AIM: To observe the protective effect of Radix Astragali injection on immune organs (lymph nodes, spleen and thymus) of rats with obstructive jaundice (OJ) and its mechanism. METHODS: SD rats were randomly divided int...AIM: To observe the protective effect of Radix Astragali injection on immune organs (lymph nodes, spleen and thymus) of rats with obstructive jaundice (OJ) and its mechanism. METHODS: SD rats were randomly divided into sham-operation group, model control group and Radix Astragali treatment group. On days 7, 14, 21 and 28 after operation, mortality rate of rats, pathological changes in immune organs, expression levels of Bax and nuclear factor (NF)-κB p65 proteins, apoptosis indexes and serum tumor necrosis factor (TNF)-α level in spleen and thymus were observed, respectively.RESULTS: Compared to model control group, the number of dead OJ rats in Radix Astragali treatment group decreased (P > 0.05). The TNF-α level (27.62 ± 12.61 vs 29.55 ± 18.02, 24.61 ± 9.09 vs 31.52 ± 10.95) on days 7 and 21, the pathological severity score for spleen [0.0 (0.0) vs 0.0 (2.0) on days 7 and 14 and for lymph nodes [0.0 (1.0) vs 1.0 (2.0), 1.0 (0.0) vs 2.0 (1.0)] on days 21 and 28, the product staining intensity and positive rate of Bax protein in spleen [0.0 (0.0) vs 1.0 (2.0), 0.0 (1.0) vs 2.0 (1.5) and thymus [0.0 (0.0) vs 1.0 (2.0), 0.0 (1.0) vs 2.0 (1.5)] on days 14 and 28, the apoptotic indexes [0.0 (0.0) vs 0.0 (0.01)] in spleen and thymus [0.0 (0.0) vs 0.0 (0.01) on days 14 and 21 were significantly lower in Radix Astragali treatment group than in model control group (P < 0.05). CONCLUSION: Radix Astragali has protective effects on immune organs of OJ rats by relieving the pathological changes in immune organs, reducing TNF-α level and inhibiting Bax expression and apoptosis in spleen and thymus.展开更多
Objective To investigate th e changes to the strike extent of piston to cylinder after engine supercharge de sign. Methods The lubrication model between the skirt of piston and liner is established by means of piston ...Objective To investigate th e changes to the strike extent of piston to cylinder after engine supercharge de sign. Methods The lubrication model between the skirt of piston and liner is established by means of piston dynamics, combined with the hydrody namic lubrication equation. Optimized numerical analysis method is employed in s olving the dynamics and lubrication equations. The analyses about piston strike under two combustion gas pressures are performed. Results The p eak values of maximum eccentricity under supercharge condition are much greater than under non-supercharge condition, which means a stronger impulsion of pisto n to cylinder wall and a greater possibility of scuffing. The horizontal velocit ies of piston in supercharge condition are larger, which illuminate the more uns table motion state. Conclusion The analysis gives a new conclus ion. Combustion gas pressure plays an important role in the piston strike motion . Influences of supercharge should be taken into account so that the traditional product test items can be improved.展开更多
A modified tracking differentiator is proposed. Firstly, a nonlinear odd exponent continuous function is adopted which is only stable at one equilibrium point and proved the global asymptotic stability of the modified...A modified tracking differentiator is proposed. Firstly, a nonlinear odd exponent continuous function is adopted which is only stable at one equilibrium point and proved the global asymptotic stability of the modified tracking differentiator by select a Lyapunov function. Through combining of the nonlinear and linear function properly, it can be sure that the state converges to the equilibrium point with high speed automatically no matter that the state was far away from the equilibrium point or near to it, and it can prevent the chattering.?Simulation results show that the modified tracking differentiator tracking results?are?superior to the classical nonlinear tracking differentiator, and the response?of state variables tracking differentiator estimated?is?almost coincide with the real state of the variables of the given system.展开更多
Under low signal-to-noise ratio(SNR)and burst noise conditions,the speech enhancement effect of existing deep learning network models is not satisfactory.In contrast,humans can exploit the long-term correlation of spe...Under low signal-to-noise ratio(SNR)and burst noise conditions,the speech enhancement effect of existing deep learning network models is not satisfactory.In contrast,humans can exploit the long-term correlation of speech to form an integrated perception of different speech signals.Thus,describing the long-term dependencies of speech can help improve the enhancement performance under low SNR and burst noise conditions.Inspired by this feature,a time domain end-to-end monaural speech enhancement model TU-net that fuses the multi-head self-attention mechanism and U-net deep network is proposed.The TU-net model adopts the codec layer structure of U-net to achieve multi-scale feature fusion.It introduces the dual-path Transformer module using the multi-head self-attention mechanism to calculate the speech mask and better model long-term correlation.The TU-net model is trained with a weighted sum loss function in the time,time-frequency,and perceptual domains.Simulation experiments are carried out and the results show that with maintaining relatively fewer network model parameters,TU-net outperforms other similar monaural enhancement network models in several evaluation metrics such as perceptual evaluation of speech quality(PESQ),short-time objective intelligibility(STOI)and SNR gain under low SNR and burst noise conditions.展开更多
