Objective:To study the mechanism of Shengsui Jiangu Capsule promoting vitamin D_(3)regulating bone turnover in rats with alcoholic osteoporosis.Methods:120 SD rats were randomly divided into four groups:model group(al...Objective:To study the mechanism of Shengsui Jiangu Capsule promoting vitamin D_(3)regulating bone turnover in rats with alcoholic osteoporosis.Methods:120 SD rats were randomly divided into four groups:model group(alcoholic osteoporosis model group),blank control group,western medicine control group(calcium carbonate tablet and affa D_(3)control group),Chinese medicine experimental group(Shengsui Jiangu capsule experimental group),30 rats in each group.After 8,12 and 16 weeks,the serum levels of 25 hydroxyvitamin D_(3)(25(OH)D_(3)),1,25dihydroxyvitamin D_(3)(1,25(OH)_(2)D_(3)),cross-linked carboxy-terminal peptide of type 1 collagen(β-CTX)and N-terminal propeptide of type 1 collagen(P1NP)in rats and the density of the femur of rats were detected and compared.The correlation between vitamin D_(3)markers(25(OH)D_(3)and 1,25(OH)_(2)D_(3))and bone turnover indices(P1NP andβ-CTX)and bone mineral density was analyzed.Results:In the experimental group,bone mineral density(BMD)was significantly increased(P<0.01),bone repair and mineral stability and balance were maintained during bone turnover,the level of bone formation marker P1NP was significantly increased(P<0.01),and the level of bone resorption markerβ-CTX was significantly decreased(P<0.01).Serum levels of 25(OH)D_(3)and 1,25(OH)_(2)D_(3)were increased(P<0.01),and significantly higher than those in western medicine control group(P<0.05).Conclusion:Shengsui Jiangu capsule can effectively improve bone density in alcoholic osteoporosis(AOP)rats,and its mechanism may be related to promoting bone calcium absorption and regulating bone conversion.展开更多
TGF-Objective:To investigate the effect of postgraduate Shengsui Jiangu Capsule on tumor necrosis factors TNF-α,transforming growth factor TGF-β1 and empty bone lacuna in rats with alcoholic osteoporosis.Method:120 ...TGF-Objective:To investigate the effect of postgraduate Shengsui Jiangu Capsule on tumor necrosis factors TNF-α,transforming growth factor TGF-β1 and empty bone lacuna in rats with alcoholic osteoporosis.Method:120 SD rats were randomly divided into 4 groups,30 rats in each group:blank group,model group,western medicine control group and traditional Chinese medicine intervention group.Liquor gavage was used to model the disease,except for the blank group.The western medicine control group was gavaged with a suspension of calcium carbonate and afad3,while the Chinese medicine intervention group was gavaged with a suspension of Shengsui Jiangu capsules combined with 0.9%saline solution injection.The values of TNF-αand TGF-β1 in femora were measured after 8,12,and 16 weeks of intervention.After dissecting out the femoral head using the HE(hematoxylin-eosin staining)staining method,the bone lacunae were observed under a light microscope,and the empty bone lacunae rate was calculated for intergroup comparison.Results:Compared with the blank group,the model group had a significantly higher percentage of TNF-αand empty bone lacunae,and a significantly lower percentage of TGF-β1(P<0.01).Compared with the model group,the rates of TNF-αand empty bone lacunae in the western medicine control group and the Chinese medicine intervention group were significantly decreased,and TGF-β1 was significantly increased(P<0.01).The traditional Chinese medicine intervention group was more effective than the western medicine control group(P<0.05).Conclusion:Shengsui Jiangu capsule attenuates the expression of TNF-α,enhances the expression of TGF-β1,decreases the rate of empty bone lacunae,and achieves a protective effect against alcoholic osteoporosis in rats with alcoholic osteoporosis.展开更多
Objective:To observe the short-and long-term clinical efficacy differences of body acupuncture and scalp acupuncture combined with extracorporeal shock wave and simple extracorporeal shock wave.Methods:Sixty patients ...Objective:To observe the short-and long-term clinical efficacy differences of body acupuncture and scalp acupuncture combined with extracorporeal shock wave and simple extracorporeal shock wave.Methods:Sixty patients with scapulohumeral periarthritis were randomly divided into two groups:the treatment group and control group,30 cases in each one.Both groups underwent basic rehabilitation training.Patients in the treatment group were treated with body acupuncture and scalp acupuncture combined with extracorporeal shock wave.Yújì(鱼际 LU10),Hégǔ(合谷L14),Zhōngzhǔ(中渚TE3),Hòuxī(后溪SI3).There were three needles