One in five Americans experience symptoms associated with at least one mental health disorder every year. These include behavioral addictions, which have long been overlooked despite their similar neural bases with su...One in five Americans experience symptoms associated with at least one mental health disorder every year. These include behavioral addictions, which have long been overlooked despite their similar neural bases with substance addictions. Gambling addiction, a type of behavioral addiction, deserves particular attention given the significant negative effects, this addiction has on financial and interpersonal health. The purpose of this paper is to review the available literature concerning the behavioral and neural processes involved in gambling addiction, including: the anticipation of reward, the role of dopamine, and the neural substrates of the decision-making processes involved in gambling addiction. Market research has also identified solutions that integrate applied neuroscience and self-tracking systems to monitor and manage mental health issues associated with gambling addiction. The authors then propose a gambling treatment-focused mobile app solution that addresses outstanding issues with a special design aimed at reversing plasticity in order to relieve the effects of gambling addiction. .展开更多
Because of factors such as energy and time one invests in an object,the stronger the connection,value,and reluc-tance to lose said object individual will have.Hoarding behavior arises when individuals incorporate a st...Because of factors such as energy and time one invests in an object,the stronger the connection,value,and reluc-tance to lose said object individual will have.Hoarding behavior arises when individuals incorporate a strong attachment with themselves to an object.The purpose of this study is to examine the effect of self-investment on hoarding tendency and the roles of possession-self link and liking level in this connection.A hypothetical model of the relationship between self-investment,possession-self link,liking level,and hoarding tendency was tested.A convenience sampling method was used to survey 450 college students in Yunnan Province on either a paper-based or online self-report scale.The data were collected using self-investment,possession-self link,and liking level questionnaires,as well as the Saving Inventory Revised.Results showed positive relationship between the study variables,ranging from 0.37 to 0.87.College students’self-investment had a direct positive pre-dictive effect on hoarding tendency;self-investment,in turn,indirectly predicted hoarding tendency through the mediating effect of possession-self link;and individual liking level of items had a moderating effect for self-invest-ment on the possession-self link.This study shows how self-investment affects the hoarding tendency of college students,and the results of this study also help demonstrate the value of self-investment and possession-self link in optimizing students’hoarding tendency and thus promoting good psychological status.展开更多
Individuals’perceptions,attitudes,and patterns of getting along with family members are important factors influencing Chinese people’s self-evaluation.The aim of this study was to investigate the effect of family co...Individuals’perceptions,attitudes,and patterns of getting along with family members are important factors influencing Chinese people’s self-evaluation.The aim of this study was to investigate the effect of family cohesion on depression and the role of perceived social support and intentional self-regulation in this association.A hypothesized model of the association of family cohesion,perceived social support,intentional self-regulation,and depression was examined.A convenience sampling method was used to survey 1,180 college students in Yunnan Province using self-report.Data were collected using the Family Cohesion Scale,the Perceived Social Support Scale,the Intentional Self-Regulation Scale,and the Center for Epidemiological Studies Depression Scale.The findings revealed low to moderate correlation between the variables studied.College students’family cohesion was a negative predictor of their depression.This association was also mediated by the knock-on effect of perceived social support and intentional self-regulation.These findings show how family cohesion affects college students’depressive status.Specifically,these results help demonstrate the importance of family cohesion,perceived social support,and intentional self-regulation in optimizing students’depression,which in turn can promote better psychological states.展开更多
Background Parkinson’s disease(PD)is associated with perceived stigma and affects quality of life(QoL).Additional health conditions may influence these consequences of PD.Aims This study assessed the impact of health...Background Parkinson’s disease(PD)is associated with perceived stigma and affects quality of life(QoL).Additional health conditions may influence these consequences of PD.Aims This study assessed the impact of health conditions on perceived stigma and QoL in persons with PD.We hypothesised that individuals with more health conditions would report more stigma and poorer QoL.We also examined the contributions of demographic and clinical characteristics to the correlations between health conditions and perceived stigma/QoL.Methods We identified 196 eligible participants from the Boston University Online Survey Study of Parkinson’s Disease and examined their health history,performance on multiple stigma measures,and scores on the 39-item Parkinson’s Disease Questionnaire assessing QoL.Results At least one health condition was reported by 79%of the sample,with a median of 2 and a range of 0–7 health conditions.More perceived stigma and poorer QoL were associated with thyroid disease,depression,anxiety,and the total number of health conditions.These correlations were related to younger age,less education,and earlier disease onset.Other health conditions(high blood pressure,back/leg surgery,headache,cancer/tumours,and heart disease)were not significantly correlated with stigma or QoL.Conclusions Having more health conditions,or thyroid disease,depression,or anxiety,was associated with more perceived stigma and poorer QoL,with younger age,less education,and earlier disease onset affecting the associations.It is important to consider the burden of health conditions and how they affect persons with PD with specific clinical characteristics.展开更多
Apolipoprotein E4(ApoE4) is a prominent genetic risk factor for Alzheimer's disease. The purpose of this review is to explore differences in structural brain volume detected by magnetic resonance imaging between c...Apolipoprotein E4(ApoE4) is a prominent genetic risk factor for Alzheimer's disease. The purpose of this review is to explore differences in structural brain volume detected by magnetic resonance imaging between cognitively intact ApoE4 carriers and non-carriers across the lifespan(i.e., older adults, middle-aged adults, young adults, children and adolescents, and neonates). Consistent findings are found throughout various developmental stages. This area of research may elucidate the mechanisms by which ApoE4 influences risk of developing Alzheimer's disease. It could also inform potential treatment strategies and interventions for carriers of the ApoE4 allele.展开更多
