Objective：To observe the antagonistic effect of acupuncture of Shuigou （水沟 GV 26） on intravenous anesthesia for surgical operation. Methods： Forty patients received intravenous anesthesia were randomly and evenl...Objective：To observe the antagonistic effect of acupuncture of Shuigou （水沟 GV 26） on intravenous anesthesia for surgical operation. Methods： Forty patients received intravenous anesthesia were randomly and evenly divided into treatment group and control group. At the termination of anesthesia, Shuigou （GV 26） was needled for patients in treatment group, in control group patients aroused spontaneously. Recovery degrees of every patient were assessed by using modified Robertzon Scoring Scale. Results： Results showed that from the 6^th min on, the scores of treatment group were significantly bigger than those of control group （6 min： 5.3±0.42 vs 3.2±0.33, P〈0.05; 15 min： 13.7±0.32 vs 8.23±0.77, P〈0.01）, suggesting that the recovery of the patient＇s consciousness of treatment group was markedly quicker than that of control group, Conclusion：Puncturing Shuigou （GV 26） can hasten the patient＇s arousal from postoperative anesthesia and thus may be used as an effective remedy for resisting the aftereffects of intravenous anesthetics.展开更多
OBJECTIVE:To evaluate the efficacy and safety of treatment based on syndrome differentiation ofTraditional Chinese Medicine(TCM) for community-acquired pneumonia(CAP).METHODS:A total of 240 CAP patients were randomly ...OBJECTIVE:To evaluate the efficacy and safety of treatment based on syndrome differentiation ofTraditional Chinese Medicine(TCM) for community-acquired pneumonia(CAP).METHODS:A total of 240 CAP patients were randomly divided into the following two groups:thecontrol group was treated by anti-infection plus conventional medicine treatment;and the trial group was treated by TCM plus the above-mentioned treatment given to the controls.The course of treatment was 14 days,and the patients were followed up for 7 days.RESULTS:Of the 240 patients,235 accomplished the whole process of treatment.The five patients who withdrew from the study were brought into an intent-to-treat analysis.The therapeutic effects of the trial group were superior to those of the control group(P<0.01).The trial group took less time to become clinically stable,with a higher score in the quality of life(P<0.01).There were no significant differences in mortality rate(P>0.05),white blood cell count(P>0.05),bacterial clearance rate(P>0.05),and adverse reactions between the two integrated groups.CONCLUSION:Treatment based on TCM syndrome differentiation for CAP has the advantages of resulting in less time to achieve a stable clinical condition,improvement of clinical symptoms and quality of life,and is comparatively safe.展开更多
Objective： To explore the efficacy and mechanism of Lirukang Granule （利乳康颗粒, LRKG） in treating hyperplasia of mammary gland （HMG）. Methods： One hundred patients with HMG were randomly assigned to two groups...Objective： To explore the efficacy and mechanism of Lirukang Granule （利乳康颗粒, LRKG） in treating hyperplasia of mammary gland （HMG）. Methods： One hundred patients with HMG were randomly assigned to two groups, 50 in each group. The patients in the treated group were orally administered with LRKG thrice a day, one package each time, and those in the control group were given orally Rukuaixiao Tablet （乳块消, RKX） thrice a day, 4 tablets each time. The therapeutic course for both groups was 4 months. The clinical efficacy, pain alleviating rate, as well as changes of local sign and symptom scores were observed before and after treatment. The changes of serum estradiol （E2）, progesterone （P）, testosterone （T）, follicle stimulating hormone （FSH）, luteinizing hormone （LH） and prolactin （PRL） in some randomly selected patients （24 patients in the treated group and 24 in the control group） before and after treatment were measured with radioimmunoassay. Results： The