This study investigates the effects of technical cheerleading and dance cheerleading on the psychological health of female college students by utilizing the Symptom Checklist-90(SCL-90),the Comprehensive Diagnostic Sc...This study investigates the effects of technical cheerleading and dance cheerleading on the psychological health of female college students by utilizing the Symptom Checklist-90(SCL-90),the Comprehensive Diagnostic Scale for Interpersonal Relationships,and the Social Adaptability Diagnostic Scale.The findings indicate the following:(1)Technical cheerleading has a highly significant impact on sensitivity in interpersonal relationships,paranoia,and psychoticism,and a significant effect on anxiety and hostility;dance cheerleading has a highly significant effect on paranoia;(2)Both technical and dance cheerleading have minimal impact on the overall score distribution of interpersonal relationships among female college students,but the dimensions of their effects differ;(3)The impact of technical cheerleading on the social adaptability of female college students is more pronounced than that of dance cheerleading.展开更多
目的系统评价延续护理促进老年人关节功能恢复的有效性及安全性。方法检索Cochrane Library、Web of Science、PubMed、Embase数据库中有关延续护理应用于老年关节置换患者的随机对照试验和队列研究,检索时间从建库到2023年10月25日。2...目的系统评价延续护理促进老年人关节功能恢复的有效性及安全性。方法检索Cochrane Library、Web of Science、PubMed、Embase数据库中有关延续护理应用于老年关节置换患者的随机对照试验和队列研究,检索时间从建库到2023年10月25日。2名研究员独立完成文献筛选、数据提取,随机对照试验通过Cochrane偏倚风险工具进行文献偏倚分析,队列研究通过纽卡斯尔-渥太华标准进行文献质量评价。结果共纳入15篇文献,包括34186例膝关节和髋关节置换患者。促进老年髋关节置换患者功能改善的主要指标包括髋关节评分、出院后日常生活指数评分(Barthel Index)及生活质量;对老年膝关节置换患者进行延续护理明显改善的指标包括膝关节运动范围、骨关节炎指数、关节损伤和骨关节炎结果评分;延续护理对术后并发症并没有明显作用。文献质量评价显示纳入文献总体质量较高,但仅1项针对髋关节置换术后患者的研究运用了理论框架。结论延续护理在缓解膝关节疼痛、改善关节活动度及髋关节功能方面发挥了重要作用,但是对生活质量、患者满意度、经济、减少关节置换术后并发症和再次入院率方面的有效性尚需进一步明确。展开更多
Introduction: Lumbar disc herniation (LDH) refers to the rupture of the fibrous annulus of the intervertebral discs. Lumbar curvature may lead to the occurrence of lumbar disc degeneration. Fear of movement may worsen...Introduction: Lumbar disc herniation (LDH) refers to the rupture of the fibrous annulus of the intervertebral discs. Lumbar curvature may lead to the occurrence of lumbar disc degeneration. Fear of movement may worsen their disc herniation and cause further pain and injury. LDH conditions impact the individuals’ quality of life, to explore the relationship between lumbar curve, muscle strength, fear of movement and functional disability among patients with LDH. Methods: An electronic search was conducted on PubMed, Medline, Science Direct, Springerlink, Google Scholar and a hand search from reference lists was reviewed. Publications were included in human studies, patients 25 - 85 years of age, original studies and published in English language journals from January 2002 to December 2023. Result: In total, 64 articles were researched through the online search engines, and 9 papers were found through manual searches of reference lists. As a result, a total of 11 articles were included for the purpose of this review. The comprehensive analysis revealed the presence of eight cross-sectional studies, two retrospective studies and one experimental study. A minimum of 25 participants and a maximum of 360 participants were included. Ten studies included both genders, only one studies included healthy adults and patients with LDH but these studies didn’t mention gender. Results showed that the factors influencing LDH can be categorized into non-modifiable factors, such as gender, age, height or others. Modifiable factors included increased BMI, DM, smoking, alcohol, employment status, lifestyle and health problems or psychology. Conclusion: Females with greater VASC may be at risk of LDH. The lumbar extensor muscles indicated a localized disc herniation or nerve root pathology in patients with LDH. The fear of movement may lead to psychological consequences and reduce functional disability among patients with LDH.展开更多
This study conducted a 16-week comparative experiment with 160 students from Jinan No.5 Middle School in Shandong Province as the experimental subjects.During the implementation of the experiment,the subjects were div...This study conducted a 16-week comparative experiment with 160 students from Jinan No.5 Middle School in Shandong Province as the experimental subjects.During the implementation of the experiment,the subjects were divided into two groups:an experimental group and a control group.The experimental group was subjected to physical exercise interventions using sports game teaching methods during physical education class,while the control group followed traditional physical education teaching methods.The results showed that the psychological health status of the students in the experimental group was significantly better than that of the control group after the experiment.The application of sports games helps to improve the psychological health of middle school students in the course of physical education,promoting a positive and forward direction in student psychology and is an effective means to enhance the psychological health level of middle school students.展开更多
