MANY cases of pure red cell aplasia(PRCA)were mediated by over-function of immune cells,and responded well to immunosuppressive therapy.1 Sometimes refractory cases also arose.Fludarabine is an analogue of adenosine r...MANY cases of pure red cell aplasia(PRCA)were mediated by over-function of immune cells,and responded well to immunosuppressive therapy.1 Sometimes refractory cases also arose.Fludarabine is an analogue of adenosine resistant to deamination which is widely used for B-chronic lymphocytic leukemia(CLL)and other hematological malignancies.2 As a strong immunosuppressive agent,展开更多
CHRONIC myeloid leukemia (CML) is characterized by the presence of the BCR/ABL fusion gene,which is the result of a reciprocal translocation between chromosomes 9 and 22,called Philadelphia (Ph) chromosome.Imatinib me...CHRONIC myeloid leukemia (CML) is characterized by the presence of the BCR/ABL fusion gene,which is the result of a reciprocal translocation between chromosomes 9 and 22,called Philadelphia (Ph) chromosome.Imatinib mesylate (imatinib),展开更多
APLASTIC anemia(AA) is a bone marrow failure disease caused by abnormal activation of T lymphocytes,resulting in the apoptosis of hematopoietic cells and bone marrow failure.1 Currently,hematopoietic stem cell transpl...APLASTIC anemia(AA) is a bone marrow failure disease caused by abnormal activation of T lymphocytes,resulting in the apoptosis of hematopoietic cells and bone marrow failure.1 Currently,hematopoietic stem cell transplantation(HSCT),immunosuppressive therapy(IST),and supportive care(e.g.transfusion adjuvant therapy,hematopoietic展开更多
Objective:To explore correlation between red blood cell distribution width(RDW)and cervical carcinoma.Methods:50 cervical carcinoma patients and 75 healthy controls from the First Affiliated Hospital of Soochow Univer...Objective:To explore correlation between red blood cell distribution width(RDW)and cervical carcinoma.Methods:50 cervical carcinoma patients and 75 healthy controls from the First Affiliated Hospital of Soochow University from June 2020 to December 2020 were involved as the patients group and the control group respectively.Demographic data were collected from routine blood tests and biochemistry examination,the correlation of RDW with hemoglobin(Hb)and c-reactive protein(CRP)was evaluated by Spearman rank correlation,and receiver operating characteristic(ROC)curve was drawn to analyze the diagnostic value of RDW for cervical carcinoma.Result:The levels of RDW,squamous cell carcinoma antigen(SCCA)and carcinoembryonic antigen(CEA)in patients with cervical carcinoma were higher than those in the controls.The levels of high-density lipoprotein(HDL),Albumin,Prealbumin,Hb,RBC and neuron-specific enolase(NSE)in patients were lower than those in the controls(all P<0.05).There was no statistical significance on the difference in other markers between the two groups(P>0.05).The AUC of RDW in the diagnosis of cervical carcinoma was 0.834.Based on Spearman's rank correlation coefficient analysis,RDW was positively correlated with Hb(r=0.434,P<0.05)and CRP(r=0.366,P<0.05)RDW,and was negatively correlated with hematocrit(r=-0.363,P<0.05),in cervical carcinoma group,cervical carcinoma subgroupⅠ-ⅡandⅢ-Ⅳwere higher than the control group(P<0.05).Conclusions:Elevated RDW is associated with the occurrence of cervical carcinoma,and it may have clinical value in the diagnosis of cervical carcinoma and the course of reaction.展开更多
Severe bleeding is a common problem and a main cause of death in a medical setting,including surgery,trauma,congenital and acquired abnormalities of hemostasis,fulminant hepatic failure,and gastrointestinal bleeding.I...Severe bleeding is a common problem and a main cause of death in a medical setting,including surgery,trauma,congenital and acquired abnormalities of hemostasis,fulminant hepatic failure,and gastrointestinal bleeding.It has been estimated that rxcessive blood loss may contribute to approximately 30% of trauma-related deaths.Bleeding in critical locations,especially intracerebral hemorrhage,pose also a major clinical challenge.Severe bleeding often needs blood transfusion.In many patients with abnormalities of hemostasis,bleeding can be effectively corrected by replacing the defective components of the hemostatic system,of which the most widely used are factor Ⅷ concentrations and recombinant factor Ⅷ products for hemophilia A treatment,prothrombin complex concentrates and recombinant factor Ⅸ for hemophilia B treatment,and fibrinogen or cryoprecipitate for afibrinogenemia.On the other hand,all the cases of excessive bleeding require pharmacologic strategies of hemostatic agents to minimize blood loss.展开更多
