Objective To analyze the hints role of surveillance cultures of Carbapenem-resistant Enterobacteriaceae(CRE) by perianal swabs in patients with hematological diseases,and seek risk factors of CRE bloodstream infection.
Objective To investigate the risk factors of intestinal acute graft-versus-host disease(aGVHD)after allogeneic hematopoietic stem cell transplantation(allo-HSCT).Methods The clinical data of 534 cases of 533 patients ...Objective To investigate the risk factors of intestinal acute graft-versus-host disease(aGVHD)after allogeneic hematopoietic stem cell transplantation(allo-HSCT).Methods The clinical data of 534 cases of 533 patients undergoing allo-HSCT during Jan 2004 and Sep 2012were retrospectively analyzed.The effects of donor-recipient展开更多
Objective To explore the impact of interleukin-18(IL-18)single nucleotide polymorphisms on outcomes of hematologic malignancies with HLA-matched sibling donor hematopoietic stem cell transplantation(allo-HSCT).Methods...Objective To explore the impact of interleukin-18(IL-18)single nucleotide polymorphisms on outcomes of hematologic malignancies with HLA-matched sibling donor hematopoietic stem cell transplantation(allo-HSCT).Methods Single-nucleotide polymorphisms in IL-18 promoter was detected by PCR-sequence-specific primer analysis(PCR-SSP)in 93 recipients and their HLA matched sibling donors.Hematopoietic reconstitution,展开更多
Objective To explore the efficacy and prognosis of first-line autologous hematopoietic stem cell transplantation(ASCT) for newly diagnosed patients with multiple myeloma(MM).Methods From January 2005
Objective To compare the time of the recovery of neutrophils or leukocytes by pegylated recombinant human granulocyte stimulating factor(PEG-rhG-CSF)or common recombinant human granulocyte stimulating factor(rhG-CSF)i...Objective To compare the time of the recovery of neutrophils or leukocytes by pegylated recombinant human granulocyte stimulating factor(PEG-rhG-CSF)or common recombinant human granulocyte stimulating factor(rhG-CSF)in the myelosuppressive phase after induction chemotherapy in newly diagnosed acute myeloid leukemia(AML)patients.At the same time,the incidences of infection and hospitalization were compared.Methods A prospective randomized controlled trial was conducted in patients with newly diagnosed AML who met the enrollment criteria from August 2014 to December 2017.The patients were randomly divided into two groups according to a 1∶1 ratio:PEG-rhG-CSF group and rhG-CSF group.The time of neutrophil or leukocyte recovery,infection rate and hospitalization interval were compared between the two groups.Results 60 patients with newly diagnosed AML were enrolled:30 patients in the PEG-rhG-CSF group and 30 patients in the rhG-CSF group.There were no significant differences in age,chemotherapy regimen,pre-chemotherapy ANC,WBC,and induction efficacy between the two groups(P>0.05).The median time(range)of ANC or WBC recovery in patients with PEG-rhG-CSF and rhG-CSF were 19(14-35)d and 19(15-26)d,respectively,with no statistical difference(P=0.566).The incidences of infection in the PEG-rhG-CSF group and the rhG-CSF group were 90.0%and 93.3%,respectively,and there was no statistical difference(P=1.000).The median days of hospitalization(range)was 20.5(17-49)days and 21(19-43)days,respectively,with no statistical difference(P=0.530).Conclusion In AML patients after induction therapy,there was no significant difference between the application of PEG-rhG-CSF and daily rhG-CSF in ANC or WBC recovery time,infection incidence and hospitalization time.展开更多
Objective To explore the impact of IFN-γ+874 polymorphisms on the outcome in HLA matched sibling HSCT. Methods We used PCR-sequence-specific primer analysis(PCR-SSP) to analyze the polymorphisms of IFN-γ+874 T/A in ...Objective To explore the impact of IFN-γ+874 polymorphisms on the outcome in HLA matched sibling HSCT. Methods We used PCR-sequence-specific primer analysis(PCR-SSP) to analyze the polymorphisms of IFN-γ+874 T/A in 80 recipient and donor pairs展开更多
Objective To explore the clinical features of autoimmune hemolytic anemia(AIHA)with monoclonal gammopathy IgMk.Methods The clinical and laboratory features of 12 AIHA with monoclonal gammopathy Ig Mκwere retrospectiv...Objective To explore the clinical features of autoimmune hemolytic anemia(AIHA)with monoclonal gammopathy IgMk.Methods The clinical and laboratory features of 12 AIHA with monoclonal gammopathy Ig Mκwere retrospectively analyzed.Results 12 cases with monoclonal immunoglobulin Igmκwere found in 85 pa-展开更多
