Transactions of Nanjing University of Aeronautics&Astronautics(TNUAA)is a bimonthly journal facing international academic community.Emphasizing prompt and effective dissemination of key data and new scientific ins...Transactions of Nanjing University of Aeronautics&Astronautics(TNUAA)is a bimonthly journal facing international academic community.Emphasizing prompt and effective dissemination of key data and new scientific insights,TNUAA offers publication of new experimental and theoretical papers bearing on applications to all branches of aeronautics,astronautics and civil aviation.展开更多
The control of highly contagious disease spreading in campuses is a critical challenge.In residential universities,students attend classes according to a curriculum schedule,and mainly pack into classrooms,dining hall...The control of highly contagious disease spreading in campuses is a critical challenge.In residential universities,students attend classes according to a curriculum schedule,and mainly pack into classrooms,dining halls and dorms.They move from one place to another.To simulate such environments,we propose an agent-based susceptible–infected–recovered model with time-varying heterogeneous contact networks.In close environments,maintaining physical distancing is the most widely recommended and encouraged non-pharmaceutical intervention.It can be easily realized by using larger classrooms,adopting staggered dining hours,decreasing the number of students per dorm and so on.Their real-world influence remains uncertain.With numerical simulations,we obtain epidemic thresholds.The effect of such countermeasures on reducing the number of disease cases is also quantitatively evaluated.展开更多
The School of Chemistry and Chemical Engineering of Nanjing University was found in 1920,and it is one of the earliest departments of chemistry in China.Afterwards,the primeval National Central University’s Chemistry...The School of Chemistry and Chemical Engineering of Nanjing University was found in 1920,and it is one of the earliest departments of chemistry in China.Afterwards,the primeval National Central University’s Chemistry Discipline united with Jinling University’s Chemistry Discipline to form the Department of Chemistry of Nanjing University.展开更多
The products of an archival culture in colleges and universities are the final result of the development of archival cultural resources,and the development of archival cultural effects in colleges and universities sho...The products of an archival culture in colleges and universities are the final result of the development of archival cultural resources,and the development of archival cultural effects in colleges and universities should be an important part of improving the artistic level of libraries.The existing RippleNet model doesn’t consider the influence of key nodes on recommendation results,and the recommendation accuracy is not high.Therefore,based on the RippleNet model,this paper introduces the influence of complex network nodes into the model and puts forward the Cn RippleNet model.The performance of the model is verified by experiments,which provide a theoretical basis for the promotion and recommendation of its cultural products of universarchives,solve the problem that RippleNet doesn’t consider the influence of key nodes on recommendation results,and improve the recommendation accuracy.This paper also combs the development course of archival cultural products in detail.Finally,based on the Cn-RippleNet model,the cultural effect of university archives is recommended and popularized.展开更多
Based on a survey of university teachers and students in Nanjing area of 2007,this article analyzes domestic users’awareness towards Open Access(OA),and the changes by comparing the corresponding data of 2006.The sur...Based on a survey of university teachers and students in Nanjing area of 2007,this article analyzes domestic users’awareness towards Open Access(OA),and the changes by comparing the corresponding data of 2006.The survey shows that the research evaluation system,the quality of literature and the payment for OA publications are the important factors for university users to choose OA or not.The authors finally suggest that the current research evaluation system should be reformed to accommodate OA journals.Meanwhile,great efforts should be devoted to improve the quality of OA literatures,and the governments and research institutions should provide stronger support than before.展开更多
Psychosis has increasingly become a social problem,emphasizing the need to understand the relationship between mental disorders and personality.This study aimed to investigate the relationship between mental disorders...Psychosis has increasingly become a social problem,emphasizing the need to understand the relationship between mental disorders and personality.This study aimed to investigate the relationship between mental disorders and personality among psychiatric outpatients based on real-world data.Symptom Checklist 90(SCL-90)and Eysenck Personality Questionnaire(EPQ)were used to evaluate the personality and psychopathological symptoms of patients(n=8409)in the Psychiatric Outpatient Department at Nanjing Drum Tower Hospital.t-test was used to compare scores between patients and national norms.Pearson’s correlation coefficient and path analysis were used to explore the relationship between mental health status and personality.The correlation coefficient between the neuroticism(N)score and each factor score of the SCL-90 test,as well as the correlation between psychoticism(P)and hostility and paranoia,exceeded 0.4.Path analysis revealed that the standardized path coefficients of N score and SCL-90 were all higher than 0.4.In addition,the standardized path coefficient of hostility and paranoia on P score were 0.313 and 0.280,respectively.Interpersonal sensitivity,depression and obsessive-compulsive symptoms were affected by extraversion(E)score,with standardized path coefficients of-0.149,-0.138,and-0.105,respectively.The path analysis also showed the direct and indirect effects of age,gender,education,and marital status on SCL-90.Patients characterized as melancholic had higher scores in all factors of SCL-90.In conclusion,mental health was related to personality traits of neuroticism,psychoticism and introversion.展开更多
Background:Early systemic anticoagulation(SAC)is a common practice in acute necrotizing pancreatitis(ANP),and its impact on in-hospital clinical outcomes had been assessed.However,whether it affects long-term outcomes...Background:Early systemic anticoagulation(SAC)is a common practice in acute necrotizing pancreatitis(ANP),and its impact on in-hospital clinical outcomes had been assessed.However,whether it affects long-term outcomes is unknown.This study aimed to evaluate the effect of SAC on 90-day readmission and other long-term outcomes in ANP patients.Methods:During January 2013 and December 2018,ANP patients admitted within 7 days from the onset of abdominal pain were screened.The primary outcome was 90-day readmission after discharge.Cox proportional-hazards regression model and mediation analysis were used to define the relationship between early SAC and 90-day readmission.Results:A total of 241 ANP patients were enrolled,of whom 143 received early SAC during their hospitalization and 98 did not.Patients who received early SAC experienced a lower incidence of splanchnic venous thrombosis(SVT)[risk ratio(RR)=0.40,95%CI:0.26-0.60,P<0.01]and lower 90-day readmission with an RR of 0.61(95%CI:0.41-0.91,P=0.02)than those who did not.For the quality of life,patients who received early SAC had a significantly higher score in the subscale of vitality(P=0.03)while the other subscales were all comparable between the two groups.Multivariable Cox regression model showed that early SAC was an independent protective factor for 90-day readmission after adjusting for potential confounders with a hazard ratio of 0.57(95%CI:0.34-0.96,P=0.04).Mediation analysis showed that SVT mediated 37.0%of the early SAC-90-day readmission causality.Conclusions:The application of early SAC may reduce the risk of 90-day readmission in the survivors of ANP patients,and reduced SVT incidence might be the primary contributor.展开更多
