Objective: To observe the effect of simulated weightlessness on stress-strain relationship and the structural change of rabbit femoral vein. Methods: After seting up the Head-Down Tilt (-20°) (HDT) model to simul...Objective: To observe the effect of simulated weightlessness on stress-strain relationship and the structural change of rabbit femoral vein. Methods: After seting up the Head-Down Tilt (-20°) (HDT) model to simulate weightlessness, 24 healthy male New-Zealand Rabbits were randomly divided into HDT-21d group, HDT-10d group and control group, with 8 in each. Femoral venous strips and rings were used to make uniaxial tensile test of the longitudinal and circumferential specimens of the vessels. At last we observed the microstructure of femoral vein wall in 3 groups. Results : With the increasing of load stress, both longitudinal and circumferential strains of vein samples from 3 groups increased significantly (P<0. 01). With the decrease of unload stress, strains decrease obviously (P<0. 01). The unloaded longitudinal and the circumferential strain from 3 groups increased much than those of the loaded. Under the same stress (longitudinal 0-2. 0 g, circumferential 0. 5-1. 0 g) , HDT-21d group and HDT-10d group increased obviously in tlie longitudinal or circumferential strain (load and unload) than control, and HDT-21d increased much than that of HDT-10d. The contents and structures of femoral vein walls of HDT-rabbits changed significantly. Some endotheli-um cells of femoral vein became short, columnar or cubic even fell off. Smooth muscle layers became thinner. Conclusion:The compliance of femoral venous increased significantly after weightlessness-simulation and increased much obviously after 21d-HDT than that of 10 d. The structure of femoral vein wall changed obviously. The changes may be one reason for the increase of femoral vein compliance.展开更多
基金Supported by Grant from the National Natural Science Foundation of China(30000197)
文摘Objective: To observe the effect of simulated weightlessness on stress-strain relationship and the structural change of rabbit femoral vein. Methods: After seting up the Head-Down Tilt (-20°) (HDT) model to simulate weightlessness, 24 healthy male New-Zealand Rabbits were randomly divided into HDT-21d group, HDT-10d group and control group, with 8 in each. Femoral venous strips and rings were used to make uniaxial tensile test of the longitudinal and circumferential specimens of the vessels. At last we observed the microstructure of femoral vein wall in 3 groups. Results : With the increasing of load stress, both longitudinal and circumferential strains of vein samples from 3 groups increased significantly (P<0. 01). With the decrease of unload stress, strains decrease obviously (P<0. 01). The unloaded longitudinal and the circumferential strain from 3 groups increased much than those of the loaded. Under the same stress (longitudinal 0-2. 0 g, circumferential 0. 5-1. 0 g) , HDT-21d group and HDT-10d group increased obviously in tlie longitudinal or circumferential strain (load and unload) than control, and HDT-21d increased much than that of HDT-10d. The contents and structures of femoral vein walls of HDT-rabbits changed significantly. Some endotheli-um cells of femoral vein became short, columnar or cubic even fell off. Smooth muscle layers became thinner. Conclusion:The compliance of femoral venous increased significantly after weightlessness-simulation and increased much obviously after 21d-HDT than that of 10 d. The structure of femoral vein wall changed obviously. The changes may be one reason for the increase of femoral vein compliance.