目的:评价一种中药植物鞭檐犁头尖(T.flagelliforme)作为抗癌药物的临床前研究的系统综述。方法:对Scopus、PubMed、Web of Science、ScienceDirect、LILACS、EBSCO Medline、Mendeley等7个数据库进行全面检索,检索时间截止到2023年9月...目的:评价一种中药植物鞭檐犁头尖(T.flagelliforme)作为抗癌药物的临床前研究的系统综述。方法:对Scopus、PubMed、Web of Science、ScienceDirect、LILACS、EBSCO Medline、Mendeley等7个数据库进行全面检索,检索时间截止到2023年9月8日。排除了临床试验和非原创的同行评议报告后,鞭檐犁头尖的提取物,组成,或分离化合物的体内外研究且经过同行评审的英文文献均被纳入。本研究定性评估了鞭檐犁头尖对不同肿瘤细胞、肿瘤大小和作用机制的有效性。证据质量由三名独立评估人员使用ToxRTool进行评估,并验证其一致性。结果:检索后共纳入27项研究:22项体外研究,4项体内研究,1项体内外研究。结果发现鞭檐犁头尖对白血病、乳腺癌、结直肠癌和肺癌有效。大多数研究的评估为“有限制的可靠”。鞭檐犁头尖通过阻断细胞周期、活化caspase-3/-9、分解PARP、裂解DNA、减少生存素含量、降低ROS表达、抑制COX-2和HSP70表达和抑制NF-kB通路等来诱导细胞凋亡。当与干扰素联合使用时,其能阻碍血管生成。结论:尽管鞭檐犁头尖具有良好的抗癌活性,但其作为单独抗癌药物的疗效尚不确定。它似乎更适合用于癌症的补充或联合治疗。研究设计不理想,报告不完整,以及在多篇文章中没有纳入适当的阳性对照和统计分析可能是本研究缺乏结论性证据的原因。展开更多
Background: Nurses are professionally accountable for assessing and documenting patients’ vital signs. Nurses failing to fulfill this responsibility position their patients at risk. This paper presents two real-life ...Background: Nurses are professionally accountable for assessing and documenting patients’ vital signs. Nurses failing to fulfill this responsibility position their patients at risk. This paper presents two real-life cases pertaining to patients’ safety resulting in fatal outcomes, leading to the professional, legal, and ethical liability of nurses as the providers of patient care. Objective: This paper focuses on the role of organizational culture in fostering patient safety specifically in monitoring and documentation of patients’ vital signs and early recognition of warning signs. Methodology: A comprehensive literature search was conducted using various databases, examining the significance of vital signs monitoring and documentation and early warning signs in patient safety. Relevant articles combining quantitative and qualitative data were analyzed. Results: By fostering an environment of honest reporting, healthcare organizations can enhance patient safety and improve the quality of care. This paper offers valuable insights and recommendations for developing effective strategies aligned with organizational policies and protocols. Conclusion: This paper serves as a valuable resource, encouraging healthcare professionals to reflect on their practices and the organizations to assess their contributions to creating a culture of safety. It also highlights the importance of reporting and disclosing adverse events as learning opportunities and outlines the role of ethics, professionalism, legislation, and organizational support in achieving patient safety.展开更多
Introduction: Monitoring vital signs is a basic indicator of a patient’s health status and allows prompt detection of delayed recovery or adverse effects and early intervention. Patients with adverse events during ho...Introduction: Monitoring vital signs is a basic indicator of a patient’s health status and allows prompt detection of delayed recovery or adverse effects and early intervention. Patients with adverse events during hospitalization often display clinical decline for several hours before the event is observed. Non-critical care Nurses’ inconsistent recognition and response to patient deterioration lead to an increase in the length of hospital stay, unexpected admissions to the ICU, and increased morbidity and mortality. Aim: The study aimed to assess the factors that facilitate or impede the detection of early warning signs among adult patients hospitalized in tertiary care settings. Training should be provided to improve nurses’ knowledge, practice and attitude toward early warning signs of deteriorating patients leading to enhanced clinical judgment, skills and decision-making in addressing alerts. Methodology: A literature search was carried out in various databases;these were Cumulative Index to Nursing and Allied Health Literature (CINHAL), Google Scholar, PubMed, Science Direct, and Sage. The search area was narrowed from 2017 to 2022. The keywords used were “prevalence” AND “unplanned ICU admission”, “the importance of early warning signs” “outcome failure in rescue” “patient deterioration, communication” “improvement in early detection” AND “patient outcome admission” AND “early warning signs” AND “Pakistan”. After the analysis process, around 33 articles that met the inclusion criteria and were most relevant to the scope and context of the current study were considered. Conclusion: Most of the studies had reviewed literature in a qualitative retrospective observational study, content analysis, mixed method, and quasi-experimental study. The literature review identified that long hours of shift, nurse staffing levels, missed vital signs, lack of nursing training and education, and communication impact nurses’ ability to recognize and respond to early warning signs.展开更多
