Objective: The aim of this study was to investigate the cancer incidence and mortality in Huai’an area, China, 2010. Methods: On basis of the criteria of data quality from National Central Cancer Registry (NCCR), dat...Objective: The aim of this study was to investigate the cancer incidence and mortality in Huai’an area, China, 2010. Methods: On basis of the criteria of data quality from National Central Cancer Registry (NCCR), data submitted from 8 registries in Huai’an area in 2010 were checked and evaluated. Descriptive analysis included incidence and mortality stratified by areas (urban/rural), sex, age group and cancer sites. Results: The crude incidence rate was 231.17/100,000 (males 276.04/100,000, females 183.87/100,000), age-standardized incidence rate by Chinese standard population (ASIRC) was 179.53/100,000 and by World standard population (ASIRW) was 177.24/ 100,000. The incidence rates increased rapidly in people aged 40 and over, and the peak ages of incidence were at 75 - 79 (males over 85, females at 75 - 79). The cancer mortality rate was 151.26/100,000 (186.06/100,000 in males and 114.58/100,000 in females), age-standardized mortality rate by Chinese standard population (ASMRC) was 116.67/100,000 and by World standard population (ASMRW) was 115.64/100,000. The mortality rates increased rapidly after the age of 50, reaching the peak at the ages over 85 in both males and females. Esophageal, lung, gastric, liver, colorectal, breast, pancreas, lymphoma, brain and central nervous system,?cervical were the most common cancer incident sites. Esophageal, lung, liver, gastric, colorectal, pancreatic, brain and central nervous system, leukemia, breast and lymphoma were the most common cancer sites of death. Conclusions: The data quality of cancer registration is improving. As cancer burden remained high and was different between urban and rural areas, prevention and control should be implemented based on practical situation.展开更多
To understand the CH_(4) flux variations and their climatic drivers in the rice-wheat agroecosystem in the Huai River Basin of China,the CH_(4) flux was observed by using open-path eddy covariance at a typical rice-wh...To understand the CH_(4) flux variations and their climatic drivers in the rice-wheat agroecosystem in the Huai River Basin of China,the CH_(4) flux was observed by using open-path eddy covariance at a typical rice-wheat rotation system in Anhui Province,China from November 2019 to October 2021.The variations and their drivers were then analyzed with the Akaike information criterion method.CH_(4) flux showed distinct diurnal variations with single peaks during 9:00-13:00 local time.The highest peak was 2.15μg m^(-2)s^(-1)which occurred at 11:00 in the vegetative growth stage in the rice growing season(RGS).CH_(4) flux also showed significant seasonal variations.The average CH_(4)flux in the vegetative growth stage in the RGS(193.8±74.2 mg m^(-2)d^(-1))was the highest among all growth stages.The annual total CH_(4) flux in the non-rice growing season(3.2 g m^(-2))was relatively small compared to that in the RGS(23.9 g m^(-2)).CH_(4) flux increased significantly with increase in air temperature,soil temperature,and soil water content in both the RGS and the non-RGS,while it decreased significantly with increase in vapor pressure deficit in the RGS.This study provided a comprehensive understanding of the CH_(4) flux and its drivers in the rice-wheat rotation agroecosystem in the Huai River Basin of China.In addition,our findings will be helpful for the validation and adjustment of the CH_(4) models in this region.展开更多