for the scalp acupuncture with the first between Shéntíng(神庭 GV24)and Yìntáng(印堂 EX-HN3),and the other two straightly through the inner canthus and parallel to the first needle.Shock wave treatment was intensively applied in some pressure points around shoulder joint.The control group used the same shock wave therapy as the treatment group.Both groups were all treated once a day,6 times a week.Patients were treated for one course which lasted for 4 weeks.VAS score,the Constant-Murley score and the HAMA(the Hamilton Anxiety Scale)are as therapeutic effect index.30 days telephone investigation followed-up after the treatment course was evaluated.Results:Totally 28 cases completed the clinical observation in the treatment group,and 29 cases in the control group.The total effective rate of the treatment group was 85.7%(24/28),which was higher than 69.0%(20/29)of the control group(P<0.05).VAS score:There were significant statistical differences before and after the treatment in the two groups(the treatment group:6.67 ± 1.43 vs 3.47 ± 1.35,the control group:7.57 ± 1.31 vs 5.36 ± 1.45,both P<0.05).There were significant statistical differences before the treatment and at the follow-up in the two groups(the treatment group:6.67 ± 1.43 vs2.68±0.81,the control group:7.57±1.31 vs 4.56±1.35,both P<0.05).The VAS scores of the treatment group after treatment and at the follow-up were respectively lower than those of the control group(both P<0.05).Shoulder joints activity score:There were significant statistical differences before and after the treatment in the two groups(the treatment group:54.65±1.65 vs 65.54±2.19,the control group:54.32 ± 2.31 vs 61.01 ± 0.95,both P<0.05).There were significant statistical differences before treatment and at follow-up in the two groups(the treatment group:54.65 ± 1.65 vs 66.18± 1.35,the control group:54.32 ± 2.31 vs 62.11 ± 1.49,both P<0.05).The shoulder activity scores of the treatment group after treatment and at follow-up were respectively higher than those of the control group(both P<0.05).HAMA scores:There were singificant statistical differences before and after treatment in the two groups(the treatment group:16.83 ± 1.56 vs 13.26 ± 2.36,the control group:17.04 ± 1.84 vs 15.23 ±3.17,both P<0.05).There were significant statistical differences before treatment and at follow-up in the two groups(the treatment group:16.83 ± 1.56 vs 11.01 ± 3.20,the control group:17.04 ± 1.84 vs 13.68 ± 2.49,both P<0.05).The HAMA scores of the treatment group after treatment and at follow-up were lower than those of the control group(both P<0.05).Conclusion:Body acupuncture and scalp acupuncture combined with extracorporeal shock wave can relieve the clinical symptoms of patients with scapulohumeral periarthritis,ease anxiety and improve daily life activities.展开更多
BACKGROUND Receptor interacting protein kinase 1(RIPK1)-mediated cell death,including apoptosis and necroptosis,belongs to programmed cell death.It has been reported that RIPK1-mediated necroptosis exists in lesions o...BACKGROUND Receptor interacting protein kinase 1(RIPK1)-mediated cell death,including apoptosis and necroptosis,belongs to programmed cell death.It has been reported that RIPK1-mediated necroptosis exists in lesions of cerebral hemorrhage(CH).Electroacupuncture,a treatment derived from traditional Chinese medicine,could improve neurological impairment in patients with brain injury.AIM To investigate the protective role of cross electro-nape acupuncture(CENA)in CH,and clarify the potential mechanism.METHODS CH rat models were established,and CENA was applied to the experimental rats.Neurological functions and encephaledema were then measured.Necrotic cells in the brain of rats with CH were evaluated by propidium iodide staining.Necroptosis was assessed by immunofluorescence.Activation of the necroptosisrelated pathway was detected by western blot.Extraction of brain tissue,cerebrospinal fluid and serum samples was conducted to measure the expression and secretion of inflammatory cytokines by quantitative real-time polymerase chain reaction and enzyme-linked immunosorbent assay.RESULTS The necroptotic marker p-MLKL was detectable in the brains of rats with CH.Next,we found that CENA could ameliorate neurological functions in rat models of CH.Moreover,the upregulation of RIPK1-mediated necroptosis-related molecules in the brains of rats with CH were inhibited by CENA.Further investigation revealed that CENA partially blocked the interaction between RIPK1 and RIPK3.Finally,in vivo assays showed that CENA decreased the expression of the inflammatory cytokines tumor necrosis factor-α,interleukin-6 and interleukin-8 in CH rat models.CONCLUSION These findings revealed that CENA exerts a protective role in CH models by inhibiting RIPK1-mediated necroptosis.展开更多