A novel 3-D temperature field reconstruction method is proposed in this paper, which is based on multi-wavelength thermometry and Hopfield neural network computed tomography. A mathematical modelof multi-wavelength th...A novel 3-D temperature field reconstruction method is proposed in this paper, which is based on multi-wavelength thermometry and Hopfield neural network computed tomography. A mathematical modelof multi-wavelength thermometry is founded, and a neural network algorithm based on multiobjectiveoptimization is developed. Through computer simulation and comparison with the algebraic reconstructiontechnique (ART) and the filter back-projection algorithm (FBP), the reconstruction result of the newmethod is discussed in detail. The study shows that the new method always gives the best reconstructionresults. At last, temperature distribution of a section of four peaks candle flame is reconstructed with thisnovel method.展开更多
Human reliability analysis(HRA) is an expansion of man-machine engineering. It is also a new multidisciplinary based on behavioral science, cognitive science, information processing, system analysis and probability st...Human reliability analysis(HRA) is an expansion of man-machine engineering. It is also a new multidisciplinary based on behavioral science, cognitive science, information processing, system analysis and probability statistics in order to analyze, predict, reduce and prevent human errors. Firstly, the quantitative analysis model of HRA is proposed based on Markov process theory by using human error probability(HEP) and error correction cycle(ECC) as parameters. And human reliability evaluation criterion is built. Then, the HRA process considering error correction is proposed based on cognitive reliability and error analysis method(CREAM). Finally, according to the characteristics of armored vehicle system, common performance condition(CPC) in CREAM is improved.A reliability impact index is characterized by the overall contexts of tasks. Human reliability evaluation criterion of armored vehicle system is formulated. And the result of HRA is obtained based on the method presented in this paper. In addition, the relative weights are estimated by combining scale of 10/10—18/2 and analytical hierarchy process(AHP), and the triangular fuzzy number considering confidence factor and optimism index is adopted in order to reduce the subjectivity. The analysis results show that the method presented in this paper is reasonable and feasible. Meantime, the method can provide guidance for human reliability analysis of other weapon systems.展开更多
基金Supported by Technological Foundation Project of Traditional Chinese Medicine of Zhejiang Province, No. 2003C130, No. 2004C142Foundation Project for Medical Science and Technology of Zhejiang Province, No. 2003B134+3 种基金Grave foundation project for Technology and Development of Hangzhou, No. 2003123B19Intensive Foundation Project for Technology of Hangzhou, No. 2004Z006Foundation Project for Medical Science and Technology of Hangzhou, No. 2003A004Foundation Project for Technology of Hangzhou, No. 2005224
文摘AIM: To observe the protective effect of Radix Astragali injection on immune organs (lymph nodes, spleen and thymus) of rats with obstructive jaundice (OJ) and its mechanism. METHODS: SD rats were randomly divided into sham-operation group, model control group and Radix Astragali treatment group. On days 7, 14, 21 and 28 after operation, mortality rate of rats, pathological changes in immune organs, expression levels of Bax and nuclear factor (NF)-κB p65 proteins, apoptosis indexes and serum tumor necrosis factor (TNF)-α level in spleen and thymus were observed, respectively.RESULTS: Compared to model control group, the number of dead OJ rats in Radix Astragali treatment group decreased (P > 0.05). The TNF-α level (27.62 ± 12.61 vs 29.55 ± 18.02, 24.61 ± 9.09 vs 31.52 ± 10.95) on days 7 and 21, the pathological severity score for spleen [0.0 (0.0) vs 0.0 (2.0) on days 7 and 14 and for lymph nodes [0.0 (1.0) vs 1.0 (2.0), 1.0 (0.0) vs 2.0 (1.0)] on days 21 and 28, the product staining intensity and positive rate of Bax protein in spleen [0.0 (0.0) vs 1.0 (2.0), 0.0 (1.0) vs 2.0 (1.5) and thymus [0.0 (0.0) vs 1.0 (2.0), 0.0 (1.0) vs 2.0 (1.5)] on days 14 and 28, the apoptotic indexes [0.0 (0.0) vs 0.0 (0.01)] in spleen and thymus [0.0 (0.0) vs 0.0 (0.01) on days 14 and 21 were significantly lower in Radix Astragali treatment group than in model control group (P < 0.05). CONCLUSION: Radix Astragali has protective effects on immune organs of OJ rats by relieving the pathological changes in immune organs, reducing TNF-α level and inhibiting Bax expression and apoptosis in spleen and thymus.