BACKGROUND Antagonists of cannabinoid type 1 receptor(CB1)have been shown to promote body weight loss and improve insulin sensitivity.Cannabinoids decrease adiponectin,and CB1 blocker increase adiponectin.However,the ...BACKGROUND Antagonists of cannabinoid type 1 receptor(CB1)have been shown to promote body weight loss and improve insulin sensitivity.Cannabinoids decrease adiponectin,and CB1 blocker increase adiponectin.However,the mediators of CB1 actions are not well defined.AIM To investigate whether the beneficial effects of CB1 inhibition are,at least in part,mediated by adiponectin.METHODS We compared metabolic and inflammatory phenotypes of wild-type(WT)mice,CB1-null(CB1^(-/-))and CB1/adiponectin double-knockout(DKO)mice.We assessed the insulin sensitivity using insulin tolerance test and glucose tolerance test,and inflammation using flow cytometry analysis of macrophages.RESULTS CB1^(-/-)mice exhibited significantly reduced body weight and fat mass when compared to WT mice.While no significance was found in total daily food intake and locomotor activity,CB1^(-/-)mice showed increased energy expenditure,enhanced thermogenesis in brown adipose tissue(BAT),and improved insulin sensitivity compared to WT mice.DKO showed no difference in body weight,adiposity,nor insulin sensitivity;only showed a modestly elevated thermogenesis in BAT compared to CB1^(-/-)mice.The metabolic phenotype of DKO is largely similar to CB1^(-/-)mice,suggesting that adiponectin is not a key mediator of the metabolic effects of CB1.Interestingly,CB1^(-/-)mice showed reduced pro-inflammatory macrophage polarization in both peritoneal macrophages and adipose tissue macrophages compared to WT mice;in contrast,DKO mice exhibited increased pro-inflammatory macrophage polarization in these macrophages compared to CB1^(-/-)mice,suggesting that adiponectin is an important mediator of the inflammatory effect of CB1.CONCLUSION Our findings reveal that CB1 functions through both adiponectin-dependent and adiponectin-independent mechanisms:CB1 regulates energy metabolism in an adiponectin-independent manner,and inflammation in an adiponectin-dependent manner.The differential effects of adiponectin on CB1-mediated metabolic and inflammatory functions should be taken into consideration in CB1 antagonist utilization.展开更多
This study examined the moderating effects of parent-child,same-sex,opposite-sex and teacher-student relation-ships between sibling status and loneliness during COVID-19.A total of 1,591 adolescents in China completed...This study examined the moderating effects of parent-child,same-sex,opposite-sex and teacher-student relation-ships between sibling status and loneliness during COVID-19.A total of 1,591 adolescents in China completed the study questionnaires which assessed the aforementioned variables.The results showed that same-sex and teacher-student relationships moderated the association between sibling status and loneliness.The results indicated that among participants with good same-sex relationships during COVID-19,compared to non-only-children parti-cipants,the only-children participants were more likely to experience a lower level of loneliness.However,parti-cipants with poor same-sex relationships experienced similar level of loneliness regardless of whether they had siblings.Thesefindings would be helpful for parents,teachers,and other stakeholders to take effective measures to reduce loneliness feelings among Chinese adolescents.展开更多
The aim of the study was to explore the relationship between college graduates’dual self-consciousness,job search clarity and perceived stress,and reveal the mediating role of perceived stress between dual self-consc...The aim of the study was to explore the relationship between college graduates’dual self-consciousness,job search clarity and perceived stress,and reveal the mediating role of perceived stress between dual self-consciousness and job search clarity.In this study,467 college graduates were investigated using the Dual Self-Consciousness Scale,Job Search Clarity Scale,and Perceived Stress Scale.After controlling for gender,age,and region,the results revealed that:(1)private self-consciousness has a significant positive predictive effect on job search clarity;(2)perceived stress has a significant negative predictive effect on job search clarity;(3)perceived stress plays partial mediation effects between private self-consciousness and job search clarity;(4)perceived stress plays complete mediation effects between public self-consciousness and job search clarity;(5)perceived stress has suppressing effects between public self-consciousness and job search clarity.展开更多
BACKGROUND The debate regarding diagnostic classification systems in psychiatry(categorial vs dimensional systems)has essential implications for the diagnosis,prevention and treatment of stress reactions.We previously...BACKGROUND The debate regarding diagnostic classification systems in psychiatry(categorial vs dimensional systems)has essential implications for the diagnosis,prevention and treatment of stress reactions.We previously found a unique pattern of stress reaction in a study executed during the coronavirus disease 2019 pandemic using large representative samples in two countries,and termed it the Complex Stress Reaction Syndrome(CSRS).AIM To investigate CSRS,Type A(psychiatric symptoms,spanning anxiety,depression,stress symptoms,and posttraumatic stress disorder(PTSD)),with or without long-coronavirus disease(COVID)residuals(CSRS,Type B,neuropsychiatric symptoms spanning cognitive deficits and fatigue,excluding systemic symptoms).Our two-tailed hypothesis was that CSRS is a condition related to an unrecognized type of stress reaction in daily life in the general population(Type A)or that it is related to the severe acute respiratory syndrome coronavirus 2 infection and its long-COVID residuals(Type B).METHODS 977 individuals in four continents(North America,Europe,Australia and the Middle East)completed the online study questionnaire in six languages using the Qualtrics platform.The study was managed by six teams in six countries that promoted the study on social media.The questionnaire assessed anxiety,depression,stress symptoms and PTSD(CSRS,Type A),cognitive deficits and fatigue(CSRS,Type B).The data were analyzed using Proportion Analyses,Multivariate Analysis of Co-Variance(MANCOVA),linear regression analyses and validated clinical cutoff points.RESULTS The results of the Proportion Analyses showed that the prevalence of 4 symptoms spanning anxiety,depression,stress