This pilot study was conducted to evaluate the impact of spices added to broccoli, cauliflower, and spinach on amount and rate of vegetable consumption. Twenty overweight subjects who routinely ate less than three dai...This pilot study was conducted to evaluate the impact of spices added to broccoli, cauliflower, and spinach on amount and rate of vegetable consumption. Twenty overweight subjects who routinely ate less than three daily servings of vegetables were recruited. On six occasions, subjects were assigned in random order to eat broccoli, cauliflower, or spinach with or without added spices. Dishes were placed on a modified Universal Eating Monitor (UEM) that recorded rate of eating (g/sec), duration of eating (min) and total amount consumed (g). Total intake and duration of eating were increased significantly for broccoli with spices compared to plain broccoli, but there was no significant difference for cauliflower or spinach. No significant differences were noted in any of the visual analog scale (VAS) responses. This study suggests that adding spices may increase vegetable intake, but more studies in greater numbers of subjects are needed.展开更多
Objective: Diabetes mellitus type 2 has been associated with increased cancer risk and cancer related mortality. Metformin, one of the most widely used anti-diabetic medications, has been found to have important antic...Objective: Diabetes mellitus type 2 has been associated with increased cancer risk and cancer related mortality. Metformin, one of the most widely used anti-diabetic medications, has been found to have important anticancer properties in addition to hypoglycemic effects. The effects of metformin on clinical outcomes in oral cavity (OC) and oropharyngeal (OP) squamous cell carcinoma (SCC) have not been thoroughly analyzed. The purpose of this study was to evaluate the effects of metformin use on cancer recurrence in diabetic patients with oral cavity and oropharyngeal squamous cell carcinoma. Design: Retrospective review. Setting: Academic tertiary medical center. Patients: Seventy-seven patients with diabetes mellitus type 2 and oral cavity or oropharyngeal squamous cell carcinoma were treated and followed at our tertiary academic institution and the Veterans Affairs Greater Los Angeles Healthcare System from 1998 to 2012. Main Outcome Measure: Cox proportional hazards models and Kaplan-Meier curves were constructed to determine if metformin has an effect on disease recurrence after primary cancer treatment. Results: Metformin does not appear to have a significant effect on disease recurrence in patients with OC/OP SCC and diabetes mellitus type 2 (p = 0.53). Even when including only patients with stage I or II disease, metformin still did not decrease recurrence (p = 0.60). Conclusion: Herein, our data suggest that metformin use does not significantly impact time until recurrence for diabetic patients with OC/OP SCC.展开更多
BACKGROUND Critically ill neonates and pediatric patients commonly require multiple low flow infusions.Volume limitations are imposed by small body habitus and comorbidities like cardiopulmonary disease,renal failure,...BACKGROUND Critically ill neonates and pediatric patients commonly require multiple low flow infusions.Volume limitations are imposed by small body habitus and comorbidities like cardiopulmonary disease,renal failure,or fluid overload.Vascular access is limited by diminutive veins.Maintenance fluids or parenteral nutrition in conjunction with actively titrated infusions such as insulin,fentanyl,prostaglandins,inotropes and vasopressors may necessitate simultaneous infusions using a single lumen to maintain vascular catheter patency.This requirement for multiple titratable infusions requires concentrated medications at low flows,rather than more dilute drugs at higher flows that in combination may volume overload small infants.AIM To determine whether carrier fluid reduces variability that variability of low flow drug infusions is proportional to syringe size in pediatric critical care.METHODS We assessed concentrations of orange“drug”in a 0.2 mL/h low flow clinical model with blue dyed carrier fluid at 5 mL/h,using 3-,10-,or 60-mL syringes.A graduated volumetric pipette was used to measure total flow.Mean time to target concentration was 30,21,and 46 min in 3-,10-,and 60-mL syringes,respectively(P=0.42).After achieving target concentration,more dilute drug was delivered by 60-mL(P<0.001)and 10-mL syringes(P=0.04)compared to 3-mL syringes.Drug overdoses were observed during the initial 45 min of infusion in 10-and 60-mL syringes.Total volumes infused after target concentration were less in the 60-mL condition compared to 3-mL(P<0.01)and 10-mL(P<0.001)syringes.RESULTS Linear mixed effects models demonstrated lesser delivered drug concentrations in the initial 30 min by 3-mL compared to 10-and 60-mL syringes(P=0.005 and P<0.001,respectively)but greater drug concentrations and total infused drug in the subsequent 30-60 and 60-90 min intervals with the 3-and 10-mL compared to 60-mL syringes.CONCLUSION With carrier fluid,larger syringes were associated with significantly less drug delivery,less total volume delivered,and other flow problems in our low flow drug model.Carrier fluid should not be used to compensate for inappropriately large syringes in critical low flow drug infusions.展开更多