Management of cardiovascular risk factors in diabetes demands special attention due to their co-existence.Pioglitazone(PIO) and telmisartan(TLM) combination can be beneficial in effective control of cardiovascular com...Management of cardiovascular risk factors in diabetes demands special attention due to their co-existence.Pioglitazone(PIO) and telmisartan(TLM) combination can be beneficial in effective control of cardiovascular complication in diabetes. In this research, we developed and validated a high throughput LC–MS/MS method for simultaneous quantitation of PIO and TLM in rat plasma. This developed method is more sensitive and can quantitate the analytes in relatively shorter period of time compared to the previously reported methods for their individual quantification. Moreover, till date, there is no bioanalytical method available to simultaneously quantitate PIO and TLM in a single run. The method was validated according to the USFDA guidelines for bioanalytical method validation. A linear response of the analytes was observed over the range of 0.005–10 μg/m L with satisfactory precision and accuracy. Accuracy at four quality control levels was within 94.27%–106.10%.The intra-and inter-day precision ranged from 2.32% to 10.14% and 5.02% to 8.12%, respectively. The method was reproducible and sensitive enough to quantitate PIO and TLM in rat plasma samples of a preclinical pharmacokinetic study. Due to the potential of PIO-TLM combination to be therapeutically explored, this method is expected to have significant usefulness in future.展开更多
Objective:To assess the immunopotentiality of Ayurvedic polyherbal preparations,"Saribadi" and "Anantamul Salsa".Methods: Freshly prepared BALB/c mice splenocytes were cultured with "Saribadi&...Objective:To assess the immunopotentiality of Ayurvedic polyherbal preparations,"Saribadi" and "Anantamul Salsa".Methods: Freshly prepared BALB/c mice splenocytes were cultured with "Saribadi" or"Anantamul Salsa" treatment [doses of 0.25%, 0.50%, 0.75%, 1.00%, 1.50%, 2.00%,3.00% and 4.00%(v/v)] at 37C for 5 days. The immunoglobulin M(IgM) production and lymphocytes proliferation were determined by ELISA and MTT methods, respectively.Endotoxin contamination was assessed by treating the preparations with polymyxin B.Results: The doses of "Saribadi" [0.25%, 0.50%, 0.75% and 1.00%(v/v)] significantly increased IgM productions(0.966, 0.728, 0.695 and 0.615 mg/m L vs. control 0.265 mg/m L)and lymphocytes proliferation [absorbance 0.311, 0.394, 0.372 and 0.334 optical density(OD) vs. control 0.162 OD]. Similarly, the doses of "Anantamul Salsa" [0.50%, 0.75%,1.00% and 1.50%(v/v)] promoted IgM productions(0.933, 0.919, 0.917 and 0.892 mg/m L vs. control 0.502 mg/m L) and the doses of "Anantamul Salsa" [0.50%, 0.75%, 1.00%,1.50%, 2.00%, and 3.00%(v/v)] stimulated lymphocytes proliferation(absorbance 0.395,0.326, 0.440, 0.398, 0.452 and 0.355 OD vs. control 0.199 OD). The activity of "Saribadi"and "Anantamul Salsa" was not retarded by the treatment of preparations with polymyxin B.Conclusions: Immunomodulatory activity of "Saribadi" and "Anantamul Salsa" was unveiled for the first time. "Saribadi" and "Anantamul Salsa" possess immunostimulating potential acting through the induction of lymphocyte proliferation and IgM production.These preparations may be useful in strengthening immune responses. However, further cellular and in vivo studies are required.展开更多
In the healthcare system,the Internet of Things(IoT)based distributed systems play a vital role in transferring the medical-related documents and information among the organizations to reduce the replication in medica...In the healthcare system,the Internet of Things(IoT)based distributed systems play a vital role in transferring the medical-related documents and information among the organizations to reduce the replication in medical tests.This datum is sensitive,and hence security is a must in transforming the sensational contents.In this paper,an Evolutionary Algorithm,namely the Memetic Algorithm is used for encrypting the text messages.The encrypted information is then inserted into the medical images using Discrete Wavelet Transform 1 level and 2 levels.The reverse method of the Memetic Algorithm is implemented when extracting a hidden message from the encoded letter.To show its precision,equivalent to five RGB images and five Grayscale images are used to test the proposed algorithm.The results of the proposed algorithm were analyzed using statistical methods,and the proposed algorithm showed the importance of data transfer in healthcare systems in a stable environment.In the future,to embed the privacy-preserving of medical data,it can be extended with blockchain technology.展开更多