total clinical efficacy in the treated group was superior to that in the control group, significant difference was shown between the two groups （P〈 0.01）. The cure-effective rate and total effective rate in the treated group were 70.0%and 88.0% respectively, significantly higher than those in the control group （38.0% and 64.0%） respectively （P〈 0.01）, and the pain alleviating rate in the treated group was also significantly higher in the former than that in the latter （88.0% vs 64.0%, P 〈 0.05）. Moreover, the treated group showed obvious superiority in improving the patients＇ symptom and sign scores （P 〈 0.01）, and abnormalities of gonadal hormone as compared with the respective items in the control group （P〈0.01）. Conclusion： LRKG has good efficacy in the treatment of HMG, and its mechanism may be related to the regulation on endocrine and immune function.展开更多
Objective: To study the effect of Yuyin recipe (愈银方, YYR), a Ch inese composite recipe, on cultured human epithelial cell proliferation in vitro .Methods: YYR in different concentrations was added separately in ...Objective: To study the effect of Yuyin recipe (愈银方, YYR), a Ch inese composite recipe, on cultured human epithelial cell proliferation in vitro .Methods: YYR in different concentrations was added separately in to the keratinocyte CoLo-16 line, after the latter had been cultured 24 hrs, to be co-cultured for different periods of time (24-72 hrs). A blank contro l group was set up in the meantime. Effect of YYR with different concentrations and different acting time on keratinocyte proliferation was observed by MTT meth od.Results: YYR in different concentrations showed significant inhib itory effect on keratinocyte CoLo-16 line in concentration-dependent and a cting-time-dependent manner.Conclusion: Inhibition on over proliferation of epithelial cells may be one of the mechanisms of YYR in curing psoriasis.展开更多
MicroRNAs(miRs) have been shown to be differentially expressed in the serum of cancer patients and controls,and can thus be used as biomarkers for cancer screening.We detected the expression level of miR-155 in the se...MicroRNAs(miRs) have been shown to be differentially expressed in the serum of cancer patients and controls,and can thus be used as biomarkers for cancer screening.We detected the expression level of miR-155 in the serum of female breast cancer patients and healthy controls to investigate whether serum miR-155 could discriminate patients with early-stage breast cancer.Serum samples were collected from 20 female patients with newly diagnosed breast cancer and 10 healthy controls.Real-time quantitative PCR was used to detect the expression level of miR-155.The expression level of miR-155 was significantly increased in the serum of breast cancer patients compared with in the serum of normal controls.MiR-155 may be useful as a blood-based biomarker for breast cancer screening.展开更多
文摘Objective：To observe the antagonistic effect of acupuncture of Shuigou （水沟 GV 26） on intravenous anesthesia for surgical operation. Methods： Forty patients received intravenous anesthesia were randomly and evenly divided into treatment group and control group. At the termination of anesthesia, Shuigou （GV 26） was needled for patients in treatment group, in control group patients aroused spontaneously. Recovery degrees of every patient were assessed by using modified Robertzon Scoring Scale. Results： Results showed that from the 6^th min on, the scores of treatment group were significantly bigger than those of control group （6 min： 5.3±0.42 vs 3.2±0.33, P〈0.05; 15 min： 13.7±0.32 vs 8.23±0.77, P〈0.01）, suggesting that the recovery of the patient＇s consciousness of treatment group was markedly quicker than that of control group, Conclusion：Puncturing Shuigou （GV 26） can hasten the patient＇s arousal from postoperative anesthesia and thus may be used as an effective remedy for resisting the aftereffects of intravenous anesthetics.
