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Single-pulse ultrafast real-time simultaneous planar imaging of femtosecond laser-nanoparticle dynamics in flames
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作者 Yogeshwar Nath Mishra Peng Wang +2 位作者 Florian J.Bauer Murthy S.Gudipati Lihong V.Wang 《Light(Science & Applications)》 SCIE EI CSCD 2024年第10期2312-2320,共9页
The creation of carbonaceous nanoparticles and their dynamics in hydrocarbon flames are still debated in environmental,combustion,and material sciences.In this study,we introduce single-pulse femtosecond laser sheetco... The creation of carbonaceous nanoparticles and their dynamics in hydrocarbon flames are still debated in environmental,combustion,and material sciences.In this study,we introduce single-pulse femtosecond laser sheetcompressed ultrafast photography(fsLS-CUP),an ultrafast imaging technique specifically designed to shed light on and capture ultrafast dynamics stemming from interactions between femtosecond lasers and nanoparticles in flames in a single-shot.fsLS-CUP enables the first-time real-time billion frames-per-second(Gfps)simultaneous twodimensional(2D)imaging of laser-induced fluorescence(LIF)and laser-induced heating(LIH)that are originated from polycyclic aromatic hydrocarbons(PAHs)and soot particles,respectively.Furthermore,fsLS-CUP provides the real-time spatiotemporal map of femtosecond laser-soot interaction as elastic light scattering(ELS)at an astonishing 250 Gfps.In contrast to existing single-shot ultrafast imaging approaches,which are limited to millions of frames per second only and require multiple laser pulses,our method employs only a single pulse and captures the entire dynamics of laserinduced signals at hundreds of Gfps.Using a single pulse does not change the optical properties of nanoparticles for a following pulse,thus allowing reliable spatiotemporal mapping.Moreover,we found that particle inception and growth are derived from precursors.In essence,as an imaging modality,fsLS-CUP offers ultrafast 2D diagnostics,contributing to the fundamental understanding of nanoparticle’s inception and broader applications across different fields,such as material science and biomedical engineering. 展开更多
关键词 PULSE SCATTERING dynamics
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In vivo tumor ultrasound-switchable fluorescence imaging via intravenous injections of size-controlled thermosensitive nanoparticles 被引量:2
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作者 Liqin Ren Yang Liu +2 位作者 Tingfeng Yao Kytai TNguyen Baohong Yuan 《Nano Research》 SCIE EI CSCD 2023年第1期1009-1020,共12页
Near-infrared fluorescence imaging has emerged as a noninvasive,inexpensive,and ionizing-radiation-free monitoring tool for assessing tumor growth and treatment efficacy.In particular,ultrasound switchable fluorescenc... Near-infrared fluorescence imaging has emerged as a noninvasive,inexpensive,and ionizing-radiation-free monitoring tool for assessing tumor growth and treatment efficacy.In particular,ultrasound switchable fluorescence(USF)imaging has been explored with improved imaging sensitivity and spatial resolution in centimeter-deep tissues.This study achieved the size control of polymer-based and indocyanine green(ICG)encapsulated USF contrast agents,capable of accumulating in the tumor after intravenous injections.These nanoprobes varied in size from 58 to 321 nm.The bioimaging profiles demonstrated that the proposed nanoparticles can efficiently eliminate the background light from normal tissue and show a tumor-specific fluorescence enhancement in the BxPC-3 tumor-bearing mice models possibly via the enhanced permeability and retention effect.In vivo tumor USF imaging further demonstrated that these nanoprobes can effectively be switched“ON”with enhanced fluorescence in response to a focused ultrasound stimulation in the tumor microenvironment,contributing to the high-resolution USF images.Therefore,our findings suggest that ICG-encapsulated nanoparticles are good candidates for USF imaging of tumors in live animals,indicating their great potential in optical tumor imaging in deep tissue. 展开更多
关键词 in vivo tumor imaging deep tissue near-infrared(NIR)imaging high resolution ultrasound-switchable fluorescence imaging indocyanine green(ICG)
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Single-pulse real-time billion-frames-per-second planar imaging of ultrafast nanoparticle-laser dynamics and temperature in flames 被引量:2
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作者 Yogeshwar Nath Mishra Peng Wang +4 位作者 Florian J.Bauer Yide Zhang Dag Hanstorp Stefan Will Lihong V.Wang 《Light(Science & Applications)》 SCIE EI CAS CSCD 2023年第3期379-390,共12页