A previously healthy 47-year-old Chinese man presented in January 2009 with extreme fatigue,fever,and night sweats.Hepatomegaly (palpable,2 cm in the right hypochondrium) and splenomegaly (palpable,2 cm in the left hy...A previously healthy 47-year-old Chinese man presented in January 2009 with extreme fatigue,fever,and night sweats.Hepatomegaly (palpable,2 cm in the right hypochondrium) and splenomegaly (palpable,2 cm in the left hypochondrium) were identified,and axillary lymph nodes were swollen.A laboratory investigation showed a white blood cell (WBC) count of 39.8 × 109/L with eosinophils 52％ (absolute eosinophil count of 20.7 × 109/L),hemoglobin level of 14.9 g/dl and platelet count of 50.0 × 109/L.展开更多
Rhabdomyolysis is a syndrome which involves myoglobin and other intracellular proteins and electrolytes that occurs from breakdown of skeletal muscleand leak into the circulation.1 The clinical symptoms of rhabdomyoly...Rhabdomyolysis is a syndrome which involves myoglobin and other intracellular proteins and electrolytes that occurs from breakdown of skeletal muscleand leak into the circulation.1 The clinical symptoms of rhabdomyolysis include myalgia,tenderness on palpation,weakness,brown urine,fever,myoglobinuria,electrolyte imbalance,and acute renal failure.Rhabdomyolysis can be severe enough to be life threatening.2 The causes of rhabdomyolysis include alcohol,electrolyte imbalance (potassium,phosphorus,and magnesium depletion),viral myositis,trauma,connective tissue diseases,drug reaction,toxication,exercise,metabolic diseases,seizures,and hereditary enzyme deficiencies.The exact mechanisms underlying rhabdomyolysis are not fully understood,but it is clear that muscle damage can be caused by direct muscle injury or metabolic inequalities between energy production and energy consumption.展开更多
基金Supported by the Natural Science Foundation of Jiangsu Province(2004BK424)the 135 Key Department Fund of Jiangsu Province(135XY0416)the Outstanding Person Fund of the First Affiliated Hospital of Soochow University(2004YQG05)
文摘MANY cases of pure red cell aplasia(PRCA)were mediated by over-function of immune cells,and responded well to immunosuppressive therapy.1 Sometimes refractory cases also arose.Fludarabine is an analogue of adenosine resistant to deamination which is widely used for B-chronic lymphocytic leukemia(CLL)and other hematological malignancies.2 As a strong immunosuppressive agent,
基金Supported by Key Provincial Talents Program of Jiangsu(H201126)the Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD)
文摘CHRONIC myeloid leukemia (CML) is characterized by the presence of the BCR/ABL fusion gene,which is the result of a reciprocal translocation between chromosomes 9 and 22,called Philadelphia (Ph) chromosome.Imatinib mesylate (imatinib),
基金Supported by Key Provincial Talents Program of Jiangsu(H201126)the Natural Science Fund for Colleges and Universities of Jiangsu Province (09KJB320015)+1 种基金Key Projects in the National Science & Technology Pillar Program (2008BAI61B02 and 2008ZX09312-026)the Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)
文摘APLASTIC anemia(AA) is a bone marrow failure disease caused by abnormal activation of T lymphocytes,resulting in the apoptosis of hematopoietic cells and bone marrow failure.1 Currently,hematopoietic stem cell transplantation(HSCT),immunosuppressive therapy(IST),and supportive care(e.g.transfusion adjuvant therapy,hematopoietic
基金National Natural Science Foundation of China(No.81873431)。