Objective To explore the diagnosis and differential diagnosis of refractory cytopenia of children(RCC) according to WHO classification,and discuss the relationship between the cytology reviewed by hematologists and hi...Objective To explore the diagnosis and differential diagnosis of refractory cytopenia of children(RCC) according to WHO classification,and discuss the relationship between the cytology reviewed by hematologists and histology reviewed by pathologists.展开更多
Objective To explore the clinical and laboratory characteristics,treatment,prognostic factors of acute lymphoblastic leukemia(ALL)in adolescents.Methods Adolescents de novo ALL patients in Blood Disease Hospital,Pekin...Objective To explore the clinical and laboratory characteristics,treatment,prognostic factors of acute lymphoblastic leukemia(ALL)in adolescents.Methods Adolescents de novo ALL patients in Blood Disease Hospital,Peking Union Medical College,Chinese Academy of Medical Sciences from September 1999 to September2013 were enrolled in this study.Clinical data,thera-展开更多
Objective To summarize clinical and genetic features of childhood dyskeratosis congenital(DC)patients with bone marrow failure.Methods The clinical data of 8 DC patients with bone marrow failure diagnosed between Sept...Objective To summarize clinical and genetic features of childhood dyskeratosis congenital(DC)patients with bone marrow failure.Methods The clinical data of 8 DC patients with bone marrow failure diagnosed between September 2010 and September 2015 were collected.Whole exons with flanking regions of the 16展开更多
Objective To investigate the treatment outcomes of autologous stem cell transplantation(ASCT)as first-line treatment in patients with high risk lymphoblastic lymphoma(LBL)and compare the effect of different induction ...Objective To investigate the treatment outcomes of autologous stem cell transplantation(ASCT)as first-line treatment in patients with high risk lymphoblastic lymphoma(LBL)and compare the effect of different induction regimen on prognosis.Methods Thirty LBL patients in complete remission received ASCT from 1996 to 2012in our hospital were retrospectively analyzed.展开更多
Objective To explore the efficacy and safety of bortezomib(btz) based chemotherapy in multiple myeloma(MM) patients with renal-function impairment(RI).Methods Fifty-six MM patients with impaired renal
Objective To compare the efficacy and toxicities of combining homoharringtonine(HHT)±daunorubicin(DNR)with all-transretinoic acid(ATRA)based therapy and DNR plus ATRA based therapy in newly diagnosed low/intermed...Objective To compare the efficacy and toxicities of combining homoharringtonine(HHT)±daunorubicin(DNR)with all-transretinoic acid(ATRA)based therapy and DNR plus ATRA based therapy in newly diagnosed low/intermediate risk acute promyelocytic leukemia(APL).Methods A total of 96 newly diagnosed pa-展开更多
Objective To investigate nucleophosmin (NPM) gene mutations in patients with de novo acute myeloid leukemia (AML) with normal cytogenetics and primary myelodysplastic syndromes (MDS). Methods Genomic DNA corresponding...Objective To investigate nucleophosmin (NPM) gene mutations in patients with de novo acute myeloid leukemia (AML) with normal cytogenetics and primary myelodysplastic syndromes (MDS). Methods Genomic DNA corresponding to exon 12 of NPM gene was amplified by polymerase chain reaction (PCR) in 40 AML patients (28 case untreated and 12 in first remission)展开更多
Objective To compare short-term therapeutic effect of different regimens combining recombinant human thrombopoietin(rh TPO)with immunosuppressive therapy(IST)applied in severe aplastic anemia(SAA).Methods The clinical...Objective To compare short-term therapeutic effect of different regimens combining recombinant human thrombopoietin(rh TPO)with immunosuppressive therapy(IST)applied in severe aplastic anemia(SAA).Methods The clinical data of newly diagnosed adult SAA patients treated with first-line IST,including 18展开更多
Objective To determine whether cyclosporine A(CsA)plus andronges was as effective as the current standard immunosuppressive therapy(IST)for transfusion-dependent nonsevere aplastic anemia(TD-NSAA).
