While progress has been made in information source localization,it has overlooked the prevalent friend and adversarial relationships in social networks.This paper addresses this gap by focusing on source localization ...While progress has been made in information source localization,it has overlooked the prevalent friend and adversarial relationships in social networks.This paper addresses this gap by focusing on source localization in signed network models.Leveraging the topological characteristics of signed networks and transforming the propagation probability into effective distance,we propose an optimization method for observer selection.Additionally,by using the reverse propagation algorithm we present a method for information source localization in signed networks.Extensive experimental results demonstrate that a higher proportion of positive edges within signed networks contributes to more favorable source localization,and the higher the ratio of propagation rates between positive and negative edges,the more accurate the source localization becomes.Interestingly,this aligns with our observation that,in reality,the number of friends tends to be greater than the number of adversaries,and the likelihood of information propagation among friends is often higher than among adversaries.In addition,the source located at the periphery of the network is not easy to identify.Furthermore,our proposed observer selection method based on effective distance achieves higher operational efficiency and exhibits higher accuracy in information source localization,compared with three strategies for observer selection based on the classical full-order neighbor coverage.展开更多
BACKGROUND Individuals with refractory ascites in the context of liver cirrhosis typically face an adverse prognosis.The transjugular intrahepatic portosystemic shunt(TIPS)is an efficacious intervention,but there is a...BACKGROUND Individuals with refractory ascites in the context of liver cirrhosis typically face an adverse prognosis.The transjugular intrahepatic portosystemic shunt(TIPS)is an efficacious intervention,but there is a lack of reliable tools for postoperative pro-gnosis assessment.Previously utilized clinical biochemical markers,such as the serum albumin concentration(Alb),sodium(Na+)concentration,and serum creatinine(Scr),have limited predictive value.Therefore,the quest for novel,specific biomarkers to evaluate the post-TIPS prognosis in patients with liver cirrhosis and refractory ascites holds significant practical importance.A retrospective analysis was conducted on 75 patients with liver cirrhosis and refractory ascites who underwent TIPS at our institution from August 2019 to August 2021.These patients were followed up regularly for two years,and the death toll was meticulously documented.The patients were allocated into a survival group(n=45 patients)or a deceased group(n=30 patients)based on their prognosis status.The clinical data of the two groups were collected,and Child-Pugh scores and MELD scores were calculated for analysis.Spearman correlation analysis was carried out to evaluate the correlation of prognosis with Child-Pugh grade,MELD score,and Cys C level.Additionally,a multiple-factor analysis utilizing the Cox proportional hazard model was used to identify independent risk factors affecting the post-TIPS prognosis of patients with liver cirrhosis and refractory ascites.The receiver operating characteristic curve(ROC)ascertained the predictive value of the Cys C concen-tration,Child-Pugh grade,and MELD score for the prognosis of liver cirrhosis with refractory ascites in post-TIPS patients.RESULTS During a 2-year follow-up period,among 75 patients with liver cirrhosis and refractory ascites who underwent TIPS treatment,30 patients(40.00%)passed away.The deceased cohort exhibited heightened aspartate aminotrans-ferase,alanine aminotransferase,total bilirubin,Scr,prothrombin time,Cys C,international normalized ratio,Child-Pugh,and MELD scores compared to those of the survival cohort,while Alb and Na+levels were attenuated in the deceased group(P<0.05).Spearman analysis revealed moderate to high positive correlations between prognosis and Child-Pugh score,MELD score,and Cys C level(r=0.709,0.749,0.671,P<0.05).Multivariate analysis using the Cox proportional hazard model demonstrated that the independent risk factors for post-TIPS prognosis in patients with liver cirrhosis and refractory ascites were Cys C(HR=3.802;95%CI:1.313-11.015),Child-Pugh(HR=3.030;95%CI:1.858-4.943),and MELD(HR=1.222;95%CI:1.073-1.393)scores.ROC analysis confirmed that,compared to those of the classic prognostic models for Child-Pugh and MELD scores,the predictive accuracy of Cys C for post-TIPS prognosis in patients with liver cirrhosis and refractory ascites was slightly lower.This analysis yielded sensitivity and specificity values of 83.33%and 82.22%,respectively.The area under the curve value at this juncture was 0.883,with an optimal cutoff value set at 1.95 mg/L.CONCLUSION Monitoring the serum Cys C concentration is valuable for assessing the post-TIPS prognosis in patients with liver cirrhosis and refractory ascites.Predictive models based on serum Cys C levels,as opposed to Scr levels,are more beneficial for evaluating the condition and prognosis of patients with ascites due to cirrhosis.展开更多
Herein, a stable and efficient CoS_(2)-ReS_(2) electrocatalyst is successfully constructed by using the different molar ratios of CoS_(2) on ReS_(2). The size and morphology of the catalysts are significantly changed ...Herein, a stable and efficient CoS_(2)-ReS_(2) electrocatalyst is successfully constructed by using the different molar ratios of CoS_(2) on ReS_(2). The size and morphology of the catalysts are significantly changed after the CoS_(2) is grown on ReS_(2), providing regulation of the catalytic activity of ReS_(2). Particularly, the optimized CoS_(2)-ReS_(2) shows superior electrocatalytic properties with a low voltage of 1.48 V at 20 mA cm^(-2) for overall water splitting in 1.0 M KOH, which is smaller than the noble metal-based catalysts(1.77 V at 20 mA cm^(-2)). The XPS, XAS, and theoretical data confirm that the interfacial regulation of ReS_(2) by CoS_(2) can provide rich edge catalytic sites, which greatly optimizes the catalytic kinetics and drop the energy barrier for oxygen/hydrogen evolution reactions. Our results demonstrated that interfacial engineering is an efficient route for fabricating high-performance water splitting electrocatalysts.展开更多