Background:Radiographers were at risk of x-ray radiation.Ministry of Heath of Indonesia made a regulation act no.33 year 2007 to secure radiographers on ionizing radiations by using radiation protection equipment(RPE)...Background:Radiographers were at risk of x-ray radiation.Ministry of Heath of Indonesia made a regulation act no.33 year 2007 to secure radiographers on ionizing radiations by using radiation protection equipment(RPE).Objective:This study identified the factors affecting compliance towards RPE among radiographers and determined the correlation between influencing factors and compliance towards RPEs.Methods:The study conducted a quantitative descriptive-correlational design in a cross sectional approach.A total of 103 radiographers answered the online self administered questionnaires from 9 government hospitals at Jakarta,Indonesia.Results:It was identified that personal factors were the knowledge and motivations while the availability of RPEs and standard operating procedures were environmental factors.The knowledge(p=0.001,r=0.321)and motivations(p=0.018,r=0.232),and availability of RPE(p=0.138,r=0.146)and standard operating procedures(p=0.023,r=0.224)were factors affecting a compliance to RPEs.It was however determined that gender(p=0.251,r=0.113),and place of work(p=0.479,r=0.070)were not correlated to both personal and environmental factors.On the contrary,age(p=0.031,r=0.212),highest educational attainment(p=0.039,r=0.203),years of experience(p=0.001,r=0.336),and training(p=0.001,r=0.341)influenced both personal and environmental factors affecting compliance of radiographers towards RPEs.Findings:It was found that Dr.Cipto Mangunkusumo(p=0.271),Persahabatan(p=0.133),Fatmawati(p=0.357),Otak Nasional(p=0.238),Pasar Rebo(p=0.356),Tarakan(0.255),and Koja(p=0.199)hospitals were not probable to comply towards RPEs.Only Infeksi Sulianti Suroso(p=0.21),and Budhi Asih(p=0.0002)hospitals were most probable to comply towards RPEs.展开更多
Objective: The present study explored the effects of the combined herbal therapy consisting of curcumin(CUR) and Fructus Ligustri Lucidi(FLL) on aspects of bone regeneration.Methods: Prior to analyzing the ability of ...Objective: The present study explored the effects of the combined herbal therapy consisting of curcumin(CUR) and Fructus Ligustri Lucidi(FLL) on aspects of bone regeneration.Methods: Prior to analyzing the ability of this novel combined herbal therapy to promote aspects of bone regeneration, its cytotoxicity was determined using MC3 T3-E1 cells(pre-osteoblast model). Cell proliferation was evaluated using phase-contrast microscopy and cell differentiation was estimated using alkaline phosphatase activity. The effect of the combined herbal therapy(CUR + FLL) was also assessed in terms of mineralization in the extracellular matrix(ECM) of cultured cells. Further, to explore the molecular mechanisms of bone formation, time-dependent expression of bone-regulating protein biomarkers was also evaluated.Results: Combined herbal therapy(CUR + FLL) significantly upregulated the viability, proliferation and differentiation of MC3 T3-E1 cells compared to the monotherapy of CUR or FLL. The magnitude of ECM mineralization(calcium deposition) was also higher in MC3 T3-E1 cells treated with combined therapy.The time-dependent expression of bone-forming protein biomarkers revealed that the tendency of expression of these bone-regulating proteins was remarkably higher in cells treated with combined therapy.Conclusion: The co-administration of CUR and FLL had superior promotion of elements of bone regeneration in cultured cells, thus could be a promising alternative herbal therapy for the management of bone erosive disorders such as osteoporosis.展开更多
Objective: To evaluate the effect of ethanolic extract of Pericampylus glaucus (Lam) Merr (P. glaucus) on biochemical parameters in high fats diets treated rats. Methods: The effect of P. glaucus extract on biochemica...Objective: To evaluate the effect of ethanolic extract of Pericampylus glaucus (Lam) Merr (P. glaucus) on biochemical parameters in high fats diets treated rats. Methods: The effect of P. glaucus extract on biochemical parameters was studied in male Sprague Dawley rats. The high-fat diets along with standard normal laboratory rat's diets were given for a period of 28 days along with ethanolic extract of P. glaucus and standard drug. The standard group was treated with simvastatin at dose of 80 mg/kg and the tested groups were treated with ethanol extract of P. glaucus at 400, 600 and 800 mg/kg daily for 28 days of the experiment. The weight of animals in each group was measured weekly and the effect of extract and standard on serum lipids profile was evaluated at the end of the study. Results: The results showed that the ethanolic extract of P. glaucus at different doses of 400, 600 and 800 mg/kg and standard drug induced a significant reduction in the body weight (P< 0.001), total cholesterol, triglycerides (TG), low density lipoproteins (LDL) and uric acid levels and increase (P < 0.001) in high density lipoproteins (HDL) as compared to untreated hyperlipidemic group. Conclusions: The present work indicates that the ethanolic extract significantly suppressed the biochemical parameters in high fats diet treated animals, suggesting the antihyperlipidemic potential of P. glaucus.展开更多