Synucleinopathies are neurodegenerative diseases char-acterized by accumulation of misfoldedα-synuclein(α-syn)inclusions in neuronal and/or glial cells.Despite differences in the underlying pathophysiology,synucle-i...Synucleinopathies are neurodegenerative diseases char-acterized by accumulation of misfoldedα-synuclein(α-syn)inclusions in neuronal and/or glial cells.Despite differences in the underlying pathophysiology,synucle-inopathies often are misdiagnosed,especially in early stages,due to the overlapping clinical symptoms[1].展开更多
Background andAims:Hepatitis C(HCV)is a medical and public health concern.Once infected individuals are identified,management includes not only education but also the use of antiviral therapy.Although screening for HC...Background andAims:Hepatitis C(HCV)is a medical and public health concern.Once infected individuals are identified,management includes not only education but also the use of antiviral therapy.Although screening for HCV is readily available,barriers exist which prevent assessment and treatment in individuals potentially infected with HCV.Methods:This is a retrospective study of patients screened for HCV within the University of California,Los Angeles Health Care System between February 22 and July 9,2018.We defined linkage to care as:1)confirmatory HCV RNA test after screening HCV antibody test found a positive result;and 2)follow-up appointment for treatment was established with a specialist.Demographic and baseline laboratory values were collected.Factors potentially associated with prohibiting linkage of care were evaluated.Results:During the study period,17,512 individuals were screened for HCV.A total of 238(1.35%)were found to have detectable HCV antibodies.Of the individuals with detectable HCV antibodies,48(20%)did not undergo confirmatory testing with viral levels.Of the 190 individuals who underwent further testing,70 patients were noted to be viremic.Among them,17 of the 70(24%)were not linked to a specialist for further care.Younger patients(p=0.02)and people who inject drugs(p=0.02)were less likely to be referred for specialty care.Conclusions:The results of our study highlight that younger patients and people who inject drugs are less likely to be referred to specialty care for HCV treatment.Efforts are needed to engage these populations.展开更多
文摘This pilot study was conducted to evaluate the impact of spices added to broccoli, cauliflower, and spinach on amount and rate of vegetable consumption. Twenty overweight subjects who routinely ate less than three daily servings of vegetables were recruited. On six occasions, subjects were assigned in random order to eat broccoli, cauliflower, or spinach with or without added spices. Dishes were placed on a modified Universal Eating Monitor (UEM) that recorded rate of eating (g/sec), duration of eating (min) and total amount consumed (g). Total intake and duration of eating were increased significantly for broccoli with spices compared to plain broccoli, but there was no significant difference for cauliflower or spinach. No significant differences were noted in any of the visual analog scale (VAS) responses. This study suggests that adding spices may increase vegetable intake, but more studies in greater numbers of subjects are needed.
文摘Objective: Diabetes mellitus type 2 has been associated with increased cancer risk and cancer related mortality. Metformin, one of the most widely used anti-diabetic medications, has been found to have important anticancer properties in addition to hypoglycemic effects. The effects of metformin on clinical outcomes in oral cavity (OC) and oropharyngeal (OP) squamous cell carcinoma (SCC) have not been thoroughly analyzed. The purpose of this study was to evaluate the effects of metformin use on cancer recurrence in diabetic patients with oral cavity and oropharyngeal squamous cell carcinoma. Design: Retrospective review. Setting: Academic tertiary medical center. Patients: Seventy-seven patients with diabetes mellitus type 2 and oral cavity or oropharyngeal squamous cell carcinoma were treated and followed at our tertiary academic institution and the Veterans Affairs Greater Los Angeles Healthcare System from 1998 to 2012. Main Outcome Measure: Cox proportional hazards models and Kaplan-Meier curves were constructed to determine if metformin has an effect on disease recurrence after primary cancer treatment. Results: Metformin does not appear to have a significant effect on disease recurrence in patients with OC/OP SCC and diabetes mellitus type 2 (p = 0.53). Even when including only patients with stage I or II disease, metformin still did not decrease recurrence (p = 0.60). Conclusion: Herein, our data suggest that metformin use does not significantly impact time until recurrence for diabetic patients with OC/OP SCC.
基金Supported by NIH National Center for Advancing Translational Sciences(NCATS)UCLA CTSI,No.UL1TR001881.