Objective： To introduce electroacupuncture （EA） treatment on cervical spondylosis radiculopathy （CSR） at home and abroad in the prior ten years. Methods： EA, combined EA and other treatments for NCS are classifi...Objective： To introduce electroacupuncture （EA） treatment on cervical spondylosis radiculopathy （CSR） at home and abroad in the prior ten years. Methods： EA, combined EA and other treatments for NCS are classified and analyzed. Results： The most commonly used acupoints are JiaJi （Ex-B2）, Fengchi （GB 20）, Waiguan （TE 5）, Quchi （LI 11）. EA is widely applied to treat CSR because of its definite therapeutic effects and safety. Conclusion： The validity of other evaluation indexes needs to be proved by more rigorously designed randomized controlled trials （RCT） with scientific methods.展开更多
Objective:To observe the clinical therapeutic effects on nervous olfactory disorder treated with acupuncture at three nasal points and scalp acupuncture.Methods:Acupuncture was applied in 30 eligible patients with ner...Objective:To observe the clinical therapeutic effects on nervous olfactory disorder treated with acupuncture at three nasal points and scalp acupuncture.Methods:Acupuncture was applied in 30 eligible patients with nervous olfactory disorder.The points included three nasal points,i.e.,Yíngxiāng(迎香 LI 20),Shàngyíngxiāng(上迎香 EX-HN 8)and Yìntáng(印堂EX-HN 3),ézhōngxiàn(额中线 middle line of forehead,MS1)and bilateral Nièhòuxiàn(颖后线 posterior temporal line,MS11).The even-needling technique was used to stimulate the three nasal points to ensure deqi. In scalp acupuncture,the needle was rotated continuously at 200 times per min,for 2 min at each scalp acupuncture line.The needles were retained for 40 min at above points and lines and were manipulated once every 20 min during needle retaining.The treatment was given once a day,6-day treatment was as one course and the next course of treatment started after the interval of 1 day.Totally,4 courses of treatment were required.Before and after treatment,T&T olfactory was adopted to test the olfactory function and the score was compared in order to evaluate the therapeutic effect.Results:Of 30 cases,8 cases were cured,20 cases remarkably effective and 2 cases failed.The total effective rate was 93%.Conclusion:Acupuncture at three nasal points and scalp acupuncture are effective approach to nervous olfactory disorder.展开更多
Objective:To observe the clinical efficacy of acupuncture for Meige’s syndrome Ⅱ.Methods:Fourteen patients of Meige’s syndrome Ⅱ were treated with acupuncture.The acupoints included bilateral Tāichōng(太冲LR3),S...Objective:To observe the clinical efficacy of acupuncture for Meige’s syndrome Ⅱ.Methods:Fourteen patients of Meige’s syndrome Ⅱ were treated with acupuncture.The acupoints included bilateral Tāichōng(太冲LR3),Sānyīnjiāo(三阴交SP6),Tāixī(太溪KI3),dance tremor control area of scalp acupuncture(舞蹈震颤控制区),Yángbái(阳白GB14),Sīzhúkōng(丝竹空TE23),Yíngxiāng(迎香LI20),Dìcāng(地仓ST4),Jiāchē(颊车ST6) and Xiàguān(下关ST7),and the needle retention continued for 40 min.The treatment was applied once a day,and there was a 5-day treatment and a 2-day rest every week.One course of treatment included a week,and there were 4 courses of treatment in total.After treatment,the clinical efficacy of the patients was evaluated.Results:4 cases were cured,9 cases were effective,1 case was ineffective,and the effective rate was 92.9%.Conclusions:Acupuncture had a satisfactory clinical therapeutic effect on patients of Meige’s syndrome Ⅱ.展开更多
Two new C-glucoside oxanthrones, 6-methoxyl-10-hydroxyaloin A （1） and 6-methoxyl-10-hydroxyaloin B （2）, were isolated from the roots of Rumex gmelini Turcz. Their structures were elucidated on the basis of spectro...Two new C-glucoside oxanthrones, 6-methoxyl-10-hydroxyaloin A （1） and 6-methoxyl-10-hydroxyaloin B （2）, were isolated from the roots of Rumex gmelini Turcz. Their structures were elucidated on the basis of spectroscopic techniques and chemical means C 2009 Zhen Yue Wang. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All fights reserved.展开更多