Active ingredients from highland barley have received considerable attention as natural products for developing treatments and dietary supplements against obesity.In practical application,the research of food combinat...Active ingredients from highland barley have received considerable attention as natural products for developing treatments and dietary supplements against obesity.In practical application,the research of food combinations is more significant than a specific food component.This study investigated the lipid-lowering effect of highland barley polyphenols via lipase assay in vitro and HepG2 cells induced by oleic acid(OA).Five indexes,triglyceride(TG),total cholesterol(T-CHO),low density lipoprotein-cholesterol(LDL-C),aspartate aminotransferase(AST),and alanine aminotransferase(ALT),were used to evaluate the lipidlowering effect of highland barley extract.We also preliminary studied the lipid-lowering mechanism by Realtime fluorescent quantitative polymerase chain reaction(q PCR).The results indicated that highland barley extract contains many components with lipid-lowering effects,such as hyperoside and scoparone.In vitro,the lipase assay showed an 18.4%lipase inhibition rate when the additive contents of highland barley extract were 100μg/m L.The intracellular lipid-lowering effect of highland barley extract was examined using 0.25 mmol/L OA-induced HepG2 cells.The results showed that intracellular TG,LDL-C,and T-CHO content decreased by 34.4%,51.2%,and 18.4%,respectively.ALT and AST decreased by 51.6%and 20.7%compared with the untreated hyperlipidemic HepG2 cells.q PCR results showed that highland barley polyphenols could up-regulation the expression of lipid metabolism-related genes such as PPARγand Fabp4.展开更多
The global ionosphere maps(GIM)provided by the International GNSS Service(IGS)are extensively utilized for ionospheric morphology monitoring,scientific research,and practical application.Assessing the credibility of G...The global ionosphere maps(GIM)provided by the International GNSS Service(IGS)are extensively utilized for ionospheric morphology monitoring,scientific research,and practical application.Assessing the credibility of GIM products in data-sparse regions is of paramount importance.In this study,measurements from the Crustal Movement Observation Network of China(CMONOC)are leveraged to evaluate the suitability of IGS-GIM products over China region in 2013-2014.The indices of mean error(ME),root mean square error(RMSE),and normalized RMSE(NRMSE)are then utilized to quantify the accuracy of IGS-GIM products.Results revealed distinct local time and latitudinal dependencies in IGS-GIM errors,with substantially high errors at nighttime(NRMSE:39%)and above 40°latitude(NRMSE:49%).Seasonal differences also emerged,with larger equinoctial deviations(NRMSE:33.5%)compared with summer(20%).A preliminary analysis implied that the irregular assimilation of sparse IGS observations,compounded by China’s distinct geomagnetic topology,may manifest as error variations.These results suggest that modeling based solely on IGS-GIM observations engenders inadequate representations across China and that a thorough examination would proffer the necessary foundation for advancing regional total electron content(TEC)constructions.展开更多
Both the attribution of historical change and future projections of droughts rely heavily on climate modeling. However,reasonable drought simulations have remained a challenge, and the related performances of the curr...Both the attribution of historical change and future projections of droughts rely heavily on climate modeling. However,reasonable drought simulations have remained a challenge, and the related performances of the current state-of-the-art Coupled Model Intercomparison Project phase 6(CMIP6) models remain unknown. Here, both the strengths and weaknesses of CMIP6 models in simulating droughts and corresponding hydrothermal conditions in drylands are assessed.While the general patterns of simulated meteorological elements in drylands resemble the observations, the annual precipitation is overestimated by ~33%(with a model spread of 2.3%–77.2%), along with an underestimation of potential evapotranspiration(PET) by ~32%(17.5%–47.2%). The water deficit condition, measured by the difference between precipitation and PET, is 50%(29.1%–71.7%) weaker than observations. The CMIP6 models show weaknesses in capturing the climate mean drought characteristics in drylands, particularly with the occurrence and duration largely underestimated in the hyperarid Afro-Asian areas. Nonetheless, the drought-associated meteorological anomalies, including reduced precipitation, warmer temperatures, higher evaporative demand, and increased water deficit conditions, are reasonably reproduced. The simulated magnitude of precipitation(water deficit) associated with dryland droughts is overestimated by 28%(24%) compared to observations. The observed increasing trends in drought fractional area,occurrence, and corresponding meteorological anomalies during 1980–2014 are reasonably reproduced. Still, the increase in drought characteristics, associated precipitation and water deficit are obviously underestimated after the late 1990s,especially for mild and moderate droughts, indicative of a weaker response of dryland drought changes to global warming in CMIP6 models. Our results suggest that it is imperative to employ bias correction approaches in drought-related studies over drylands by using CMIP6 outputs.展开更多
Despite the growing recognition of women’s increasing role in the household and corresponding empowerment programs in sub-Saharan Africa,intensive research on the relationship between women’s influence and household...Despite the growing recognition of women’s increasing role in the household and corresponding empowerment programs in sub-Saharan Africa,intensive research on the relationship between women’s influence and household food consumption is minimal.Using the most recent(2017-2018)national household survey data from Tanzania,this study examined the influence of women’s empowerment on household food consumption.First,we compared the monthly consumption of eight food categories between female-headed households(FHHs)and male-headed households(MHHs)using both descriptive statistics and the propensity score matching(PSM)method.Furthermore,we adopted the two-stage Linear Expenditure System and Almost Ideal Demand System model(LES-AIDS)to estimate income and price elasticities for the two household types.The results show that FHHs consume bread and cereals,fish,oils and fats,vegetables,and confectionery(sugar,jam,honey,chocolate,etc.)more than MHHs.Moreover,FHHs have a significantly higher income elasticity of demand for all food groups than MHHs.They are also more price elastic than MHHs in meat,fish,oils,fats,sugar,jam,honey,chocolate,etc.展开更多
