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Decoding molecular mechanisms:brain aging and Alzheimer's disease
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作者 Mahnoor Hayat Rafay Ali Syed +9 位作者 Hammad Qaiser Mohammad Uzair Khalid Al-Regaiey Roaa Khallaf Lubna Abdullah Mohammed Albassam Imdad Kaleem Xueyi Wang Ran Wang Mehwish SBhatti Shahid Bashir 《Neural Regeneration Research》 SCIE CAS 2025年第8期2279-2299,共21页
The complex morphological,anatomical,physiological,and chemical mechanisms within the aging brain have been the hot topic of research for centuries.The aging process alters the brain structure that affects functions a... The complex morphological,anatomical,physiological,and chemical mechanisms within the aging brain have been the hot topic of research for centuries.The aging process alters the brain structure that affects functions and cognitions,but the worsening of such processes contributes to the pathogenesis of neurodegenerative disorders,such as Alzheimer's disease.Beyond these observable,mild morphological shifts,significant functional modifications in neurotransmission and neuronal activity critically influence the aging brain.Understanding these changes is important for maintaining cognitive health,especially given the increasing prevalence of age-related conditions that affect cognition.This review aims to explore the age-induced changes in brain plasticity and molecular processes,differentiating normal aging from the pathogenesis of Alzheimer's disease,thereby providing insights into predicting the risk of dementia,particularly Alzheimer's disease. 展开更多
关键词 Alzheimer’s disease brain aging cognitive health DEMENTIA molecular mechanisms neuronal activity NEUROPLASTICITY NEUROTRANSMISSION
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Hard exudates referral system in eye fundus utilizing speeded up robust features 被引量:1
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作者 Syed Ali Gohar Naqvi Hafiz Muhammad Faisal Zafar Ihsanul Haq 《International Journal of Ophthalmology(English edition)》 SCIE CAS 2017年第7期1171-1174,共4页
In the paper a referral system to assist the medical experts in the screening/referral of diabetic retinopathy is suggested. The system has been developed by a sequential use of different existing mathematical techniq... In the paper a referral system to assist the medical experts in the screening/referral of diabetic retinopathy is suggested. The system has been developed by a sequential use of different existing mathematical techniques. These techniques involve speeded up robust features(SURF), K-means clustering and visual dictionaries(VD). Three databases are mixed to test the working of the system when the sources are dissimilar. When experiments were performed an area under the curve(AUC) of 0.9343 was attained. The results acquired from the system are promising. 展开更多
关键词 referral system speeded up robust features eye fundus visual dictionaries
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Electrostatic Rayleigh-Taylor Mode in Electron-Positron-Ion Quantum Plasma
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作者 Sajad Ali Mushtaq Ahmad 《Journal of Modern Physics》 2017年第4期636-653,共18页
Electrostatic Rayleigh-Taylor (ERT) mode/instability is studied in a non-uni-form quantum magnetoplasma, whose constituents are electrons and positrons with fraction of ions. The effects of quantum corrections (i.e. B... Electrostatic Rayleigh-Taylor (ERT) mode/instability is studied in a non-uni-form quantum magnetoplasma, whose constituents are electrons and positrons with fraction of ions. The effects of quantum corrections (i.e. Bohm potential and temperature degeneracy) and magnetic field on ERT mode are investigated with astrophysical plasma application. A generalized dispersion relation is deduced under the drift wave approximation. The presence of positron makes the dispersion relation a cubic equation. Different roots of both real and imaginary parts of the RT mode are examined by applying the Cardano’s method of solving the cubic equation. The dispersion relation and the growth rates of RT instability are examined both analytically and numerically with effects of electron and positron density, and magnetic field variations. It is shown that the magnetic field and positron density have stabilizing effectuates on ERT mode while due to electron density the mode becomes unstable. The present work is antici-pated to be of physical relevance in the studies of laboratory laser-produced plasmas as well as in the study of compact magnetized astrophysical objects like white dwarfs. 展开更多
关键词 RAYLEIGH-TAYLOR Instability DRIFT Wave Approximation Quantum MAGNETO HYDRODYNAMICS Cardano’s Method
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