Combined acupuncture and Chinese herb decoction were applied for 5 cases with graphospasm.Acupuncture included scalp acupuncture and body acupuncture.Using transcranial repeated needling,Baihui(百会GV20),Chorea-trembl...Combined acupuncture and Chinese herb decoction were applied for 5 cases with graphospasm.Acupuncture included scalp acupuncture and body acupuncture.Using transcranial repeated needling,Baihui(百会GV20),Chorea-trembling controlled area,Emotional area,as well as Dazhui(大椎GV14),Fengchi(风池GB20),and Yingxiang(迎香EX-HN8)etc.were stimulated by proposed by Sun Shentian.Meanwhile,the patients took orally Chinese herb decoction,on the basis of the Siwu decoction(四物汤four substances decoction)addition and subtraction,relieve symptoms under syndrome differentiation.The treatment was carried out for 4 courses in total.One course consisted of 5 days,with an interval of 2 days between two courses.After treatment of 5 patients,2 patients were cured,2 patients achieved markedly effective response,and 1 patient achieved effective response.展开更多
Objective:To observe and compare the clinical effect on knee osteoarthritis(KOA)between Fu’s subcutaneous needling therapy(FSN)and convention acupuncture.Methods:A total of 80 outpatients with KOA were divided into a...Objective:To observe and compare the clinical effect on knee osteoarthritis(KOA)between Fu’s subcutaneous needling therapy(FSN)and convention acupuncture.Methods:A total of 80 outpatients with KOA were divided into a FSN group(40 cases)and a conventional acupuncture group(40 cases)according to random number table.Within 1 week of treatment,FSN was used once every two days in the FSN group.The needle tip of Fu’s subcutaneous needle was inserted toward the affected muscle,about 5 mm in depth,at the angle of 15 to 25°.After the needle body lifted slightly,the needle went forward subcutaneously for 25 to 35 mm in depth and was swiped side to side horizontally with even exertion for about 1 min.According to the distribution of affected muscle,the reperfusion approach was repeated for 3 times consecutively.In the conventional acupuncture group conventional acupuncture was given,once a day,for 6 times totally.The scores of Western Ontario and McMaster universities osteoarthritis index(WOMAC)and Lysholm knee scoring scale(Lysholm)were compared between the two groups before and after 1-week treatment.The clinical effect of the two groups was analyzed statistically and evaluated.Results:After 1-week treatment with FSN,in the FSN group,the score of WOMACpain was reduced to be7.7±1.9 from 18.5±3.2,the score of WOMACstiffnessto be 1.5±0.7 from 4.5±1.8,WOMACfunction to be22.7±3.9 from 45.7±2.7 and the score of WOMACoverall to be 31.9±5.3 from 69.7±6.5.The differences were significant in comparison before and after treatment(all P<0.05).In the conventional acupuncture group,after 1-week treatment with conventional acupuncture,the score of WOMACpain was reduced to be11.3±2.8 from 18.2±3.0,the score of WOMACstiffness to be 3.0±1.6 from 5.6±1.7,WOMACfunction to be29.8±5.1 from 44.3±2.9 and the score of WOMACoverall to be 44.1±7.8 from 69.1±7.3.The differences were significant in comparison before and after treatment(all P<0.05).WOMAC score of every item in the FSN group was lower obviously than that in the conventional acupuncture group(P<0.01).After 1-week treatment,Lysholm score was increased to be 78.52±18.4 from 59.64±18.3 in the FSN group and it was to be 69.27±11.9 from 58.17±12.5 in the conventional acupuncture group.The differences were significant in comparison before and after treatment in either group(both P<0.05).Lysholm score in the FSN group was higher than that in the conventional acupuncture group(P<0.05).The total effective rate was 92.5%in the FSN group,higher than 77.5%in the conventional acupuncture group(P<0.05).Conclusion:Fu’s subcutaneous needling therapy effectively relieves the clinical symptoms of KOA and improves knee joint function.The therapeutic effect is better than that of the regular acupuncture.展开更多
Objective:To observe clinical efficacy differences of regular acupuncture at empirical acupoints combined with join valley needling at ashi point compared with simple join valley needling at ashi point for scapulohume...Objective:To observe clinical efficacy differences of regular acupuncture at empirical acupoints combined with join valley needling at ashi point compared with simple join valley needling at ashi point for scapulohumeral periarthritis.Methods:Sixty-four patients of scapulohumeral periarthritis were randomly divided into an observation group and a control group,32 cases in each one.Both groups underwent basic rehabilitation training.Patients in the observation group were treated with acupuncture at empirical acupoints combined with join valley needling at ashi point,while the patients of the control group were treated with simple join valley needling at ashi point.Both groups were all treated once a day,6 times a week.Patients were treated for one course which lasted for 4 weeks.The visual analog scale(VAS)score,the Constant-Murley score and the Hamilton Anxiety