Post-stroke depression is associated with reduced expression of brain-derived neurotrophic factor(BDNF). In this study, we evaluated whether BDNF overexpression affects depression-like behavior in a rat model of post-...Post-stroke depression is associated with reduced expression of brain-derived neurotrophic factor(BDNF). In this study, we evaluated whether BDNF overexpression affects depression-like behavior in a rat model of post-stroke depression. The middle cerebral artery was occluded to produce a model of focal cerebral ischemia. These rats were then subjected to isolation-housing combined with chronic unpredictable mild stress to generate a model of post-stroke depression. A BDNF gene lentiviral vector was injected into the hippocampus. At 7 days after injection, western blot assay and real-time quantitative PCR revealed that BDNF expression in the hippocampus was increased in depressive rats injected with BDNF lentivirus compared with depressive rats injected with control vector. Furthermore, sucrose solution consumption was higher, and horizontal and vertical movement scores were increased in the open field test in these rats as well. These findings suggest that BDNF overexpression in the hippocampus of post-stroke depressive rats alleviates depression-like behaviors.展开更多
Because there is no curative treatment for spinal cord injury,establishing an ideal animal model is important to identify injury mechanisms and develop therapies for individuals suffering from spinal cord injuries.In ...Because there is no curative treatment for spinal cord injury,establishing an ideal animal model is important to identify injury mechanisms and develop therapies for individuals suffering from spinal cord injuries.In this article,we systematically review and analyze various kinds of animal models of spinal cord injury and assess their advantages and disadvantages for further studies.展开更多
Lamprotula leai is one of the most commercially important freshwater pearl mussels in China, but there is limited data on its genetic diversity and population structure. In the present study, 119 individuals from four...Lamprotula leai is one of the most commercially important freshwater pearl mussels in China, but there is limited data on its genetic diversity and population structure. In the present study, 119 individuals from four major geographical populations were investigated using 15 microsatellite loci identified via cross-species amplification. A total of 114 alleles were detected, with an average of 7.6 alleles per locus(range: 2 to 21). Among the four stocks, those from Hung-tse Lake and Poyang Lake had the lowest(0.412) and highest(0.455) observed heterozygosity respectively. The polymorphism information content(PIC) ranged from 0.374 to 0.927(mean: 0.907). AMOVA showed that 12.56% and 44.68% genetic variances were among populations and within individuals, respectively. Pairwise Fst ranged from 0.073 to 0.146, indicating medium genetic differentiation among the populations. In aggregate, our results suggest that inbreeding is a crucial factor accounting for deviations from Hardy–Weinberg equilibrium at 12 loci. Moreover, the genetic distance among four stocks ranged from 0.192 to 0.890. Poyang Lake and Hung-tse Lake were clustered together, joined with Dongting Lake and Anqing Lake. Given that specimens from Hungtse Lake showed the highest average allele richness, expected heterozygosity and PIC, this location may be the source of the highest quality germplasm resources and the stock from this area may be the best for future breeding efforts.展开更多
A new complex [Co(4,4'-bpy)2(H2O)2(4-FBA)2]·(4,4'-bpy)(1) has been hydro-thermally synthesized using cobalt,4,4'-bipyridyl(4,4'-bpy) and 4-fluorobenzoic acid(4-HFBA),and characterized by thermal a...A new complex [Co(4,4'-bpy)2(H2O)2(4-FBA)2]·(4,4'-bpy)(1) has been hydro-thermally synthesized using cobalt,4,4'-bipyridyl(4,4'-bpy) and 4-fluorobenzoic acid(4-HFBA),and characterized by thermal analysis,single-crystal X-ray diffraction and magnetic property.The complex crystallizes in the triclinic system,space group P,Z = 1.Crystal data:C54H44CoF2N8O6,Mr = 997.90,a = 9.134(2),b = 11.555(2),c = 12.867(3) ,α = 66.02(3),β = 77.96(3),= 73.11(3)°,V = 1180.9(4) 3,Dc = 1.403 g/cm3,μ(MoKα) = 0.433 mm-1,F(000) = 517,the final R = 0.0633 and wR = 0.1171 for 2152 observed reflections(I > 2σ(I)).The title complex is assembled into 1D supramolecular chains parallel to [001] based on the adjacent molecular ··· stacking interactions and hydrogen bonds.The variable temperature magnetic measurements show a weak ferromagnetic behavior over 300-160 K followed by antiferromagnetic behavior below 160 K for the title complex.展开更多
This study compared the accumulation of Zn2+and Cu2+in the ovaries and ova of loaches under different concentrations of Zn2+(1.00, 2.50 and 5.00 mg/L respectively) and Cu2+(0.10, 0.25 and 0.50 mg/L respectively). The ...This study compared the accumulation of Zn2+and Cu2+in the ovaries and ova of loaches under different concentrations of Zn2+(1.00, 2.50 and 5.00 mg/L respectively) and Cu2+(0.10, 0.25 and 0.50 mg/L respectively). The results showed that both Zn2+and Cu2+accumulated in the ovaries, and that the relationship between accumulation and time was linear over 20 days of exposure. The accumulation of the metals in ovaries was closely related to the concentration of exposure in the solutions(P<0.05), and was obviously affected by the time and doses. However, the Cu2+concentration was significantly higher than Zn2+(P<0.05). The development level of ova in the ovaries also correlated with the concentration and exposure period in the Zn2+and Cu2+solutions.展开更多
In order to confirm whether the rice sample was exposed to gamma radiation,the changes in starch pasting viscosity of rice irradiated by different absorbed doses with additive acid solution and distilled water were in...In order to confirm whether the rice sample was exposed to gamma radiation,the changes in starch pasting viscosity of rice irradiated by different absorbed doses with additive acid solution and distilled water were investigated.The peak viscosity of irradiated rice sample was significantly decreased with the increment of absorbed doses even for the samples stored over 360 days.Irradiation samples can be distinguished from non-irradiated samples by their RVA profile as in the acid solution(pH=2.5),the starch pasting viscosities of irradiated rice samples were apparently higher while the starch pasting viscosities of non-irradiated rice samples were lower than that in distilled water(pH=7.0).The irradiation absorbed dose can be estimated accurately by the regression equation constructed with peak viscosity and absorbed doses.展开更多
