Background Youth suicide has been a pressing public mental health concern in China,yet there is a lack of gatekeeper intervention programmes developed locally to prevent suicide among Chinese adolescents.Aims The curr...Background Youth suicide has been a pressing public mental health concern in China,yet there is a lack of gatekeeper intervention programmes developed locally to prevent suicide among Chinese adolescents.Aims The current Delphi study was the first step in the systematic development of the Life Gatekeeper programme,the first gatekeeper programme to be developed locally in China that aims to equip teachers and parents with the knowledge,skills and ability to identify and intervene with students at high risk of suicide.Methods The Delphi method was used to elicit a consensus of experts who were invited to evaluate the importance of training content,the feasibility of the training delivery method,the possibility of achieving the training goals and,finally,the appropriateness of the training materials.Two Delphi rounds were conducted among local experts with diversified professional backgrounds in suicide research and practice.Statements were accepted for inclusion in the adjusted training programme if they were endorsed by at least 80%of the panel.Results Consensus was achieved on 201 out of 207 statements for inclusion into the adapted guidelines for the gatekeeper programme,with 151 from the original questionnaire and 50 generated from comments of the panel members.These endorsed statements were synthesised to develop the content of the Life Gatekeeper training programme.Conclusions This Delphi study provided an evidence base for developing the first gatekeeper training programme systematically and locally in China.We hope that the current study can pave the way for more evidence-based suicide prevention programmes in China.Further study is warranted to evaluate the effectiveness of the Life Gatekeeper training programme.展开更多
Introduction Nitrous oxide(N2O/laughing gas)has been used in medical practice as an inhalational anaesthetic and analgesic for more than 150 years.1 In the past decades,N2O exhibited increasing popularity among recrea...Introduction Nitrous oxide(N2O/laughing gas)has been used in medical practice as an inhalational anaesthetic and analgesic for more than 150 years.1 In the past decades,N2O exhibited increasing popularity among recreational drug users for its euphoric effects,potentially through its interaction with the endogenous opioid system.2 Recreational use of N2O emerged as the seventh most used drug globally in the past decade.3 The use of N2O can cause myelopathy,myocardial injury,anaemia,severe mood disorders,sensory and motor neuropathy,and psychotic symptoms.45 Prolonged N2O intake results in vitamin B12 deficiency and inhibits methionine synthetase,folate and DNA production,leading to plasma homocysteine(HCY)level elevation and bone marrow haematopoietic dysfunction.6 This study aimed to investigate the neurological symptoms of nitrous oxide use and then explore the relapse trajectory and risk factors for relapse.展开更多
According to the report of the World Health Organization(WHO),as of April 20,2022,the cumulative number of confirmed cases of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)in the world had exceeded 500 mi...According to the report of the World Health Organization(WHO),as of April 20,2022,the cumulative number of confirmed cases of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)in the world had exceeded 500 million,with 6.20 million deaths and over 580,000 new confirmed cases on that day(1).As many countries have announced to relax quarantine policies,China is facing increasing pressure from overseas imports.All 31 provincial-level administrative divisions(PLADs)of China have reported a total of 191,112 local confirmed cases,with 2,761 new confirmed cases,17,166 new asymptomatic infections,and 7 new deaths(all in Shanghai Municipality)on April 19(2).Recently,several local outbreaks in clusters have appeared in China,presenting a grim and complex situation with multiple spots,wide coverage,and frequent occurrence(3).展开更多
Introduction:In late 2022,a rapid transmission of Omicron variants of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)occurred throughout China.The purpose of this study was to provide the latest data and e...Introduction:In late 2022,a rapid transmission of Omicron variants of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)occurred throughout China.The purpose of this study was to provide the latest data and evaluate trends of SARS-CoV-2 infection in rural China among the community population.Methods:Data on SARS-CoV-2 infection among approximately 90,000 participants in rural China were collected by the National Sentinel Community-Based Surveillance(NSCS)system.Participants were tested for SARS-CoV-2 infection(defined as positive for SARS-CoV-2 nucleic acid or antigen)twice weekly from December 16,2022 to January 12,2023.The daily average of newly positive rate and its estimated daily percentage change were calculated to describe the national and regional trends of SARS-CoV-2 infection in rural China.Results:In rural China,the daily average new positive rate of SARS-CoV-2 infection peaked at 4.79%between December 20–22,2022 and then decreased to 0.57%between January 10–12,2023,with an average decrease of 29.95%per round.The peak of new SARS-CoV-2 infection was slightly earlier and lower in North China(5.28%between December 20–22,2022)than in South China(5.63%between December 23–26,2022),and then converged from December 30,2022 to January 2,2023.The peak of 6.09%occurred between December 20–22,2022 in eastern China,while the peak of 5.99%occurred later,between December 27–29,2022,in central China.Conclusions:Overall,the epidemic wave in rural China peaked between December 20–22,2022,and passed quickly following the optimization of prevention and control measures.Currently,SARSCoV-2 infection in community populations in rural China is sporadic.展开更多