Jasmine(Jasminum sambac Aiton)is a well-known cultivated plant species for its fragrant flowers used in the perfume industry and cosmetics.However,the genetic basis of its floral scent is largely unknown.In this study...Jasmine(Jasminum sambac Aiton)is a well-known cultivated plant species for its fragrant flowers used in the perfume industry and cosmetics.However,the genetic basis of its floral scent is largely unknown.In this study,using PacBio,Illumina,10×Genomics and highthroughput chromosome conformation capture(Hi-C)sequencing technologies,a high-quality chromosome-level reference genome for J.sambac was obtained,exploiting a double-petal phenotype cultivar‘Shuangbanmoli’(JSSB).The results showed that the final assembled genome of JSSB is 580.33 Mb in size(contig N50=1.05 Mb;scaffold N50=45.07 Mb)with a total of 39618 predicted protein-coding genes.Our analyses revealed that the JSSB genome has undergone an ancient whole-genome duplication(WGD)event at 91.68 million years ago(Mya).It was estimated that J.sambac diverged from the lineage leading to Olea europaea and Osmanthus fragrans about 28.8 Mya.On the basis of a combination of genomic,transcriptomic and metabolomic analyses,a range of floral scent volatiles and genes were identified involved in the benzenoid/phenylpropanoid and terpenoid biosynthesis pathways.The results provide new insights into the molecular mechanism of its fragrance biosynthesis in jasmine.展开更多
The arc ignition system based on charring polymers has advantages of simple structure,low ignition power consumption and multiple ignitions,which bringing it broadly application prospect in hybrid propulsion system of...The arc ignition system based on charring polymers has advantages of simple structure,low ignition power consumption and multiple ignitions,which bringing it broadly application prospect in hybrid propulsion system of micro/nano satellite.However,charring polymers alone need a relatively high input voltage to achieve pyrolysis and ignition,which increases the burden and cost of the power system of micro/nano satellite in practical application.Adding conductive substance into charring polymers can effectively decrease the conducting voltage which can realize low voltage and low power consumption repeated ignition of arc ignition system.In this paper,a charring conductive polymer ignition grain with a cavity geometry in precombustion chamber,which is composed of PLA and multiwall carbon nanotubes(MWCNT)was proposed.The detailed ignition processes were analyzed and two different ignition mechanisms in the cavity of charring conductive polymers were revealed.The ignition characteristics of charring conductive polymers were also investigated at different input voltages,ignition grain structures,ignition locations and injection schemes in a visual ignition combustor.The results demonstrated that the ignition delay and external energy required for ignition were inversely correlated with the voltages applied to ignition grain.Moreover,the incremental depth of cavity shortened the ignition delay and external energy required for ignition while accelerated the propagation of flame.As the depth of cavity increased from 2 to 6 mm(at 50 V),the time of flame propagating out of ignition grain changed from 235.6 to 108 ms,and values of mean ignition delay time and mean external energy required for ignition decreased from 462.8 to 320 ms and 16.2 to 10.75 J,respectively.The rear side of the cavity was the ideal ignition position which had a shorter ignition delay and a faster flame propagation speed in comparison to other ignition positions.Compared to direct injection scheme,swirling injection provided a more favorable flow field environment in the cavity,which was beneficial to ignition and initial flame propagation,but the ignition position needed to be away from the outlet of swirling injector.At last,the repeated ignition characteristic of charring conductive polymers was also investigated.The ignition delay time and external energy required for ignition decreased with repeated ignition times but the variation was decreasing gradually.展开更多
Central nervous system injuries have a high rate of resulting in disability and mortality;however,at present,effective treatments are lacking.Programmed cell death,which is a genetically determined fo rm of active and...Central nervous system injuries have a high rate of resulting in disability and mortality;however,at present,effective treatments are lacking.Programmed cell death,which is a genetically determined fo rm of active and ordered cell death with many types,has recently attra cted increasing attention due to its functions in determining the fate of cell survival.A growing number of studies have suggested that programmed cell death is involved in central nervous system injuries and plays an important role in the progression of brain damage.In this review,we provide an ove rview of the role of programmed cell death in central nervous system injuries,including the pathways involved in mitophagy,pyroptosis,ferroptosis,and necroptosis,and the underlying mechanisms by which mitophagy regulates pyroptosis,ferroptosis,and necro ptosis.We also discuss the new direction of therapeutic strategies to rgeting mitophagy for the treatment of central nervous system injuries,with the aim to determine the connection between programmed cell death and central nervous system injuries and to identify new therapies to modulate programmed cell death following central nervous system injury.In conclusion,based on these properties and effects,interventions targeting programmed cell death could be developed as potential therapeutic agents for central nervous system injury patients.展开更多
The dramatic increase in intracranial pressure after subarachnoid hemorrhage leads to a decrease in cerebral perfusion pressure and a reduction in cerebral blood flow.Mitochondria are directly affected by direct facto...The dramatic increase in intracranial pressure after subarachnoid hemorrhage leads to a decrease in cerebral perfusion pressure and a reduction in cerebral blood flow.Mitochondria are directly affected by direct factors such as ischemia,hypoxia,excitotoxicity,and toxicity of free hemoglobin and its degradation products,which trigger mitochondrial dysfunction.Dysfunctional mitochondria release large amounts of reactive oxygen species,inflammatory mediators,and apoptotic proteins that activate apoptotic pathways,further damaging cells.In response to this array of damage,cells have adopted multiple mitochondrial quality control mechanisms through evolution,including mitochondrial protein quality control,mitochondrial dynamics,mitophagy,mitochondrial biogenesis,and intercellular mitochondrial transfer,to maintain mitochondrial homeostasis under pathological conditions.Specific interventions targeting mitochondrial quality control mechanisms have emerged as promising therapeutic strategies for subarachnoid hemorrhage.This review provides an overview of recent research advances in mitochondrial pathophysiological processes after subarachnoid hemorrhage,particularly mitochondrial quality control mechanisms.It also presents potential therapeutic strategies to target mitochondrial quality control in subarachnoid hemorrhage.展开更多