symptoms,and PTSD was significantly higher than the most prevalent combinations of fewer symptoms across 4 continents,age groups,and gender.This supports the transdiagnostic argument embedded in the CSRS(Type A).The same pattern of results was found in infected/recovered individuals.The prevalence of the 4 psychiatric symptoms combination was significantly greater than that of 5 and 6 symptoms,when adding cognitive deficits and fatigue,respectively.MANCOVA showed a significant three-way interaction(age×gender×continent).Further analyses showed that the sources of this three-way interaction were threefold relating to two sub-populations at-risk:(1)Individuals that self-identified as non-binary gender scored significantly higher on all 4 psychiatric symptoms of the CSRS,Type A at young age groups(<50 years old)in North America compared to(self-identified)women and men located in the 4 continents studied,and to other ages across the adult life span;and(2)This pattern of results(CSRS,Type A)was found also in women at young ages(<40 years old)in North America who scored higher compared to men and women in other continents and other ages.Linear regression analyses confirmed the MANCOVA results.CONCLUSION These results show a combined mental health risk factor related to stress reactivity,suggesting that the CSRS is sensitive to populations at risk and may be applied to future identification of other vulnerable sub-populations.It also supports the transdiagnostic approach for more accurate prevention and treatment.Time will tell if such transdiagnostic syndromes will be part of the discussions on the next revisions of the traditional classification systems or whether the crisis in psychiatry further evolves.展开更多
Visual cortical prostheses have the potential to restore partial vision. Still limited by the low-resolution visual percepts provided by visual cortical prostheses, implant wearers can currently only "see" p...Visual cortical prostheses have the potential to restore partial vision. Still limited by the low-resolution visual percepts provided by visual cortical prostheses, implant wearers can currently only "see" pixelized images, and how to obtain the specific brain responses to different pixelized images in the primary visual cortex(the implant area) is still unknown. We conducted a functional magnetic resonance imaging experiment on normal human participants to investigate the brain activation patterns in response to 18 different pixelized images. There were 100 voxels in the brain activation pattern that were selected from the primary visual cortex, and voxel size was 4 mm × 4 mm × 4 mm. Multi-voxel pattern analysis was used to test if these 18 different brain activation patterns were specific. We chose a Linear Support Vector Machine(LSVM) as the classifier in this study. The results showed that the classification accuracies of different brain activation patterns were significantly above chance level, which suggests that the classifier can successfully distinguish the brain activation patterns. Our results suggest that the specific brain activation patterns to different pixelized images can be obtained in the primary visual cortex using a 4 mm × 4 mm × 4 mm voxel size and a 100-voxel pattern.展开更多
Current Neuroscience dogma holds that transections or ablations of a segment of peripheral nerves produce:(1) Immediate loss of axonal continuity, sensory signaling, and motor control;(2) Wallerian rapid(1-3 days) deg...Current Neuroscience dogma holds that transections or ablations of a segment of peripheral nerves produce:(1) Immediate loss of axonal continuity, sensory signaling, and motor control;(2) Wallerian rapid(1-3 days) degeneration of severed distal axons, muscle atrophy, and poor behavioral recovery after many months(if ever, after ablations) by slowly-regenerating(1 mm/d), proximal-stump outgrowths that must specifically reinnervate denervated targets;(3) Poor acceptance of microsutured nerve allografts, even if tissue-matched and immune-suppressed. Repair of transections/ablations by neurorrhaphy and well-specified-sequences of PEG-fusion solutions(one containing polyethylene glycol, PEG) successfully address these problems. However, conundrums and confusions regarding unorthodox and dramatic results of PEG-fusion repair in animal model systems often lead to misunderstandings. For example,(1) Axonal continuity and signaling is re-established within minutes by non-specifically PEG-fusing(connecting) severed motor and sensory axons across each lesion site, but remarkable behavioral recovery to near-unoperated levels takes several weeks;(2) Many distal stumps of inappropriately-reconnected, PEG-fused axons do not ever(Wallerian) degenerate and continuously innervate muscle fibers that undergo much less atrophy than otherwise-denervated muscle fibers;(3) Host rats do not reject PEG-fused donor nerve allografts in a non-immuno-privileged environment with no tissue matching or immunosuppression;(4) PEG fuses apposed open axonal ends or seals each shut(thereby preventing PEG-fusion), depending on the experimental protocol;(5) PEG-fusion protocols produce similar results in animal model systems and early human case studies. Hence, iconoclastic PEG-fusion data appropriately understood might provoke a re-thinking of some Neuroscience dogma and a paradigm shift in clinical treatment of peripheral nerve injuries.展开更多
An individual’s perception,attitude,feeling and behavior about their body are important factors for mental health(depression).This study aims to explore the impact of body investment on depression,and the role of sel...An individual’s perception,attitude,feeling and behavior about their body are important factors for mental health(depression).This study aims to explore the impact of body investment on depression,and the role of self-efficacy and self-esteem in this connection.A hypothetical model about the relationship between body investment,selfefficacy,self-esteem and depression was tested.Using convenient sampling methods,a self-rated cross-sectional survey comprised of paper-based and online modes was conducted among 1,164 college students in Yunnan Province,China from July 2021 to August 2021.The data collection used the body investment scale,self-efficacy scale,self-esteem scale and depression scale.The results show that there is a low to moderate positive correlation(ranging between-0.11 and-0.59)between the research variables.The body investment of college students has a negative predictive effect(B=16.23,SE=0.65)on depression.This connection is also regulated by the mediating role of self-esteem and self-efficacy.All these factors explain 37.83%variability of research participation.These findings show how body investment affects the depressive state of college students.Further,these results help to demonstrate that self-efficacy and self-esteem are academically important for optimizing students’depression,so as to promote a good mental state.展开更多