Summary What is already known about this topic?Maintaining a healthy diet and appropriate weight during pregnancy is crucial for both the expectant mother and the fetus.Unhealthy eating behaviors(UEBs)such as eating o...Summary What is already known about this topic?Maintaining a healthy diet and appropriate weight during pregnancy is crucial for both the expectant mother and the fetus.Unhealthy eating behaviors(UEBs)such as eating out frequently are becoming increasingly prevalent across the globe.However,there is a dearth of research investigating the relationship between UEBs and gestational weight gain(GWG)specifically in the context of Chinese women.展开更多
目的:依据药物基因组学结果,探讨抗精神病药对首发精神分裂症患者疗效和药物不良反应的影响。方法:纳入2020年1月至2022年6月淮安市第三人民医院的首发精神分裂症患者,分为研究组和对照组各100例,研究组根据基因检测结果指导用药,对照...目的:依据药物基因组学结果,探讨抗精神病药对首发精神分裂症患者疗效和药物不良反应的影响。方法:纳入2020年1月至2022年6月淮安市第三人民医院的首发精神分裂症患者,分为研究组和对照组各100例,研究组根据基因检测结果指导用药,对照组依据医师经验用药,分别于治疗前、治疗后4、8、12、16周使用阳性和阴性症状量表(positive and negative syndrome scale,PANSS)、临床疗效总评量表(clinical global impression,CGI)评定疗效,威斯康星卡片分类测验(Wisconsin card classification tests,WCST)及个人和社会功能评估量表(personal and social function assessment scales,PSP)评定认知及社会功能,并在治疗前后和两组之间比较,同时评定药物副反应量表(treatment emergent symptom scale,TESS)及作实验室检查,了解药物不良反应。结果:两组患者治疗后的PANSS总分、CGI、TESS、PSP、WCST等评分均较治疗前显著改善(P<0.05或P<0.001),研究组患者明显好于对照组(P<0.05或P<0.001),治疗后12~16周肝功能损害也轻于对照组,差异均有统计学意义(P<0.05或P<0.001)。血常规等实验室结果两组间差异无统计学意义(P>0.05)。结论:应用基因检测可提高精神分裂症患者药物治疗临床效果,减少不良反应的发生,指导临床合理、精准用药和个体化治疗。展开更多
目的 建立一种Qu ECh ERS EMR-Lipid净化结合同位素稀释-超高效液相色谱-串联质谱技术(UPLC-MS/MS)同时测定蜂房及其制剂中10种真菌毒素的检测方法。方法 样品经80%乙腈水溶液提取,Qu ECh ERS EMRLipid净化,采用UPLC-MS/MS,在多反应监测...目的 建立一种Qu ECh ERS EMR-Lipid净化结合同位素稀释-超高效液相色谱-串联质谱技术(UPLC-MS/MS)同时测定蜂房及其制剂中10种真菌毒素的检测方法。方法 样品经80%乙腈水溶液提取,Qu ECh ERS EMRLipid净化,采用UPLC-MS/MS,在多反应监测(MRM)模式下进行测定,内标法定量。结果 10种真菌毒素含量在各自质量浓度范围内具有较好的线性关系(r>0.999),目标化合物在低、中、高3个质量浓度下的平均回收率为83.8%~107.1%(RSD<6.5%),定量限(LOQ)为0.18~129μg/kg。结论 该法前处理步骤简便,净化效果良好,提高了样品检测效率,内标法定量精准可靠,适用于蜂房及其制剂中10种真菌毒素的同时检测。展开更多
文摘Objective: The aim of this study was to investigate the cancer incidence and mortality in Huai’an area, China, 2010. Methods: On basis of the criteria of data quality from National Central Cancer Registry (NCCR), data submitted from 8 registries in Huai’an area in 2010 were checked and evaluated. Descriptive analysis included incidence and mortality stratified by areas (urban/rural), sex, age group and cancer sites. Results: The crude incidence rate was 231.17/100,000 (males 276.04/100,000, females 183.87/100,000), age-standardized incidence rate by Chinese standard population (ASIRC) was 179.53/100,000 and by World standard population (ASIRW) was 177.24/ 100,000. The incidence rates increased rapidly in people aged 40 and over, and the peak ages of incidence were at 75 - 79 (males over 85, females at 75 - 79). The cancer mortality rate was 151.26/100,000 (186.06/100,000 in males and 114.58/100,000 in females), age-standardized mortality rate by Chinese standard population (ASMRC) was 116.67/100,000 and by World standard population (ASMRW) was 115.64/100,000. The mortality rates increased rapidly after the age of 50, reaching the peak at the ages over 85 in both males and females. Esophageal, lung, gastric, liver, colorectal, breast, pancreas, lymphoma, brain and central nervous system,?cervical were the most common cancer incident sites. Esophageal, lung, liver, gastric, colorectal, pancreatic, brain and central nervous system, leukemia, breast and lymphoma were the most common cancer sites of death. Conclusions: The data quality of cancer registration is improving. As cancer burden remained high and was different between urban and rural areas, prevention and control should be implemented based on practical situation.