This study compared the accumulation of Zn^(2+)and Cu^(2+)in the ovaries and ova of loaches under different concentrations of Zn^(2+)(1.00,2.50 and 5.00 mg/L respectively)and Cu^(2+)(0.10,0.25 and 0.50 mg/L respective...This study compared the accumulation of Zn^(2+)and Cu^(2+)in the ovaries and ova of loaches under different concentrations of Zn^(2+)(1.00,2.50 and 5.00 mg/L respectively)and Cu^(2+)(0.10,0.25 and 0.50 mg/L respectively).The results showed that both Zn^(2+)and Cu^(2+)accumulated in the ovaries,and that the relationship between accumulation and time was linear over 20 days of exposure.The accumulation of the metals in ovaries was closely related to the concentration of exposure in the solutions(P<0.05),and was obviously affected by the time and doses.However,the Cu^(2+)concentration was significantly higher than Zn^(2+)(P<0.05).The development level of ova in the ovaries also correlated with the concentration and exposure period in the Zn^(2+)and Cu^(2+)solutions.展开更多
The highly sensitive giant magneto-impedance effect in a solenoid containing a magnetic core of Fe36Co36Nb4Si4.8B19.2(FeCo-based) ribbon under a weak magnetic field(WMF) is presented in this paper.The FeCo-based amorp...The highly sensitive giant magneto-impedance effect in a solenoid containing a magnetic core of Fe36Co36Nb4Si4.8B19.2(FeCo-based) ribbon under a weak magnetic field(WMF) is presented in this paper.The FeCo-based amorphous ribbon is prepared by single roller quenching and annealed with Joule heat in a flowing nitrogen atmosphere.The giant magnetoimpedance effect in solenoid(GMIES) profiles are measured with an HP4294A impedance analyzer.The result shows that the GMIES responds to the WMF sensitively(as high as 1580 %/A·m 1).The high sensitivity can be obtained in a moderate narrow range of annealing current density(30-34 A/mm 2) and closely depends on the driven current frequency.The highest sensitivity(1580 %/A·m 1) is obtained when the FeCobased amorphous ribbon is annealed at 32 A/mm 2 for 10 min and then driven with an alterning current(AC) at the frequency of 350 kHz.The highly sensitive GMIES under the WMF may result from the multiple magnetic-anisotropic structure,which is induced by the temperature gradient produced during Joule-heating the ribbon.展开更多
One novel binuclear Co(Ⅱ) coordination polymer 1[Co2(4,4'-bpy)2(L)4](1, bpy = bipyridine, HL = 2-fluorbenzoic acid) has been hydrothermally synthesized and structurally characterized by elemental analysis, IR and...One novel binuclear Co(Ⅱ) coordination polymer 1[Co2(4,4'-bpy)2(L)4](1, bpy = bipyridine, HL = 2-fluorbenzoic acid) has been hydrothermally synthesized and structurally characterized by elemental analysis, IR and X-ray single-crystal diffraction. Complex 1 crystallizes in the monoclinic system, space group P21/c with a = 11.163(2), b = 21.943(4), c = 9.6381(19)?, β = 113.92(3)°, V = 2158.2(7) ?_3, Z = 4, Dc = 1.518 g/cm3, Mr = 493.31, F(000) =1004, R = 0.0303 and w R = 0.0808 for 3614 observed reflections(I > 2σ(I)). Complex 1 exhibits a 3D Schlafli symbol(4.62)(4.66.83) topological framework, and the magnetic characterization shows weak antiferromagnetic coupling exchange between two Co ions.展开更多
[Objective] To investigate the combined immunization of porcine circovirus 2( PCV2) inactivated vaccine with Po IL-2,4. [Methods] A total of 60 crossbred piglets were randomly divided into three groups,including the t...[Objective] To investigate the combined immunization of porcine circovirus 2( PCV2) inactivated vaccine with Po IL-2,4. [Methods] A total of 60 crossbred piglets were randomly divided into three groups,including the test group( inoculation of 0. 5 dose PCV2 inactivated vaccine with 0. 1 m L Po IL-2,4 at 14 and 28 day-old),the positive control group( inoculation of 0. 5 dose PCV2 inactivated vaccine) and the blank control group. [Results]The immune organ index,the lymphocyte transformation rates under different ages and the number of leukocytes and lymphocytes in peripheral blood increased significantly in test group,compared with control group. Moreover,the antibody and neutralizing antibody were also significantly higher in test group than that in control group. The clinical symptoms and pathological changes were not found,and the PCV2 was not detected in serum and tissue after challenge test in test group,which indicated that the combined immunization of PCV2 inactivated vaccine with Po IL-2,4 significantly improved the lymphocyte transformation rate,effectively prevented the replication of PCV2 in organism,and enhanced the growth performance of piglets.展开更多
Based on the development prospect of the industry of keeping in good health and caring for the senior and practical exploration on the Lishui Citys construction of "Health Blessed Land" in Yangtze River Delt...Based on the development prospect of the industry of keeping in good health and caring for the senior and practical exploration on the Lishui Citys construction of "Health Blessed Land" in Yangtze River Delta, the position, function and facing problems of agritainment in the system of industrial economy of keeping in good health and caring for the senior in Lishui City. From the view of the industry integration, this paper puts forward the new strategies of developing agritainment in terms of design concepts at the top level, guarantee conditions in the government, layout strategies stressing on resources, target assessment focusing on nourishing of life, the basic promoting connotation.展开更多