Government city management is facing higher requirements with the development of the number of migrant workers.Therefore,improving their subjective well-being is a significant practical problem that the government mus...Government city management is facing higher requirements with the development of the number of migrant workers.Therefore,improving their subjective well-being is a significant practical problem that the government must consider in public governance.This research discusses the influence of public service satisfaction on the well-being of urban migrant workers from the perspective of social comparison theory and the role of the sense of social equity and social conflict in the process of this influence.Using the structural equation modeling and moderated mediating mechanism analysis,the results show that:(1)the satisfaction of social and economic public service significantly and positively affects subjective well-being.(2)The sense of social equity completely mediated the influence of the satisfaction of public social service on well-being and partly mediated the influence of the satisfaction of public financial service on well-being.(3)The sense of social equity and conflict have a moderated mediating effect for social and economic public service satisfaction on well-being.Finally,the article concludes with some suggestions to improve the well-being of migrant workers based on the conclusion of the study.展开更多
Multiple sclerosis is a neurodegenerative and inflammatory disease, a hallmark of which is demyelinating lesions in the white matter. We hypothesized that alterations in white matter microstructures can be non-invasiv...Multiple sclerosis is a neurodegenerative and inflammatory disease, a hallmark of which is demyelinating lesions in the white matter. We hypothesized that alterations in white matter microstructures can be non-invasively characterized by advanced diffusion magnetic resonance imaging. Seven diffusion metrics were extracted from hybrid diffusion imaging acquisitions via classic diffusion tensor imaging, neurite orientation dispersion and density imaging, and q-space imaging. We investigated the sensitivity of the diffusion metrics in 36 sets of regions of interest in the brain white matter of six female patients(age 52.8 ± 4.3 years) with multiple sclerosis. Each region of interest set included a conventional T2-defined lesion, a matched perilesion area, and normal-appearing white matter. Six patients with multiple sclerosis(n = 5) or clinically isolated syndrome(n = 1) at a mild to moderate disability level were recruited. The patients exhibited microstructural alterations from normal-appearing white matter transitioning to perilesion areas and lesions, consistent with decreased tissue restriction, decreased axonal density, and increased classic diffusion tensor imaging diffusivity. The findings suggest that diffusion compartment modeling and q-spa ce analysis appeared to be sensitive for detecting subtle microstructural alterations between perilesion areas and normal-appearing white matter.展开更多
BACKGROUND Single-nucleotide polymorphisms(SNPs)of the serotonin type 3 receptor subunit(HTR3)genes have been associated with psychosomatic symptoms,but it is not clear whether these associations exist in irritable bo...BACKGROUND Single-nucleotide polymorphisms(SNPs)of the serotonin type 3 receptor subunit(HTR3)genes have been associated with psychosomatic symptoms,but it is not clear whether these associations exist in irritable bowel syndrome(IBS).AIM To assess the association of HTR3 polymorphisms with depressive,anxiety,and somatization symptoms in individuals with IBS.METHODS In this retrospective study,623 participants with IBS were recruited from five specialty centers in Germany,Sweden,the United States,the United Kingdom,and Ireland.Depressive,anxiety,and somatization symptoms and sociodemographic characteristics were collected.Four functional SNPs—HTR3A c.-42C>T,HTR3B c.386A>C,HTR3C c.489C>A,and HTR3E c.*76G>A—were genotyped and analyzed using the dominant and recessive models.We also performed separate analyses for sex and IBS subtypes.SNP scores were calculated as the number of minor alleles of the SNPs above.The impact of HTR3C c.489C>A was tested by radioligand-binding and calcium influx assays.RESULTS Depressive and anxiety symptoms significantly worsened with increasing numbers of minor HTR3C c.489C>A alleles in the dominant model(F_(depressive)=7.475,P_(depressive)=0.006;F_(anxiety)=6.535,P_(anxiety)=0.011).A higher SNP score(range 0-6)was linked to a worsened depressive symptoms score(F=7.710,P-linear trend=0.006)in IBS.The potential relevance of the HTR3C SNP was corroborated,showing changes in the expression level of 5-HT3AC variant receptors.CONCLUSION We have provided the first evidence that HTR3C c.489C>A is involved in depressive and anxiety symptoms in individuals with IBS.The SNP score indicated that an increasing number of minor alleles is linked to the worsening of depressive symptoms in IBS.展开更多
Dear Editor,When two stimuli such as a tone and a visual stimulus are repeatedly presented together,individuals diagnosed with hallucinations tend to report hearing the tone subsequently in response to the visual stim...Dear Editor,When two stimuli such as a tone and a visual stimulus are repeatedly presented together,individuals diagnosed with hallucinations tend to report hearing the tone subsequently in response to the visual stimulus alone [1].Such conditioned hallucinations involved evoked sensory representations as evidenced by increased neural activation in tone-responsive brain regions during the conditioned hallucinations.These and other observations underscore the importance of prior associative experiences in driving hallucinatory perception,and reflect new efforts to conceptualize and understand psychosis from a cognitive perspective.展开更多
文摘One in five Americans experience symptoms associated with at least one mental health disorder every year. These include behavioral addictions, which have long been overlooked despite their similar neural bases with substance addictions. Gambling addiction, a type of behavioral addiction, deserves particular attention given the significant negative effects, this addiction has on financial and interpersonal health. The purpose of this paper is to review the available literature concerning the behavioral and neural processes involved in gambling addiction, including: the anticipation of reward, the role of dopamine, and the neural substrates of the decision-making processes involved in gambling addiction. Market research has also identified solutions that integrate applied neuroscience and self-tracking systems to monitor and manage mental health issues associated with gambling addiction. The authors then propose a gambling treatment-focused mobile app solution that addresses outstanding issues with a special design aimed at reversing plasticity in order to relieve the effects of gambling addiction. .