Objective To explore the cytogenetic and prognostic significance of monosomal karyotype(MK)in adult patients with acute myeloid leukemia(AML).Methods From September 2002 to Nevember 2014 in Blood Diseases Hospital,Chi...Objective To explore the cytogenetic and prognostic significance of monosomal karyotype(MK)in adult patients with acute myeloid leukemia(AML).Methods From September 2002 to Nevember 2014 in Blood Diseases Hospital,Chinese Academy of Medical Sciences,97Cases with AML were enrolled,including 96 cases展开更多
Objective To evaluate the prognostic value of JAK2,MPL and CALR mutations in Chinese patients with primary myelofibrosis(PMF).Methods Four hundred and two Chinese patients with PMF were retrospectively analyzed.The Ka...Objective To evaluate the prognostic value of JAK2,MPL and CALR mutations in Chinese patients with primary myelofibrosis(PMF).Methods Four hundred and two Chinese patients with PMF were retrospectively analyzed.The Kaplan-Meier method,the Log-rank test,the likelihood ratio test and the Cox展开更多
Objective To analyze the clinical characteristics and to evaluate immunosuppressive therapy(IST)response and survival in hepatitis-associated aplastic anemia(HAAA).Methods We retrospectively analyzed clinical characte...Objective To analyze the clinical characteristics and to evaluate immunosuppressive therapy(IST)response and survival in hepatitis-associated aplastic anemia(HAAA).Methods We retrospectively analyzed clinical characteristics,IST response,long-term survival and clonal evolution in 41 HAAA patients,and展开更多
Objective To analyze the clinical, laboratory characteristics and prognosis of adult early T-cell precursor acute lymphoblastic leukemia (EiTP-ALL). Methods The clinical data of 13 adult (ETP-ALL) patients from Januar...Objective To analyze the clinical, laboratory characteristics and prognosis of adult early T-cell precursor acute lymphoblastic leukemia (EiTP-ALL). Methods The clinical data of 13 adult (ETP-ALL) patients from January 2009 to March 2017 were retrospectively analyzed and compared with non-ETP ALL patients.展开更多
文摘Objective To analyze the hints role of surveillance cultures of Carbapenem-resistant Enterobacteriaceae(CRE) by perianal swabs in patients with hematological diseases,and seek risk factors of CRE bloodstream infection.
文摘Objective To investigate the risk factors of intestinal acute graft-versus-host disease(aGVHD)after allogeneic hematopoietic stem cell transplantation(allo-HSCT).Methods The clinical data of 534 cases of 533 patients undergoing allo-HSCT during Jan 2004 and Sep 2012were retrospectively analyzed.The effects of donor-recipient
文摘Objective To explore the impact of interleukin-18(IL-18)single nucleotide polymorphisms on outcomes of hematologic malignancies with HLA-matched sibling donor hematopoietic stem cell transplantation(allo-HSCT).Methods Single-nucleotide polymorphisms in IL-18 promoter was detected by PCR-sequence-specific primer analysis(PCR-SSP)in 93 recipients and their HLA matched sibling donors.Hematopoietic reconstitution,
文摘Objective To explore the efficacy and prognosis of first-line autologous hematopoietic stem cell transplantation(ASCT) for newly diagnosed patients with multiple myeloma(MM).Methods From January 2005
文摘Objective To compare the time of the recovery of neutrophils or leukocytes by pegylated recombinant human granulocyte stimulating factor(PEG-rhG-CSF)or common recombinant human granulocyte stimulating factor(rhG-CSF)in the myelosuppressive phase after induction chemotherapy in newly diagnosed acute myeloid leukemia(AML)patients.At the same time,the incidences of infection and hospitalization were compared.Methods A prospective randomized controlled trial was conducted in patients with newly diagnosed AML who met the enrollment criteria from August 2014 to December 2017.The patients were randomly divided into two groups according to a 1∶1 ratio:PEG-rhG-CSF group and rhG-CSF group.The time of neutrophil or leukocyte recovery,infection rate and hospitalization interval were compared between the two groups.Results 60 patients with newly diagnosed AML were enrolled:30 patients in the PEG-rhG-CSF group and 30 patients in the rhG-CSF group.There were no significant differences in age,chemotherapy regimen,pre-chemotherapy ANC,WBC,and induction efficacy between the two groups(P>0.05).The median time(range)of ANC or WBC recovery in patients with PEG-rhG-CSF and rhG-CSF were 19(14-35)d and 19(15-26)d,respectively,with no statistical difference(P=0.566).The incidences of infection in the PEG-rhG-CSF group and the rhG-CSF group were 90.0%and 93.3%,respectively,and there was no statistical difference(P=1.000).The median days of hospitalization(range)was 20.5(17-49)days and 21(19-43)days,respectively,with no statistical difference(P=0.530).Conclusion In AML patients after induction therapy,there was no significant difference between the application of PEG-rhG-CSF and daily rhG-CSF in ANC or WBC recovery time,infection incidence and hospitalization time.