This study proposed three types of Al—Hf reactive materials with particle size ratios(a),which were almost completely dense(porosity of<5.40%)owing to their preparation using hot-pressing technology.Microstructure...This study proposed three types of Al—Hf reactive materials with particle size ratios(a),which were almost completely dense(porosity of<5.40%)owing to their preparation using hot-pressing technology.Microstructure characteristics and phase composition were analyzed,and the influence of particle size ratios on dynamic mechanical behavior and damage mechanism were investigated.The prepared sample with a=0.1 exhibited continuous wrapping of the Hf phase by the Al phase.Hf—Hf contact(continuous Hf phase)within the sample gradually increased with increasing a,and a small amount of fine Hf appeared for the sample with a=1.The reactive materials exhibited clear strain-rate sensitivity,with flow stressσ0.05and failure strainεfincreasing approximately linearly with increasing strain rate.ε.It is found that the plastic deformation of the material increased with increasing strain rate.As a increased from 0.1 to 1,the flow stress gradually increased.Impact failure of the material was dominated by ductile fracture with a large Al phase plastic deformation band for lower a,while brittle fracture with crushed Hf particles occurred at higher a.Finally,a constitutive model based on BP neural network was proposed to describe the stress-strain relationships of the materials,with an average relative error of 2.22%.展开更多
Land use and cover change(LUCC)is important for the provision of ecosystem services.An increasing number of recent studies link LUCC processes to ecosystem services and human well-being at different scales recently.Ho...Land use and cover change(LUCC)is important for the provision of ecosystem services.An increasing number of recent studies link LUCC processes to ecosystem services and human well-being at different scales recently.However,the dynamic of land use and its drivers receive insufficient attention within ecological function areas,particularly in quantifying the dynamic roles of climate change and human activities on land use based on a long time series.This study utilizes geospatial analysis and geographical detectors to examine the temporal dynamics of land use patterns and their underlying drivers in the Hedong Region of the Gansu Province from 1990 to 2020.Results indicated that grassland,cropland,and forestland collectively accounted for approximately 99% of the total land area.Cropland initially increased and then decreased after 2000,while grassland decreased with fluctuations.In contrast,forestland and construction land were continuously expanded,with net growth areas of 6235.2 and 455.9 km^(2),respectively.From 1990 to 2020,cropland was converted to grassland,and both of them were converted to forestland as a whole.The expansion of construction land primarily originated from cropland.From 2000 to 2005,land use experienced intensified temporal dynamics and a shift of relatively active zones from the central to the southeastern region.Grain yield,economic factors,and precipitation were the major factors accounting for most land use changes.Climatic impacts on land use changes were stronger before 1995,succeeded by the impact of animal husbandry during 1995-2000,followed by the impacts of grain production and gross domestic product(GDP)after 2000.Moreover,agricultural and pastoral activities,coupled with climate change,exhibited stronger enhancement effects after 2000 through their interaction with population and economic factors.These patterns closely correlated with ecological restoration projects in China since 1999.This study implies the importance of synergy between human activity and climate change for optimizing land use via ecological patterns in the ecological function area.展开更多
Monitoring shear deformation of sliding zones is of great significance for understanding the landslide evolution mechanism,in which fiber optic strain sensing has shown great potential.However,the cor-relation between...Monitoring shear deformation of sliding zones is of great significance for understanding the landslide evolution mechanism,in which fiber optic strain sensing has shown great potential.However,the cor-relation between strain measurements of quasi-distributed fiber Bragg grating(FBG)sensing arrays and shear displacements of surrounding soil remains elusive.In this study,a direct shear model test was conducted to simulate the shear deformation of sliding zones,in which the soil internal deformation was captured using FBG strain sensors and the soil surface deformation was measured by particle image velocimetry(PIV).The test results show that there were two main slip surfaces and two secondary ones,developing a spindle-shaped shear band in the soil.The formation of the shear band was successfully captured by FBG sensors.A sinusoidal model was proposed to describe the fiber optic cable deformation behavior.On this basis,the shear displacements and shear band widths were calculated by using strain measurements.This work provides important insight into the deduction of soil shear deformation using soil-embedded FBG strain sensors.展开更多
Using archival Fermi-LAT data with a time span of~12 yr,we study the population of Millisecond Pulsars(MSPs)in Globular Clusters(GlCs)and investigate their dependence on cluster dynamical evolution in the Milky Way.We...Using archival Fermi-LAT data with a time span of~12 yr,we study the population of Millisecond Pulsars(MSPs)in Globular Clusters(GlCs)and investigate their dependence on cluster dynamical evolution in the Milky Way.We show that theγ-ray luminosity(L_(γ))and emissivity(i.e.,ε_(γ)=L_(γ)/M,with M the cluster mass)are good indicators of the population and abundance of MSPs in GlCs,and they are highly dependent on the dynamical evolution history of the host clusters.Specifically speaking,the dynamically older GlCs with more compact structures are more likely to have larger L_(γ)andε_(γ),and these trends can be summarized as strong correlations with cluster stellar encounter rateΓand the specific encounter rate(Λ=Γ/M),with L_(γ)∝Γ^(0.7±0.11)andε_(γ)∝Λ^(0.73±0.13)for dynamically normal GlCs.However,as GlCs evolve into deep core collapse,these trends are found to be reversed,implying that strong encounters may have lead to the disruption of Low-Mass X-ray Binaries and ejection of MSPs from core-collapsed systems.Besides,the GlCs are found to exhibit largerε_(γ)with increasing stellar mass function slope(ε_(γ)∝10^((0.52±0.1)α)),decreasing tidal radius(ε_(γ)∝R_(t)^(-10±0.22))and distances from the Galactic Center(GC,ε_(γ)∝R_(gc)^(-1.13±0.21)).These correlations indicate that,as GlCs losing kinetic energy and spiral in toward the GC,tidal stripping and mass segregation have a preference in leading to the loss of normal stars from GlCs,while MSPs are more likely to concentrate to cluster center and be deposited into the GC.Moreover,we gaugeε_(γ)of GlCs is~10-1000 times larger than the Galactic bulge,the latter is thought to reside thousands of unresolved MSPs and may be responsible for the GC 7-ray excess,which supports that GlCs are generous contributors to the population of MSPs in the GC.展开更多
文摘Transactions of Nanjing University of Aeronautics&Astronautics(TNUAA)is a bimonthly journal facing international academic community.Emphasizing prompt and effective dissemination of key data and new scientific insights,TNUAA offers publication of new experimental and theoretical papers bearing on applications to all branches of aeronautics,astronautics and civil aviation.