The Global Fund has long been the largest international assistance in human immunodeficiency virus(HIV)responses for three Southeast Asian countries,including Myanmar,Laos,and Vietnam.However,it recently decided to re...The Global Fund has long been the largest international assistance in human immunodeficiency virus(HIV)responses for three Southeast Asian countries,including Myanmar,Laos,and Vietnam.However,it recently decided to reduce or withdraw its funding from countries not yet going through donor phase out,aiming to make these countries respond with their own resources.In examining whether these three countries are well-prepared to donor transition,we uncover potential challenges that will appear in their healthcare systems and especially in the prevention and control for vulnerable populations.By reviewing China's succesful experience in donor transition,we propose recommendations for these pre transition countries,in terms of program operation,budget allocation,and social stigmatization.展开更多
Introduction:On December 7,2022,China implemented“Ten New Measures”to optimize prevention and control measures for coronavirus disease 2019(COVID-19).The purpose of this study was to evaluate the national and region...Introduction:On December 7,2022,China implemented“Ten New Measures”to optimize prevention and control measures for coronavirus disease 2019(COVID-19).The purpose of this study was to evaluate the national and regional trends of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection among couriers in China from December 2022 to January 2023.Methods:Data from the National Sentinel Community-based Surveillance in China was utilized,including participants from 31 provincial-level administrative divisions and Xinjiang Production and Construction Corps.Participants were tested for SARS-CoV-2 infection twice a week from December 16,2022 to January 12,2023.Infection was defined as a positive result for SARS-CoV-2 nucleic acid or antigen.The daily average newly positive rate of SARSCoV-2 infection and the estimated daily percentage change(EDPC)were calculated.Results:In this cohort,8 rounds of data were collected.The daily average newly positive rate of SARS-CoV-2 infection decreased from 4.99%in Round 1 to 0.41%in Round 8,with an EDPC of−33.0%.Similar trends of the positive rate were also observed in the eastern(EDPC:−27.7%),central(EDPC:−38.0%)and western regions(EDPC:−25.5%).Couriers and community population showed a similar temporal trend,with the peak daily average newly positive rate of couriers being higher than that of community population.After Round 2,the daily average newly positive rate of couriers decreased sharply,becoming lower than that of community population in the same period.Conclusions:The peak of SARS-CoV-2 infection among couriers in China has passed.As couriers are a key population for SARS-CoV-2 infection,they should be monitored continuously.展开更多
Since its outbreak in late 2019,coronavirus disease 2019(COVID-19)has remained a global pandemic for nearly two years,which poses a huge test on the resilience of global public health system(1).After experiencing the ...Since its outbreak in late 2019,coronavirus disease 2019(COVID-19)has remained a global pandemic for nearly two years,which poses a huge test on the resilience of global public health system(1).After experiencing the large-scale epidemic in February 2020,China has entered a normalization stage of prevention and control since May 2020(2).In response to the spread of the highly transmissible Delta variant,China adopted a new strategy called“Dynamic COVID-zero”from August 2021.This strategy is a summary of China’s experience in dealing with the spread of the Delta variant,considering how to control the epidemic at a higher level,at a lower cost,and in a shorter time(3).The most important purpose is to minimize the impact of the epidemic on the economy,society,production,and people’s normal lives,and to balance the prevention and control of this disease with socioeconomic stability.For instance,multiple outbreaks that occurred in Beijing were controlled in 2 maximum incubation periods(within 28 days)by this strategy(Figure 1).展开更多
BACKGROUND Surveillance is a critical component of epidemiological and public health practice,playing a significant role in the prevention,control,and management of major public health risks(1).Historically,surveillan...BACKGROUND Surveillance is a critical component of epidemiological and public health practice,playing a significant role in the prevention,control,and management of major public health risks(1).Historically,surveillance methods were primarily based on hospital data(e.g.,sentinel hospital monitoring for influenza)or specific populations[such as the human immunodeficiency virus/acquired immunodeficiency syndrome(HIV/AIDS)population]for sentinel surveillance.展开更多
基金funding from Research Fund of VankeSchool of Public Health(100009001)funding from Shuimu Tsinghua Scholarfunding from Beijing High Level Public HealthTechnical Specialist Development Fund(Discipline backbone-02-07).