The use of natural products as a source of remedies has long history since ancient times.Currently,medicinal plants are traditional practices for an extensive range of therapeutics and pharmacological activities like ...The use of natural products as a source of remedies has long history since ancient times.Currently,medicinal plants are traditional practices for an extensive range of therapeutics and pharmacological activities like hypoglycemic,immunological,antiviral,anti-inflammatory,anti-hepatic,cardiovascular and central nervous effect.In the past,the use of plant based medicines was mainly restricted to developing countries because of insufficient resources,but currently the trend is changed and natural products as a source of medicines are growing rapidly in developed countries.It is confirmed from research articles that nearly about 75%-80%of the reserved zone inhabitants used natural products for their health remedies.In all,about 250000-500000 species of plants exist worldwide and almost 800 plants have been documented for use in folklore systems of medicine.Regarding to this,Malaysia is being accepted as one of the largest biodiversity countries.In Malaysia,12000 species of natural products exist and 1200 are documented to have remedial potential against various diseases.In the market,a variety of allopathic drugs are available,but are linked to various side effects.Hence,there is rising interest in the direction to plant based medicines remedies with a basic tactic towards the nature.The anti-diabetic drugs from natural products source in current use and their same way of producing action are preferred mainly due to affordable price,easy availability and minor harmful effect on human beings.Therefore,the aim of the present research work was to review various Malaysian medicinal plants having potential in attenuation of high level of blood glucose.All over the world,diabetes mellitus is claimed to be one of the most common chronic hereditary non-communicable disease,fourth leading cause of mortality in the most developed countries.The disease is also spreading in many developing and newly industrialized nations.According to International Diabetes Federation,the diabetes will affect 592 million people in 2035.展开更多
文摘This study investigates the effects of technical cheerleading and dance cheerleading on the psychological health of female college students by utilizing the Symptom Checklist-90(SCL-90),the Comprehensive Diagnostic Scale for Interpersonal Relationships,and the Social Adaptability Diagnostic Scale.The findings indicate the following:(1)Technical cheerleading has a highly significant impact on sensitivity in interpersonal relationships,paranoia,and psychoticism,and a significant effect on anxiety and hostility;dance cheerleading has a highly significant effect on paranoia;(2)Both technical and dance cheerleading have minimal impact on the overall score distribution of interpersonal relationships among female college students,but the dimensions of their effects differ;(3)The impact of technical cheerleading on the social adaptability of female college students is more pronounced than that of dance cheerleading.
文摘目的系统评价延续护理促进老年人关节功能恢复的有效性及安全性。方法检索Cochrane Library、Web of Science、PubMed、Embase数据库中有关延续护理应用于老年关节置换患者的随机对照试验和队列研究,检索时间从建库到2023年10月25日。2名研究员独立完成文献筛选、数据提取,随机对照试验通过Cochrane偏倚风险工具进行文献偏倚分析,队列研究通过纽卡斯尔-渥太华标准进行文献质量评价。结果共纳入15篇文献,包括34186例膝关节和髋关节置换患者。促进老年髋关节置换患者功能改善的主要指标包括髋关节评分、出院后日常生活指数评分(Barthel Index)及生活质量;对老年膝关节置换患者进行延续护理明显改善的指标包括膝关节运动范围、骨关节炎指数、关节损伤和骨关节炎结果评分;延续护理对术后并发症并没有明显作用。文献质量评价显示纳入文献总体质量较高,但仅1项针对髋关节置换术后患者的研究运用了理论框架。结论延续护理在缓解膝关节疼痛、改善关节活动度及髋关节功能方面发挥了重要作用,但是对生活质量、患者满意度、经济、减少关节置换术后并发症和再次入院率方面的有效性尚需进一步明确。
文摘Introduction: Lumbar disc herniation (LDH) refers to the rupture of the fibrous annulus of the intervertebral discs. Lumbar curvature may lead to the occurrence of lumbar disc degeneration. Fear of movement may worsen their disc herniation and cause further pain and injury. LDH conditions impact the individuals’ quality of life, to explore the relationship between lumbar curve, muscle strength, fear of movement and functional disability among patients with LDH. Methods: An electronic search was conducted on PubMed, Medline, Science Direct, Springerlink, Google Scholar and a hand search from reference lists was reviewed. Publications were included in human studies, patients 25 - 85 years of age, original studies and published in English language journals from January 2002 to December 2023. Result: In total, 64 articles were researched through the online search engines, and 9 papers were found through manual searches of reference lists. As a result, a total of 11 articles were included for the purpose of this review. The comprehensive analysis revealed the presence of eight cross-sectional studies, two retrospective studies and one experimental study. A minimum of 25 participants and a maximum of 360 participants were included. Ten studies included both genders, only one studies included healthy adults and patients with LDH but these studies didn’t mention gender. Results showed that the factors influencing LDH can be categorized into non-modifiable factors, such as gender, age, height or others. Modifiable factors included increased BMI, DM, smoking, alcohol, employment status, lifestyle and health problems or psychology. Conclusion: Females with greater VASC may be at risk of LDH. The lumbar extensor muscles indicated a localized disc herniation or nerve root pathology in patients with LDH. The fear of movement may lead to psychological consequences and reduce functional disability among patients with LDH.