基金Project supported by the National Natural Science Foundation of China(Grant No.61871234).
文摘The control of highly contagious disease spreading in campuses is a critical challenge.In residential universities,students attend classes according to a curriculum schedule,and mainly pack into classrooms,dining halls and dorms.They move from one place to another.To simulate such environments,we propose an agent-based susceptible–infected–recovered model with time-varying heterogeneous contact networks.In close environments,maintaining physical distancing is the most widely recommended and encouraged non-pharmaceutical intervention.It can be easily realized by using larger classrooms,adopting staggered dining hours,decreasing the number of students per dorm and so on.Their real-world influence remains uncertain.With numerical simulations,we obtain epidemic thresholds.The effect of such countermeasures on reducing the number of disease cases is also quantitatively evaluated.
文摘The School of Chemistry and Chemical Engineering of Nanjing University was found in 1920,and it is one of the earliest departments of chemistry in China.Afterwards,the primeval National Central University’s Chemistry Discipline united with Jinling University’s Chemistry Discipline to form the Department of Chemistry of Nanjing University.
文摘The products of an archival culture in colleges and universities are the final result of the development of archival cultural resources,and the development of archival cultural effects in colleges and universities should be an important part of improving the artistic level of libraries.The existing RippleNet model doesn’t consider the influence of key nodes on recommendation results,and the recommendation accuracy is not high.Therefore,based on the RippleNet model,this paper introduces the influence of complex network nodes into the model and puts forward the Cn RippleNet model.The performance of the model is verified by experiments,which provide a theoretical basis for the promotion and recommendation of its cultural products of universarchives,solve the problem that RippleNet doesn’t consider the influence of key nodes on recommendation results,and improve the recommendation accuracy.This paper also combs the development course of archival cultural products in detail.Finally,based on the Cn-RippleNet model,the cultural effect of university archives is recommended and popularized.
文摘Based on a survey of university teachers and students in Nanjing area of 2007,this article analyzes domestic users’awareness towards Open Access(OA),and the changes by comparing the corresponding data of 2006.The survey shows that the research evaluation system,the quality of literature and the payment for OA publications are the important factors for university users to choose OA or not.The authors finally suggest that the current research evaluation system should be reformed to accommodate OA journals.Meanwhile,great efforts should be devoted to improve the quality of OA literatures,and the governments and research institutions should provide stronger support than before.
基金supported by a grant from the Health Commission of Nanjing(Grant Number:ZKX22019),China.
文摘Psychosis has increasingly become a social problem,emphasizing the need to understand the relationship between mental disorders and personality.This study aimed to investigate the relationship between mental disorders and personality among psychiatric outpatients based on real-world data.Symptom Checklist 90(SCL-90)and Eysenck Personality Questionnaire(EPQ)were used to evaluate the personality and psychopathological symptoms of patients(n=8409)in the Psychiatric Outpatient Department at Nanjing Drum Tower Hospital.t-test was used to compare scores between patients and national norms.Pearson’s correlation coefficient and path analysis were used to explore the relationship between mental health status and personality.The correlation coefficient between the neuroticism(N)score and each factor score of the SCL-90 test,as well as the correlation between psychoticism(P)and hostility and paranoia,exceeded 0.4.Path analysis revealed that the standardized path coefficients of N score and SCL-90 were all higher than 0.4.In addition,the standardized path coefficient of hostility and paranoia on P score were 0.313 and 0.280,respectively.Interpersonal sensitivity,depression and obsessive-compulsive symptoms were affected by extraversion(E)score,with standardized path coefficients of-0.149,-0.138,and-0.105,respectively.The path analysis also showed the direct and indirect effects of age,gender,education,and marital status on SCL-90.Patients characterized as melancholic had higher scores in all factors of SCL-90.In conclusion,mental health was related to personality traits of neuroticism,psychoticism and introversion.
基金supported by grants from the National Natural Science Foundation of China (82070665 and 81900592)
文摘Background:Early systemic anticoagulation(SAC)is a common practice in acute necrotizing pancreatitis(ANP),and its impact on in-hospital clinical outcomes had been assessed.However,whether it affects long-term outcomes is unknown.This study aimed to evaluate the effect of SAC on 90-day readmission and other long-term outcomes in ANP patients.Methods:During January 2013 and December 2018,ANP patients admitted within 7 days from the onset of abdominal pain were screened.The primary outcome was 90-day readmission after discharge.Cox proportional-hazards regression model and mediation analysis were used to define the relationship between early SAC and 90-day readmission.Results:A total of 241 ANP patients were enrolled,of whom 143 received early SAC during their hospitalization and 98 did not.Patients who received early SAC experienced a lower incidence of splanchnic venous thrombosis(SVT)[risk ratio(RR)=0.40,95%CI:0.26-0.60,P<0.01]and lower 90-day readmission with an RR of 0.61(95%CI:0.41-0.91,P=0.02)than those who did not.For the quality of life,patients who received early SAC had a significantly higher score in the subscale of vitality(P=0.03)while the other subscales were all comparable between the two groups.Multivariable Cox regression model showed that early SAC was an independent protective factor for 90-day readmission after adjusting for potential confounders with a hazard ratio of 0.57(95%CI:0.34-0.96,P=0.04).Mediation analysis showed that SVT mediated 37.0%of the early SAC-90-day readmission causality.Conclusions:The application of early SAC may reduce the risk of 90-day readmission in the survivors of ANP patients,and reduced SVT incidence might be the primary contributor.