Unburnt hydrocarbon flames produce soot,which is the second biggest contributor to global warming and harmful to human health.The state-of-the-art high-speed imaging techniques,developed to study non-repeatable turbul... Unburnt hydrocarbon flames produce soot,which is the second biggest contributor to global warming and harmful to human health.The state-of-the-art high-speed imaging techniques,developed to study non-repeatable turbulent flames,are limited to million-frames-per-second imaging rates,falling short in capturing the dynamics of critical species.Unfortunately,these techniques do not provide a complete picture of flame-laser interactions,important for understanding soot formation.Furthermore,thermal effects induced by multiple consecutive pulses modify the optical properties of soot nanoparticles,thus making single-pulse imaging essential.Here,we report single-shot laser-sheet compressed ultrafast photography(LS-CUP)for billion-frames-per-second planar imaging of flame-laser dynamics.We observed laser-induced incandescence,elastic light scattering,and fluorescence of soot precursors-polycyclic aromatic hydrocarbons(PAHs)in real-time using a single nanosecond laser pulse.The spatiotemporal maps of the PAHs emission,soot temperature,primary nanoparticle size,soot aggregate size,and the number of monomers,present strong experimental evidence in support of the theory and modeling of soot inception and growth mechanism in flames.LS-CUP represents a generic and indispensable tool that combines a portfolio of ultrafast combustion diagnostic techniques,covering the entire lifecycle of soot nanoparticles,for probing extremely short-lived(picoseconds to nanoseconds)species in the spatiotemporal domain in non-repeatable turbulent environments.Finally,LS-CUP’s unparalleled capability of ultrafast wide-field temperature imaging in real-time is envisioned to unravel mysteries in modern physics such as hot plasma, sonoluminescence, and nuclear fusion. 展开更多
关键词 dynamics PULSE TURBULENT
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Recent Advances in Photoacoustic Tomography
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作者 Lei Li Lihong V.Wang 《Biomedical Engineering Frontiers》 2021年第1期27-43,共17页
Photoacoustic tomography(PAT)that integrates the molecular contrast of optical imaging with the high spatial resolution of ultrasound imaging in deep tissue has widespread applications in basic biological science,prec... Photoacoustic tomography(PAT)that integrates the molecular contrast of optical imaging with the high spatial resolution of ultrasound imaging in deep tissue has widespread applications in basic biological science,preclinical research,and clinical trials.Recently,tremendous progress has been made in PAT regarding technical innovations,preclinical applications,and clinical translations.Here,we selectively review the recent progresses and advances in PAT,including the development of advanced PAT systems for small-animal and human imaging,newly engineered optical probes for molecular imaging,broad-spectrum PAT for label-free imaging of biological tissues,high-throughput snapshot photoacoustic topography,and integration of machine learning for image reconstruction and processing.We envision that PAT will have further technical developments and more impactful applications in biomedicine. 展开更多
关键词 CLINICAL TOPOGRAPHY INTEGRATE
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Single-shot real-time femtosecond imaging of temporal focusing 被引量:22
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作者 Jinyang Liang Liren Zhu Lihong V.Wang 《Light(Science & Applications)》 SCIE EI CAS CSCD 2018年第1期593-602,共10页
While the concept of focusing usually applies to the spatial domain,it is equally applicable to the time domain.Realtime imaging of temporal focusing of single ultrashort laser pulses is of great significance in explo... While the concept of focusing usually applies to the spatial domain,it is equally applicable to the time domain.Realtime imaging of temporal focusing of single ultrashort laser pulses is of great significance in exploring the physics of the space–time duality and finding diverse applications.The drastic changes in the width and intensity of an ultrashort laser pulse during temporal focusing impose a requirement for femtosecond-level exposure to capture the instantaneous light patterns generated in this exquisite phenomenon.Thus far,established ultrafast imaging techniques either struggle to reach the desired exposure time or require repeatable measurements.We have developed single-shot 10-trillion-frame-per-second compressed ultrafast photography(T-CUP),which passively captures dynamic events with 100-fs frame intervals in a single camera exposure.The synergy between compressed sensing and the Radon transformation empowers T-CUP to significantly reduce the number of projections needed for reconstructing a high-quality three-dimensional spatiotemporal datacube.As the only currently available real-time,passive imaging modality with a femtosecond exposure time,T-CUP was used to record the first-ever movie of nonrepeatable temporal focusing of a single ultrashort laser pulse in a dynamic scattering medium.T-CUP’s unprecedented ability to clearly reveal the complex evolution in the shape,intensity,and width of a temporally focused pulse in a single measurement paves the way for single-shot characterization of ultrashort pulses,experimental investigation of nonlinear light-matter interactions,and real-time wavefront engineering for deep-tissue light focusing. 展开更多
