期刊文献+
共找到1篇文章
< 1 >
每页显示 20 50 100
Alpha-fetoprotein expression is a potential prognostic marker in hepatocellular carcinoma 被引量:6
1
作者 Dénes Grg János Regly-Mérei +2 位作者 Sándor Paku László Kopper Péter Nagy 《World Journal of Gastroenterology》 SCIE CAS CSCD 2005年第32期5015-5018,共4页
AIM: To characterize the alpha-fetoprotein (AFP) positive and negative hepatocellular carcinoma (HCC) samples. METHODS: Thirty-seven paraffin-embedded human HCC samples were analyzed by immunohistochemistry for ... AIM: To characterize the alpha-fetoprotein (AFP) positive and negative hepatocellular carcinoma (HCC) samples. METHODS: Thirty-seven paraffin-embedded human HCC samples were analyzed by immunohistochemistry for the following antigens: AFP,β-catenin, p53, CD44, MSH-2, MLH-1, and HNF-4. The tumors were divided into two groups based on the AFP expression. The immunophenotypic data and important clinical parameters were studied between the two groups. RESULTS: Twenty-one of the thirty-seven examined HCCs were AFP positive. Seven with nudear p53 staining were AFP positive, while seven tumors with nuclear β-catenin staining were AFP negative. CD44 staining and high histological tumor grade were more frequent among the AFP-positive HCCs. The other immunophenotypical and dinical parameters did not show statistically significant difference in their distribution between the AFP positive and negative samples. CONCLUSION: AFP expression in HCC correlates with unfavorable prognostic factors, while nuclear β-catenin positivity is more common among the AFP-negative liver tumors. This observation supports the microarray data on in vivo human tumors. 展开更多
关键词 Hepatocellular carcinoma ALPHA-FETOPROTEIN P53 Β-CATENIN CD44
下载PDF
上一页 1 下一页 到第
使用帮助 返回顶部