Advanced Glycation End Products (AGEs) have been associated as a possible <span>cause in inflammation-mediated chronic diseases such as diabetes, Alzhei</span>mer’s and cardiovascular disorders. Thus, inh...Advanced Glycation End Products (AGEs) have been associated as a possible <span>cause in inflammation-mediated chronic diseases such as diabetes, Alzhei</span>mer’s and cardiovascular disorders. Thus, inhibition of AGE formation repre<span>sents a prospective therapeutic target for the prevention and treatment of</span> these complications. This study investigated the individual and combined effect</span><span style="font-size:10.0pt;font-family:"">s</span><span style="font-size:10.0pt;font-family:""> of dietary ingredients, spices, on lowering AGEs formation in meat pat<span>ties. In the study, Carboxymethyllysine (CML), a well-investigated AGE is</span> used as a marker for AGEs and malondialdehyde (MDA) as an indicator for <span>lipid peroxidation. Nine spices were selected based on their ability to inhibit </span>the formation of AGEs at different stages of Maillard reactions. Individually, all the 9 selected spices significantly inhibited the formation of AGEs. Among <span>the 33 combinations of spices, 26 combinations significantly inhibited the</span> formation of AGEs. The highest reduction (84%) was found by the combination <span>of Black Pepper</span></span><span style="font-size:10.0pt;font-family:"">-</span><span style="font-size:10.0pt;font-family:"">Rose</span><span style="font-size:10.0pt;font-family:"">-</span><span style="font-size:10.0pt;font-family:"">Cumin. The individual spices failed to significantly </span><span style="font-size:10.0pt;font-family:"">lower the MDA </span><span style="font-size:10.0pt;font-family:"">concentration</span><span style="font-size:10.0pt;font-family:"">;however, all 33 combinations were able to signifi<span>cantly reduce MDA </span></span><span style="font-size:10.0pt;font-family:"">concentration</span><span style="font-size:10.0pt;font-family:"">. The results of this study showed that</span><span style="font-size:10.0pt;font-family:""> </span><span style="font-size:10.0pt;font-family:"">spices when supplemented in combinations are more effective in inhibiting <span>the formation of AGEs and in decreasing MDA </span></span><span style="font-size:10.0pt;font-family:"">concentration</span><span style="font-size:10.0pt;font-family:""> in meat patties.展开更多
In the last two decades,the issue on exposure to air pollution,especially fine particulate matter(PM_(2.5)),and its health effects has been a global concern.PM2.5 can enter the bronchi,lung cells,and subsequently the ...In the last two decades,the issue on exposure to air pollution,especially fine particulate matter(PM_(2.5)),and its health effects has been a global concern.PM2.5 can enter the bronchi,lung cells,and subsequently the body,thus causing adverse health effects.One of these health effects include damage to the reproductive system.However,this has not gained much attention.In addition,PM_(2.5) contain toxic compounds,such as heavy metals or PAHs,which can cross various barriers,including epithelial barrier and blood-testis barrier,causing hormonal disorders in both,men and women,thus resulting in infertility.In this review,an attempt was made to provide useful information about effects of PM_(2.5) on the reproductive system.展开更多
The contamination of fish type products such as silver pomfret fish fillets by potentially toxic elements(PTEs)has raised global health concerns.Related studies regarding the concentration of PTEs in fillets of silver...The contamination of fish type products such as silver pomfret fish fillets by potentially toxic elements(PTEs)has raised global health concerns.Related studies regarding the concentration of PTEs in fillets of silver pomfret fish were retrieved among some international databases such as Scopus,Pub Med and Embase between 1 January 1983 and 10 March 2020.The pooled(mean)concentration of PTEs in fillets of silver pomfret fish was meta-analyzed with the aid of a random-effect model(REM).Also,the non-carcinogenic risk was estimated via calculating the 95 th percentile of the total target hazard quotient(TTHQ).The meta-analysis of 21 articles(containing 25 studies or data reports)indicated that the ranking of PTEs in fillets of silver pomfret fish was Fe(11,414.81μg/kg wet weight,ww)>Zn(6055.72μg/kg ww)>Cr(1825.79μg/kg ww)>Pb(1486.44μg/kg ww)>Se(1053.47μg/kg ww)>Cd(992.50μg/kg ww)>Ni(745.23μg/kg ww)>Cu(669.71μg/kg ww)>total As(408.24μg/kg ww)>Co(87.03μg/kg ww)>methyl Hg(46.58μg/kg ww).The rank order of health risk assessment by country based on the TTHQ for adult consumers was Malaysia(2.500)>Bangladesh(0.886)>Iran(0.144)>China(0.045)>Pakistan(0.020)>India(0.015),while the corresponding values for child consumers was Malaysia(11.790)>Bangladesh(4.146)>Iran(0.675)>China(0.206)>Pakistan(0.096)>India(0.077).The adult consumers in Malaysia and children in Malaysia and Bangladesh were at considerable non-carcinogenic risk.Therefore,following the recommended control plans in order to reduce the health risk associated with the ingestion of PTEs via consumption of silver pomfret fish fillets is crucial.展开更多