The important issues of network TCP congestion control are how to compute the link price according to the link status and regulate the data sending rate based on link congestion pricing feedback information.However,it...The important issues of network TCP congestion control are how to compute the link price according to the link status and regulate the data sending rate based on link congestion pricing feedback information.However,it is difficult to predict the congestion state of the link-end accurately at the source.In this paper,we presented an improved NUMFabric algorithm for calculating the overall congestion price.In the proposed scheme,the whole network structure had been obtained by the central control server in the Software Defined Network,and a kind of dual-hierarchy algorithm for calculating overall network congestion price had been demonstrated.In this scheme,the first hierarchy algorithm was set up in a central control server like Opendaylight and the guiding parameter B is obtained based on the intelligent data of global link state information.Based on the historical data,the congestion state of the network and the guiding parameter B is accurately predicted by the machine learning algorithm.The second hierarchy algorithm was installed in the Openflow link and the link price was calculated based on guiding parameter B given by the first algorithm.We evaluate this evolved NUMFabric algorithm in NS3,which demonstrated that the proposed NUMFabric algorithm could efficiently increase the link bandwidth utilization of cloud computing IoT datacenters.展开更多
A simple and economical method based on dSPACE system is developed to measure the effect of cable vibration control.The experiments,numerical simulation and hardware-in-the-loop(HIL)simulation are carried out for the ...A simple and economical method based on dSPACE system is developed to measure the effect of cable vibration control.The experiments,numerical simulation and hardware-in-the-loop(HIL)simulation are carried out for the vibration control of stay cables with dampers.Firstly,the test results of solid cable vibration under harmonic excitation are compared with the numerical simulation results of cable vibration to ensure the correctness of the simulation of cable module.Then,the vibration test results of solid cable with damper under harmonic excitation are compared with the numerical simulation results of solid cable with damper to ensure the correctness of the relevant modules.Finally,the external load and the cable are imported into the real-time simulation system to simulate the control effect of the damper under the current excitation in real time.The results show that the simulation is correct and the HIL simulation is feasible in the bridge engineering.展开更多
Pathological alterations in the brain can cause microglial activation(MA).Thus,inhibiting MA could provide a new approach for treating neurodegenerative disorders.To investigate the effect of C16 peptide and angiopoie...Pathological alterations in the brain can cause microglial activation(MA).Thus,inhibiting MA could provide a new approach for treating neurodegenerative disorders.To investigate the effect of C16 peptide and angiopoietin-1(Ang1)on inflammation following MA,we stimulated microglial BV-2 cells with lipopolysaccharide(LPS)and used dexmedetomidine(DEX)as a positive control.Specific inhibitors of Tie2,avβ3 and a5β1 integrins,and PI3K/Akt were applied to investigate the neuron-protective and anti-inflammatory effects and signaling pathway of C16+Angl treatment in the LPS-induced BV-2 cells.Our results showed that C16+Ang1 treatment reduced the microglia M1 phenotype but promoted the microglia M2 phenotype.展开更多
Cadmium(Cd)pollution poses a serious threat to plant growth and yield.Nanomaterials have shown great application potential for alleviation of Cd toxicity to plants.In this study,we applied graphitic carbon nitride nan...Cadmium(Cd)pollution poses a serious threat to plant growth and yield.Nanomaterials have shown great application potential for alleviation of Cd toxicity to plants.In this study,we applied graphitic carbon nitride nanosheets(g-C_(3)N_(4)NSs)for alleviation of Cd-toxicity to soybean(Glycine max L.).The g-C_(3)N_(4)NSs supplementation significantly improved plant growth and reduced oxidative damage in the Cd-toxicated soybean seedlings through hydroponic culture.Particularly,the g-C_(3)N_(4)NSs dynamically regulated the root cell wall(RCW)components by increasing pectin content and modifying its demethylation via enhancing pectin methylesterase(PME)activity,therefore greatly enhanced stronger RCW-Cd retention(up to 82.8%)and reduced Cd migration to the shoot.Additionally,the g-C_(3)N_(4)NSs reversed the Cd-induced chlorosis,increased photosynthetic efficiency because of enhancement in F_v/F_mration,Y(Ⅱ)and sugars content.These results provide new insights into the alleviation of Cd toxicity to plants by g-C_(3)N_(4)NSs,and shed light on the application of low-cost and environmental-friendly carbon-based NMs for alleviating heavy metal toxicity to plants.展开更多
The pollutant control performance of exhaust hoods plays a crucial role in the indoor air quality and energy consumption of ventilation systems in industrial buildings.To better understand the impact of local ventilat...The pollutant control performance of exhaust hoods plays a crucial role in the indoor air quality and energy consumption of ventilation systems in industrial buildings.To better understand the impact of local ventilation on the industrial indoor environment,this paper presents a literature review of exhaust hood performance and its improvement technologies.To create an index for evaluating the performance of exhaust hoods,the capture velocity,capture efficiency,flow ratio of pollutant emissions and exhaust airflow and energy consumption are first introduced.A number of factors affecting exhaust hood performance are assessed such as hood type,hood opening size,exhaust rate,installation distance,pollution source emission and environmental disturbance.Compared to structural improvement methods,the use of active airflow is a more effective way to improve the exhaust hood performance.The most commonly used methods for determining the exhaust rate are the controlled speed method and the flow ratio method.The use of an exhaust hood with an appropriate exhaust rate and jet parameters(for an active air-assisted hood)can effectively improve the pollutant control performance and reduce the energy consumption that would be wasted on the redundant exhaust rate.With more information focused on exhaust hood performance,this work suggests more effective strategies for improving indoor air quality and reducing energy consumption in industrial buildings.展开更多
基金Project supported by the National Natural Science Foundation of China(Grant Nos.62103375 and 62006106)the Zhejiang Provincial Philosophy and Social Science Planning Project(Grant No.22NDJC009Z)+1 种基金the Education Ministry Humanities and Social Science Foundation of China(Grant Nos.19YJCZH056 and 21YJC630120)the Natural Science Foundation of Zhejiang Province of China(Grant Nos.LY23F030003 and LQ21F020005).