关键词 ULTRASHORT PASSIVE SCATTERING
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Physical picture of the optical memory effect 被引量:11
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作者 Honglin Liu Zhentao Liu +2 位作者 Meijun Chen Shensheng Han Lihong V.Wang 《Photonics Research》 SCIE EI CSCD 2019年第11期1323-1330,共8页
The optical memory effect is an interesting phenomenon that has attracted considerable attention in recent decades. Here, we present a new physical picture of the optical memory effect, in which the memory effect and ... The optical memory effect is an interesting phenomenon that has attracted considerable attention in recent decades. Here, we present a new physical picture of the optical memory effect, in which the memory effect and the conventional spatial shift invariance are united. Based on this picture we depict the role of thickness, scattering times, and anisotropy factor and derive equations to calculate the ranges of the angular memory effect(AME) of different scattering components(ballistic light, singly scattered, doubly scattered, etc.), and hence a more accurate equation for the real AME ranges of volumetric turbid media. A conventional random phase mask model is modified according to the new picture. The self-consistency of the simulation model and its agreement with the experiment demonstrate the rationality of the model and the physical picture, which provide powerful tools for more sophisticated studies of the memory-effect-related phenomena and wavefront-sensitive techniques, such as wavefront shaping, optical phase conjugation, and optical trapping in/through scattering media. 展开更多
关键词 EFFECT SCATTERED hence
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High-resolution photoacoustic microscope for rat brain imaging in vivo 被引量:4
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作者 杨孝全 蔡鑫 +2 位作者 Konstantin Maslov 汪立宏 骆清铭 《Chinese Optics Letters》 SCIE EI CAS CSCD 2010年第6期609-611,共3页
A reflection-mode photoacoustic microscope(PAM) for rat brain imaging in vivo is constructed.A pulsed laser is used as an excitation source,and a focused ultrasound transducer is adopted to collect the photoacoustic... A reflection-mode photoacoustic microscope(PAM) for rat brain imaging in vivo is constructed.A pulsed laser is used as an excitation source,and a focused ultrasound transducer is adopted to collect the photoacoustic signal.Raster scanning is applied to acquire three-dimensional(3D) data.The obtained measurements of the lateral and axial resolutions of the microscope are 45 and 15μm,respectively.The imaging depth in the chicken breast tissue is 3.1 mm at a signal-to-noise ratio(SNR) of 20 dB without any signal averaging.The imaging speed is 30 A-line/s.Experimental results in vivo demonstrate the capability of 3D imaging of the brain vessels of the rat after removing the skull. 展开更多
关键词 Acoustic microscopes Laser excitation Photoacoustic effect Photoacoustic microscopy Pulsed laser applications Pulsed lasers Signal to noise ratio Ultrasonic transducers
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A green synthesis of carbon nanoparticles from honey and their use in real-time photoacoustic imaging 被引量:3
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作者 Lina Wu Xin Cai +9 位作者 Kate Nelson Wenxin Xing Jun Xia Ruiying Zhang Allen J. Stacy Micah Luderer Gregory M. Lanza Lihong V. Wang Baozhong Shen Dipanjan Pan 《Nano Research》 SCIE EI CAS CSCD 2013年第5期312-325,共14页
Imaging sentinel lymph nodes (SLN) could provide us with critical information about the progression of a cancerous disease. Real-time high-resolution intrao- perative photoacoustic imaging (PAI) in conjunction wit... Imaging sentinel lymph nodes (SLN) could provide us with critical information about the progression of a cancerous disease. Real-time high-resolution intrao- perative photoacoustic imaging (PAI) in conjunction with a near-infrared (NIR) probe may offer opportunities for the immediate imaging for direct identification and resection of SLN or collecting tissue samples. In this work a commercially amenable synthetic methodology is revealed for fabricating luminescent carbon nanoparticles with rapid clearance properties. A one-pot "green" technique is pursued, which involved rapid surface passivation of carbon nanopartides with organic macromolecules (e.g., polysorbate, polyethyleneglycol) in solvent-free conditions. Interestingly, the naked carbon nanoparticles are derived for the first time, from commercial food grade honey. Surface coated particles are markedly smaller (-7 nm) than previously explored particles (gold, single-walled carbon nanotubes, copper) for SLN imaging. The results indicate an exceptionally rapid signal enhancement (-2 min) of the SLN. Owing to their strong optical absorption in the NIR region, tiny size and rapid lymphatic transport, this platform offers great potential for faster resection of SLN and may lower complications caused in axillary investigation by mismarking with dyes or low-resolution imaging techniques. 展开更多