文摘BACKGROUND Critically ill neonates and pediatric patients commonly require multiple low flow infusions.Volume limitations are imposed by small body habitus and comorbidities like cardiopulmonary disease,renal failure,or fluid overload.Vascular access is limited by diminutive veins.Maintenance fluids or parenteral nutrition in conjunction with actively titrated infusions such as insulin,fentanyl,prostaglandins,inotropes and vasopressors may necessitate simultaneous infusions using a single lumen to maintain vascular catheter patency.This requirement for multiple titratable infusions requires concentrated medications at low flows,rather than more dilute drugs at higher flows that in combination may volume overload small infants.AIM To determine whether carrier fluid reduces variability that variability of low flow drug infusions is proportional to syringe size in pediatric critical care.METHODS We assessed concentrations of orange“drug”in a 0.2 mL/h low flow clinical model with blue dyed carrier fluid at 5 mL/h,using 3-,10-,or 60-mL syringes.A graduated volumetric pipette was used to measure total flow.Mean time to target concentration was 30,21,and 46 min in 3-,10-,and 60-mL syringes,respectively(P=0.42).After achieving target concentration,more dilute drug was delivered by 60-mL(P<0.001)and 10-mL syringes(P=0.04)compared to 3-mL syringes.Drug overdoses were observed during the initial 45 min of infusion in 10-and 60-mL syringes.Total volumes infused after target concentration were less in the 60-mL condition compared to 3-mL(P<0.01)and 10-mL(P<0.001)syringes.RESULTS Linear mixed effects models demonstrated lesser delivered drug concentrations in the initial 30 min by 3-mL compared to 10-and 60-mL syringes(P=0.005 and P<0.001,respectively)but greater drug concentrations and total infused drug in the subsequent 30-60 and 60-90 min intervals with the 3-and 10-mL compared to 60-mL syringes.CONCLUSION With carrier fluid,larger syringes were associated with significantly less drug delivery,less total volume delivered,and other flow problems in our low flow drug model.Carrier fluid should not be used to compensate for inappropriately large syringes in critical low flow drug infusions.
基金supported by grants from the MSA Coalition 2017-10-007(GB)California Department of Public Health 18-10926(GB)+5 种基金The Alzheimer’s Association,The Michael J.Fox Foundation,Weston Brain Institute,and Alzheimer’s Research UK Biomarkers Across Neurodegenerative Diseases(BAND 3)17990(GB)CurePSP 665-2019-07(GB)The Michael J.Fox Foundation 18303(GB)The National Ataxia Foundation 20201551(GB and BLF),Cure Sanfilippo Foundation 20215318(GB)NIH/NIEHS ES10544(BR)generous gifts from the Karen Toffler Charitable Trust and the Binder Foundation。
文摘Synucleinopathies are neurodegenerative diseases char-acterized by accumulation of misfoldedα-synuclein(α-syn)inclusions in neuronal and/or glial cells.Despite differences in the underlying pathophysiology,synucle-inopathies often are misdiagnosed,especially in early stages,due to the overlapping clinical symptoms[1].
基金The research described was supported by NIH/National Center for Advancing Translational Science(NCATS)UCLA CTSI Grant Number UL1TR001881
文摘Background andAims:Hepatitis C(HCV)is a medical and public health concern.Once infected individuals are identified,management includes not only education but also the use of antiviral therapy.Although screening for HCV is readily available,barriers exist which prevent assessment and treatment in individuals potentially infected with HCV.Methods:This is a retrospective study of patients screened for HCV within the University of California,Los Angeles Health Care System between February 22 and July 9,2018.We defined linkage to care as:1)confirmatory HCV RNA test after screening HCV antibody test found a positive result;and 2)follow-up appointment for treatment was established with a specialist.Demographic and baseline laboratory values were collected.Factors potentially associated with prohibiting linkage of care were evaluated.Results:During the study period,17,512 individuals were screened for HCV.A total of 238(1.35%)were found to have detectable HCV antibodies.Of the individuals with detectable HCV antibodies,48(20%)did not undergo confirmatory testing with viral levels.Of the 190 individuals who underwent further testing,70 patients were noted to be viremic.Among them,17 of the 70(24%)were not linked to a specialist for further care.Younger patients(p=0.02)and people who inject drugs(p=0.02)were less likely to be referred for specialty care.Conclusions:The results of our study highlight that younger patients and people who inject drugs are less likely to be referred to specialty care for HCV treatment.Efforts are needed to engage these populations.