Scale(HAMA)are compared between the two groups before and after the treatment,and the efficacy was evaluated after the treatment.Telephone investigation was applied as the followed-up after one month of the treatment.Results:The total effective rate in the observation group was 87.5%(28/32),and that in the control group was 71.9%(23/32),and there was statistically significant difference between the two groups(P<0.05).The VAS scores,Constant-Murley scores,and HAMA scores in the patients of the observation group were lower than those of the corresponding indicators in the patients of the control group respectively,and there were statistically significant differences(all P<0.05).Conclusions:Compared with simple join valley needling at ashi point,regular acupuncture at empirical acupoints combined with join valley needling at ashi point can relieve the clinical symptoms of patients with scapulohumeral periarthritis,attenuate pains,ease anxiety and improve daily life activities better.展开更多
基金Joint Orientation Program of the Heilongjiang Nature Foundation(NO.LH2020H086)Chinese Medicine Council of Heilongjiang(NO.ZHY10-W22)。
文摘Objective:To study the mechanism of Shengsui Jiangu Capsule promoting vitamin D_(3)regulating bone turnover in rats with alcoholic osteoporosis.Methods:120 SD rats were randomly divided into four groups:model group(alcoholic osteoporosis model group),blank control group,western medicine control group(calcium carbonate tablet and affa D_(3)control group),Chinese medicine experimental group(Shengsui Jiangu capsule experimental group),30 rats in each group.After 8,12 and 16 weeks,the serum levels of 25 hydroxyvitamin D_(3)(25(OH)D_(3)),1,25dihydroxyvitamin D_(3)(1,25(OH)_(2)D_(3)),cross-linked carboxy-terminal peptide of type 1 collagen(β-CTX)and N-terminal propeptide of type 1 collagen(P1NP)in rats and the density of the femur of rats were detected and compared.The correlation between vitamin D_(3)markers(25(OH)D_(3)and 1,25(OH)_(2)D_(3))and bone turnover indices(P1NP andβ-CTX)and bone mineral density was analyzed.Results:In the experimental group,bone mineral density(BMD)was significantly increased(P<0.01),bone repair and mineral stability and balance were maintained during bone turnover,the level of bone formation marker P1NP was significantly increased(P<0.01),and the level of bone resorption markerβ-CTX was significantly decreased(P<0.01).Serum levels of 25(OH)D_(3)and 1,25(OH)_(2)D_(3)were increased(P<0.01),and significantly higher than those in western medicine control group(P<0.05).Conclusion:Shengsui Jiangu capsule can effectively improve bone density in alcoholic osteoporosis(AOP)rats,and its mechanism may be related to promoting bone calcium absorption and regulating bone conversion.
基金Joint Orientation Program of the Heilongjiang Nature Foundation(No.LH2020H086)Chinese Medicine Council of Heilongjiang(No.ZHY10-W22)。
文摘TGF-Objective:To investigate the effect of postgraduate Shengsui Jiangu Capsule on tumor necrosis factors TNF-α,transforming growth factor TGF-β1 and empty bone lacuna in rats with alcoholic osteoporosis.Method:120 SD rats were randomly divided into 4 groups,30 rats in each group:blank group,model group,western medicine control group and traditional Chinese medicine intervention group.Liquor gavage was used to model the disease,except for the blank group.The western medicine control group was gavaged with a suspension of calcium carbonate and afad3,while the Chinese medicine intervention group was gavaged with a suspension of Shengsui Jiangu capsules combined with 0.9%saline solution injection.The values of TNF-αand TGF-β1 in femora were measured after 8,12,and 16 weeks of intervention.After dissecting out the femoral head using the HE(hematoxylin-eosin staining)staining method,the bone lacunae were observed under a light microscope,and the empty bone lacunae rate was calculated for intergroup comparison.Results:Compared with the blank group,the model group had a significantly higher percentage of TNF-αand empty bone lacunae,and a significantly lower percentage of TGF-β1(P<0.01).Compared with the model group,the rates of TNF-αand empty bone lacunae in the western medicine control group and the Chinese medicine intervention group were significantly decreased,and TGF-β1 was significantly increased(P<0.01).The traditional Chinese medicine intervention group was more effective than the western medicine control group(P<0.05).Conclusion:Shengsui Jiangu capsule attenuates the expression of TNF-α,enhances the expression of TGF-β1,decreases the rate of empty bone lacunae,and achieves a protective effect against alcoholic osteoporosis in rats with alcoholic osteoporosis.