关键词 carbon nanoparticle honey contrast agents photoacoustictomography real-time imaging
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Deep learning acceleration of multiscale superresolution localization photoacoustic imaging 被引量:4
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作者 Jongbeom Kim Gyuwon Kim +7 位作者 Lei Li Pengfei Zhang Jin Young Kim Yeonggeun Kim Hyung Ham Kkim Lihong V.Wang Seungchul Lee Chulhong Kim 《Light(Science & Applications)》 SCIE EI CAS CSCD 2022年第6期1166-1177,共12页
A superresolution imaging approach that localizes very small targets,such as red blood cells or droplets of injected photoacoustic dye,has significantly improved spatial resolution in various biological and medical im... A superresolution imaging approach that localizes very small targets,such as red blood cells or droplets of injected photoacoustic dye,has significantly improved spatial resolution in various biological and medical imaging modalities.However,this superior spatial resolution is achieved by sacrificing temporal resolution because many raw image frames,each containing the localization target,must be superimposed to form a sufficiently sampled high-density superresolution image.Here,we demonstrate a computational strategy based on deep neural networks(DNNs)to reconstruct high-density superresolution images from far fewer raw image frames.The localization strategy can be applied for both 3D label-free localization optical-resolution photoacoustic microscopy(OR-PAM)and 2D labeled localization photoacoustic computed tomography(PACT).For the former,the required number of raw volumetric frames is reduced from tens to fewer than ten.For the latter,the required number of raw 2D frames is reduced by 12 fold.Therefore,our proposed method has simultaneously improved temporal(via the DNN)and spatial(via the localization method)resolutions in both label-free microscopy and labeled tomography.Deep-learning powered localization PA imaging can potentially provide a practical tool in preclinical and clinical studies requiring fast temporal and fine spatial resolutions. 展开更多
关键词 DEEP FRAMES NETWORKS
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Temperature-sensitive polymeric nanogels encapsulating withβ-cyclodextrin and ICG complex for high-resolution deep-tissue ultrasound-switchable fluorescence imaging 被引量:1
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作者 Ruilin Liu Tingfeng Yao +5 位作者 Yang Liu Shuai Yu Liqin Ren Yi Hong Kytai T.Nguyen Baohong Yuan 《Nano Research》 SCIE EI CAS CSCD 2020年第4期1100-1110,共11页
One of the thorny problems currently impeding the applications of the fluorescence imaging technique is the poor spatial resolution in deep tissue.Ultrasound-switchable fluorescence(USF)imaging is a novel imaging tool... One of the thorny problems currently impeding the applications of the fluorescence imaging technique is the poor spatial resolution in deep tissue.Ultrasound-switchable fluorescence(USF)imaging is a novel imaging tool that has recently been explored to possibly surmount the above-mentioned bottleneck.Herein,αβ-cyclodextrin/indocyanine green(ICG)complex-encapsulated poly(N-isopropylacrylamide)(PNIPAM)nanogel was synthesized and studied for ex vivo/in vivo deep tissue/high-resolution near infrared USF(NIR-USF)imaging.To be specific,our results revealed that the average diameter of the as-prepared nanogels was significantly decreased to-32 nm from-335 nm compared to the reported ICG-PNIPAM nanoparticles.Additionally,the excitation/emission characteristics of the ICG itself in present nanogels were almost completely retained,and the resultant nanogel exhibited high physiological stability and positive biocompatibility.In particular,the signal-to-noise ratio of the USF image for the PNIPAM/P-cyclodextrin/ICG nanogel(33.01±2.42 dB)was prominently higher than that of the ICG-PNIPAM nanoparticles(18.73±0.33 dB)in 1.5-cm-thick chicken breast tissues.The NIR-USF imaging in 3.5-cm-thick chicken breast tissues was achieved using this new probe.The e x v iv o NIR-USF imaging of the mouse liver was also successfully obtained.Animal experiments showed that the present nanogels were able to be effectively accumulated into U87 tumor-bearing mice via enhanced permeability and retention effects,and the high-resolution NIR-USF imaging of in v ivo tumor was efficiently acquired.The metabolism and in vivo biodistribution of the nanogels were evaluated.Overall,the results suggest that the current nanogel is a highly promising NIR-USF probe for deep tissue and high-resolution USF imaging. 展开更多
