Objective: Genome-wide association studies have demonstrated that single nucleotide polymorphisms (SNPs) are important risk factors for the development of prostate cancer (PCa). Preliminary studies have suggested that...Objective: Genome-wide association studies have demonstrated that single nucleotide polymorphisms (SNPs) are important risk factors for the development of prostate cancer (PCa). Preliminary studies have suggested that the incidence of PCa in Saudi males is low but is probably familial or genetically related.Methods: To identify any possible association of SNP with PCa development in Saudi patients, we investigated a group of SNPs in Saudi PCa patients (n=85) and compared the outcomes to healthy normal controls (n=115) and nodular hyperplasia patients (n=120). DNA was extracted from paraffin-embedded formalin fixed tissue or whole blood from both patients’ groups and healthy control group. A total of thirteen SNPs were genotyped using TaqMan® minor groove binder polymerase chain reaction assay.Results: The rs16901979A, s629242T and rs1447295A alleles were found at significantly higher frequency in PCa patients than controls (p< 0.05). The rs16901979 CA genotype was found at significantly greater frequency in PCa patients than in healthy controls (43% vs. 14%, odds ratio=4.6, p=0.0001) and benign hyperplasia group (43% vs. 25%, odds ratio=2.2, p=0.009).Conclusion: Our study has highlighted the association of rs16901979 SNP with PCa in Saudi males. Such findings have important implications in the PCa diagnosis and in screening unaffected family members of Saudi patients.展开更多
Epidemic hemorrhagic fever has been an ongoing threat to laboratory personnel involved in animal care and use. Laboratory transmissions and severe infections occurred over the past twenty years, even though the standa...Epidemic hemorrhagic fever has been an ongoing threat to laboratory personnel involved in animal care and use. Laboratory transmissions and severe infections occurred over the past twenty years, even though the standards and regulations for laboratory biosafety have been issued, upgraded, and implemented in China. Therefore, there is an urgent need to identify risk factors and to seek effective preventive measures that can curb the incidences of epidemic hemorrhagic fever among laboratory personnel. In the present study, we reviewed literature that relevant to animals laboratory-acquired hemorrhagic fever infections reported from 1995 to 2015, and analyzed these incidences using fault tree analysis （FTA）.展开更多
In recent years,researches on improving high-voltage performance of lithium-ion batteries incorporating LiNi_(0.5)Co_(0.2)Mn_(0.3)O_(2)(NCM523)and artificial graphite(AG)have been widely reported.However,limited atten...In recent years,researches on improving high-voltage performance of lithium-ion batteries incorporating LiNi_(0.5)Co_(0.2)Mn_(0.3)O_(2)(NCM523)and artificial graphite(AG)have been widely reported.However,limited attentions have been paid to understand the effects and influence mechanisms of charge and discharge rates and charge limit currents on cyclability of NCM523/AG cells.Herein,a∼1.9 Ah NCM523/AG pouch cell is employed,whose electrochemical and structural evolutions after 800 cycles at various rates are comprehensively investigated.We find that cycling performances are strongly influenced by charge rate,followed by limit current and discharge rate.The cell charged at a high rate and cell charged until reaching a low limit current both exhibit low capacity retentions compared to the cell discharged at a high rate.Possible failure reasons are analyzed by advanced characterizations.Results reveal that NCM523 cathodes of the cells deteriorated early experience severe transition metal dissolution,lattice distortion,and partial phase transformation.Meanwhile,the deposited transition metals on AG anodes catalyze the electrolyte consumption,lithium plating and active area loss.Finally,these side reactions notably increase cell impedance and electrochemical polarization.Undoubtedly,these findings clearly outline the challenges and optimization direction for high-rate NCM523/AG cells.展开更多
基金supported by King Fahad Medical City,Riyadh,Saudi Arabia(IRF No:017-059).
文摘Objective: Genome-wide association studies have demonstrated that single nucleotide polymorphisms (SNPs) are important risk factors for the development of prostate cancer (PCa). Preliminary studies have suggested that the incidence of PCa in Saudi males is low but is probably familial or genetically related.Methods: To identify any possible association of SNP with PCa development in Saudi patients, we investigated a group of SNPs in Saudi PCa patients (n=85) and compared the outcomes to healthy normal controls (n=115) and nodular hyperplasia patients (n=120). DNA was extracted from paraffin-embedded formalin fixed tissue or whole blood from both patients’ groups and healthy control group. A total of thirteen SNPs were genotyped using TaqMan® minor groove binder polymerase chain reaction assay.Results: The rs16901979A, s629242T and rs1447295A alleles were found at significantly higher frequency in PCa patients than controls (p< 0.05). The rs16901979 CA genotype was found at significantly greater frequency in PCa patients than in healthy controls (43% vs. 14%, odds ratio=4.6, p=0.0001) and benign hyperplasia group (43% vs. 25%, odds ratio=2.2, p=0.009).Conclusion: Our study has highlighted the association of rs16901979 SNP with PCa in Saudi males. Such findings have important implications in the PCa diagnosis and in screening unaffected family members of Saudi patients.
基金supported by Special Fund for Health Sector of China[Grant No.201302006]
文摘Epidemic hemorrhagic fever has been an ongoing threat to laboratory personnel involved in animal care and use. Laboratory transmissions and severe infections occurred over the past twenty years, even though the standards and regulations for laboratory biosafety have been issued, upgraded, and implemented in China. Therefore, there is an urgent need to identify risk factors and to seek effective preventive measures that can curb the incidences of epidemic hemorrhagic fever among laboratory personnel. In the present study, we reviewed literature that relevant to animals laboratory-acquired hemorrhagic fever infections reported from 1995 to 2015, and analyzed these incidences using fault tree analysis （FTA）.
基金We thank the Natural Science Foundation of Zhejiang Province,China(grant Nos.LQ21B030004 and LQ21E040001)the National Natural Science Foundation of China(grant No.12147219)。
文摘In recent years,researches on improving high-voltage performance of lithium-ion batteries incorporating LiNi_(0.5)Co_(0.2)Mn_(0.3)O_(2)(NCM523)and artificial graphite(AG)have been widely reported.However,limited attentions have been paid to understand the effects and influence mechanisms of charge and discharge rates and charge limit currents on cyclability of NCM523/AG cells.Herein,a∼1.9 Ah NCM523/AG pouch cell is employed,whose electrochemical and structural evolutions after 800 cycles at various rates are comprehensively investigated.We find that cycling performances are strongly influenced by charge rate,followed by limit current and discharge rate.The cell charged at a high rate and cell charged until reaching a low limit current both exhibit low capacity retentions compared to the cell discharged at a high rate.Possible failure reasons are analyzed by advanced characterizations.Results reveal that NCM523 cathodes of the cells deteriorated early experience severe transition metal dissolution,lattice distortion,and partial phase transformation.Meanwhile,the deposited transition metals on AG anodes catalyze the electrolyte consumption,lithium plating and active area loss.Finally,these side reactions notably increase cell impedance and electrochemical polarization.Undoubtedly,these findings clearly outline the challenges and optimization direction for high-rate NCM523/AG cells.