基金supported by Yunnan Provincial Philosophy and Social Science Planning Youth Project under Grant No.QN2018055.
文摘Because of factors such as energy and time one invests in an object,the stronger the connection,value,and reluc-tance to lose said object individual will have.Hoarding behavior arises when individuals incorporate a strong attachment with themselves to an object.The purpose of this study is to examine the effect of self-investment on hoarding tendency and the roles of possession-self link and liking level in this connection.A hypothetical model of the relationship between self-investment,possession-self link,liking level,and hoarding tendency was tested.A convenience sampling method was used to survey 450 college students in Yunnan Province on either a paper-based or online self-report scale.The data were collected using self-investment,possession-self link,and liking level questionnaires,as well as the Saving Inventory Revised.Results showed positive relationship between the study variables,ranging from 0.37 to 0.87.College students’self-investment had a direct positive pre-dictive effect on hoarding tendency;self-investment,in turn,indirectly predicted hoarding tendency through the mediating effect of possession-self link;and individual liking level of items had a moderating effect for self-invest-ment on the possession-self link.This study shows how self-investment affects the hoarding tendency of college students,and the results of this study also help demonstrate the value of self-investment and possession-self link in optimizing students’hoarding tendency and thus promoting good psychological status.
基金This study was supported by the Youth Project of Yunnan Provincial Philosophy and Social Science Planning,Project No.QN2018055.
文摘Individuals’perceptions,attitudes,and patterns of getting along with family members are important factors influencing Chinese people’s self-evaluation.The aim of this study was to investigate the effect of family cohesion on depression and the role of perceived social support and intentional self-regulation in this association.A hypothesized model of the association of family cohesion,perceived social support,intentional self-regulation,and depression was examined.A convenience sampling method was used to survey 1,180 college students in Yunnan Province using self-report.Data were collected using the Family Cohesion Scale,the Perceived Social Support Scale,the Intentional Self-Regulation Scale,and the Center for Epidemiological Studies Depression Scale.The findings revealed low to moderate correlation between the variables studied.College students’family cohesion was a negative predictor of their depression.This association was also mediated by the knock-on effect of perceived social support and intentional self-regulation.These findings show how family cohesion affects college students’depressive status.Specifically,these results help demonstrate the importance of family cohesion,perceived social support,and intentional self-regulation in optimizing students’depression,which in turn can promote better psychological states.
基金Funding ACG was employed at Boston University,Boston,Massachusetts,USA.She has received funding on grants from the American Parkinson’s Disease Association,NIH U01 EB029856(PIs Boas,Kiran),R01 AG063775(PI Reinhart),NIH R01 AG050595(PIs Lyons,Kremen),the Boston University Alzheimer’s Disease Center,and the Swiss National Science Foundation.She received compensation for editorial service for the journal Psychological Science。
文摘Background Parkinson’s disease(PD)is associated with perceived stigma and affects quality of life(QoL).Additional health conditions may influence these consequences of PD.Aims This study assessed the impact of health conditions on perceived stigma and QoL in persons with PD.We hypothesised that individuals with more health conditions would report more stigma and poorer QoL.We also examined the contributions of demographic and clinical characteristics to the correlations between health conditions and perceived stigma/QoL.Methods We identified 196 eligible participants from the Boston University Online Survey Study of Parkinson’s Disease and examined their health history,performance on multiple stigma measures,and scores on the 39-item Parkinson’s Disease Questionnaire assessing QoL.Results At least one health condition was reported by 79%of the sample,with a median of 2 and a range of 0–7 health conditions.More perceived stigma and poorer QoL were associated with thyroid disease,depression,anxiety,and the total number of health conditions.These correlations were related to younger age,less education,and earlier disease onset.Other health conditions(high blood pressure,back/leg surgery,headache,cancer/tumours,and heart disease)were not significantly correlated with stigma or QoL.Conclusions Having more health conditions,or thyroid disease,depression,or anxiety,was associated with more perceived stigma and poorer QoL,with younger age,less education,and earlier disease onset affecting the associations.It is important to consider the burden of health conditions and how they affect persons with PD with specific clinical characteristics.
文摘Apolipoprotein E4(ApoE4) is a prominent genetic risk factor for Alzheimer's disease. The purpose of this review is to explore differences in structural brain volume detected by magnetic resonance imaging between cognitively intact ApoE4 carriers and non-carriers across the lifespan(i.e., older adults, middle-aged adults, young adults, children and adolescents, and neonates). Consistent findings are found throughout various developmental stages. This area of research may elucidate the mechanisms by which ApoE4 influences risk of developing Alzheimer's disease. It could also inform potential treatment strategies and interventions for carriers of the ApoE4 allele.