文摘While progress has been made in information source localization,it has overlooked the prevalent friend and adversarial relationships in social networks.This paper addresses this gap by focusing on source localization in signed network models.Leveraging the topological characteristics of signed networks and transforming the propagation probability into effective distance,we propose an optimization method for observer selection.Additionally,by using the reverse propagation algorithm we present a method for information source localization in signed networks.Extensive experimental results demonstrate that a higher proportion of positive edges within signed networks contributes to more favorable source localization,and the higher the ratio of propagation rates between positive and negative edges,the more accurate the source localization becomes.Interestingly,this aligns with our observation that,in reality,the number of friends tends to be greater than the number of adversaries,and the likelihood of information propagation among friends is often higher than among adversaries.In addition,the source located at the periphery of the network is not easy to identify.Furthermore,our proposed observer selection method based on effective distance achieves higher operational efficiency and exhibits higher accuracy in information source localization,compared with three strategies for observer selection based on the classical full-order neighbor coverage.
文摘BACKGROUND Individuals with refractory ascites in the context of liver cirrhosis typically face an adverse prognosis.The transjugular intrahepatic portosystemic shunt(TIPS)is an efficacious intervention,but there is a lack of reliable tools for postoperative pro-gnosis assessment.Previously utilized clinical biochemical markers,such as the serum albumin concentration(Alb),sodium(Na+)concentration,and serum creatinine(Scr),have limited predictive value.Therefore,the quest for novel,specific biomarkers to evaluate the post-TIPS prognosis in patients with liver cirrhosis and refractory ascites holds significant practical importance.A retrospective analysis was conducted on 75 patients with liver cirrhosis and refractory ascites who underwent TIPS at our institution from August 2019 to August 2021.These patients were followed up regularly for two years,and the death toll was meticulously documented.The patients were allocated into a survival group(n=45 patients)or a deceased group(n=30 patients)based on their prognosis status.The clinical data of the two groups were collected,and Child-Pugh scores and MELD scores were calculated for analysis.Spearman correlation analysis was carried out to evaluate the correlation of prognosis with Child-Pugh grade,MELD score,and Cys C level.Additionally,a multiple-factor analysis utilizing the Cox proportional hazard model was used to identify independent risk factors affecting the post-TIPS prognosis of patients with liver cirrhosis and refractory ascites.The receiver operating characteristic curve(ROC)ascertained the predictive value of the Cys C concen-tration,Child-Pugh grade,and MELD score for the prognosis of liver cirrhosis with refractory ascites in post-TIPS patients.RESULTS During a 2-year follow-up period,among 75 patients with liver cirrhosis and refractory ascites who underwent TIPS treatment,30 patients(40.00%)passed away.The deceased cohort exhibited heightened aspartate aminotrans-ferase,alanine aminotransferase,total bilirubin,Scr,prothrombin time,Cys C,international normalized ratio,Child-Pugh,and MELD scores compared to those of the survival cohort,while Alb and Na+levels were attenuated in the deceased group(P<0.05).Spearman analysis revealed moderate to high positive correlations between prognosis and Child-Pugh score,MELD score,and Cys C level(r=0.709,0.749,0.671,P<0.05).Multivariate analysis using the Cox proportional hazard model demonstrated that the independent risk factors for post-TIPS prognosis in patients with liver cirrhosis and refractory ascites were Cys C(HR=3.802;95%CI:1.313-11.015),Child-Pugh(HR=3.030;95%CI:1.858-4.943),and MELD(HR=1.222;95%CI:1.073-1.393)scores.ROC analysis confirmed that,compared to those of the classic prognostic models for Child-Pugh and MELD scores,the predictive accuracy of Cys C for post-TIPS prognosis in patients with liver cirrhosis and refractory ascites was slightly lower.This analysis yielded sensitivity and specificity values of 83.33%and 82.22%,respectively.The area under the curve value at this juncture was 0.883,with an optimal cutoff value set at 1.95 mg/L.CONCLUSION Monitoring the serum Cys C concentration is valuable for assessing the post-TIPS prognosis in patients with liver cirrhosis and refractory ascites.Predictive models based on serum Cys C levels,as opposed to Scr levels,are more beneficial for evaluating the condition and prognosis of patients with ascites due to cirrhosis.