基金Supported by Key scientific research project of Heilongjiang administration of traditional Chinese medicine:No.ZHY18-065Inheritance studio project of national fa-mous traditional Chinese medicine experts Sun Yuanzheng,National education of traditional Chinese medicine:No.[2014]20Postgraduate innovative research project of Heilongjiang University of traditional Chinese medicine:No.2018yjscx047
文摘Objective:To observe the short-and long-term clinical efficacy differences of body acupuncture and scalp acupuncture combined with extracorporeal shock wave and simple extracorporeal shock wave.Methods:Sixty patients with scapulohumeral periarthritis were randomly divided into two groups:the treatment group and control group,30 cases in each one.Both groups underwent basic rehabilitation training.Patients in the treatment group were treated with body acupuncture and scalp acupuncture combined with extracorporeal shock wave.Yújì(鱼际 LU10),Hégǔ(合谷L14),Zhōngzhǔ(中渚TE3),Hòuxī(后溪SI3).There were three needles for the scalp acupuncture with the first between Shéntíng(神庭 GV24)and Yìntáng(印堂 EX-HN3),and the other two straightly through the inner canthus and parallel to the first needle.Shock wave treatment was intensively applied in some pressure points around shoulder joint.The control group used the same shock wave therapy as the treatment group.Both groups were all treated once a day,6 times a week.Patients were treated for one course which lasted for 4 weeks.VAS score,the Constant-Murley score and the HAMA(the Hamilton Anxiety Scale)are as therapeutic effect index.30 days telephone investigation followed-up after the treatment course was evaluated.Results:Totally 28 cases completed the clinical observation in the treatment group,and 29 cases in the control group.The total effective rate of the treatment group was 85.7%(24/28),which was higher than 69.0%(20/29)of the control group(P<0.05).VAS score:There were significant statistical differences before and after the treatment in the two groups(the treatment group:6.67 ± 1.43 vs 3.47 ± 1.35,the control group:7.57 ± 1.31 vs 5.36 ± 1.45,both P<0.05).There were significant statistical differences before the treatment and at the follow-up in the two groups(the treatment group:6.67 ± 1.43 vs2.68±0.81,the control group:7.57±1.31 vs 4.56±1.35,both P<0.05).The VAS scores of the treatment group after treatment and at the follow-up were respectively lower than those of the control group(both P<0.05).Shoulder joints activity score:There were significant statistical differences before and after the treatment in the two groups(the treatment group:54.65±1.65 vs 65.54±2.19,the control group:54.32 ± 2.31 vs 61.01 ± 0.95,both P<0.05).There were significant statistical differences before treatment and at follow-up in the two groups(the treatment group:54.65 ± 1.65 vs 66.18± 1.35,the control group:54.32 ± 2.31 vs 62.11 ± 1.49,both P<0.05).The shoulder activity scores of the treatment group after treatment and at follow-up were respectively higher than those of the control group(both P<0.05).HAMA scores:There were singificant statistical differences before and after treatment in the two groups(the treatment group:16.83 ± 1.56 vs 13.26 ± 2.36,the control group:17.04 ± 1.84 vs 15.23 ±3.17,both P<0.05).There were significant statistical differences before treatment and at follow-up in the two groups(the treatment group:16.83 ± 1.56 vs 11.01 ± 3.20,the control group:17.04 ± 1.84 vs 13.68 ± 2.49,both P<0.05).The HAMA scores of the treatment group after treatment and at follow-up were lower than those of the control group(both P<0.05).Conclusion:Body acupuncture and scalp acupuncture combined with extracorporeal shock wave can relieve the clinical symptoms of patients with scapulohumeral periarthritis,ease anxiety and improve daily life activities.
基金Supported by State Administration of Traditional Chinese Medicine of Heilongjiang Province,No.ZHY16-027Harbin Municipal Science and Technology BureauYouth Reserve Talent Project,No.2017RAQXJ170
文摘BACKGROUND Receptor interacting protein kinase 1(RIPK1)-mediated cell death,including apoptosis and necroptosis,belongs to programmed cell death.It has been reported that RIPK1-mediated necroptosis exists in lesions of cerebral hemorrhage(CH).Electroacupuncture,a treatment derived from traditional Chinese medicine,could improve neurological impairment in patients with brain injury.AIM To investigate the protective role of cross electro-nape acupuncture(CENA)in CH,and clarify the potential mechanism.METHODS CH rat models were established,and CENA was applied to the experimental rats.Neurological functions and encephaledema were then measured.Necrotic cells in the brain of rats with CH were evaluated by propidium iodide staining.Necroptosis was assessed by immunofluorescence.Activation of the necroptosisrelated pathway was detected by western blot.Extraction of brain tissue,cerebrospinal fluid and serum samples was conducted to measure the expression and secretion of inflammatory cytokines by quantitative real-time polymerase chain reaction and enzyme-linked immunosorbent assay.RESULTS The necroptotic marker p-MLKL was detectable in the brains of rats with CH.Next,we found that CENA could ameliorate neurological functions in rat models of CH.Moreover,the upregulation of RIPK1-mediated necroptosis-related molecules in the brains of rats with CH were inhibited by CENA.Further investigation revealed that CENA partially blocked the interaction between RIPK1 and RIPK3.Finally,in vivo assays showed that CENA decreased the expression of the inflammatory cytokines tumor necrosis factor-α,interleukin-6 and interleukin-8 in CH rat models.CONCLUSION These findings revealed that CENA exerts a protective role in CH models by inhibiting RIPK1-mediated necroptosis.
