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Molecular basis of cleft palates in mice 被引量:2
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作者 Noriko Funato Masataka Nakamura Hiromi Yanagisawa 《World Journal of Biological Chemistry》 CAS 2015年第3期121-138,共18页
Cleft palate, including complete or incomplete cleft palates, soft palate clefts, and submucosal cleft palates, is the most frequent congenital craniofacial anomaly in humans. Multifactorial conditions, including gene... Cleft palate, including complete or incomplete cleft palates, soft palate clefts, and submucosal cleft palates, is the most frequent congenital craniofacial anomaly in humans. Multifactorial conditions, including genetic and environmental factors, induce the formation of cleft palates. The process of palatogenesis is temporospatially regulated by transcription factors, growth factors, extracellular matrix proteins, and membranous molecules; a single ablation of these molecules can result in a cleft palate in vivo. Studies on knockout mice were reviewed in order to identify genetic errors that lead to cleft palates. In this review, we systematically describe these mutant mice and discuss the molecular mechanisms of palatogenesis. 展开更多
关键词 Tbx1 SUBMUCOSAL CLEFT PALATE Incomplete CLEFT PALATE Palatal shelf PALATOGENESIS KNOCKOUT MICE
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Microglial dynamics during brain development
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作者 tomomi okajima fuminori tsuruta 《Neural Regeneration Research》 SCIE CAS CSCD 2018年第2期222-223,共2页
Microglia are the resident immune cells of the central nervous system (CNS), In the normal state, microglia have a ramified shape and con- tinuously survey the conditions of the brain.
关键词 Microglial dynamics during brain development
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