基金financially supported by the National Key Research and Development Program of China(2021YFD2100904)the National Natural Science Foundation of China(31871729,32172147)+2 种基金the Modern Agriculture key Project of Jiangsu Province of China(BE2022317)the Modern Agricultural Industrial Technology System Construction Project of Jiangsu Province of China(JATS[2021]522)a project funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD)。
文摘Active ingredients from highland barley have received considerable attention as natural products for developing treatments and dietary supplements against obesity.In practical application,the research of food combinations is more significant than a specific food component.This study investigated the lipid-lowering effect of highland barley polyphenols via lipase assay in vitro and HepG2 cells induced by oleic acid(OA).Five indexes,triglyceride(TG),total cholesterol(T-CHO),low density lipoprotein-cholesterol(LDL-C),aspartate aminotransferase(AST),and alanine aminotransferase(ALT),were used to evaluate the lipidlowering effect of highland barley extract.We also preliminary studied the lipid-lowering mechanism by Realtime fluorescent quantitative polymerase chain reaction(q PCR).The results indicated that highland barley extract contains many components with lipid-lowering effects,such as hyperoside and scoparone.In vitro,the lipase assay showed an 18.4%lipase inhibition rate when the additive contents of highland barley extract were 100μg/m L.The intracellular lipid-lowering effect of highland barley extract was examined using 0.25 mmol/L OA-induced HepG2 cells.The results showed that intracellular TG,LDL-C,and T-CHO content decreased by 34.4%,51.2%,and 18.4%,respectively.ALT and AST decreased by 51.6%and 20.7%compared with the untreated hyperlipidemic HepG2 cells.q PCR results showed that highland barley polyphenols could up-regulation the expression of lipid metabolism-related genes such as PPARγand Fabp4.
基金the National Key R&D Program of China(Grant No.2022YFF0503702)the National Natural Science Foundation of China(Grant Nos.42074186,41831071,42004136,and 42274195)+1 种基金the Natural Science Foundation of Jiangsu Province(Grant No.BK20211036)the Specialized Research Fund for State Key Laboratories,and the University of Science and Technology of China Research Funds of the Double First-Class Initiative(Grant No.YD2080002013).
文摘The global ionosphere maps(GIM)provided by the International GNSS Service(IGS)are extensively utilized for ionospheric morphology monitoring,scientific research,and practical application.Assessing the credibility of GIM products in data-sparse regions is of paramount importance.In this study,measurements from the Crustal Movement Observation Network of China(CMONOC)are leveraged to evaluate the suitability of IGS-GIM products over China region in 2013-2014.The indices of mean error(ME),root mean square error(RMSE),and normalized RMSE(NRMSE)are then utilized to quantify the accuracy of IGS-GIM products.Results revealed distinct local time and latitudinal dependencies in IGS-GIM errors,with substantially high errors at nighttime(NRMSE:39%)and above 40°latitude(NRMSE:49%).Seasonal differences also emerged,with larger equinoctial deviations(NRMSE:33.5%)compared with summer(20%).A preliminary analysis implied that the irregular assimilation of sparse IGS observations,compounded by China’s distinct geomagnetic topology,may manifest as error variations.These results suggest that modeling based solely on IGS-GIM observations engenders inadequate representations across China and that a thorough examination would proffer the necessary foundation for advancing regional total electron content(TEC)constructions.
基金supported by Ministry of Science and Technology of China (Grant No. 2018YFA0606501)National Natural Science Foundation of China (Grant No. 42075037)+1 种基金Key Laboratory Open Research Program of Xinjiang Science and Technology Department (Grant No. 2022D04009)the National Key Scientific and Technological Infrastructure project “Earth System Numerical Simulation Facility” (EarthLab)。
文摘Both the attribution of historical change and future projections of droughts rely heavily on climate modeling. However,reasonable drought simulations have remained a challenge, and the related performances of the current state-of-the-art Coupled Model Intercomparison Project phase 6(CMIP6) models remain unknown. Here, both the strengths and weaknesses of CMIP6 models in simulating droughts and corresponding hydrothermal conditions in drylands are assessed.While the general patterns of simulated meteorological elements in drylands resemble the observations, the annual precipitation is overestimated by ~33%(with a model spread of 2.3%–77.2%), along with an underestimation of potential evapotranspiration(PET) by ~32%(17.5%–47.2%). The water deficit condition, measured by the difference between precipitation and PET, is 50%(29.1%–71.7%) weaker than observations. The CMIP6 models show weaknesses in capturing the climate mean drought characteristics in drylands, particularly with the occurrence and duration largely underestimated in the hyperarid Afro-Asian areas. Nonetheless, the drought-associated meteorological anomalies, including reduced precipitation, warmer temperatures, higher evaporative demand, and increased water deficit conditions, are reasonably reproduced. The simulated magnitude of precipitation(water deficit) associated with dryland droughts is overestimated by 28%(24%) compared to observations. The observed increasing trends in drought fractional area,occurrence, and corresponding meteorological anomalies during 1980–2014 are reasonably reproduced. Still, the increase in drought characteristics, associated precipitation and water deficit are obviously underestimated after the late 1990s,especially for mild and moderate droughts, indicative of a weaker response of dryland drought changes to global warming in CMIP6 models. Our results suggest that it is imperative to employ bias correction approaches in drought-related studies over drylands by using CMIP6 outputs.
基金This study was supported by the Chinese University Scientific Fund(2023TC105)the National Nature Science Foundation of China(72361147521&72061147002).
文摘Despite the growing recognition of women’s increasing role in the household and corresponding empowerment programs in sub-Saharan Africa,intensive research on the relationship between women’s influence and household food consumption is minimal.Using the most recent(2017-2018)national household survey data from Tanzania,this study examined the influence of women’s empowerment on household food consumption.First,we compared the monthly consumption of eight food categories between female-headed households(FHHs)and male-headed households(MHHs)using both descriptive statistics and the propensity score matching(PSM)method.Furthermore,we adopted the two-stage Linear Expenditure System and Almost Ideal Demand System model(LES-AIDS)to estimate income and price elasticities for the two household types.The results show that FHHs consume bread and cereals,fish,oils and fats,vegetables,and confectionery(sugar,jam,honey,chocolate,etc.)more than MHHs.Moreover,FHHs have a significantly higher income elasticity of demand for all food groups than MHHs.They are also more price elastic than MHHs in meat,fish,oils,fats,sugar,jam,honey,chocolate,etc.