关键词 deep tissue imaging HIGH-RESOLUTION ultrasound-switchable NIR fluorescence imaging in vivo imaging
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Learning-based super-resolution interpolation for sub-Nyquist sampled laser speckles 被引量:2
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作者 HUANHAO LI ZHIPENG YU +8 位作者 QI ZHAO YUNQI LUO SHENGFU CHENG TIANTING ZHONG CHI MAN WOO HONGLIN LIU LIHONG V.WANG YUANJIN ZHENG PUXIANG LAI 《Photonics Research》 SCIE EI CAS CSCD 2023年第4期631-642,共12页
Information retrieval from visually random optical speckle patterns is desired in many scenarios yet considered challenging.It requires accurate understanding or mapping of the multiple scattering process,or reliable ... Information retrieval from visually random optical speckle patterns is desired in many scenarios yet considered challenging.It requires accurate understanding or mapping of the multiple scattering process,or reliable capability to reverse or compensate for the scattering-induced phase distortions.In whatever situation,effective resolving and digitization of speckle patterns are necessary.Nevertheless,on some occasions,to increase the acquisition speed and/or signal-to-noise ratio(SNR),speckles captured by cameras are inevitably sampled in the sub-Nyquist domain via pixel binning(one camera pixel contains multiple speckle grains)due to finite size or limited bandwidth of photosensors.Such a down-sampling process is irreversible;it undermines the fine structures of speckle grains and hence the encoded information,preventing successful information extraction.To retrace the lost information,super-resolution interpolation for such sub-Nyquist sampled speckles is needed.In this work,a deep neural network,namely SpkSRNet,is proposed to effectively up sample speckles that are sampled below 1/10 of the Nyquist criterion to well-resolved ones that not only resemble the comprehensive morphology of original speckles(decompose multiple speckle grains from one camera pixel)but also recover the lost complex information(human face in this study)with high fidelity under normal-and low-light conditions,which is impossible with classic interpolation methods.These successful speckle super-resolution interpolation demonstrations are essentially enabled by the strong implicit correlation among speckle grains,which is non-quantifiable but could be discovered by the well-trained network.With further engineering,the proposed learning platform may benefit many scenarios that are physically inaccessible,enabling fast acquisition of speckles with sufficient SNR and opening up new avenues for seeing big and seeing clearly simultaneously in complex scenarios. 展开更多
关键词 SPECKLE INTERPOLATION hence
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Non-invasive photoacoustic computed tomography of rat heart anatomy and function 被引量:1
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作者 Li Lin Xin Tong +5 位作者 Susana Cavallero Yide Zhang Shuai Na Rui Cao Tzung K.Hsiai Lihong V.Wang 《Light(Science & Applications)》 SCIE EI CAS CSCD 2023年第1期109-117,共9页
Complementary to mainstream cardiac imaging modalities for preclinical research,photoacoustic computed tomography(PACT)can provide functional optical contrast with high imaging speed and resolution.However,PACT has no... Complementary to mainstream cardiac imaging modalities for preclinical research,photoacoustic computed tomography(PACT)can provide functional optical contrast with high imaging speed and resolution.However,PACT has not been demonstrated to reveal the dynamics of whole cardiac anatomy or vascular system without surgical procedure(thoracotomy)for tissue penetration.Here,we achieved non-invasive imaging of rat hearts using the recently developed three-dimensional PACT(3D-PACT)platform,demonstrating the regulated illumination and detection schemes to reduce the effects of optical attenuation and acoustic distortion through the chest wall;thereby,enabling unimpeded visualization of the cardiac anatomy and intracardiac hemodynamics following rapidly scanning the heart within 10 s.We further applied 3D-PACT to reveal distinct cardiac structural and functional changes among the healthy,hypertensive,and obese rats,with optical contrast to uncover differences in cardiac chamber size,wall thickness,and hemodynamics.Accordingly,3D-PACT provides high imaging speed and nonionizing penetration to capture the whole heart for diagnosing the animal models,holding promises for clinical translation to cardiac imaging of human neonates. 展开更多
关键词 ANATOMY HYPERTENSIVE ILLUMINATION
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Polarization patterns of light enable geolocalization in oceans