文摘Objective： To introduce electroacupuncture （EA） treatment on cervical spondylosis radiculopathy （CSR） at home and abroad in the prior ten years. Methods： EA, combined EA and other treatments for NCS are classified and analyzed. Results： The most commonly used acupoints are JiaJi （Ex-B2）, Fengchi （GB 20）, Waiguan （TE 5）, Quchi （LI 11）. EA is widely applied to treat CSR because of its definite therapeutic effects and safety. Conclusion： The validity of other evaluation indexes needs to be proved by more rigorously designed randomized controlled trials （RCT） with scientific methods.
文摘Objective:To observe the clinical therapeutic effects on nervous olfactory disorder treated with acupuncture at three nasal points and scalp acupuncture.Methods:Acupuncture was applied in 30 eligible patients with nervous olfactory disorder.The points included three nasal points,i.e.,Yíngxiāng(迎香 LI 20),Shàngyíngxiāng(上迎香 EX-HN 8)and Yìntáng(印堂EX-HN 3),ézhōngxiàn(额中线 middle line of forehead,MS1)and bilateral Nièhòuxiàn(颖后线 posterior temporal line,MS11).The even-needling technique was used to stimulate the three nasal points to ensure deqi. In scalp acupuncture,the needle was rotated continuously at 200 times per min,for 2 min at each scalp acupuncture line.The needles were retained for 40 min at above points and lines and were manipulated once every 20 min during needle retaining.The treatment was given once a day,6-day treatment was as one course and the next course of treatment started after the interval of 1 day.Totally,4 courses of treatment were required.Before and after treatment,T&T olfactory was adopted to test the olfactory function and the score was compared in order to evaluate the therapeutic effect.Results:Of 30 cases,8 cases were cured,20 cases remarkably effective and 2 cases failed.The total effective rate was 93%.Conclusion:Acupuncture at three nasal points and scalp acupuncture are effective approach to nervous olfactory disorder.
基金Supported by the Construction Project of The Third Traditional Chinese Medicine Master Inheritance Studiothe National Famous Traditional Chinese Medicine Inheritance Studio:20180713
文摘Objective:To observe the clinical efficacy of acupuncture for Meige’s syndrome Ⅱ.Methods:Fourteen patients of Meige’s syndrome Ⅱ were treated with acupuncture.The acupoints included bilateral Tāichōng(太冲LR3),Sānyīnjiāo(三阴交SP6),Tāixī(太溪KI3),dance tremor control area of scalp acupuncture(舞蹈震颤控制区),Yángbái(阳白GB14),Sīzhúkōng(丝竹空TE23),Yíngxiāng(迎香LI20),Dìcāng(地仓ST4),Jiāchē(颊车ST6) and Xiàguān(下关ST7),and the needle retention continued for 40 min.The treatment was applied once a day,and there was a 5-day treatment and a 2-day rest every week.One course of treatment included a week,and there were 4 courses of treatment in total.After treatment,the clinical efficacy of the patients was evaluated.Results:4 cases were cured,9 cases were effective,1 case was ineffective,and the effective rate was 92.9%.Conclusions:Acupuncture had a satisfactory clinical therapeutic effect on patients of Meige’s syndrome Ⅱ.
基金supported by the National Natural Science Foundation of China(No.30270156).
文摘Two new C-glucoside oxanthrones, 6-methoxyl-10-hydroxyaloin A （1） and 6-methoxyl-10-hydroxyaloin B （2）, were isolated from the roots of Rumex gmelini Turcz. Their structures were elucidated on the basis of spectroscopic techniques and chemical means C 2009 Zhen Yue Wang. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All fights reserved.
文摘Combined acupuncture and Chinese herb decoction were applied for 5 cases with graphospasm.Acupuncture included scalp acupuncture and body acupuncture.Using transcranial repeated needling,Baihui(百会GV20),Chorea-trembling controlled area,Emotional area,as well as Dazhui(大椎GV14),Fengchi(风池GB20),and Yingxiang(迎香EX-HN8)etc.were stimulated by proposed by Sun Shentian.Meanwhile,the patients took orally Chinese herb decoction,on the basis of the Siwu decoction(四物汤four substances decoction)addition and subtraction,relieve symptoms under syndrome differentiation.The treatment was carried out for 4 courses in total.One course consisted of 5 days,with an interval of 2 days between two courses.After treatment of 5 patients,2 patients were cured,2 patients achieved markedly effective response,and 1 patient achieved effective response.