基金supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIT)(NRF-2022R1A2C2093415) and (NRF-2018R1A2B6006721)Institute for Basic Science of Korea (IBS-R011-D1)the Korea Medical Device Development Fund grant funded by the Korean government (the Ministry of Science and ICT, the Ministry of Trade, Industry and Energy, the Ministry of Health & Welfare, the Ministry of Food and Drug Safety) (Project Number: KMDF_PR_20200901_0004)。
文摘Herein, a stable and efficient CoS_(2)-ReS_(2) electrocatalyst is successfully constructed by using the different molar ratios of CoS_(2) on ReS_(2). The size and morphology of the catalysts are significantly changed after the CoS_(2) is grown on ReS_(2), providing regulation of the catalytic activity of ReS_(2). Particularly, the optimized CoS_(2)-ReS_(2) shows superior electrocatalytic properties with a low voltage of 1.48 V at 20 mA cm^(-2) for overall water splitting in 1.0 M KOH, which is smaller than the noble metal-based catalysts(1.77 V at 20 mA cm^(-2)). The XPS, XAS, and theoretical data confirm that the interfacial regulation of ReS_(2) by CoS_(2) can provide rich edge catalytic sites, which greatly optimizes the catalytic kinetics and drop the energy barrier for oxygen/hydrogen evolution reactions. Our results demonstrated that interfacial engineering is an efficient route for fabricating high-performance water splitting electrocatalysts.
基金supported by a grant from the Experimental Animal Science and Technology Project of Zhejiang Province in China,No.2012C37083
文摘Post-stroke depression is associated with reduced expression of brain-derived neurotrophic factor(BDNF). In this study, we evaluated whether BDNF overexpression affects depression-like behavior in a rat model of post-stroke depression. The middle cerebral artery was occluded to produce a model of focal cerebral ischemia. These rats were then subjected to isolation-housing combined with chronic unpredictable mild stress to generate a model of post-stroke depression. A BDNF gene lentiviral vector was injected into the hippocampus. At 7 days after injection, western blot assay and real-time quantitative PCR revealed that BDNF expression in the hippocampus was increased in depressive rats injected with BDNF lentivirus compared with depressive rats injected with control vector. Furthermore, sucrose solution consumption was higher, and horizontal and vertical movement scores were increased in the open field test in these rats as well. These findings suggest that BDNF overexpression in the hippocampus of post-stroke depressive rats alleviates depression-like behaviors.
文摘Because there is no curative treatment for spinal cord injury,establishing an ideal animal model is important to identify injury mechanisms and develop therapies for individuals suffering from spinal cord injuries.In this article,we systematically review and analyze various kinds of animal models of spinal cord injury and assess their advantages and disadvantages for further studies.
基金Public Welfare Projects of Technology Office in Zhejiang Province （2011C32SA700049） Major Science and Technology Specific Projects of Zhejiang Province （2012C12907-9） Science and Technology Plan Projects of Jinhua City （2011A22020）
ACKNOWLEDGEMENTS We would like to thank the Weiwang Pearl Cultivation Base for providing samples. We are also grateful to Professor Yongjiu Chen （Zhejiang Ocean University） for assistance with the manuscript.
文摘Lamprotula leai is one of the most commercially important freshwater pearl mussels in China, but there is limited data on its genetic diversity and population structure. In the present study, 119 individuals from four major geographical populations were investigated using 15 microsatellite loci identified via cross-species amplification. A total of 114 alleles were detected, with an average of 7.6 alleles per locus(range: 2 to 21). Among the four stocks, those from Hung-tse Lake and Poyang Lake had the lowest(0.412) and highest(0.455) observed heterozygosity respectively. The polymorphism information content(PIC) ranged from 0.374 to 0.927(mean: 0.907). AMOVA showed that 12.56% and 44.68% genetic variances were among populations and within individuals, respectively. Pairwise Fst ranged from 0.073 to 0.146, indicating medium genetic differentiation among the populations. In aggregate, our results suggest that inbreeding is a crucial factor accounting for deviations from Hardy–Weinberg equilibrium at 12 loci. Moreover, the genetic distance among four stocks ranged from 0.192 to 0.890. Poyang Lake and Hung-tse Lake were clustered together, joined with Dongting Lake and Anqing Lake. Given that specimens from Hungtse Lake showed the highest average allele richness, expected heterozygosity and PIC, this location may be the source of the highest quality germplasm resources and the stock from this area may be the best for future breeding efforts.
文摘A new complex [Co(4,4'-bpy)2(H2O)2(4-FBA)2]·(4,4'-bpy)(1) has been hydro-thermally synthesized using cobalt,4,4'-bipyridyl(4,4'-bpy) and 4-fluorobenzoic acid(4-HFBA),and characterized by thermal analysis,single-crystal X-ray diffraction and magnetic property.The complex crystallizes in the triclinic system,space group P,Z = 1.Crystal data:C54H44CoF2N8O6,Mr = 997.90,a = 9.134(2),b = 11.555(2),c = 12.867(3) ,α = 66.02(3),β = 77.96(3),= 73.11(3)°,V = 1180.9(4) 3,Dc = 1.403 g/cm3,μ(MoKα) = 0.433 mm-1,F(000) = 517,the final R = 0.0633 and wR = 0.1171 for 2152 observed reflections(I > 2σ(I)).The title complex is assembled into 1D supramolecular chains parallel to [001] based on the adjacent molecular ··· stacking interactions and hydrogen bonds.The variable temperature magnetic measurements show a weak ferromagnetic behavior over 300-160 K followed by antiferromagnetic behavior below 160 K for the title complex.
基金Natural Science Foundation of Zhejiang(LY12C03006),China
文摘This study compared the accumulation of Zn2+and Cu2+in the ovaries and ova of loaches under different concentrations of Zn2+(1.00, 2.50 and 5.00 mg/L respectively) and Cu2+(0.10, 0.25 and 0.50 mg/L respectively). The results showed that both Zn2+and Cu2+accumulated in the ovaries, and that the relationship between accumulation and time was linear over 20 days of exposure. The accumulation of the metals in ovaries was closely related to the concentration of exposure in the solutions(P<0.05), and was obviously affected by the time and doses. However, the Cu2+concentration was significantly higher than Zn2+(P<0.05). The development level of ova in the ovaries also correlated with the concentration and exposure period in the Zn2+and Cu2+solutions.