基金Supported by the National Program on Key Basic Research Project(973 Program)(Grant NO.2006CB504605)the Program for New Century Excellent Talents at the University of Henan Province(Grant NO.006HANCET-05)
文摘OBJECTIVE:To evaluate the efficacy and safety of treatment based on syndrome differentiation ofTraditional Chinese Medicine(TCM) for community-acquired pneumonia(CAP).METHODS:A total of 240 CAP patients were randomly divided into the following two groups:thecontrol group was treated by anti-infection plus conventional medicine treatment;and the trial group was treated by TCM plus the above-mentioned treatment given to the controls.The course of treatment was 14 days,and the patients were followed up for 7 days.RESULTS:Of the 240 patients,235 accomplished the whole process of treatment.The five patients who withdrew from the study were brought into an intent-to-treat analysis.The therapeutic effects of the trial group were superior to those of the control group(P<0.01).The trial group took less time to become clinically stable,with a higher score in the quality of life(P<0.01).There were no significant differences in mortality rate(P>0.05),white blood cell count(P>0.05),bacterial clearance rate(P>0.05),and adverse reactions between the two integrated groups.CONCLUSION:Treatment based on TCM syndrome differentiation for CAP has the advantages of resulting in less time to achieve a stable clinical condition,improvement of clinical symptoms and quality of life,and is comparatively safe.
基金Supported by The First Affiliated Hospital of the General Hospital of PLA (No ZZ2004020)
文摘Objective： To explore the efficacy and mechanism of Lirukang Granule （利乳康颗粒, LRKG） in treating hyperplasia of mammary gland （HMG）. Methods： One hundred patients with HMG were randomly assigned to two groups, 50 in each group. The patients in the treated group were orally administered with LRKG thrice a day, one package each time, and those in the control group were given orally Rukuaixiao Tablet （乳块消, RKX） thrice a day, 4 tablets each time. The therapeutic course for both groups was 4 months. The clinical efficacy, pain alleviating rate, as well as changes of local sign and symptom scores were observed before and after treatment. The changes of serum estradiol （E2）, progesterone （P）, testosterone （T）, follicle stimulating hormone （FSH）, luteinizing hormone （LH） and prolactin （PRL） in some randomly selected patients （24 patients in the treated group and 24 in the control group） before and after treatment were measured with radioimmunoassay. Results： The total clinical efficacy in the treated group was superior to that in the control group, significant difference was shown between the two groups （P〈 0.01）. The cure-effective rate and total effective rate in the treated group were 70.0%and 88.0% respectively, significantly higher than those in the control group （38.0% and 64.0%） respectively （P〈 0.01）, and the pain alleviating rate in the treated group was also significantly higher in the former than that in the latter （88.0% vs 64.0%, P 〈 0.05）. Moreover, the treated group showed obvious superiority in improving the patients＇ symptom and sign scores （P 〈 0.01）, and abnormalities of gonadal hormone as compared with the respective items in the control group （P〈0.01）. Conclusion： LRKG has good efficacy in the treatment of HMG, and its mechanism may be related to the regulation on endocrine and immune function.
文摘Objective: To study the effect of Yuyin recipe (愈银方, YYR), a Ch inese composite recipe, on cultured human epithelial cell proliferation in vitro .Methods: YYR in different concentrations was added separately in to the keratinocyte CoLo-16 line, after the latter had been cultured 24 hrs, to be co-cultured for different periods of time (24-72 hrs). A blank contro l group was set up in the meantime. Effect of YYR with different concentrations and different acting time on keratinocyte proliferation was observed by MTT meth od.Results: YYR in different concentrations showed significant inhib itory effect on keratinocyte CoLo-16 line in concentration-dependent and a cting-time-dependent manner.Conclusion: Inhibition on over proliferation of epithelial cells may be one of the mechanisms of YYR in curing psoriasis.
基金supported by the Jiangsu Provincial Hospital of TCM
文摘MicroRNAs(miRs) have been shown to be differentially expressed in the serum of cancer patients and controls,and can thus be used as biomarkers for cancer screening.We detected the expression level of miR-155 in the serum of female breast cancer patients and healthy controls to investigate whether serum miR-155 could discriminate patients with early-stage breast cancer.Serum samples were collected from 20 female patients with newly diagnosed breast cancer and 10 healthy controls.Real-time quantitative PCR was used to detect the expression level of miR-155.The expression level of miR-155 was significantly increased in the serum of breast cancer patients compared with in the serum of normal controls.MiR-155 may be useful as a blood-based biomarker for breast cancer screening.