文摘Objective To investigate th e changes to the strike extent of piston to cylinder after engine supercharge de sign. Methods The lubrication model between the skirt of piston and liner is established by means of piston dynamics, combined with the hydrody namic lubrication equation. Optimized numerical analysis method is employed in s olving the dynamics and lubrication equations. The analyses about piston strike under two combustion gas pressures are performed. Results The p eak values of maximum eccentricity under supercharge condition are much greater than under non-supercharge condition, which means a stronger impulsion of pisto n to cylinder wall and a greater possibility of scuffing. The horizontal velocit ies of piston in supercharge condition are larger, which illuminate the more uns table motion state. Conclusion The analysis gives a new conclus ion. Combustion gas pressure plays an important role in the piston strike motion . Influences of supercharge should be taken into account so that the traditional product test items can be improved.
文摘A modified tracking differentiator is proposed. Firstly, a nonlinear odd exponent continuous function is adopted which is only stable at one equilibrium point and proved the global asymptotic stability of the modified tracking differentiator by select a Lyapunov function. Through combining of the nonlinear and linear function properly, it can be sure that the state converges to the equilibrium point with high speed automatically no matter that the state was far away from the equilibrium point or near to it, and it can prevent the chattering.?Simulation results show that the modified tracking differentiator tracking results?are?superior to the classical nonlinear tracking differentiator, and the response?of state variables tracking differentiator estimated?is?almost coincide with the real state of the variables of the given system.
基金supported by the National Natural Science Foundation of China(62071484)。
文摘Under low signal-to-noise ratio(SNR)and burst noise conditions,the speech enhancement effect of existing deep learning network models is not satisfactory.In contrast,humans can exploit the long-term correlation of speech to form an integrated perception of different speech signals.Thus,describing the long-term dependencies of speech can help improve the enhancement performance under low SNR and burst noise conditions.Inspired by this feature,a time domain end-to-end monaural speech enhancement model TU-net that fuses the multi-head self-attention mechanism and U-net deep network is proposed.The TU-net model adopts the codec layer structure of U-net to achieve multi-scale feature fusion.It introduces the dual-path Transformer module using the multi-head self-attention mechanism to calculate the speech mask and better model long-term correlation.The TU-net model is trained with a weighted sum loss function in the time,time-frequency,and perceptual domains.Simulation experiments are carried out and the results show that with maintaining relatively fewer network model parameters,TU-net outperforms other similar monaural enhancement network models in several evaluation metrics such as perceptual evaluation of speech quality(PESQ),short-time objective intelligibility(STOI)and SNR gain under low SNR and burst noise conditions.
基金This project was supported by China Aeronautical Basic Science Foundation under Grant No. 00156004 by Foundation of Jiangxi Test Technology and Control Engineering Center under Grant No. KG200104002.
文摘A novel 3-D temperature field reconstruction method is proposed in this paper, which is based on multi-wavelength thermometry and Hopfield neural network computed tomography. A mathematical modelof multi-wavelength thermometry is founded, and a neural network algorithm based on multiobjectiveoptimization is developed. Through computer simulation and comparison with the algebraic reconstructiontechnique (ART) and the filter back-projection algorithm (FBP), the reconstruction result of the newmethod is discussed in detail. The study shows that the new method always gives the best reconstructionresults. At last, temperature distribution of a section of four peaks candle flame is reconstructed with thisnovel method.
基金the Technical Basis Projects of China’s Ministry of Industry and Information Technology(No.ZQ092012B003)
文摘Human reliability analysis(HRA) is an expansion of man-machine engineering. It is also a new multidisciplinary based on behavioral science, cognitive science, information processing, system analysis and probability statistics in order to analyze, predict, reduce and prevent human errors. Firstly, the quantitative analysis model of HRA is proposed based on Markov process theory by using human error probability(HEP) and error correction cycle(ECC) as parameters. And human reliability evaluation criterion is built. Then, the HRA process considering error correction is proposed based on cognitive reliability and error analysis method(CREAM). Finally, according to the characteristics of armored vehicle system, common performance condition(CPC) in CREAM is improved.A reliability impact index is characterized by the overall contexts of tasks. Human reliability evaluation criterion of armored vehicle system is formulated. And the result of HRA is obtained based on the method presented in this paper. In addition, the relative weights are estimated by combining scale of 10/10—18/2 and analytical hierarchy process(AHP), and the triangular fuzzy number considering confidence factor and optimism index is adopted in order to reduce the subjectivity. The analysis results show that the method presented in this paper is reasonable and feasible. Meantime, the method can provide guidance for human reliability analysis of other weapon systems.