文摘Advanced Glycation End Products (AGEs) have been associated as a possible <span>cause in inflammation-mediated chronic diseases such as diabetes, Alzhei</span>mer’s and cardiovascular disorders. Thus, inhibition of AGE formation repre<span>sents a prospective therapeutic target for the prevention and treatment of</span> these complications. This study investigated the individual and combined effect</span><span style="font-size:10.0pt;font-family:"">s</span><span style="font-size:10.0pt;font-family:""> of dietary ingredients, spices, on lowering AGEs formation in meat pat<span>ties. In the study, Carboxymethyllysine (CML), a well-investigated AGE is</span> used as a marker for AGEs and malondialdehyde (MDA) as an indicator for <span>lipid peroxidation. Nine spices were selected based on their ability to inhibit </span>the formation of AGEs at different stages of Maillard reactions. Individually, all the 9 selected spices significantly inhibited the formation of AGEs. Among <span>the 33 combinations of spices, 26 combinations significantly inhibited the</span> formation of AGEs. The highest reduction (84%) was found by the combination <span>of Black Pepper</span></span><span style="font-size:10.0pt;font-family:"">-</span><span style="font-size:10.0pt;font-family:"">Rose</span><span style="font-size:10.0pt;font-family:"">-</span><span style="font-size:10.0pt;font-family:"">Cumin. The individual spices failed to significantly </span><span style="font-size:10.0pt;font-family:"">lower the MDA </span><span style="font-size:10.0pt;font-family:"">concentration</span><span style="font-size:10.0pt;font-family:"">;however, all 33 combinations were able to signifi<span>cantly reduce MDA </span></span><span style="font-size:10.0pt;font-family:"">concentration</span><span style="font-size:10.0pt;font-family:"">. The results of this study showed that</span><span style="font-size:10.0pt;font-family:""> </span><span style="font-size:10.0pt;font-family:"">spices when supplemented in combinations are more effective in inhibiting <span>the formation of AGEs and in decreasing MDA </span></span><span style="font-size:10.0pt;font-family:"">concentration</span><span style="font-size:10.0pt;font-family:""> in meat patties.
文摘In the last two decades,the issue on exposure to air pollution,especially fine particulate matter(PM_(2.5)),and its health effects has been a global concern.PM2.5 can enter the bronchi,lung cells,and subsequently the body,thus causing adverse health effects.One of these health effects include damage to the reproductive system.However,this has not gained much attention.In addition,PM_(2.5) contain toxic compounds,such as heavy metals or PAHs,which can cross various barriers,including epithelial barrier and blood-testis barrier,causing hormonal disorders in both,men and women,thus resulting in infertility.In this review,an attempt was made to provide useful information about effects of PM_(2.5) on the reproductive system.
基金the student research committee at Shahid Beheshti University of Medical Sciences for the financial grants supporting this study(1398/9920)。
文摘The contamination of fish type products such as silver pomfret fish fillets by potentially toxic elements(PTEs)has raised global health concerns.Related studies regarding the concentration of PTEs in fillets of silver pomfret fish were retrieved among some international databases such as Scopus,Pub Med and Embase between 1 January 1983 and 10 March 2020.The pooled(mean)concentration of PTEs in fillets of silver pomfret fish was meta-analyzed with the aid of a random-effect model(REM).Also,the non-carcinogenic risk was estimated via calculating the 95 th percentile of the total target hazard quotient(TTHQ).The meta-analysis of 21 articles(containing 25 studies or data reports)indicated that the ranking of PTEs in fillets of silver pomfret fish was Fe(11,414.81μg/kg wet weight,ww)>Zn(6055.72μg/kg ww)>Cr(1825.79μg/kg ww)>Pb(1486.44μg/kg ww)>Se(1053.47μg/kg ww)>Cd(992.50μg/kg ww)>Ni(745.23μg/kg ww)>Cu(669.71μg/kg ww)>total As(408.24μg/kg ww)>Co(87.03μg/kg ww)>methyl Hg(46.58μg/kg ww).The rank order of health risk assessment by country based on the TTHQ for adult consumers was Malaysia(2.500)>Bangladesh(0.886)>Iran(0.144)>China(0.045)>Pakistan(0.020)>India(0.015),while the corresponding values for child consumers was Malaysia(11.790)>Bangladesh(4.146)>Iran(0.675)>China(0.206)>Pakistan(0.096)>India(0.077).The adult consumers in Malaysia and children in Malaysia and Bangladesh were at considerable non-carcinogenic risk.Therefore,following the recommended control plans in order to reduce the health risk associated with the ingestion of PTEs via consumption of silver pomfret fish fillets is crucial.