基金Supported by the NIH,No.DK118334 and No.AG064869and the BrightFocus,No.A2019630S(to Sun Y).
文摘BACKGROUND Antagonists of cannabinoid type 1 receptor(CB1)have been shown to promote body weight loss and improve insulin sensitivity.Cannabinoids decrease adiponectin,and CB1 blocker increase adiponectin.However,the mediators of CB1 actions are not well defined.AIM To investigate whether the beneficial effects of CB1 inhibition are,at least in part,mediated by adiponectin.METHODS We compared metabolic and inflammatory phenotypes of wild-type(WT)mice,CB1-null(CB1^(-/-))and CB1/adiponectin double-knockout(DKO)mice.We assessed the insulin sensitivity using insulin tolerance test and glucose tolerance test,and inflammation using flow cytometry analysis of macrophages.RESULTS CB1^(-/-)mice exhibited significantly reduced body weight and fat mass when compared to WT mice.While no significance was found in total daily food intake and locomotor activity,CB1^(-/-)mice showed increased energy expenditure,enhanced thermogenesis in brown adipose tissue(BAT),and improved insulin sensitivity compared to WT mice.DKO showed no difference in body weight,adiposity,nor insulin sensitivity;only showed a modestly elevated thermogenesis in BAT compared to CB1^(-/-)mice.The metabolic phenotype of DKO is largely similar to CB1^(-/-)mice,suggesting that adiponectin is not a key mediator of the metabolic effects of CB1.Interestingly,CB1^(-/-)mice showed reduced pro-inflammatory macrophage polarization in both peritoneal macrophages and adipose tissue macrophages compared to WT mice;in contrast,DKO mice exhibited increased pro-inflammatory macrophage polarization in these macrophages compared to CB1^(-/-)mice,suggesting that adiponectin is an important mediator of the inflammatory effect of CB1.CONCLUSION Our findings reveal that CB1 functions through both adiponectin-dependent and adiponectin-independent mechanisms:CB1 regulates energy metabolism in an adiponectin-independent manner,and inflammation in an adiponectin-dependent manner.The differential effects of adiponectin on CB1-mediated metabolic and inflammatory functions should be taken into consideration in CB1 antagonist utilization.
基金supported by Key Laboratory of Ethnic Languages and Information Technology of Ministry of Education of China,Northwest Minzu University,Lanzhou,Gansu,730030,China(KFKT202013,KFKT202016,KFKT202012,and 1001161310)The Young Doctor Foundation of Higher Education in Gansu Province“Research on the educational effect mechanism of the socialist core value‘unity of knowing and doing’of college students for nationalities in the new era”(No.2021QB-071)The 14th Five-Year Planning Project of Education Science in Gansu Province 2021“A study on the core behavior of patriotism of children in the new era”.Fundamental Research Funds for the Central Universities“Research on influencing factors of online education in post-epidemic era”(No.31920210125).
文摘This study examined the moderating effects of parent-child,same-sex,opposite-sex and teacher-student relation-ships between sibling status and loneliness during COVID-19.A total of 1,591 adolescents in China completed the study questionnaires which assessed the aforementioned variables.The results showed that same-sex and teacher-student relationships moderated the association between sibling status and loneliness.The results indicated that among participants with good same-sex relationships during COVID-19,compared to non-only-children parti-cipants,the only-children participants were more likely to experience a lower level of loneliness.However,parti-cipants with poor same-sex relationships experienced similar level of loneliness regardless of whether they had siblings.Thesefindings would be helpful for parents,teachers,and other stakeholders to take effective measures to reduce loneliness feelings among Chinese adolescents.
基金supported by the academic requirements for the National Education Science Planning Project of China under Grant No.BBA210041.
文摘The aim of the study was to explore the relationship between college graduates’dual self-consciousness,job search clarity and perceived stress,and reveal the mediating role of perceived stress between dual self-consciousness and job search clarity.In this study,467 college graduates were investigated using the Dual Self-Consciousness Scale,Job Search Clarity Scale,and Perceived Stress Scale.After controlling for gender,age,and region,the results revealed that:(1)private self-consciousness has a significant positive predictive effect on job search clarity;(2)perceived stress has a significant negative predictive effect on job search clarity;(3)perceived stress plays partial mediation effects between private self-consciousness and job search clarity;(4)perceived stress plays complete mediation effects between public self-consciousness and job search clarity;(5)perceived stress has suppressing effects between public self-consciousness and job search clarity.