文摘This study conducted a 16-week comparative experiment with 160 students from Jinan No.5 Middle School in Shandong Province as the experimental subjects.During the implementation of the experiment,the subjects were divided into two groups:an experimental group and a control group.The experimental group was subjected to physical exercise interventions using sports game teaching methods during physical education class,while the control group followed traditional physical education teaching methods.The results showed that the psychological health status of the students in the experimental group was significantly better than that of the control group after the experiment.The application of sports games helps to improve the psychological health of middle school students in the course of physical education,promoting a positive and forward direction in student psychology and is an effective means to enhance the psychological health level of middle school students.
文摘目的:评价一种中药植物鞭檐犁头尖(T.flagelliforme)作为抗癌药物的临床前研究的系统综述。方法:对Scopus、PubMed、Web of Science、ScienceDirect、LILACS、EBSCO Medline、Mendeley等7个数据库进行全面检索,检索时间截止到2023年9月8日。排除了临床试验和非原创的同行评议报告后,鞭檐犁头尖的提取物,组成,或分离化合物的体内外研究且经过同行评审的英文文献均被纳入。本研究定性评估了鞭檐犁头尖对不同肿瘤细胞、肿瘤大小和作用机制的有效性。证据质量由三名独立评估人员使用ToxRTool进行评估,并验证其一致性。结果:检索后共纳入27项研究:22项体外研究,4项体内研究,1项体内外研究。结果发现鞭檐犁头尖对白血病、乳腺癌、结直肠癌和肺癌有效。大多数研究的评估为“有限制的可靠”。鞭檐犁头尖通过阻断细胞周期、活化caspase-3/-9、分解PARP、裂解DNA、减少生存素含量、降低ROS表达、抑制COX-2和HSP70表达和抑制NF-kB通路等来诱导细胞凋亡。当与干扰素联合使用时,其能阻碍血管生成。结论:尽管鞭檐犁头尖具有良好的抗癌活性,但其作为单独抗癌药物的疗效尚不确定。它似乎更适合用于癌症的补充或联合治疗。研究设计不理想,报告不完整,以及在多篇文章中没有纳入适当的阳性对照和统计分析可能是本研究缺乏结论性证据的原因。
文摘Background: Nurses are professionally accountable for assessing and documenting patients’ vital signs. Nurses failing to fulfill this responsibility position their patients at risk. This paper presents two real-life cases pertaining to patients’ safety resulting in fatal outcomes, leading to the professional, legal, and ethical liability of nurses as the providers of patient care. Objective: This paper focuses on the role of organizational culture in fostering patient safety specifically in monitoring and documentation of patients’ vital signs and early recognition of warning signs. Methodology: A comprehensive literature search was conducted using various databases, examining the significance of vital signs monitoring and documentation and early warning signs in patient safety. Relevant articles combining quantitative and qualitative data were analyzed. Results: By fostering an environment of honest reporting, healthcare organizations can enhance patient safety and improve the quality of care. This paper offers valuable insights and recommendations for developing effective strategies aligned with organizational policies and protocols. Conclusion: This paper serves as a valuable resource, encouraging healthcare professionals to reflect on their practices and the organizations to assess their contributions to creating a culture of safety. It also highlights the importance of reporting and disclosing adverse events as learning opportunities and outlines the role of ethics, professionalism, legislation, and organizational support in achieving patient safety.
文摘Introduction: Monitoring vital signs is a basic indicator of a patient’s health status and allows prompt detection of delayed recovery or adverse effects and early intervention. Patients with adverse events during hospitalization often display clinical decline for several hours before the event is observed. Non-critical care Nurses’ inconsistent recognition and response to patient deterioration lead to an increase in the length of hospital stay, unexpected admissions to the ICU, and increased morbidity and mortality. Aim: The study aimed to assess the factors that facilitate or impede the detection of early warning signs among adult patients hospitalized in tertiary care settings. Training should be provided to improve nurses’ knowledge, practice and attitude toward early warning signs of deteriorating patients leading to enhanced clinical judgment, skills and decision-making in addressing alerts. Methodology: A literature search was carried out in various databases;these were Cumulative Index to Nursing and Allied Health Literature (CINHAL), Google Scholar, PubMed, Science Direct, and Sage. The search area was narrowed from 2017 to 2022. The keywords used were “prevalence” AND “unplanned ICU admission”, “the importance of early warning signs” “outcome failure in rescue” “patient deterioration, communication” “improvement in early detection” AND “patient outcome admission” AND “early warning signs” AND “Pakistan”. After the analysis process, around 33 articles that met the inclusion criteria and were most relevant to the scope and context of the current study were considered. Conclusion: Most of the studies had reviewed literature in a qualitative retrospective observational study, content analysis, mixed method, and quasi-experimental study. The literature review identified that long hours of shift, nurse staffing levels, missed vital signs, lack of nursing training and education, and communication impact nurses’ ability to recognize and respond to early warning signs.