基金Supported by Special Funds for Agro-scientific Research in the Public Interest(No.201103007)
文摘In order to confirm whether the rice sample was exposed to gamma radiation,the changes in starch pasting viscosity of rice irradiated by different absorbed doses with additive acid solution and distilled water were investigated.The peak viscosity of irradiated rice sample was significantly decreased with the increment of absorbed doses even for the samples stored over 360 days.Irradiation samples can be distinguished from non-irradiated samples by their RVA profile as in the acid solution(pH=2.5),the starch pasting viscosities of irradiated rice samples were apparently higher while the starch pasting viscosities of non-irradiated rice samples were lower than that in distilled water(pH=7.0).The irradiation absorbed dose can be estimated accurately by the regression equation constructed with peak viscosity and absorbed doses.
基金Natural Science Foundation of Zhejiang(LY12C03006),China。
文摘This study compared the accumulation of Zn^(2+)and Cu^(2+)in the ovaries and ova of loaches under different concentrations of Zn^(2+)(1.00,2.50 and 5.00 mg/L respectively)and Cu^(2+)(0.10,0.25 and 0.50 mg/L respectively).The results showed that both Zn^(2+)and Cu^(2+)accumulated in the ovaries,and that the relationship between accumulation and time was linear over 20 days of exposure.The accumulation of the metals in ovaries was closely related to the concentration of exposure in the solutions(P<0.05),and was obviously affected by the time and doses.However,the Cu^(2+)concentration was significantly higher than Zn^(2+)(P<0.05).The development level of ova in the ovaries also correlated with the concentration and exposure period in the Zn^(2+)and Cu^(2+)solutions.
基金Project supported by the National Natural Science Foundation of China (Grant Nos. 50871104 and 11079029)the Natural Science Foundation of Zhejiang Province,China (Grant Nos. Y4080324 and Y6110246)the Natural Science Foundation of Shanxi Province, China (Grant No. Sj08e101)
文摘The highly sensitive giant magneto-impedance effect in a solenoid containing a magnetic core of Fe36Co36Nb4Si4.8B19.2(FeCo-based) ribbon under a weak magnetic field(WMF) is presented in this paper.The FeCo-based amorphous ribbon is prepared by single roller quenching and annealed with Joule heat in a flowing nitrogen atmosphere.The giant magnetoimpedance effect in solenoid(GMIES) profiles are measured with an HP4294A impedance analyzer.The result shows that the GMIES responds to the WMF sensitively(as high as 1580 %/A·m 1).The high sensitivity can be obtained in a moderate narrow range of annealing current density(30-34 A/mm 2) and closely depends on the driven current frequency.The highest sensitivity(1580 %/A·m 1) is obtained when the FeCobased amorphous ribbon is annealed at 32 A/mm 2 for 10 min and then driven with an alterning current(AC) at the frequency of 350 kHz.The highly sensitive GMIES under the WMF may result from the multiple magnetic-anisotropic structure,which is induced by the temperature gradient produced during Joule-heating the ribbon.
基金supported by the National Natural Science Foundation of China(51343003)the Scientific Research Projects of Zhejiang Provincial Education Department(Y201224707)
文摘One novel binuclear Co(Ⅱ) coordination polymer 1[Co2(4,4'-bpy)2(L)4](1, bpy = bipyridine, HL = 2-fluorbenzoic acid) has been hydrothermally synthesized and structurally characterized by elemental analysis, IR and X-ray single-crystal diffraction. Complex 1 crystallizes in the monoclinic system, space group P21/c with a = 11.163(2), b = 21.943(4), c = 9.6381(19)?, β = 113.92(3)°, V = 2158.2(7) ?_3, Z = 4, Dc = 1.518 g/cm3, Mr = 493.31, F(000) =1004, R = 0.0303 and w R = 0.0808 for 3614 observed reflections(I > 2σ(I)). Complex 1 exhibits a 3D Schlafli symbol(4.62)(4.66.83) topological framework, and the magnetic characterization shows weak antiferromagnetic coupling exchange between two Co ions.
基金Supported by the Science and Technology Project of Zhejiang Province(2011C22093)
文摘[Objective] To investigate the combined immunization of porcine circovirus 2( PCV2) inactivated vaccine with Po IL-2,4. [Methods] A total of 60 crossbred piglets were randomly divided into three groups,including the test group( inoculation of 0. 5 dose PCV2 inactivated vaccine with 0. 1 m L Po IL-2,4 at 14 and 28 day-old),the positive control group( inoculation of 0. 5 dose PCV2 inactivated vaccine) and the blank control group. [Results]The immune organ index,the lymphocyte transformation rates under different ages and the number of leukocytes and lymphocytes in peripheral blood increased significantly in test group,compared with control group. Moreover,the antibody and neutralizing antibody were also significantly higher in test group than that in control group. The clinical symptoms and pathological changes were not found,and the PCV2 was not detected in serum and tissue after challenge test in test group,which indicated that the combined immunization of PCV2 inactivated vaccine with Po IL-2,4 significantly improved the lymphocyte transformation rate,effectively prevented the replication of PCV2 in organism,and enhanced the growth performance of piglets.