文摘Objective To explore the impact of IFN-γ+874 polymorphisms on the outcome in HLA matched sibling HSCT. Methods We used PCR-sequence-specific primer analysis(PCR-SSP) to analyze the polymorphisms of IFN-γ+874 T/A in 80 recipient and donor pairs
文摘Objective To explore the clinical features of autoimmune hemolytic anemia(AIHA)with monoclonal gammopathy IgMk.Methods The clinical and laboratory features of 12 AIHA with monoclonal gammopathy Ig Mκwere retrospectively analyzed.Results 12 cases with monoclonal immunoglobulin Igmκwere found in 85 pa-
文摘Objective To explore the diagnosis and differential diagnosis of refractory cytopenia of children(RCC) according to WHO classification,and discuss the relationship between the cytology reviewed by hematologists and histology reviewed by pathologists.
文摘Objective To explore the clinical and laboratory characteristics,treatment,prognostic factors of acute lymphoblastic leukemia(ALL)in adolescents.Methods Adolescents de novo ALL patients in Blood Disease Hospital,Peking Union Medical College,Chinese Academy of Medical Sciences from September 1999 to September2013 were enrolled in this study.Clinical data,thera-
文摘Objective To summarize clinical and genetic features of childhood dyskeratosis congenital(DC)patients with bone marrow failure.Methods The clinical data of 8 DC patients with bone marrow failure diagnosed between September 2010 and September 2015 were collected.Whole exons with flanking regions of the 16
文摘Objective To investigate the treatment outcomes of autologous stem cell transplantation(ASCT)as first-line treatment in patients with high risk lymphoblastic lymphoma(LBL)and compare the effect of different induction regimen on prognosis.Methods Thirty LBL patients in complete remission received ASCT from 1996 to 2012in our hospital were retrospectively analyzed.
文摘Objective To explore the efficacy and safety of bortezomib(btz) based chemotherapy in multiple myeloma(MM) patients with renal-function impairment(RI).Methods Fifty-six MM patients with impaired renal
文摘Objective To compare the efficacy and toxicities of combining homoharringtonine(HHT)±daunorubicin(DNR)with all-transretinoic acid(ATRA)based therapy and DNR plus ATRA based therapy in newly diagnosed low/intermediate risk acute promyelocytic leukemia(APL).Methods A total of 96 newly diagnosed pa-
文摘Objective To investigate nucleophosmin (NPM) gene mutations in patients with de novo acute myeloid leukemia (AML) with normal cytogenetics and primary myelodysplastic syndromes (MDS). Methods Genomic DNA corresponding to exon 12 of NPM gene was amplified by polymerase chain reaction (PCR) in 40 AML patients (28 case untreated and 12 in first remission)
文摘Objective To compare short-term therapeutic effect of different regimens combining recombinant human thrombopoietin(rh TPO)with immunosuppressive therapy(IST)applied in severe aplastic anemia(SAA).Methods The clinical data of newly diagnosed adult SAA patients treated with first-line IST,including 18
文摘Objective To determine whether cyclosporine A(CsA)plus andronges was as effective as the current standard immunosuppressive therapy(IST)for transfusion-dependent nonsevere aplastic anemia(TD-NSAA).
文摘Objective To explore the cytogenetic and prognostic significance of monosomal karyotype(MK)in adult patients with acute myeloid leukemia(AML).Methods From September 2002 to Nevember 2014 in Blood Diseases Hospital,Chinese Academy of Medical Sciences,97Cases with AML were enrolled,including 96 cases
文摘Objective To evaluate the prognostic value of JAK2,MPL and CALR mutations in Chinese patients with primary myelofibrosis(PMF).Methods Four hundred and two Chinese patients with PMF were retrospectively analyzed.The Kaplan-Meier method,the Log-rank test,the likelihood ratio test and the Cox
文摘Objective To analyze the clinical characteristics and to evaluate immunosuppressive therapy(IST)response and survival in hepatitis-associated aplastic anemia(HAAA).Methods We retrospectively analyzed clinical characteristics,IST response,long-term survival and clonal evolution in 41 HAAA patients,and
文摘Objective To analyze the clinical, laboratory characteristics and prognosis of adult early T-cell precursor acute lymphoblastic leukemia (EiTP-ALL). Methods The clinical data of 13 adult (ETP-ALL) patients from January 2009 to March 2017 were retrospectively analyzed and compared with non-ETP ALL patients.