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作者 Lihong V.Wang 《Light(Science & Applications)》 SCIE EI CSCD 2023年第11期2264-2265,共2页
The deep ocean,characterized by its immense depths and absence of global positioning system(GPS)functionality,presents considerable challenges for search and rescue missions.Inspired by the geolocalization capabilitie... The deep ocean,characterized by its immense depths and absence of global positioning system(GPS)functionality,presents considerable challenges for search and rescue missions.Inspired by the geolocalization capabilities of migratory marine animals,Bai et al.present a novel method for underwater geolocalization using the polarization patterns of light in the underwater environment.Emulating a sextant using these underwater polarization patterns,the study determines geolocation in underwater settings.Despite prior skepticism,even in low-visibility waters,these patterns,learned through a deep neural network,provide geolocation accuracies of 55 km at 8m and 255 km at 50 m.This pioneering approach offers implications for search and rescue and hints at navigation mechanisms in marine animals. 展开更多
关键词 UNDERWATER enable VISIBILITY
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Deep learning-enhanced microscopy with extended depth-of-field
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作者 Yide Zhang 《Light(Science & Applications)》 SCIE EI CSCD 2023年第12期2548-2550,共3页
A computational imaging platform utilizing a physics-incorporated,deep-learned design of binary phase filter and a jointly optimized deconvolution neural network has been reported,achieving high-resolution,high-contra... A computational imaging platform utilizing a physics-incorporated,deep-learned design of binary phase filter and a jointly optimized deconvolution neural network has been reported,achieving high-resolution,high-contrast imaging over extended depth ranges without the need for serial refocusing. 展开更多
关键词 utilizing jointly DEEP
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In vivo superresolution photoacoustic computed tomography by localization of single dyed droplets 被引量:9
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作者 Pengfei Zhang Lei Li +2 位作者 Li Lin Junhui Shi Lihong V.Wang 《Light(Science & Applications)》 SCIE EI CAS CSCD 2019年第1期884-892,共9页
Photoacoustic(PA)computed tomography(PACT)is a noninvasive hybrid imaging technique that combines optical excitation and acoustic detection to realize high contrast,high resolution,and deep penetration in biological t... Photoacoustic(PA)computed tomography(PACT)is a noninvasive hybrid imaging technique that combines optical excitation and acoustic detection to realize high contrast,high resolution,and deep penetration in biological tissues.However,the spatial resolution of PACT is limited by acoustic diffraction.Here,we report in vivo superresolution PACT,which breaks the acoustic diffraction limit by localizing the centers of single dyed droplets that are flowing in blood vessels.The droplets were prepared by dissolving hydrophobic absorbing dye in oil,followed by mixing with water.The dyed droplets generate much higher-amplitude PA signals than blood and can flow smoothly in vessels;thus,they are excellent tracers for localization-based superresolution imaging.The in vivo resolution enhancement was demonstrated by continuously imaging the cortical layer of a mouse brain during droplet injection.The droplets that were flowing in the vessels were localized,and their center positions were used to construct a superresolution image that exhibits sharper features and more finely resolved vascular details.An improvement in spatial resolution by a factor of 6 has been realized in vivo by the droplet localization technique. 展开更多
关键词 technique. RESOLUTION DYE
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Focusing light into scattering media with ultrasound-induced field perturbation 被引量:7
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作者 Zhongtao Cheng Lihong V.Wang 《Light(Science & Applications)》 SCIE EI CAS CSCD 2021年第9期1702-1713,共12页
Focusing light into scattering media,although challenging,is highly desirable in many realms.With the invention of time-reversed ultrasonically encoded(TRUE)optical focusing,acousto-optic modulation was demonstrated a... Focusing light into scattering media,although challenging,is highly desirable in many realms.With the invention of time-reversed ultrasonically encoded(TRUE)optical focusing,acousto-optic modulation was demonstrated as a promising guidestar mechanism for achieving noninvasive and addressable optical focusing into scattering media.Here,we report a new ultrasound-assisted technique,ultrasound-induced field perturbation optical focusing,abbreviated as UFP.Unlike in conventional TRUE optical focusing,where only the weak frequency-shifted