文摘Management of cardiovascular risk factors in diabetes demands special attention due to their co-existence.Pioglitazone(PIO) and telmisartan(TLM) combination can be beneficial in effective control of cardiovascular complication in diabetes. In this research, we developed and validated a high throughput LC–MS/MS method for simultaneous quantitation of PIO and TLM in rat plasma. This developed method is more sensitive and can quantitate the analytes in relatively shorter period of time compared to the previously reported methods for their individual quantification. Moreover, till date, there is no bioanalytical method available to simultaneously quantitate PIO and TLM in a single run. The method was validated according to the USFDA guidelines for bioanalytical method validation. A linear response of the analytes was observed over the range of 0.005–10 μg/m L with satisfactory precision and accuracy. Accuracy at four quality control levels was within 94.27%–106.10%.The intra-and inter-day precision ranged from 2.32% to 10.14% and 5.02% to 8.12%, respectively. The method was reproducible and sensitive enough to quantitate PIO and TLM in rat plasma samples of a preclinical pharmacokinetic study. Due to the potential of PIO-TLM combination to be therapeutically explored, this method is expected to have significant usefulness in future.
基金Partially Supported by Ministry of Higher Education and Universiti Teknologi MARA,Malaysia(Grant No.LESTARI:600-RMI/DANA 5/3/LESTARI(52/2015)
文摘Objective:To assess the immunopotentiality of Ayurvedic polyherbal preparations,"Saribadi" and "Anantamul Salsa".Methods: Freshly prepared BALB/c mice splenocytes were cultured with "Saribadi" or"Anantamul Salsa" treatment [doses of 0.25%, 0.50%, 0.75%, 1.00%, 1.50%, 2.00%,3.00% and 4.00%(v/v)] at 37C for 5 days. The immunoglobulin M(IgM) production and lymphocytes proliferation were determined by ELISA and MTT methods, respectively.Endotoxin contamination was assessed by treating the preparations with polymyxin B.Results: The doses of "Saribadi" [0.25%, 0.50%, 0.75% and 1.00%(v/v)] significantly increased IgM productions(0.966, 0.728, 0.695 and 0.615 mg/m L vs. control 0.265 mg/m L)and lymphocytes proliferation [absorbance 0.311, 0.394, 0.372 and 0.334 optical density(OD) vs. control 0.162 OD]. Similarly, the doses of "Anantamul Salsa" [0.50%, 0.75%,1.00% and 1.50%(v/v)] promoted IgM productions(0.933, 0.919, 0.917 and 0.892 mg/m L vs. control 0.502 mg/m L) and the doses of "Anantamul Salsa" [0.50%, 0.75%, 1.00%,1.50%, 2.00%, and 3.00%(v/v)] stimulated lymphocytes proliferation(absorbance 0.395,0.326, 0.440, 0.398, 0.452 and 0.355 OD vs. control 0.199 OD). The activity of "Saribadi"and "Anantamul Salsa" was not retarded by the treatment of preparations with polymyxin B.Conclusions: Immunomodulatory activity of "Saribadi" and "Anantamul Salsa" was unveiled for the first time. "Saribadi" and "Anantamul Salsa" possess immunostimulating potential acting through the induction of lymphocyte proliferation and IgM production.These preparations may be useful in strengthening immune responses. However, further cellular and in vivo studies are required.
文摘In the healthcare system,the Internet of Things(IoT)based distributed systems play a vital role in transferring the medical-related documents and information among the organizations to reduce the replication in medical tests.This datum is sensitive,and hence security is a must in transforming the sensational contents.In this paper,an Evolutionary Algorithm,namely the Memetic Algorithm is used for encrypting the text messages.The encrypted information is then inserted into the medical images using Discrete Wavelet Transform 1 level and 2 levels.The reverse method of the Memetic Algorithm is implemented when extracting a hidden message from the encoded letter.To show its precision,equivalent to five RGB images and five Grayscale images are used to test the proposed algorithm.The results of the proposed algorithm were analyzed using statistical methods,and the proposed algorithm showed the importance of data transfer in healthcare systems in a stable environment.In the future,to embed the privacy-preserving of medical data,it can be extended with blockchain technology.
文摘Background:Radiographers were at risk of x-ray radiation.Ministry of Heath of Indonesia made a regulation act no.33 year 2007 to secure radiographers on ionizing radiations by using radiation protection equipment(RPE).Objective:This study identified the factors affecting compliance towards RPE among radiographers and determined the correlation between influencing factors and compliance towards RPEs.Methods:The study conducted a quantitative descriptive-correlational design in a cross sectional approach.A total of 103 radiographers answered the online self administered questionnaires from 9 government hospitals at Jakarta,Indonesia.Results:It was identified that personal factors were the knowledge and motivations while the availability of RPEs and standard operating procedures were environmental factors.The knowledge(p=0.001,r=0.321)and motivations(p=0.018,r=0.232),and availability of RPE(p=0.138,r=0.146)and standard operating procedures(p=0.023,r=0.224)were factors affecting a compliance to RPEs.It was however determined that gender(p=0.251,r=0.113),and place of work(p=0.479,r=0.070)were not correlated to both personal and environmental factors.On the contrary,age(p=0.031,r=0.212),highest educational attainment(p=0.039,r=0.203),years of experience(p=0.001,r=0.336),and training(p=0.001,r=0.341)influenced both personal and environmental factors affecting compliance of radiographers towards RPEs.Findings:It was found that Dr.Cipto Mangunkusumo(p=0.271),Persahabatan(p=0.133),Fatmawati(p=0.357),Otak Nasional(p=0.238),Pasar Rebo(p=0.356),Tarakan(0.255),and Koja(p=0.199)hospitals were not probable to comply towards RPEs.Only Infeksi Sulianti Suroso(p=0.21),and Budhi Asih(p=0.0002)hospitals were most probable to comply towards RPEs.
