Iron deficiency anemia(IDA)continues to be a global public health problem.Oral iron is the universally accepted first-line therapy,and most children have a prompt and favorable response to oral formulations.In subsets...Iron deficiency anemia(IDA)continues to be a global public health problem.Oral iron is the universally accepted first-line therapy,and most children have a prompt and favorable response to oral formulations.In subsets of children who fail to respond due to intolerance,poor adherence,or inadequate intestinal absorption,parenteral iron is indicated.Despite numerous studies in adults with IDA of diverse etiologies,pediatric studies on parenteral iron use are very limited.Although mostly retrospective and small,these studies have documented the efficacy and safety profile of intravenous iron formulations.In this editorial the author comments on the most important published data and underscores the need to seriously consider parenteral iron use in children unresponsive to oral therapy.展开更多
The etiology of childhood cancer remains largely unknown.Recent evidence suggests that genetic factors play a substantial role in pediatric tumorigenesis.Unlike adult cancers,pediatric cancers typically have a higher ...The etiology of childhood cancer remains largely unknown.Recent evidence suggests that genetic factors play a substantial role in pediatric tumorigenesis.Unlike adult cancers,pediatric cancers typically have a higher prevalence of germline pathogenic variants in cancer predisposition genes.Inherited cancer predisposition syndromes account for approximately 10%of all childhood cancers.Over the years,the diagnosis of cancer predisposition syndromes was based on clinical suspicion prompting referral to a specialized geneticist.However,advances in molecular technologies have led to a shift toward a“genotypefirst”approach.Identification of genetic variants related to cancer predisposition enables tailored treatment,improves clinical outcome,optimizes surveillance,and facilitates genetic counseling of the affected child and the family.展开更多
文摘Iron deficiency anemia(IDA)continues to be a global public health problem.Oral iron is the universally accepted first-line therapy,and most children have a prompt and favorable response to oral formulations.In subsets of children who fail to respond due to intolerance,poor adherence,or inadequate intestinal absorption,parenteral iron is indicated.Despite numerous studies in adults with IDA of diverse etiologies,pediatric studies on parenteral iron use are very limited.Although mostly retrospective and small,these studies have documented the efficacy and safety profile of intravenous iron formulations.In this editorial the author comments on the most important published data and underscores the need to seriously consider parenteral iron use in children unresponsive to oral therapy.
文摘The etiology of childhood cancer remains largely unknown.Recent evidence suggests that genetic factors play a substantial role in pediatric tumorigenesis.Unlike adult cancers,pediatric cancers typically have a higher prevalence of germline pathogenic variants in cancer predisposition genes.Inherited cancer predisposition syndromes account for approximately 10%of all childhood cancers.Over the years,the diagnosis of cancer predisposition syndromes was based on clinical suspicion prompting referral to a specialized geneticist.However,advances in molecular technologies have led to a shift toward a“genotypefirst”approach.Identification of genetic variants related to cancer predisposition enables tailored treatment,improves clinical outcome,optimizes surveillance,and facilitates genetic counseling of the affected child and the family.