文摘Based on the development prospect of the industry of keeping in good health and caring for the senior and practical exploration on the Lishui Citys construction of "Health Blessed Land" in Yangtze River Delta, the position, function and facing problems of agritainment in the system of industrial economy of keeping in good health and caring for the senior in Lishui City. From the view of the industry integration, this paper puts forward the new strategies of developing agritainment in terms of design concepts at the top level, guarantee conditions in the government, layout strategies stressing on resources, target assessment focusing on nourishing of life, the basic promoting connotation.
基金supported by National Key R&D Program of China—Industrial Internet Application Demonstration-Sub-topic Intelligent Network Operation and Security Protection(2018YFB1802400).
文摘The important issues of network TCP congestion control are how to compute the link price according to the link status and regulate the data sending rate based on link congestion pricing feedback information.However,it is difficult to predict the congestion state of the link-end accurately at the source.In this paper,we presented an improved NUMFabric algorithm for calculating the overall congestion price.In the proposed scheme,the whole network structure had been obtained by the central control server in the Software Defined Network,and a kind of dual-hierarchy algorithm for calculating overall network congestion price had been demonstrated.In this scheme,the first hierarchy algorithm was set up in a central control server like Opendaylight and the guiding parameter B is obtained based on the intelligent data of global link state information.Based on the historical data,the congestion state of the network and the guiding parameter B is accurately predicted by the machine learning algorithm.The second hierarchy algorithm was installed in the Openflow link and the link price was calculated based on guiding parameter B given by the first algorithm.We evaluate this evolved NUMFabric algorithm in NS3,which demonstrated that the proposed NUMFabric algorithm could efficiently increase the link bandwidth utilization of cloud computing IoT datacenters.
基金National Natural Science Foundation of China(No.50178430)。
文摘A simple and economical method based on dSPACE system is developed to measure the effect of cable vibration control.The experiments,numerical simulation and hardware-in-the-loop(HIL)simulation are carried out for the vibration control of stay cables with dampers.Firstly,the test results of solid cable vibration under harmonic excitation are compared with the numerical simulation results of cable vibration to ensure the correctness of the simulation of cable module.Then,the vibration test results of solid cable with damper under harmonic excitation are compared with the numerical simulation results of solid cable with damper to ensure the correctness of the relevant modules.Finally,the external load and the cable are imported into the real-time simulation system to simulate the control effect of the damper under the current excitation in real time.The results show that the simulation is correct and the HIL simulation is feasible in the bridge engineering.
文摘Pathological alterations in the brain can cause microglial activation(MA).Thus,inhibiting MA could provide a new approach for treating neurodegenerative disorders.To investigate the effect of C16 peptide and angiopoietin-1(Ang1)on inflammation following MA,we stimulated microglial BV-2 cells with lipopolysaccharide(LPS)and used dexmedetomidine(DEX)as a positive control.Specific inhibitors of Tie2,avβ3 and a5β1 integrins,and PI3K/Akt were applied to investigate the neuron-protective and anti-inflammatory effects and signaling pathway of C16+Angl treatment in the LPS-induced BV-2 cells.Our results showed that C16+Ang1 treatment reduced the microglia M1 phenotype but promoted the microglia M2 phenotype.
基金financial support from the National Natural Science Foundation of China(Nos.30800705,31101599)the Natural Science Foundation of Zhejiang Provincial(Nos.LY18C150007,LY15C150004)+1 种基金Key Research and Development Projects of Social Development of Jinhua Science and Technology Program(No.2021C22750)the Zhejiang Provincial Key Laboratory of Subtropic Soil and Plant Nutrition,China。
文摘Cadmium(Cd)pollution poses a serious threat to plant growth and yield.Nanomaterials have shown great application potential for alleviation of Cd toxicity to plants.In this study,we applied graphitic carbon nitride nanosheets(g-C_(3)N_(4)NSs)for alleviation of Cd-toxicity to soybean(Glycine max L.).The g-C_(3)N_(4)NSs supplementation significantly improved plant growth and reduced oxidative damage in the Cd-toxicated soybean seedlings through hydroponic culture.Particularly,the g-C_(3)N_(4)NSs dynamically regulated the root cell wall(RCW)components by increasing pectin content and modifying its demethylation via enhancing pectin methylesterase(PME)activity,therefore greatly enhanced stronger RCW-Cd retention(up to 82.8%)and reduced Cd migration to the shoot.Additionally,the g-C_(3)N_(4)NSs reversed the Cd-induced chlorosis,increased photosynthetic efficiency because of enhancement in F_v/F_mration,Y(Ⅱ)and sugars content.These results provide new insights into the alleviation of Cd toxicity to plants by g-C_(3)N_(4)NSs,and shed light on the application of low-cost and environmental-friendly carbon-based NMs for alleviating heavy metal toxicity to plants.
文摘The pollutant control performance of exhaust hoods plays a crucial role in the indoor air quality and energy consumption of ventilation systems in industrial buildings.To better understand the impact of local ventilation on the industrial indoor environment,this paper presents a literature review of exhaust hood performance and its improvement technologies.To create an index for evaluating the performance of exhaust hoods,the capture velocity,capture efficiency,flow ratio of pollutant emissions and exhaust airflow and energy consumption are first introduced.A number of factors affecting exhaust hood performance are assessed such as hood type,hood opening size,exhaust rate,installation distance,pollution source emission and environmental disturbance.Compared to structural improvement methods,the use of active airflow is a more effective way to improve the exhaust hood performance.The most commonly used methods for determining the exhaust rate are the controlled speed method and the flow ratio method.The use of an exhaust hood with an appropriate exhaust rate and jet parameters(for an active air-assisted hood)can effectively improve the pollutant control performance and reduce the energy consumption that would be wasted on the redundant exhaust rate.With more information focused on exhaust hood performance,this work suggests more effective strategies for improving indoor air quality and reducing energy consumption in industrial buildings.
