VD sufficiency, 28% insufficiency, and 6% showed the deficiency. There was a significant difference in VD levels between the stages of sexual maturation for boys and girls. Overweight patients had lower serum VD levels. The correlation analysis indicated a positive correlation between VD and fasting glycemia and HDL-c, but with no significant difference. A negative correlation was observed between VD and cholesterol, LDL-c and triglycerides, but also with no significant difference. Once VD is crucial for bone health, and as it seems it is necessary to the homeostasis of glycemia, lipids, and body weight, we suggest that more studies should be conducted to confirm the precise role of this vitamin in the promotion and maintenance of health in this population.
基金This study was partially supported by grants from the National Natural Science Foundation of China （No. 30270636 and 30671015）.
文摘Background Visfatin, a visceral fat-derived adipocytokine, plays a significant physiological function in lipid metabolism. However, the precise function of visfatin and its regulation by thyroid hormones are still unknown. This study observed the plasma visfatin concentrations in subjects with hyperthyroidism and hypothyroidism in vivo, and investigated the possible reaulation mechanism between visfatin and tri-iodothvronine （T3） in vitro as a further interpretation.