文摘Objective: The present study explored the effects of the combined herbal therapy consisting of curcumin(CUR) and Fructus Ligustri Lucidi(FLL) on aspects of bone regeneration.Methods: Prior to analyzing the ability of this novel combined herbal therapy to promote aspects of bone regeneration, its cytotoxicity was determined using MC3 T3-E1 cells(pre-osteoblast model). Cell proliferation was evaluated using phase-contrast microscopy and cell differentiation was estimated using alkaline phosphatase activity. The effect of the combined herbal therapy(CUR + FLL) was also assessed in terms of mineralization in the extracellular matrix(ECM) of cultured cells. Further, to explore the molecular mechanisms of bone formation, time-dependent expression of bone-regulating protein biomarkers was also evaluated.Results: Combined herbal therapy(CUR + FLL) significantly upregulated the viability, proliferation and differentiation of MC3 T3-E1 cells compared to the monotherapy of CUR or FLL. The magnitude of ECM mineralization(calcium deposition) was also higher in MC3 T3-E1 cells treated with combined therapy.The time-dependent expression of bone-forming protein biomarkers revealed that the tendency of expression of these bone-regulating proteins was remarkably higher in cells treated with combined therapy.Conclusion: The co-administration of CUR and FLL had superior promotion of elements of bone regeneration in cultured cells, thus could be a promising alternative herbal therapy for the management of bone erosive disorders such as osteoporosis.
文摘Objective: To evaluate the effect of ethanolic extract of Pericampylus glaucus (Lam) Merr (P. glaucus) on biochemical parameters in high fats diets treated rats. Methods: The effect of P. glaucus extract on biochemical parameters was studied in male Sprague Dawley rats. The high-fat diets along with standard normal laboratory rat's diets were given for a period of 28 days along with ethanolic extract of P. glaucus and standard drug. The standard group was treated with simvastatin at dose of 80 mg/kg and the tested groups were treated with ethanol extract of P. glaucus at 400, 600 and 800 mg/kg daily for 28 days of the experiment. The weight of animals in each group was measured weekly and the effect of extract and standard on serum lipids profile was evaluated at the end of the study. Results: The results showed that the ethanolic extract of P. glaucus at different doses of 400, 600 and 800 mg/kg and standard drug induced a significant reduction in the body weight (P< 0.001), total cholesterol, triglycerides (TG), low density lipoproteins (LDL) and uric acid levels and increase (P < 0.001) in high density lipoproteins (HDL) as compared to untreated hyperlipidemic group. Conclusions: The present work indicates that the ethanolic extract significantly suppressed the biochemical parameters in high fats diet treated animals, suggesting the antihyperlipidemic potential of P. glaucus.
文摘The use of natural products as a source of remedies has long history since ancient times.Currently,medicinal plants are traditional practices for an extensive range of therapeutics and pharmacological activities like hypoglycemic,immunological,antiviral,anti-inflammatory,anti-hepatic,cardiovascular and central nervous effect.In the past,the use of plant based medicines was mainly restricted to developing countries because of insufficient resources,but currently the trend is changed and natural products as a source of medicines are growing rapidly in developed countries.It is confirmed from research articles that nearly about 75%-80%of the reserved zone inhabitants used natural products for their health remedies.In all,about 250000-500000 species of plants exist worldwide and almost 800 plants have been documented for use in folklore systems of medicine.Regarding to this,Malaysia is being accepted as one of the largest biodiversity countries.In Malaysia,12000 species of natural products exist and 1200 are documented to have remedial potential against various diseases.In the market,a variety of allopathic drugs are available,but are linked to various side effects.Hence,there is rising interest in the direction to plant based medicines remedies with a basic tactic towards the nature.The anti-diabetic drugs from natural products source in current use and their same way of producing action are preferred mainly due to affordable price,easy availability and minor harmful effect on human beings.Therefore,the aim of the present research work was to review various Malaysian medicinal plants having potential in attenuation of high level of blood glucose.All over the world,diabetes mellitus is claimed to be one of the most common chronic hereditary non-communicable disease,fourth leading cause of mortality in the most developed countries.The disease is also spreading in many developing and newly industrialized nations.According to International Diabetes Federation,the diabetes will affect 592 million people in 2035.