first-order diffracted photons due to acousto-optic modulation are useful,here UFP leverages the brighter zeroth-order photons diffracted by an ultrasonic guidestar as information carriers to guide optical focusing.We find that the zeroth-order diffracted photons,although not frequency-shifted,do have a field perturbation caused by the existence of the ultrasonic guidestar.By detecting and time-reversing the differential field of the frequency-unshifted photons when the ultrasound is alternately ON and OFF,we can focus light to the position where the field perturbation occurs inside the scattering medium.We demonstrate here that UFP optical focusing has superior performance to conventional TRUE optical focusing,which benefits from the more intense zeroth-order photons.We further show that UFP optical focusing can be easily and flexibly developed into double-shot realization or even single-shot realization,which is desirable for high-speed wavefront shaping.This new method upsets conventional thinking on the utility of an ultrasonic guidestar and broadens the horizon of light control in scattering media.We hope that it provides a more efficient and flexible mechanism for implementing ultrasound-guided wavefront shaping. 展开更多
关键词 PERTURBATION MEDIA REALIZATION
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Harnessing a multi-dimensional fibre laser using genetic wavefront shaping 被引量:9
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作者 Xiaoming Wei Joseph C.Jing +1 位作者 Yuecheng Shen Lihong V.Wang 《Light(Science & Applications)》 SCIE EI CAS CSCD 2020年第1期593-602,共10页
The multi-dimensional laser is a fascinating platform not only for the discovery and understanding of new higherdimensional coherent lightwaves but also for the frontier study of the complex three-dimensional(3D)nonli... The multi-dimensional laser is a fascinating platform not only for the discovery and understanding of new higherdimensional coherent lightwaves but also for the frontier study of the complex three-dimensional(3D)nonlinear dynamics and solitary waves widely involved in physics,chemistry,biology and materials science.Systemically controlling coherent lightwave oscillation in multi-dimensional lasers,however,is challenging and has largely been unexplored;yet,it is crucial for both designing 3D coherent light fields and unveiling any underlying nonlinear complexities.Here,for the first time,we genetically harness a multi-dimensional fibre laser using intracavity wavefront shaping technology such that versatile lasing characteristics can be manipulated.We demonstrate that the output power,mode profile,optical spectrum and mode-locking operation can be genetically optimized by appropriately designing the objective function of the genetic algorithm.It is anticipated that this genetic and systematic intracavity control technology for multi-dimensional lasers will be an important step for obtaining high-performance 3D lasing and presents many possibilities for exploring multi-dimensional nonlinear dynamics and solitary waves that may enable new applications. 展开更多
关键词 FIBRE dimensional coherent
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Multifocal photoacoustic microscopy using a single-element ultrasonic transducer through an ergodic relay 被引量:6
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作者 Yang Li Terence T.W.Wong +2 位作者 Junhui Shi Hsun-Chia Hsu Lihong V.Wang 《Light(Science & Applications)》 SCIE EI CAS CSCD 2020年第1期717-723,共7页
Optical-resolution photoacoustic microscopy(OR-PAM)has demonstrated high-spatial-resolution imaging of optical absorption in biological tissue.To date,most OR-PAM systems rely on mechanical scanning with confocally al... Optical-resolution photoacoustic microscopy(OR-PAM)has demonstrated high-spatial-resolution imaging of optical absorption in biological tissue.To date,most OR-PAM systems rely on mechanical scanning with confocally aligned optical excitation and ultrasonic detection,limiting the wide-field imaging speed of these systems.Although several multifocal OR-PA(MFOR-PA)systems have attempted to address this limitation,they are hindered by the complex design in a constrained physical space.Here,we present a two-dimensional(2D)MFOR-PAM system that utilizes a 2D microlens array and an acoustic ergodic relay.Using a single-element ultrasonic transducer,this system can detect PA signals generated from 400 optical foci in parallel and then raster scan the optical foci patterns to form an MFOR-PAM image.This system improves the imaging resolution of an acoustic ergodic relay system from 220 to 13μm and enables 400-folds shorter scanning time than that of a conventional OR-PAM system at the same resolution and laser repetition rate.We demonstrated the imaging ability of the system with both in vitro and in vivo experiments. 展开更多
关键词 ELEMENT RESOLUTION utilize
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