基金Supported by Outstanding Innovation Talent Support Project of Heilongjiang University of Traditional Chinese Medicine:2018RCD10:the ForthTerm National Chinese Medicine(Clinical and Basic Research)Outstanding Talent Advanced Training Program,State Administration of Traditional Chinese Medicine:National TCM Education[2017]24.
文摘Objective:To observe and compare the clinical effect on knee osteoarthritis(KOA)between Fu’s subcutaneous needling therapy(FSN)and convention acupuncture.Methods:A total of 80 outpatients with KOA were divided into a FSN group(40 cases)and a conventional acupuncture group(40 cases)according to random number table.Within 1 week of treatment,FSN was used once every two days in the FSN group.The needle tip of Fu’s subcutaneous needle was inserted toward the affected muscle,about 5 mm in depth,at the angle of 15 to 25°.After the needle body lifted slightly,the needle went forward subcutaneously for 25 to 35 mm in depth and was swiped side to side horizontally with even exertion for about 1 min.According to the distribution of affected muscle,the reperfusion approach was repeated for 3 times consecutively.In the conventional acupuncture group conventional acupuncture was given,once a day,for 6 times totally.The scores of Western Ontario and McMaster universities osteoarthritis index(WOMAC)and Lysholm knee scoring scale(Lysholm)were compared between the two groups before and after 1-week treatment.The clinical effect of the two groups was analyzed statistically and evaluated.Results:After 1-week treatment with FSN,in the FSN group,the score of WOMACpain was reduced to be7.7±1.9 from 18.5±3.2,the score of WOMACstiffnessto be 1.5±0.7 from 4.5±1.8,WOMACfunction to be22.7±3.9 from 45.7±2.7 and the score of WOMACoverall to be 31.9±5.3 from 69.7±6.5.The differences were significant in comparison before and after treatment(all P<0.05).In the conventional acupuncture group,after 1-week treatment with conventional acupuncture,the score of WOMACpain was reduced to be11.3±2.8 from 18.2±3.0,the score of WOMACstiffness to be 3.0±1.6 from 5.6±1.7,WOMACfunction to be29.8±5.1 from 44.3±2.9 and the score of WOMACoverall to be 44.1±7.8 from 69.1±7.3.The differences were significant in comparison before and after treatment(all P<0.05).WOMAC score of every item in the FSN group was lower obviously than that in the conventional acupuncture group(P<0.01).After 1-week treatment,Lysholm score was increased to be 78.52±18.4 from 59.64±18.3 in the FSN group and it was to be 69.27±11.9 from 58.17±12.5 in the conventional acupuncture group.The differences were significant in comparison before and after treatment in either group(both P<0.05).Lysholm score in the FSN group was higher than that in the conventional acupuncture group(P<0.05).The total effective rate was 92.5%in the FSN group,higher than 77.5%in the conventional acupuncture group(P<0.05).Conclusion:Fu’s subcutaneous needling therapy effectively relieves the clinical symptoms of KOA and improves knee joint function.The therapeutic effect is better than that of the regular acupuncture.
基金Supported by National Traditional Chinese Medicine clinical characteristic technology inheritance backbone talent training program:National Administration of Traditional Chinese Medicine 2019 No.36Innovative research project for postgraduates of Heilongjiang University of Traditional Chinese Medicine:2018yjscx047
文摘Objective:To observe clinical efficacy differences of regular acupuncture at empirical acupoints combined with join valley needling at ashi point compared with simple join valley needling at ashi point for scapulohumeral periarthritis.Methods:Sixty-four patients of scapulohumeral periarthritis were randomly divided into an observation group and a control group,32 cases in each one.Both groups underwent basic rehabilitation training.Patients in the observation group were treated with acupuncture at empirical acupoints combined with join valley needling at ashi point,while the patients of the control group were treated with simple join valley needling at ashi point.Both groups were all treated once a day,6 times a week.Patients were treated for one course which lasted for 4 weeks.The visual analog scale(VAS)score,the Constant-Murley score and the Hamilton Anxiety Scale(HAMA)are compared between the two groups before and after the treatment,and the efficacy was evaluated after the treatment.Telephone investigation was applied as the followed-up after one month of the treatment.Results:The total effective rate in the observation group was 87.5%(28/32),and that in the control group was 71.9%(23/32),and there was statistically significant difference between the two groups(P<0.05).The VAS scores,Constant-Murley scores,and HAMA scores in the patients of the observation group were lower than those of the corresponding indicators in the patients of the control group respectively,and there were statistically significant differences(all P<0.05).Conclusions:Compared with simple join valley needling at ashi point,regular acupuncture at empirical acupoints combined with join valley needling at ashi point can relieve the clinical symptoms of patients with scapulohumeral periarthritis,attenuate pains,ease anxiety and improve daily life activities better.
