In this study, we tested the hypotheses that 1) diabetes-induced disturbances in cardiac my-ATPase activity would be attributed to not only myosin heavy chain (MHC) isoform transitions, but also reduced amounts in MHC...In this study, we tested the hypotheses that 1) diabetes-induced disturbances in cardiac my-ATPase activity would be attributed to not only myosin heavy chain (MHC) isoform transitions, but also reduced amounts in MHC protein;and 2) if diabetes results in declines in the MHC protein content, this change would relate to oxidative damage to MHC. Diabetes was induced by a single intraperitoneal injection of streptozotocin. After 6 weeks of injection, the left ventricles were excised for mechanical and biochemical analyses. Peak twitch tension and the rate of force development in papillary muscles were decreased by 23.4% and 34.1%, respectively. A 33.5% reduction in myofibrillar ATPase activity occurred in conjunction with a 9.5% decrease in MHC protein as well as MHC isoform transitions towards a slower phenotype. The decreased MHC content was not accompanied by elevations in carbonyl groups present in MHC. Whole muscle analyses indicated that the contents of malondialdehyde and reduced glutathione were elevated. These results suggest that decreases in the MHC content may be associated, at least in part, with a diabetes-related inactivation of cardiac my-ATPase and may not be due to accumulation of oxidative damage to protein.展开更多
It is well-established that individual innovativeness is an indispensable quality for employees working in a variety of workplace environments.However,the interaction between the psychological and organizational facto...It is well-established that individual innovativeness is an indispensable quality for employees working in a variety of workplace environments.However,the interaction between the psychological and organizational factors influencing innovativeness remains unclear.This study seeks to address that research gap by examining a model comprising a mix of psychological factors(implicit theory and goal orientation)and organizational culture.Data were collected from 315 staff members working in 34 different departments/schools at Tampere University,Finland.The study employed a Bayesian multilevel path analysis that matched the hierarchical structure of the data to test the hypotheses.The results suggest that psychological factors reflecting goal orientation are the most important for interpreting individual innovativeness.Specifically,mastery goal orientation was shown to be a positive predictor and performance-approach goal orientation a negative predictor of innovativeness.Unexpectedly,departmental culture had neither a direct effect on innovativeness nor a moderation effect on the relationships between the psychological variables and innovativeness.Plausible explanations for these results and implications for future research are discussed.展开更多
文摘In this study, we tested the hypotheses that 1) diabetes-induced disturbances in cardiac my-ATPase activity would be attributed to not only myosin heavy chain (MHC) isoform transitions, but also reduced amounts in MHC protein;and 2) if diabetes results in declines in the MHC protein content, this change would relate to oxidative damage to MHC. Diabetes was induced by a single intraperitoneal injection of streptozotocin. After 6 weeks of injection, the left ventricles were excised for mechanical and biochemical analyses. Peak twitch tension and the rate of force development in papillary muscles were decreased by 23.4% and 34.1%, respectively. A 33.5% reduction in myofibrillar ATPase activity occurred in conjunction with a 9.5% decrease in MHC protein as well as MHC isoform transitions towards a slower phenotype. The decreased MHC content was not accompanied by elevations in carbonyl groups present in MHC. Whole muscle analyses indicated that the contents of malondialdehyde and reduced glutathione were elevated. These results suggest that decreases in the MHC content may be associated, at least in part, with a diabetes-related inactivation of cardiac my-ATPase and may not be due to accumulation of oxidative damage to protein.
文摘It is well-established that individual innovativeness is an indispensable quality for employees working in a variety of workplace environments.However,the interaction between the psychological and organizational factors influencing innovativeness remains unclear.This study seeks to address that research gap by examining a model comprising a mix of psychological factors(implicit theory and goal orientation)and organizational culture.Data were collected from 315 staff members working in 34 different departments/schools at Tampere University,Finland.The study employed a Bayesian multilevel path analysis that matched the hierarchical structure of the data to test the hypotheses.The results suggest that psychological factors reflecting goal orientation are the most important for interpreting individual innovativeness.Specifically,mastery goal orientation was shown to be a positive predictor and performance-approach goal orientation a negative predictor of innovativeness.Unexpectedly,departmental culture had neither a direct effect on innovativeness nor a moderation effect on the relationships between the psychological variables and innovativeness.Plausible explanations for these results and implications for future research are discussed.