基金supported by the Natural Science Foundation of Jiangsu Province,China(BK20220017)the Innovation Development Project of China Meteorological Administration(CXFZ2023J073)+1 种基金the Key Research and Development Program of Anhui Province,China(2022M07020003)the Graduate Student Practice and Innovation Program of Jiangsu Province,China(SJCX22_0374)。
文摘To understand the CH_(4) flux variations and their climatic drivers in the rice-wheat agroecosystem in the Huai River Basin of China,the CH_(4) flux was observed by using open-path eddy covariance at a typical rice-wheat rotation system in Anhui Province,China from November 2019 to October 2021.The variations and their drivers were then analyzed with the Akaike information criterion method.CH_(4) flux showed distinct diurnal variations with single peaks during 9:00-13:00 local time.The highest peak was 2.15μg m^(-2)s^(-1)which occurred at 11:00 in the vegetative growth stage in the rice growing season(RGS).CH_(4) flux also showed significant seasonal variations.The average CH_(4)flux in the vegetative growth stage in the RGS(193.8±74.2 mg m^(-2)d^(-1))was the highest among all growth stages.The annual total CH_(4) flux in the non-rice growing season(3.2 g m^(-2))was relatively small compared to that in the RGS(23.9 g m^(-2)).CH_(4) flux increased significantly with increase in air temperature,soil temperature,and soil water content in both the RGS and the non-RGS,while it decreased significantly with increase in vapor pressure deficit in the RGS.This study provided a comprehensive understanding of the CH_(4) flux and its drivers in the rice-wheat rotation agroecosystem in the Huai River Basin of China.In addition,our findings will be helpful for the validation and adjustment of the CH_(4) models in this region.
基金This study was funded by grants to XX from China Medical Board Open Competition Program(21-416)grants to XZ from Jiangsu Maternal and Child Health Program(F201932)+1 种基金Key Medical Program of Jiangsu Health Commission(ZD2021044)Huai’an Science and Technology Program(HAB202043).
文摘Summary What is already known about this topic?Maintaining a healthy diet and appropriate weight during pregnancy is crucial for both the expectant mother and the fetus.Unhealthy eating behaviors(UEBs)such as eating out frequently are becoming increasingly prevalent across the globe.However,there is a dearth of research investigating the relationship between UEBs and gestational weight gain(GWG)specifically in the context of Chinese women.
文摘目的:依据药物基因组学结果,探讨抗精神病药对首发精神分裂症患者疗效和药物不良反应的影响。方法:纳入2020年1月至2022年6月淮安市第三人民医院的首发精神分裂症患者,分为研究组和对照组各100例,研究组根据基因检测结果指导用药,对照组依据医师经验用药,分别于治疗前、治疗后4、8、12、16周使用阳性和阴性症状量表(positive and negative syndrome scale,PANSS)、临床疗效总评量表(clinical global impression,CGI)评定疗效,威斯康星卡片分类测验(Wisconsin card classification tests,WCST)及个人和社会功能评估量表(personal and social function assessment scales,PSP)评定认知及社会功能,并在治疗前后和两组之间比较,同时评定药物副反应量表(treatment emergent symptom scale,TESS)及作实验室检查,了解药物不良反应。结果:两组患者治疗后的PANSS总分、CGI、TESS、PSP、WCST等评分均较治疗前显著改善(P<0.05或P<0.001),研究组患者明显好于对照组(P<0.05或P<0.001),治疗后12~16周肝功能损害也轻于对照组,差异均有统计学意义(P<0.05或P<0.001)。血常规等实验室结果两组间差异无统计学意义(P>0.05)。结论:应用基因检测可提高精神分裂症患者药物治疗临床效果,减少不良反应的发生,指导临床合理、精准用药和个体化治疗。