文摘BACKGROUND The debate regarding diagnostic classification systems in psychiatry(categorial vs dimensional systems)has essential implications for the diagnosis,prevention and treatment of stress reactions.We previously found a unique pattern of stress reaction in a study executed during the coronavirus disease 2019 pandemic using large representative samples in two countries,and termed it the Complex Stress Reaction Syndrome(CSRS).AIM To investigate CSRS,Type A(psychiatric symptoms,spanning anxiety,depression,stress symptoms,and posttraumatic stress disorder(PTSD)),with or without long-coronavirus disease(COVID)residuals(CSRS,Type B,neuropsychiatric symptoms spanning cognitive deficits and fatigue,excluding systemic symptoms).Our two-tailed hypothesis was that CSRS is a condition related to an unrecognized type of stress reaction in daily life in the general population(Type A)or that it is related to the severe acute respiratory syndrome coronavirus 2 infection and its long-COVID residuals(Type B).METHODS 977 individuals in four continents(North America,Europe,Australia and the Middle East)completed the online study questionnaire in six languages using the Qualtrics platform.The study was managed by six teams in six countries that promoted the study on social media.The questionnaire assessed anxiety,depression,stress symptoms and PTSD(CSRS,Type A),cognitive deficits and fatigue(CSRS,Type B).The data were analyzed using Proportion Analyses,Multivariate Analysis of Co-Variance(MANCOVA),linear regression analyses and validated clinical cutoff points.RESULTS The results of the Proportion Analyses showed that the prevalence of 4 symptoms spanning anxiety,depression,stress symptoms,and PTSD was significantly higher than the most prevalent combinations of fewer symptoms across 4 continents,age groups,and gender.This supports the transdiagnostic argument embedded in the CSRS(Type A).The same pattern of results was found in infected/recovered individuals.The prevalence of the 4 psychiatric symptoms combination was significantly greater than that of 5 and 6 symptoms,when adding cognitive deficits and fatigue,respectively.MANCOVA showed a significant three-way interaction(age×gender×continent).Further analyses showed that the sources of this three-way interaction were threefold relating to two sub-populations at-risk:(1)Individuals that self-identified as non-binary gender scored significantly higher on all 4 psychiatric symptoms of the CSRS,Type A at young age groups(<50 years old)in North America compared to(self-identified)women and men located in the 4 continents studied,and to other ages across the adult life span;and(2)This pattern of results(CSRS,Type A)was found also in women at young ages(<40 years old)in North America who scored higher compared to men and women in other continents and other ages.Linear regression analyses confirmed the MANCOVA results.CONCLUSION These results show a combined mental health risk factor related to stress reactivity,suggesting that the CSRS is sensitive to populations at risk and may be applied to future identification of other vulnerable sub-populations.It also supports the transdiagnostic approach for more accurate prevention and treatment.Time will tell if such transdiagnostic syndromes will be part of the discussions on the next revisions of the traditional classification systems or whether the crisis in psychiatry further evolves.
基金supported by the National Natural Science Foundation of China,No.31070758,31271060the Natural Science Foundation of Chongqing in China,No.cstc2013jcyj A10085
文摘Visual cortical prostheses have the potential to restore partial vision. Still limited by the low-resolution visual percepts provided by visual cortical prostheses, implant wearers can currently only "see" pixelized images, and how to obtain the specific brain responses to different pixelized images in the primary visual cortex(the implant area) is still unknown. We conducted a functional magnetic resonance imaging experiment on normal human participants to investigate the brain activation patterns in response to 18 different pixelized images. There were 100 voxels in the brain activation pattern that were selected from the primary visual cortex, and voxel size was 4 mm × 4 mm × 4 mm. Multi-voxel pattern analysis was used to test if these 18 different brain activation patterns were specific. We chose a Linear Support Vector Machine(LSVM) as the classifier in this study. The results showed that the classification accuracies of different brain activation patterns were significantly above chance level, which suggests that the classifier can successfully distinguish the brain activation patterns. Our results suggest that the specific brain activation patterns to different pixelized images can be obtained in the primary visual cortex using a 4 mm × 4 mm × 4 mm voxel size and a 100-voxel pattern.
文摘Current Neuroscience dogma holds that transections or ablations of a segment of peripheral nerves produce:(1) Immediate loss of axonal continuity, sensory signaling, and motor control;(2) Wallerian rapid(1-3 days) degeneration of severed distal axons, muscle atrophy, and poor behavioral recovery after many months(if ever, after ablations) by slowly-regenerating(1 mm/d), proximal-stump outgrowths that must specifically reinnervate denervated targets;(3) Poor acceptance of microsutured nerve allografts, even if tissue-matched and immune-suppressed. Repair of transections/ablations by neurorrhaphy and well-specified-sequences of PEG-fusion solutions(one containing polyethylene glycol, PEG) successfully address these problems. However, conundrums and confusions regarding unorthodox and dramatic results of PEG-fusion repair in animal model systems often lead to misunderstandings. For example,(1) Axonal continuity and signaling is re-established within minutes by non-specifically PEG-fusing(connecting) severed motor and sensory axons across each lesion site, but remarkable behavioral recovery to near-unoperated levels takes several weeks;(2) Many distal stumps of inappropriately-reconnected, PEG-fused axons do not ever(Wallerian) degenerate and continuously innervate muscle fibers that undergo much less atrophy than otherwise-denervated muscle fibers;(3) Host rats do not reject PEG-fused donor nerve allografts in a non-immuno-privileged environment with no tissue matching or immunosuppression;(4) PEG fuses apposed open axonal ends or seals each shut(thereby preventing PEG-fusion), depending on the experimental protocol;(5) PEG-fusion protocols produce similar results in animal model systems and early human case studies. Hence, iconoclastic PEG-fusion data appropriately understood might provoke a re-thinking of some Neuroscience dogma and a paradigm shift in clinical treatment of peripheral nerve injuries.
基金supported by Yunnan Provincial Philosophy and Social Science Planning Youth Project under Grant No.QN2018055the Young Doctor Foundation of Higher Education in Gansu Province(No.2021QB-071)the 14th five-year Planning project of Education science in Gansu Province 2021“A study on the core behavior of patriotism of children in the new era”.