文摘Objective:To explore correlation between red blood cell distribution width(RDW)and cervical carcinoma.Methods:50 cervical carcinoma patients and 75 healthy controls from the First Affiliated Hospital of Soochow University from June 2020 to December 2020 were involved as the patients group and the control group respectively.Demographic data were collected from routine blood tests and biochemistry examination,the correlation of RDW with hemoglobin(Hb)and c-reactive protein(CRP)was evaluated by Spearman rank correlation,and receiver operating characteristic(ROC)curve was drawn to analyze the diagnostic value of RDW for cervical carcinoma.Result:The levels of RDW,squamous cell carcinoma antigen(SCCA)and carcinoembryonic antigen(CEA)in patients with cervical carcinoma were higher than those in the controls.The levels of high-density lipoprotein(HDL),Albumin,Prealbumin,Hb,RBC and neuron-specific enolase(NSE)in patients were lower than those in the controls(all P<0.05).There was no statistical significance on the difference in other markers between the two groups(P>0.05).The AUC of RDW in the diagnosis of cervical carcinoma was 0.834.Based on Spearman's rank correlation coefficient analysis,RDW was positively correlated with Hb(r=0.434,P<0.05)and CRP(r=0.366,P<0.05)RDW,and was negatively correlated with hematocrit(r=-0.363,P<0.05),in cervical carcinoma group,cervical carcinoma subgroupⅠ-ⅡandⅢ-Ⅳwere higher than the control group(P<0.05).Conclusions:Elevated RDW is associated with the occurrence of cervical carcinoma,and it may have clinical value in the diagnosis of cervical carcinoma and the course of reaction.
基金supported by a Project Funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions
文摘Severe bleeding is a common problem and a main cause of death in a medical setting,including surgery,trauma,congenital and acquired abnormalities of hemostasis,fulminant hepatic failure,and gastrointestinal bleeding.It has been estimated that rxcessive blood loss may contribute to approximately 30% of trauma-related deaths.Bleeding in critical locations,especially intracerebral hemorrhage,pose also a major clinical challenge.Severe bleeding often needs blood transfusion.In many patients with abnormalities of hemostasis,bleeding can be effectively corrected by replacing the defective components of the hemostatic system,of which the most widely used are factor Ⅷ concentrations and recombinant factor Ⅷ products for hemophilia A treatment,prothrombin complex concentrates and recombinant factor Ⅸ for hemophilia B treatment,and fibrinogen or cryoprecipitate for afibrinogenemia.On the other hand,all the cases of excessive bleeding require pharmacologic strategies of hemostatic agents to minimize blood loss.
文摘A previously healthy 47-year-old Chinese man presented in January 2009 with extreme fatigue,fever,and night sweats.Hepatomegaly (palpable,2 cm in the right hypochondrium) and splenomegaly (palpable,2 cm in the left hypochondrium) were identified,and axillary lymph nodes were swollen.A laboratory investigation showed a white blood cell (WBC) count of 39.8 × 109/L with eosinophils 52％ (absolute eosinophil count of 20.7 × 109/L),hemoglobin level of 14.9 g/dl and platelet count of 50.0 × 109/L.
文摘Rhabdomyolysis is a syndrome which involves myoglobin and other intracellular proteins and electrolytes that occurs from breakdown of skeletal muscleand leak into the circulation.1 The clinical symptoms of rhabdomyolysis include myalgia,tenderness on palpation,weakness,brown urine,fever,myoglobinuria,electrolyte imbalance,and acute renal failure.Rhabdomyolysis can be severe enough to be life threatening.2 The causes of rhabdomyolysis include alcohol,electrolyte imbalance (potassium,phosphorus,and magnesium depletion),viral myositis,trauma,connective tissue diseases,drug reaction,toxication,exercise,metabolic diseases,seizures,and hereditary enzyme deficiencies.The exact mechanisms underlying rhabdomyolysis are not fully understood,but it is clear that muscle damage can be caused by direct muscle injury or metabolic inequalities between energy production and energy consumption.
基金This work was supported by grants from the National Natural Science funds （No. 81500103）, Natural Science Foundation of Jiangsu Province （BK-20151230）, and the high-level medical talents training project （No. 2016CZLJ027）.