基金financially supported by the National Natural Science Foundation of China(Grant No.31772338)the Basic Scientific Research Business Special Project of Jiangsu Academy of Agricultural Sciences(Grant No.0090756100ZX)。
文摘Jasmine(Jasminum sambac Aiton)is a well-known cultivated plant species for its fragrant flowers used in the perfume industry and cosmetics.However,the genetic basis of its floral scent is largely unknown.In this study,using PacBio,Illumina,10×Genomics and highthroughput chromosome conformation capture(Hi-C)sequencing technologies,a high-quality chromosome-level reference genome for J.sambac was obtained,exploiting a double-petal phenotype cultivar‘Shuangbanmoli’(JSSB).The results showed that the final assembled genome of JSSB is 580.33 Mb in size(contig N50=1.05 Mb;scaffold N50=45.07 Mb)with a total of 39618 predicted protein-coding genes.Our analyses revealed that the JSSB genome has undergone an ancient whole-genome duplication(WGD)event at 91.68 million years ago(Mya).It was estimated that J.sambac diverged from the lineage leading to Olea europaea and Osmanthus fragrans about 28.8 Mya.On the basis of a combination of genomic,transcriptomic and metabolomic analyses,a range of floral scent volatiles and genes were identified involved in the benzenoid/phenylpropanoid and terpenoid biosynthesis pathways.The results provide new insights into the molecular mechanism of its fragrance biosynthesis in jasmine.
基金the Fundamental Research Funds for the Central Universities(Grant No.30920041102)National Natural Science Foundation of China(Grant No.11802134).
文摘The arc ignition system based on charring polymers has advantages of simple structure,low ignition power consumption and multiple ignitions,which bringing it broadly application prospect in hybrid propulsion system of micro/nano satellite.However,charring polymers alone need a relatively high input voltage to achieve pyrolysis and ignition,which increases the burden and cost of the power system of micro/nano satellite in practical application.Adding conductive substance into charring polymers can effectively decrease the conducting voltage which can realize low voltage and low power consumption repeated ignition of arc ignition system.In this paper,a charring conductive polymer ignition grain with a cavity geometry in precombustion chamber,which is composed of PLA and multiwall carbon nanotubes(MWCNT)was proposed.The detailed ignition processes were analyzed and two different ignition mechanisms in the cavity of charring conductive polymers were revealed.The ignition characteristics of charring conductive polymers were also investigated at different input voltages,ignition grain structures,ignition locations and injection schemes in a visual ignition combustor.The results demonstrated that the ignition delay and external energy required for ignition were inversely correlated with the voltages applied to ignition grain.Moreover,the incremental depth of cavity shortened the ignition delay and external energy required for ignition while accelerated the propagation of flame.As the depth of cavity increased from 2 to 6 mm(at 50 V),the time of flame propagating out of ignition grain changed from 235.6 to 108 ms,and values of mean ignition delay time and mean external energy required for ignition decreased from 462.8 to 320 ms and 16.2 to 10.75 J,respectively.The rear side of the cavity was the ideal ignition position which had a shorter ignition delay and a faster flame propagation speed in comparison to other ignition positions.Compared to direct injection scheme,swirling injection provided a more favorable flow field environment in the cavity,which was beneficial to ignition and initial flame propagation,but the ignition position needed to be away from the outlet of swirling injector.At last,the repeated ignition characteristic of charring conductive polymers was also investigated.The ignition delay time and external energy required for ignition decreased with repeated ignition times but the variation was decreasing gradually.
基金supported by the National Natural Science Foundation of China,No.82101461(to ZL)。
文摘Central nervous system injuries have a high rate of resulting in disability and mortality;however,at present,effective treatments are lacking.Programmed cell death,which is a genetically determined fo rm of active and ordered cell death with many types,has recently attra cted increasing attention due to its functions in determining the fate of cell survival.A growing number of studies have suggested that programmed cell death is involved in central nervous system injuries and plays an important role in the progression of brain damage.In this review,we provide an ove rview of the role of programmed cell death in central nervous system injuries,including the pathways involved in mitophagy,pyroptosis,ferroptosis,and necroptosis,and the underlying mechanisms by which mitophagy regulates pyroptosis,ferroptosis,and necro ptosis.We also discuss the new direction of therapeutic strategies to rgeting mitophagy for the treatment of central nervous system injuries,with the aim to determine the connection between programmed cell death and central nervous system injuries and to identify new therapies to modulate programmed cell death following central nervous system injury.In conclusion,based on these properties and effects,interventions targeting programmed cell death could be developed as potential therapeutic agents for central nervous system injury patients.
基金supported by the National Natural Science Foundation of China,Nos.82130037(to CH),81971122(to CH),82171323(to WL)the Natural Science Foundation of Jiangsu Province of China,No.BK20201113(to WL)。
文摘The dramatic increase in intracranial pressure after subarachnoid hemorrhage leads to a decrease in cerebral perfusion pressure and a reduction in cerebral blood flow.Mitochondria are directly affected by direct factors such as ischemia,hypoxia,excitotoxicity,and toxicity of free hemoglobin and its degradation products,which trigger mitochondrial dysfunction.Dysfunctional mitochondria release large amounts of reactive oxygen species,inflammatory mediators,and apoptotic proteins that activate apoptotic pathways,further damaging cells.In response to this array of damage,cells have adopted multiple mitochondrial quality control mechanisms through evolution,including mitochondrial protein quality control,mitochondrial dynamics,mitophagy,mitochondrial biogenesis,and intercellular mitochondrial transfer,to maintain mitochondrial homeostasis under pathological conditions.Specific interventions targeting mitochondrial quality control mechanisms have emerged as promising therapeutic strategies for subarachnoid hemorrhage.This review provides an overview of recent research advances in mitochondrial pathophysiological processes after subarachnoid hemorrhage,particularly mitochondrial quality control mechanisms.It also presents potential therapeutic strategies to target mitochondrial quality control in subarachnoid hemorrhage.