文摘An individual’s perception,attitude,feeling and behavior about their body are important factors for mental health(depression).This study aims to explore the impact of body investment on depression,and the role of self-efficacy and self-esteem in this connection.A hypothetical model about the relationship between body investment,selfefficacy,self-esteem and depression was tested.Using convenient sampling methods,a self-rated cross-sectional survey comprised of paper-based and online modes was conducted among 1,164 college students in Yunnan Province,China from July 2021 to August 2021.The data collection used the body investment scale,self-efficacy scale,self-esteem scale and depression scale.The results show that there is a low to moderate positive correlation(ranging between-0.11 and-0.59)between the research variables.The body investment of college students has a negative predictive effect(B=16.23,SE=0.65)on depression.This connection is also regulated by the mediating role of self-esteem and self-efficacy.All these factors explain 37.83%variability of research participation.These findings show how body investment affects the depressive state of college students.Further,these results help to demonstrate that self-efficacy and self-esteem are academically important for optimizing students’depression,so as to promote a good mental state.
基金supported by Yunnan Provincial Philosophy and Social Science Planning Youth Project under Grant No.QN2018055.
文摘Government city management is facing higher requirements with the development of the number of migrant workers.Therefore,improving their subjective well-being is a significant practical problem that the government must consider in public governance.This research discusses the influence of public service satisfaction on the well-being of urban migrant workers from the perspective of social comparison theory and the role of the sense of social equity and social conflict in the process of this influence.Using the structural equation modeling and moderated mediating mechanism analysis,the results show that:(1)the satisfaction of social and economic public service significantly and positively affects subjective well-being.(2)The sense of social equity completely mediated the influence of the satisfaction of public social service on well-being and partly mediated the influence of the satisfaction of public financial service on well-being.(3)The sense of social equity and conflict have a moderated mediating effect for social and economic public service satisfaction on well-being.Finally,the article concludes with some suggestions to improve the well-being of migrant workers based on the conclusion of the study.
基金supported by Indiana University-Purdue University Indianapolis Imaging Technology Development Program(IUPUI ITDP)National Institutes of Health(NIH)grant R21 NS075791,and R01 AG053993
文摘Multiple sclerosis is a neurodegenerative and inflammatory disease, a hallmark of which is demyelinating lesions in the white matter. We hypothesized that alterations in white matter microstructures can be non-invasively characterized by advanced diffusion magnetic resonance imaging. Seven diffusion metrics were extracted from hybrid diffusion imaging acquisitions via classic diffusion tensor imaging, neurite orientation dispersion and density imaging, and q-space imaging. We investigated the sensitivity of the diffusion metrics in 36 sets of regions of interest in the brain white matter of six female patients(age 52.8 ± 4.3 years) with multiple sclerosis. Each region of interest set included a conventional T2-defined lesion, a matched perilesion area, and normal-appearing white matter. Six patients with multiple sclerosis(n = 5) or clinically isolated syndrome(n = 1) at a mild to moderate disability level were recruited. The patients exhibited microstructural alterations from normal-appearing white matter transitioning to perilesion areas and lesions, consistent with decreased tissue restriction, decreased axonal density, and increased classic diffusion tensor imaging diffusivity. The findings suggest that diffusion compartment modeling and q-spa ce analysis appeared to be sensitive for detecting subtle microstructural alterations between perilesion areas and normal-appearing white matter.
基金results in part from collaboration and network activities promoted under the frame of the international network GENIEUR (Genes in Irritable Bowel Syndrome Research Network Europe),which has been funded by the COST program (BM1106, www.GENIEUR.eu)currently supported by the European Society of Neurogastroenterology and Motility (ESNM, www.ESNM.eu)
文摘BACKGROUND Single-nucleotide polymorphisms(SNPs)of the serotonin type 3 receptor subunit(HTR3)genes have been associated with psychosomatic symptoms,but it is not clear whether these associations exist in irritable bowel syndrome(IBS).AIM To assess the association of HTR3 polymorphisms with depressive,anxiety,and somatization symptoms in individuals with IBS.METHODS In this retrospective study,623 participants with IBS were recruited from five specialty centers in Germany,Sweden,the United States,the United Kingdom,and Ireland.Depressive,anxiety,and somatization symptoms and sociodemographic characteristics were collected.Four functional SNPs—HTR3A c.-42C>T,HTR3B c.386A>C,HTR3C c.489C>A,and HTR3E c.*76G>A—were genotyped and analyzed using the dominant and recessive models.We also performed separate analyses for sex and IBS subtypes.SNP scores were calculated as the number of minor alleles of the SNPs above.The impact of HTR3C c.489C>A was tested by radioligand-binding and calcium influx assays.RESULTS Depressive and anxiety symptoms significantly worsened with increasing numbers of minor HTR3C c.489C>A alleles in the dominant model(F_(depressive)=7.475,P_(depressive)=0.006;F_(anxiety)=6.535,P_(anxiety)=0.011).A higher SNP score(range 0-6)was linked to a worsened depressive symptoms score(F=7.710,P-linear trend=0.006)in IBS.The potential relevance of the HTR3C SNP was corroborated,showing changes in the expression level of 5-HT3AC variant receptors.CONCLUSION We have provided the first evidence that HTR3C c.489C>A is involved in depressive and anxiety symptoms in individuals with IBS.The SNP score indicated that an increasing number of minor alleles is linked to the worsening of depressive symptoms in IBS.
基金supported by the Silvo O.Conte Center (P50MH094268)supported by an Albstein Research Scholarship at Johns Hopkins University。
文摘Dear Editor,When two stimuli such as a tone and a visual stimulus are repeatedly presented together,individuals diagnosed with hallucinations tend to report hearing the tone subsequently in response to the visual stimulus alone [1].Such conditioned hallucinations involved evoked sensory representations as evidenced by increased neural activation in tone-responsive brain regions during the conditioned hallucinations.These and other observations underscore the importance of prior associative experiences in driving hallucinatory perception,and reflect new efforts to conceptualize and understand psychosis from a cognitive perspective.