文摘Background Youth suicide has been a pressing public mental health concern in China,yet there is a lack of gatekeeper intervention programmes developed locally to prevent suicide among Chinese adolescents.Aims The current Delphi study was the first step in the systematic development of the Life Gatekeeper programme,the first gatekeeper programme to be developed locally in China that aims to equip teachers and parents with the knowledge,skills and ability to identify and intervene with students at high risk of suicide.Methods The Delphi method was used to elicit a consensus of experts who were invited to evaluate the importance of training content,the feasibility of the training delivery method,the possibility of achieving the training goals and,finally,the appropriateness of the training materials.Two Delphi rounds were conducted among local experts with diversified professional backgrounds in suicide research and practice.Statements were accepted for inclusion in the adjusted training programme if they were endorsed by at least 80%of the panel.Results Consensus was achieved on 201 out of 207 statements for inclusion into the adapted guidelines for the gatekeeper programme,with 151 from the original questionnaire and 50 generated from comments of the panel members.These endorsed statements were synthesised to develop the content of the Life Gatekeeper training programme.Conclusions This Delphi study provided an evidence base for developing the first gatekeeper training programme systematically and locally in China.We hope that the current study can pave the way for more evidence-based suicide prevention programmes in China.Further study is warranted to evaluate the effectiveness of the Life Gatekeeper training programme.
基金National Natural Science Foundation of China grant(32241015,81822017)the Lingang Laboratory(LG-QS-202203-10)+1 种基金the Shanghai Municipal Education Commission-Gaofeng Clinical Medicine Grant Support(20181715)the Shanghai Municipal Commission of Health(2022JC016).
文摘Introduction Nitrous oxide(N2O/laughing gas)has been used in medical practice as an inhalational anaesthetic and analgesic for more than 150 years.1 In the past decades,N2O exhibited increasing popularity among recreational drug users for its euphoric effects,potentially through its interaction with the endogenous opioid system.2 Recreational use of N2O emerged as the seventh most used drug globally in the past decade.3 The use of N2O can cause myelopathy,myocardial injury,anaemia,severe mood disorders,sensory and motor neuropathy,and psychotic symptoms.45 Prolonged N2O intake results in vitamin B12 deficiency and inhibits methionine synthetase,folate and DNA production,leading to plasma homocysteine(HCY)level elevation and bone marrow haematopoietic dysfunction.6 This study aimed to investigate the neurological symptoms of nitrous oxide use and then explore the relapse trajectory and risk factors for relapse.
基金National Key Research and Development Program of China(2021ZD0114101,2021ZD0114104,2021ZD0114105)National Natural Science Foundation of China(7212200171934002).
文摘According to the report of the World Health Organization(WHO),as of April 20,2022,the cumulative number of confirmed cases of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)in the world had exceeded 500 million,with 6.20 million deaths and over 580,000 new confirmed cases on that day(1).As many countries have announced to relax quarantine policies,China is facing increasing pressure from overseas imports.All 31 provincial-level administrative divisions(PLADs)of China have reported a total of 191,112 local confirmed cases,with 2,761 new confirmed cases,17,166 new asymptomatic infections,and 7 new deaths(all in Shanghai Municipality)on April 19(2).Recently,several local outbreaks in clusters have appeared in China,presenting a grim and complex situation with multiple spots,wide coverage,and frequent occurrence(3).
基金National Natural Science Foundation of China(72122001,72211540398,71934002)National Key Research and Development Program of China(2021ZD0114105,2021ZD0114104,2021ZD0114101)the Shui Mu Tsinghua Scholar Program.
文摘Introduction:In late 2022,a rapid transmission of Omicron variants of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)occurred throughout China.The purpose of this study was to provide the latest data and evaluate trends of SARS-CoV-2 infection in rural China among the community population.Methods:Data on SARS-CoV-2 infection among approximately 90,000 participants in rural China were collected by the National Sentinel Community-Based Surveillance(NSCS)system.Participants were tested for SARS-CoV-2 infection(defined as positive for SARS-CoV-2 nucleic acid or antigen)twice weekly from December 16,2022 to January 12,2023.The daily average of newly positive rate and its estimated daily percentage change were calculated to describe the national and regional trends of SARS-CoV-2 infection in rural China.Results:In rural China,the daily average new positive rate of SARS-CoV-2 infection peaked at 4.79%between December 20–22,2022 and then decreased to 0.57%between January 10–12,2023,with an average decrease of 29.95%per round.The peak of new SARS-CoV-2 infection was slightly earlier and lower in North China(5.28%between December 20–22,2022)than in South China(5.63%between December 23–26,2022),and then converged from December 30,2022 to January 2,2023.The peak of 6.09%occurred between December 20–22,2022 in eastern China,while the peak of 5.99%occurred later,between December 27–29,2022,in central China.Conclusions:Overall,the epidemic wave in rural China peaked between December 20–22,2022,and passed quickly following the optimization of prevention and control measures.Currently,SARSCoV-2 infection in community populations in rural China is sporadic.