基金funded by the National Natural Science Foundation of China(Grant No.12302437)China Postdoctoral Science Foundation(Grant No.2021M701710)。
文摘This study proposed three types of Al—Hf reactive materials with particle size ratios(a),which were almost completely dense(porosity of<5.40%)owing to their preparation using hot-pressing technology.Microstructure characteristics and phase composition were analyzed,and the influence of particle size ratios on dynamic mechanical behavior and damage mechanism were investigated.The prepared sample with a=0.1 exhibited continuous wrapping of the Hf phase by the Al phase.Hf—Hf contact(continuous Hf phase)within the sample gradually increased with increasing a,and a small amount of fine Hf appeared for the sample with a=1.The reactive materials exhibited clear strain-rate sensitivity,with flow stressσ0.05and failure strainεfincreasing approximately linearly with increasing strain rate.ε.It is found that the plastic deformation of the material increased with increasing strain rate.As a increased from 0.1 to 1,the flow stress gradually increased.Impact failure of the material was dominated by ductile fracture with a large Al phase plastic deformation band for lower a,while brittle fracture with crushed Hf particles occurred at higher a.Finally,a constitutive model based on BP neural network was proposed to describe the stress-strain relationships of the materials,with an average relative error of 2.22%.
基金funded by the National Natural Science Foundation of China(U20A2098,41701219)the National Key Research and Development Program of China(2019YFC0507801)。
文摘Land use and cover change(LUCC)is important for the provision of ecosystem services.An increasing number of recent studies link LUCC processes to ecosystem services and human well-being at different scales recently.However,the dynamic of land use and its drivers receive insufficient attention within ecological function areas,particularly in quantifying the dynamic roles of climate change and human activities on land use based on a long time series.This study utilizes geospatial analysis and geographical detectors to examine the temporal dynamics of land use patterns and their underlying drivers in the Hedong Region of the Gansu Province from 1990 to 2020.Results indicated that grassland,cropland,and forestland collectively accounted for approximately 99% of the total land area.Cropland initially increased and then decreased after 2000,while grassland decreased with fluctuations.In contrast,forestland and construction land were continuously expanded,with net growth areas of 6235.2 and 455.9 km^(2),respectively.From 1990 to 2020,cropland was converted to grassland,and both of them were converted to forestland as a whole.The expansion of construction land primarily originated from cropland.From 2000 to 2005,land use experienced intensified temporal dynamics and a shift of relatively active zones from the central to the southeastern region.Grain yield,economic factors,and precipitation were the major factors accounting for most land use changes.Climatic impacts on land use changes were stronger before 1995,succeeded by the impact of animal husbandry during 1995-2000,followed by the impacts of grain production and gross domestic product(GDP)after 2000.Moreover,agricultural and pastoral activities,coupled with climate change,exhibited stronger enhancement effects after 2000 through their interaction with population and economic factors.These patterns closely correlated with ecological restoration projects in China since 1999.This study implies the importance of synergy between human activity and climate change for optimizing land use via ecological patterns in the ecological function area.
基金This work was financially supported by the National Natural Science Foundation of China(Grant Nos.42225702 and 42077235)the Open Research Project Program of the State Key Laboratory of Internet of Things for Smart City(University of Macao)(Grant No.SKL-IoTSC(UM)-2021-2023/ORP/GA10/2022)。
文摘Monitoring shear deformation of sliding zones is of great significance for understanding the landslide evolution mechanism,in which fiber optic strain sensing has shown great potential.However,the cor-relation between strain measurements of quasi-distributed fiber Bragg grating(FBG)sensing arrays and shear displacements of surrounding soil remains elusive.In this study,a direct shear model test was conducted to simulate the shear deformation of sliding zones,in which the soil internal deformation was captured using FBG strain sensors and the soil surface deformation was measured by particle image velocimetry(PIV).The test results show that there were two main slip surfaces and two secondary ones,developing a spindle-shaped shear band in the soil.The formation of the shear band was successfully captured by FBG sensors.A sinusoidal model was proposed to describe the fiber optic cable deformation behavior.On this basis,the shear displacements and shear band widths were calculated by using strain measurements.This work provides important insight into the deduction of soil shear deformation using soil-embedded FBG strain sensors.
基金supported by the Youth Program of the National Natural Science Foundation of China No.12003017。
文摘Using archival Fermi-LAT data with a time span of~12 yr,we study the population of Millisecond Pulsars(MSPs)in Globular Clusters(GlCs)and investigate their dependence on cluster dynamical evolution in the Milky Way.We show that theγ-ray luminosity(L_(γ))and emissivity(i.e.,ε_(γ)=L_(γ)/M,with M the cluster mass)are good indicators of the population and abundance of MSPs in GlCs,and they are highly dependent on the dynamical evolution history of the host clusters.Specifically speaking,the dynamically older GlCs with more compact structures are more likely to have larger L_(γ)andε_(γ),and these trends can be summarized as strong correlations with cluster stellar encounter rateΓand the specific encounter rate(Λ=Γ/M),with L_(γ)∝Γ^(0.7±0.11)andε_(γ)∝Λ^(0.73±0.13)for dynamically normal GlCs.However,as GlCs evolve into deep core collapse,these trends are found to be reversed,implying that strong encounters may have lead to the disruption of Low-Mass X-ray Binaries and ejection of MSPs from core-collapsed systems.Besides,the GlCs are found to exhibit largerε_(γ)with increasing stellar mass function slope(ε_(γ)∝10^((0.52±0.1)α)),decreasing tidal radius(ε_(γ)∝R_(t)^(-10±0.22))and distances from the Galactic Center(GC,ε_(γ)∝R_(gc)^(-1.13±0.21)).These correlations indicate that,as GlCs losing kinetic energy and spiral in toward the GC,tidal stripping and mass segregation have a preference in leading to the loss of normal stars from GlCs,while MSPs are more likely to concentrate to cluster center and be deposited into the GC.Moreover,we gaugeε_(γ)of GlCs is~10-1000 times larger than the Galactic bulge,the latter is thought to reside thousands of unresolved MSPs and may be responsible for the GC 7-ray excess,which supports that GlCs are generous contributors to the population of MSPs in the GC.