基金supported in part by the National Natural Science Foundation of China(Grant No.71904171)the Fundamental Research Funds for the Central Universities(Grant No.2020QNA7021)China Medical Board(Project No.202032).
文摘The Global Fund has long been the largest international assistance in human immunodeficiency virus(HIV)responses for three Southeast Asian countries,including Myanmar,Laos,and Vietnam.However,it recently decided to reduce or withdraw its funding from countries not yet going through donor phase out,aiming to make these countries respond with their own resources.In examining whether these three countries are well-prepared to donor transition,we uncover potential challenges that will appear in their healthcare systems and especially in the prevention and control for vulnerable populations.By reviewing China's succesful experience in donor transition,we propose recommendations for these pre transition countries,in terms of program operation,budget allocation,and social stigmatization.
基金National Natural Science Foundation of China(72122001,72211540398,71934002)National Key Research and Development Program of China(2021ZD0114105,2021ZD0114104,2021ZD0114101).
文摘Introduction:On December 7,2022,China implemented“Ten New Measures”to optimize prevention and control measures for coronavirus disease 2019(COVID-19).The purpose of this study was to evaluate the national and regional trends of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection among couriers in China from December 2022 to January 2023.Methods:Data from the National Sentinel Community-based Surveillance in China was utilized,including participants from 31 provincial-level administrative divisions and Xinjiang Production and Construction Corps.Participants were tested for SARS-CoV-2 infection twice a week from December 16,2022 to January 12,2023.Infection was defined as a positive result for SARS-CoV-2 nucleic acid or antigen.The daily average newly positive rate of SARSCoV-2 infection and the estimated daily percentage change(EDPC)were calculated.Results:In this cohort,8 rounds of data were collected.The daily average newly positive rate of SARS-CoV-2 infection decreased from 4.99%in Round 1 to 0.41%in Round 8,with an EDPC of−33.0%.Similar trends of the positive rate were also observed in the eastern(EDPC:−27.7%),central(EDPC:−38.0%)and western regions(EDPC:−25.5%).Couriers and community population showed a similar temporal trend,with the peak daily average newly positive rate of couriers being higher than that of community population.After Round 2,the daily average newly positive rate of couriers decreased sharply,becoming lower than that of community population in the same period.Conclusions:The peak of SARS-CoV-2 infection among couriers in China has passed.As couriers are a key population for SARS-CoV-2 infection,they should be monitored continuously.
基金National Key Research and Development Program of China(2021ZD0114101,2021ZD0114104,2021ZD0114105)National Natural Science Foundation of China(72122001,71934002).
文摘Since its outbreak in late 2019,coronavirus disease 2019(COVID-19)has remained a global pandemic for nearly two years,which poses a huge test on the resilience of global public health system(1).After experiencing the large-scale epidemic in February 2020,China has entered a normalization stage of prevention and control since May 2020(2).In response to the spread of the highly transmissible Delta variant,China adopted a new strategy called“Dynamic COVID-zero”from August 2021.This strategy is a summary of China’s experience in dealing with the spread of the Delta variant,considering how to control the epidemic at a higher level,at a lower cost,and in a shorter time(3).The most important purpose is to minimize the impact of the epidemic on the economy,society,production,and people’s normal lives,and to balance the prevention and control of this disease with socioeconomic stability.For instance,multiple outbreaks that occurred in Beijing were controlled in 2 maximum incubation periods(within 28 days)by this strategy(Figure 1).
基金National Natural Science Foundation of China(7212200172211540398+4 种基金71934002)Beijing Natural Science Foundation of China(L222027)National Key Research and Development Program of China(2021ZD01141052021ZD01141042021ZD0114101).
文摘BACKGROUND Surveillance is a critical component of epidemiological and public health practice,playing a significant role in the prevention,control,and management of major public health risks(1).Historically,surveillance methods were primarily based on hospital data(e.g.,sentinel hospital monitoring for influenza)or specific populations[such as the human immunodeficiency virus/acquired immunodeficiency syndrome(HIV/AIDS)population]for sentinel surveillance.
